CN101622337B - 用于与细胞扩增装置一起使用的一次性管道成套设备和无菌取样的方法 - Google Patents

用于与细胞扩增装置一起使用的一次性管道成套设备和无菌取样的方法 Download PDF

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Publication number
CN101622337B
CN101622337B CN2008800067945A CN200880006794A CN101622337B CN 101622337 B CN101622337 B CN 101622337B CN 2008800067945 A CN2008800067945 A CN 2008800067945A CN 200880006794 A CN200880006794 A CN 200880006794A CN 101622337 B CN101622337 B CN 101622337B
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China
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fluid
growth area
cellular growth
feed region
sample
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Expired - Fee Related
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CN2008800067945A
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English (en)
Chinese (zh)
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CN101622337A (zh
Inventor
G·D·安特韦勒
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Terumo BCT Inc
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Terumo BCT Inc
Gambro BCT Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/26—Inoculator or sampler
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/48—Holding appliances; Racks; Supports
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2008800067945A 2007-03-01 2008-01-28 用于与细胞扩增装置一起使用的一次性管道成套设备和无菌取样的方法 Expired - Fee Related CN101622337B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US89246007P 2007-03-01 2007-03-01
US60/892,460 2007-03-01
US97138207P 2007-09-11 2007-09-11
US60/971,382 2007-09-11
PCT/US2008/052185 WO2008109200A1 (en) 2007-03-01 2008-01-28 Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling

Publications (2)

Publication Number Publication Date
CN101622337A CN101622337A (zh) 2010-01-06
CN101622337B true CN101622337B (zh) 2013-04-24

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CN2008800067945A Expired - Fee Related CN101622337B (zh) 2007-03-01 2008-01-28 用于与细胞扩增装置一起使用的一次性管道成套设备和无菌取样的方法

Country Status (8)

Country Link
US (2) US7718430B2 (enExample)
EP (1) EP2115117A1 (enExample)
JP (1) JP5149313B2 (enExample)
KR (1) KR101440171B1 (enExample)
CN (1) CN101622337B (enExample)
AU (1) AU2008223280B2 (enExample)
CA (1) CA2679097C (enExample)
WO (1) WO2008109200A1 (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2115117A1 (en) * 2007-03-01 2009-11-11 CaridianBCT, Inc. Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling
EP2129764B1 (en) 2007-03-05 2018-10-10 Terumo BCT, Inc. Cell expansion system and methods of use
US20080220522A1 (en) * 2007-03-05 2008-09-11 Gambro Bct, Inc. Methods to Control Cell Movement in Hollow Fiber Bioreactors
US8999046B2 (en) 2008-10-27 2015-04-07 Terumo Bct, Inc. Air removal chamber for a cell expansion system and method of use associated therewith
US9284523B2 (en) * 2008-10-27 2016-03-15 Terumo Bct, Inc. Premounted fluid conveyance assembly for cell expansion system and method of use associated therewith
US8399245B2 (en) * 2009-02-18 2013-03-19 Terumo Bct, Inc. Rotation system for cell growth chamber of a cell expansion system and method of use therefor
CA2757538A1 (en) * 2009-04-03 2010-10-07 Xcellerex, Inc. Tissue and organ graft bioreactor and method of operation
GB0906836D0 (en) * 2009-04-21 2009-06-03 Cymtox Ltd Consumable component kit
WO2011090605A2 (en) * 2009-12-29 2011-07-28 Caridianbct, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
US8539672B2 (en) * 2010-10-01 2013-09-24 Zevex, Inc. Method for improving accuracy in a peristaltic pump system based on tubing material properties
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
WO2012168295A1 (en) 2011-06-06 2012-12-13 ReGenesys BVBA Expansion of stem cells in hollow fiber bioreactors
DE102012200938B4 (de) 2012-01-23 2016-08-18 Alpha Plan Gmbh Bio- und medizintechnisches Baukastensystem
US9175259B2 (en) * 2012-08-20 2015-11-03 Terumo Bct, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
JP2015526094A (ja) * 2012-08-20 2015-09-10 テルモ ビーシーティー、インコーポレーテッド 細胞成長チャンバーを循環する流体の成分を濃縮する方法
EP3068867B1 (en) 2013-11-16 2018-04-18 Terumo BCT, Inc. Expanding cells in a bioreactor
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
US10077421B2 (en) 2014-04-24 2018-09-18 Terumo Bct, Inc. Measuring flow rate
EP3198006B1 (en) 2014-09-26 2021-03-24 Terumo BCT, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CN105087380A (zh) * 2015-07-31 2015-11-25 南方医科大学珠江医院 大规模培养动物细胞的系统
GB201600315D0 (en) * 2015-08-13 2016-02-24 Gen Electric Heatseal sampling
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
CN115044471B (zh) 2016-08-27 2025-05-27 三维生物科技有限公司 生物反应器
EP3565883A1 (en) 2017-02-10 2019-11-13 Lonza Ltd Cell culture system and method
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
JP7393945B2 (ja) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
US10696961B2 (en) 2017-12-01 2020-06-30 Global Life Sciences Solutions Usa Llc Magnetic cell isolation techniques
US11932842B2 (en) 2018-02-09 2024-03-19 Global Life Sciences Solutions Usa Llc Bioprocessing apparatus
US11414639B2 (en) 2018-02-09 2022-08-16 Global Life Sciences Solutions Usa Llc Bioprocessing vessel
US12077743B2 (en) 2018-02-09 2024-09-03 Global Life Sciences Solutions Usa Llc Apparatus for fluid line management in a bioprocessing system
US11920119B2 (en) 2018-02-09 2024-03-05 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
SG11202007439TA (en) * 2018-02-09 2020-09-29 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
US11371007B2 (en) 2018-02-09 2022-06-28 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US12252682B2 (en) 2018-02-09 2025-03-18 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US10889792B2 (en) 2018-02-09 2021-01-12 Global Life Sciences Solutions Usa Llc Cell expansion vessel systems and methods
JP7225796B2 (ja) * 2018-12-27 2023-02-21 大日本印刷株式会社 サンプリング機能付き容器
JP7638277B2 (ja) * 2020-02-06 2025-03-03 テルモ株式会社 流路カセット、細胞培養キット及び細胞培養システム
GB202017182D0 (en) 2020-10-29 2020-12-16 Cytiva Sweden Ab Fluid coupling network for sampling a bioreactor
WO2023122133A1 (en) * 2021-12-22 2023-06-29 Pbs Biotech, Inc. Apparatus and methods for treating media in large-scale bioreactors
US12599710B2 (en) 2022-03-10 2026-04-14 Terumo Bct, Inc. Methods and interfaces for providing donation process feedback
US12653937B2 (en) 2022-03-10 2026-06-16 Terumo Bct, Inc. Apheresis system safety features
US12521474B2 (en) 2022-03-10 2026-01-13 Terumo Bct, Inc. Soft cassette with integrated features
US12691032B2 (en) 2022-03-10 2026-07-28 Terumo Bct, Inc. Bottle tray with magnetic coupling and load cell overload protection
US12379916B2 (en) 2022-03-10 2025-08-05 Terumo Bct, Inc. Communications and operation control of apheresis systems
US12458740B2 (en) 2022-03-10 2025-11-04 Terumo Bct, Inc. Modular serviceability sleds and interconnections
US12478551B2 (en) 2022-03-10 2025-11-25 Terumo Bct, Inc. Collection bottle with integrated cap, handle, and shield features
US20250304901A1 (en) * 2024-03-26 2025-10-02 Waters Technologies Corporation Pneumatic transfer of fluid samples over lengthy conduits

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002028996A1 (en) * 2000-10-02 2002-04-11 Cannon Thomas F Automated bioculture and bioculture experiments system
WO2002087491A1 (en) * 2001-04-27 2002-11-07 Baxter International Inc. Sealing apparatus and method
WO2006026835A1 (en) * 2004-09-10 2006-03-16 Unisearch Limited Device and method to prevent culture media degradation
WO2006119622A1 (en) * 2005-05-09 2006-11-16 Saxonia Biotec Gmbh. Apparatus for providing media to cell culture modules
US7198940B2 (en) * 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889812A (en) * 1986-05-12 1989-12-26 C. D. Medical, Inc. Bioreactor apparatus
JPH0576582A (ja) * 1991-09-20 1993-03-30 Hitachi Ltd マイクロ波滅菌方法、その滅菌装置及び培養システム
JP4837893B2 (ja) * 2001-12-10 2011-12-14 カリディアンビーシーティー、インコーポレーテッド 赤血球を白血球減少させる方法および装置
US8492140B2 (en) * 2002-04-08 2013-07-23 Octane Biotech Inc. Automated tissue engineering system
US20040009542A1 (en) * 2002-05-03 2004-01-15 Gambro, Inc. Apparatus and method for detecting bacteria in blood products
JP4668568B2 (ja) * 2003-08-26 2011-04-13 株式会社メディネット 培養容器、培養装置および細胞の培養方法
EP2115117A1 (en) 2007-03-01 2009-11-11 CaridianBCT, Inc. Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002028996A1 (en) * 2000-10-02 2002-04-11 Cannon Thomas F Automated bioculture and bioculture experiments system
US7198940B2 (en) * 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system
WO2002087491A1 (en) * 2001-04-27 2002-11-07 Baxter International Inc. Sealing apparatus and method
WO2006026835A1 (en) * 2004-09-10 2006-03-16 Unisearch Limited Device and method to prevent culture media degradation
WO2006119622A1 (en) * 2005-05-09 2006-11-16 Saxonia Biotec Gmbh. Apparatus for providing media to cell culture modules

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Publication number Publication date
WO2008109200A1 (en) 2008-09-12
US8163555B2 (en) 2012-04-24
CN101622337A (zh) 2010-01-06
JP2010519903A (ja) 2010-06-10
CA2679097A1 (en) 2008-09-12
KR20090121372A (ko) 2009-11-25
CA2679097C (en) 2015-04-28
AU2008223280A1 (en) 2008-09-12
US7718430B2 (en) 2010-05-18
KR101440171B1 (ko) 2014-09-15
US20100144037A1 (en) 2010-06-10
EP2115117A1 (en) 2009-11-11
JP5149313B2 (ja) 2013-02-20
US20080213894A1 (en) 2008-09-04
AU2008223280B2 (en) 2013-09-19

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Address after: American Colorado

Applicant after: TERUMO BCT, Inc.

Address before: American Colorado

Applicant before: GAMBRO BCT, Inc.

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Free format text: CORRECT: APPLICANT; FROM: GAMBRO BCT INC. TO: TERUMO BCT, INC.

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Granted publication date: 20130424

Termination date: 20190128