CN101601783A - The psoriatic Chinese medicine composition of a kind of treatment - Google Patents
The psoriatic Chinese medicine composition of a kind of treatment Download PDFInfo
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- CN101601783A CN101601783A CNA2009103025014A CN200910302501A CN101601783A CN 101601783 A CN101601783 A CN 101601783A CN A2009103025014 A CNA2009103025014 A CN A2009103025014A CN 200910302501 A CN200910302501 A CN 200910302501A CN 101601783 A CN101601783 A CN 101601783A
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Abstract
The invention discloses the psoriatic Chinese medicine composition of a kind of treatment, it is the medicament of being made by following bulk drugs thing: Flos Sophorae Immaturus 30-50, Herba Spirodelae 30-50, Fructus Xanthii 20-40, Herba Taraxaci 20-40, Radix Scrophulariae 18-30, Radix Scutellariae 12-18, Fructus Gardeniae 12-18, Rhizoma Osmundae 10-20, Cortex Phellodendri 9-18, Radix Saposhnikoviae 10-20, Radix Angelicae Sinensis 9-18, Radix Arnebiae (Radix Lithospermi) 9-18, Radix Glycyrrhizae 3-9.The psoriatic Chinese medicine composition of treatment of the present invention is based on traditional traditional Chinese medical science to psoriatic understanding and Therapeutic Principle, achieve with reference to modern pharmacological research, from motherland's medicine and pharmacology treasure-house, filter out have wind and heat dispersing, the medicament composing prescription of effect such as removing pathogenic heat from blood and toxic substance from the body, purging liver-fire, detoxifcation, nourishing YIN to lower pathogenic fire, nourishing blood to expel wind are moisturized forms, at the psoriatic cause of disease, the verification treatment, short term effect can not only be reached, and recurrence can also be prevented.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to the psoriatic Chinese medicine composition of a kind of treatment.
Background technology
Psoriasis is one of common refractory skin of department of dermatologry, and the traditional Chinese medical science is called " psoriasis ", is a kind of dermatosis that seriously jeopardizes human health.The evident characteristic that this is sick, be exactly that circular or polygonal inflammatory pimple or the maculopapule of pin medicated cap head to the Seem Lablab Album size arranged on the skin, be distinctive pale red, boundary is obvious, the silvery white squama of surface-coated multilamellar, slight blush is arranged on every side, divest squama and can expose semitransparent thin film, divest this film and little petechia then occurs, be called Auspitz's sign, erythra can constantly enlarge and increase, even merges in flakes.The patient is conscious not degree pruritus, goes into Night Watch very, and that scratches does not know pain, and during anxious state of mind, pruritus is aggravated thereupon.The back skin majority of scratching has the part to disturb to grab the blood crusts of friction, often disturbs to grab to form the skin lichenization, and pachyderma is dried to storiform, with desquamation, scratches and more itches, and skin lesion increases the weight of, the formation vicious cycle.But psoriasis spontaneous remission in long-term process, but easily recurrence after repeatedly worsening repeatedly, joint symptom, pustular psoriasis and erythroderma psoriaticum can occur.
Still not exclusively clear and definite to psoriatic etiology and pathology, pathogenesis at present, think that mostly heredity, dysbolismus, infection, immune dysfunction etc. may be the key factor of morbidity, seasonal variations, humidity, psychic trauma or operation etc. also may be brought out primary disease.
At present psoriasis still there is not specific short, the local topical medicine has keratoplastics, corticosteroid cream etc., the systemic administration thing has immunosuppressant, retinoic acid, antibiotic, corticosteroid etc., these medicinal applications are proper, to psoriasis short term effect preferably can be arranged, but the prolonged application side effect is big, the price height, be difficult for being accepted, and relapse rate is higher by the patient.The traditional Chinese medical science is controlled by dialectical opinion, the treatment psoriasis has certain advantage, but can't popularize, also there are some to treat psoriatic Chinese medicine pill or ointment, as FUFANG QINGDAI WAN, YUJIN YINXIE PIAN, Radix Salviae Miltiorrhizae Tabellae, Radix Tripterygii Wilfordii tablet etc., to the treatment psoriasis certain curative effect is all arranged, but often the course of treatment longer, cure rate is low.Present this disease of integrative therapy is the definite medicine of inefficacy still.
Summary of the invention
Purpose of the present invention provides a kind of determined curative effect, cure rate height, the psoriatic Chinese medicine composition of treatment that relapse rate is low.
To achieve these goals, the invention provides following technical scheme:
The psoriatic Chinese medicine composition of a kind of treatment is characterized in that it is the medicament of being made by following bulk drugs thing:
Flos Sophorae Immaturus 30-50, Herba Spirodelae 30-50, Fructus Xanthii 20-40, Herba Taraxaci 20-40, Radix Scrophulariae 18-30, Radix Scutellariae 12-18, Fructus Gardeniae 12-18, Rhizoma Osmundae 10-20, Cortex Phellodendri 9-18, Radix Saposhnikoviae 10-20, Radix Angelicae Sinensis 9-18, Radix Arnebiae (Radix Lithospermi) 9-18, Radix Glycyrrhizae 3-9.
Preferably, the psoriatic Chinese medicine composition of treatment of the present invention is made by following bulk drugs thing:
The Flos Sophorae Immaturus 40, Herba Spirodelae 40, Fructus Xanthii 30, Herba Taraxaci 30, Radix Scrophulariae 24, Radix Scutellariae 15, Fructus Gardeniae 15, Rhizoma Osmundae 15, Cortex Phellodendri 12, Radix Saposhnikoviae 15, Radix Angelicae Sinensis 12, Radix Arnebiae (Radix Lithospermi) 12, Radix Glycyrrhizae 6.
The psoriatic Chinese medicine composition of treatment of the present invention can be prepared into various peroral dosage forms, as capsule, pill, electuary, tablet etc.
Psoriasis is under the effect of some extraneous bad stimulations such as infection, wound, medicine, stress etc., cause the unusual of immunity of organism adjusting disorder and various metabolism aspect, cause vasodilation hyperemia in the skin, endotheliosis, periangiitis disease cellular infiltration, discharge multiple deleterious inflammatory mediator, induce epidermal cell proliferation excessively, poorly differentiated and form a kind of dermatosis of skin lesion.Motherland's medical science is thought, the psoriatic cause of disease causes from the beginning of the heresy retardance skin or the external mechanical stimulus that mostly are rheumatic fever, the sick impairment of YIN of consumption for a long time liquid, nutrient QI and blood being insufficient, blood-deficiency leading to hyperactivity of the liver, give birth to dry humorously, skin loses and moistens fosterly, and the local skin that pimple plumpness in blocks, drying, desquamation, shape such as cattle neck occur is as feelings will uneasiness, hypertonicity, worried worried person, easier inducing, and many recurrences.So the suitable wind and heat dispersing of treatment, eliminating fire and detoxication, dampness removing treatment skin ulcer, removing heat from blood rash, nourishing YIN to lower pathogenic fire, nourishing blood to expel wind are moisturized.
The Flos Sophorae Immaturus is the alabastrum of pulse family deciduous tree Chinese scholartree Sophora japonica L. in the prescription, has heat clearing away, removing heat from blood, hemostasis, the effect of purging liver-fire.Diseases such as saturating, the wind heat pain rash of the hot carbuncle of row, macule, skin pruritus, skin ulcer tinea, erysipelas, scald when curing mainly.The Chinese medicine modern study shows, mainly contain rutin in the Flos Sophorae Immaturus, Flos Sophorae first element, the second element, third element, compositions such as tannin, its main effective ingredient rutin and aglycon quercetin thereof have antiinflammatory, antimicrobial effect, can keep the normal resistance of blood capillary, reduce vascular permeability, can make because of fragility increases hemorrhage blood capillary and recover normal elasticity, has antiinflammatory, antibacterial action, to rat because of histamine, Ovum Gallus domesticus album, 5-hydroxy tryptamine, formaldehyde, the claw edema that periston-N causes, and hot-tempered edema of foot that hyaluronidase causes has inhibitory action, some antibacterial there is antibacterial action in vitro, to virus, fungus is also performance inhibition in vitro.The clinical psoriasis that is used for the treatment of has curative effect preferably: get the Flos Sophorae parching to brown and be ground into fine powder, each 1 money, is used warm water delivery service after meal at every day 2 times.It is for oral administration also Flos Sophorae can be made honeyed pill, and dosage is the same.Clinical observation 53 examples, 6 examples of fully recovering, marked improvement 22 examples, progressive 19 examples, invalid 6 examples.
Herba Spirodelae is the herb of plant and of its applications duckweed spirodela Spirodela polyrr-hiza Schleid. or blue or green duckweed Lemna minor L..Effect with relieving the exterior syndrome by diaphoresis, heat-clearing and toxic substances removing, inducing diuresis to remove edema; Cure mainly exterior syndrome lossless, the time diseases such as row hot carbuncle, macule saturating, wind heat pain rash, skin pruritus, edema, amenorrhea, skin ulcer tinea, erysipelas, scald.Modern pharmacy studies show that Herba Spirodelae contains materials such as red grass element, vitexin, apiose, reseda flavin, potassium acetate, potassium chloride, iodine, bromine.Pharmacological research shows Herba Spirodelae decoct and preserved material, and oral administration gives to prove refrigeration function because of injecting the rabbit that the typhoid fever mixed vaccine generates heat.
Fructus Xanthii is the fruit of the drying and ripening band involucre of feverfew Herba Xanthii Xanthium sibiricum Patr..Have dispersing wind and cold, clearing the nasal passage, wind-damp dispelling, itching relieving effect; Cure mainly diseases such as headche due to wind-cold, nasal sinusitis watery nasal discharge, rubella pruritus, arthralgia chiefly caused by damp pathogen contracture, deep abscess, leprosy, scabies, skin eczema.Modern pharmacy studies show that and contains Xanthostrumarin, alkaloid, vitamin C and pigment, fatty wet goods composition in the Fructus Xanthii.Pharmacological research shows that Fructus Xanthii has antiinflammatory action, and diterpene hydroxy acid potassium atractylate shows that through the test of rat carrageenan edema antiinflammatory action is arranged.The Fructus Xanthii decoct has some bacteriostasis external to staphylococcus aureus, and its acetone or alcohol extract also has bacteriostasis external to trichophyton.
Herba Taraxaci is the whole herb with root for Compositae herbaceos perennial Herba Taraxaci Taraxacum monggolicum Hand.-Mazz. and multiple congener thereof.Have heat-clearing and toxic substances removing, resolving carbuncle and expulsing boil, effect that dampness removing is treating stranguria; Cure mainly the carbuncle furunculosis, acute mastitis abscess of internal organ, conjunctival congestion and swelling pain, venom; Damp invasion of lower energizer, the puckery pain of pyretic stranguria; Jaundice due to damp-heat; The also available back galactostasis etc. of managing property.Modern medicine study shows, contains compositions such as taraxasterol, choline, taraxacin, caffeic acid, choline, inulin in the Herba Taraxaci plant.Herba Taraxaci has antibacterial action, and staphylococcus aureus, Hemolytic streptococcus are had stronger inhibitory action; Streptococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, Bacillus proteus, dysentery bacterium, Bacillus typhi and micrococcus catarrhalis etc. there is certain inhibitory action; In addition, still have function of gallbladder promoting, protect the liver, diuresis, be good for the stomach and laxative effective.Decoct also has the effect of excitating organism immunologic function.
Radix Scrophulariae is the dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl..Effect with clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing cures mainly pathogenic warmth join the army, cave in pericardium, maculae caused by violent heat pathogen, consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin and hinders diseases such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.Radix Scrophulariae mainly contains iridoids, the plain glycoside of phenylpropyl alcohol, still contains plant sterol, organic acid, flavonoid, triterpene saponin, volatile oil, saccharide, the monoterpene of alkaloid and trace and two terpene components etc.Pharmacological testing studies show that Radix Scrophulariae has antiinflammatory, antibacterial action, Oleum Tiglii is caused inflammation cause the swelling of mice auricular concha, and Ovum Gallus domesticus album, carrageenin and cobra venom are induced and caused the swelling of rat toes, and the granulomatous formation of mice all has the obvious suppression effect; The inhibitory effect of Radix Scrophulariae leaf is stronger, and is effective to staphylococcus aureus especially.The immunologic function that Harper ester glycosides subcutaneous injection can make deficiency of YIN mice suppress in the Radix Scrophulariae is recovered in addition, has immune-enhancing activity; The plain glycosides of phenylpropyl alcohol also has hepatoprotective effect in the Radix Scrophulariae.
Radix Scutellariae is the root of Labiatae herbaceos perennial Radix Scutellariae Scutellaria baicalensis georgi.Radix Scutellariae has heat clearing and damp drying, eliminating fire and detoxication, cooling blood for hemostasis, the antiabortive effect of heat extraction; Cure mainly that hygropyrexia fever disease in summer, damp and hot painful abdominal mass are vexed, jaundice dysentery, cough due to lung-heat, calentura excessive thirst, carbuncle sore tumefacting virus, laryngopharynx swelling and pain, heat in blood tell diseases such as nosebleed, excessive fetal movement due to heat in pregnancy.Contain noroxylin, baicalin, wogonin, wogonoside, neobaicalein, benzoic acid, β-sitoesterol etc. in the Radix Scutellariae.Modern pharmacological research shows, that Radix Scutellariae has is antibiotic, antiviral, antifungal, antiinflammatory, anti-allergic effects, the Radix Scutellariae decoct has inhibitory action to multiple coccus, bacillus, drug-fast staphylococcus aureus, influenza virus, dermatophytes, baicalin and baicalin animal experiment can suppress allergic inflammation and ooze out, reduce capillary permeability, antihistaminic and anti-acetylcholine effect are arranged.In addition, analgesic in addition, blood pressure lowering, function of gallbladder promoting of Radix Scutellariae, protect the liver, reduce functions such as capillary permeability.
Fructus Gardeniae is the mature fruit of Rubiaceae evergreen shrubs plant fruitlet Fructus Gardeniae Gardeniajasminoides Fllis.Effect with pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body cures mainly calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quenches one's thirst, conjunctival congestion, pharyngalgia, haematemesis, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains disease such as swell and ache.Contain effective ingredient such as gardenin, jasminoidin, geniposide and crocin, crocetin, ursolic acid in the Fructus Gardeniae.Pharmacological testing studies show that, jasminoidin has antiinflammatory, analgesic, function of gallbladder promoting and laxative effective, and its geniposide is the main component of antiinflammatory and treatment soft tissue injury; Chlorogenic acid is a main organic acid ester composition in the Fructus Gardeniae, has significant anti-inflammatory activity; But ursolic acid enhancing body's immunological function.The Fructus Gardeniae infusion can suppress various dermatophytess external, then can kill leptospira and schistosomicide external, and have the effect of anti-echovirus, and can obviously suppress the mice auricular concha inflammation due to the Oleum Tiglii, reduce acetic acid induced mice abdominal cavity capillary permeability.But Fructus Gardeniae ethanol extract both early stage edema of inflammation-inhibiting and oozing out under test dose, but the hamartoplasia in inflammation-inhibiting late period and the formation of granulation tissue again, and the inhibitory action that the inhibitory action that the middle and advanced stage granulation tissue forms is better than early stage edema and oozes out.
Cortex Phellodendri is the dry bark of rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phellodendronamurense Rupr..Cortex Phellodendri has heat clearing and damp drying, pathogenic fire purging removes and steams, detoxifies and treat the effect of skin ulcer, nourishing YIN to lower pathogenic fire; Cure mainly diseases such as damp-heat dysentery, jaundice, sore swollen toxin, eczema pruritus, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, hyperactivity of fire caused by deficiency of YIN.Cortex Phellodendri contains effective ingredient such as berberine, phellodendrine, obacunone, obakulactone.Pharmacological research shows, that Cortex Phellodendri has is antibiotic, antifungal, antiulcer action, and multiple malignant bacterias such as dysentery bacterium, Bacillus typhi, tubercule bacillus, staphylococcus aureus, Hemolytic streptococcus are all had inhibitory action; Some dermatophytes also there is inhibitory action; This external enwergy enhancing human body immunity function has the mouse antibodies of promotion nucleus formation; And platelet had protective effect, external can impel the absorption of subcutaneous oozing of blood.
Rhizoma Osmundae is rhizome such as Dryopteridaceae plant dryopteris crassirhizoma Dryopteris crassirhizoma Nakai, Athyriaceae plant lunathyrium acrostichoidesChing Lunathyrium acrostichoides (Sw.) Ching.Have heat-clearing and toxic substances removing, cooling blood for hemostasis, parasiticidal effect; Cure mainly seasonal pathogen sense, partial heat person, heating is heavy, aversion to cold is light, headache, pharynx are red, pharyngeal swelling, xerostomia and thirsty, red tongue, white and thin fur, floating pulse person.Rhizoma Osmundae contains green albaspidin Bp.PP (margaspidinBP.PP), Filixic Acids, white albaspidin, flavaspidic acid.Rhizoma Osmundae has anthelmintic, antiviral, effect such as antibiotic.
Radix Saposhnikoviae is the dry root of samphire Saposhnikovia divaricata (Turcz.) Schischk..Effect with expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion cures mainly diseases such as diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.It is main long-chain fat that windproof garment will contain 3-O-Radix Angelicae Sinensis acyl hamaudol, 5-O-methyl tooth A Mi alcohol, cupreol, mannitol and lignoceric acid, still contains volatile oil, peucedanin and chromogen ketoside etc.Pharmacological evaluation shows, analgesic, antimicrobial effect that Radix Saposhnikoviae has, and to the artificial fever rabbit, per os gives RADIX SAPOSHINOKOVIAE from Northeast decoct or preserved material, and the trivial solution heat effect is arranged; The Radix Saposhnikoviae press liquor has certain antibacterial action in vitro tests to bacillus pyocyaneus and staphylococcus aureus.
When the root that is classified as umbelliferae angelica Angelica sinensis (Oliv.) Diels.Radix Angelicae Sinensis have enrich blood invigorate blood circulation, the effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation, cure mainly diseases such as blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis contains Rhizoma Ligustici lactone, n-butene acyl lactone, ferulic acid, nicotinic acid, polysaccharide and several amino acids, and composition such as sesquiterpenoids.Pharmacological experiment study shows, Radix Angelicae Sinensis have antiinflammatory, antibiotic, promote effects such as substance metabolism, enhancing immunity.Radix Angelicae Sinensis can obviously suppress production of antibodies, can significantly strengthen the animal phagocytosis of macrophages, improves the clean up speed of reticuloendothelial system to dyestuff.The Radix Angelicae Sinensis aqueous extract can reduce vascular permeability, can significantly reduce the content of PGE2 in the inflammatory tissue, the complement bypass hemolytic activity had the obvious suppression effect, cott on pellet-induced granuloma formation is had the obvious suppression effect, and the acute and chronic inflammation that 1% carrageenin, 2.5% formaldehyde, 3 kinds of proinflammatory agents of fresh Ovum Gallus domesticus album are caused all has significant inhibitory effect; Radix Angelicae Sinensis all has antibacterial action to external dysentery, typhoid fever, paratyphoid fever, escherichia coli, diphtheria corynebacterium, vibrio cholera and a, β Hemolytic streptococcus etc., can quicken wound healing, contrafluxion, leukocyte and fiber are soaked into, newborn epithelium regeneration has hemostasis and strengthens the tip Circulation local organization.
Radix Arnebiae (Radix Lithospermi) is the root of comfrey Radix Arnebiae (Radix Lithospermi) (gromwell root) (Lithosper-mum erythorhizon sieb.et zucc.) and lithospermum euchromum Royle (Radix Arnebiae) [Arnebia euchro ma (Royle) Johnst.].Radix Arnebiae (Radix Lithospermi) has the effect of removing heat from blood and promoting blood circulation, heat-clearing and toxic substances removing, rash, laxation relieving constipation, cures mainly diseases such as the heat in blood poison is contained, the macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Contain acetylshikonin, beta-hydroxyisovalerylshiderivative, shikonin, β in the Radix Arnebiae (Radix Lithospermi), β '-compositions such as dimethylacrylshikonin, have the effect of resisting pathogenic microbes: Radix Arnebiae (Radix Lithospermi) all has inhibitory action to the 68-1 of capital section virus, staphylococcus aureus, escherichia coli, Bacillus typhi, dysentery bacterium and bacillus pyocyaneus acrothesium floccosum, ulotrichy microspore's tinea bacterium; Can suppress hyperfunction, the subcutaneous granuloma induced by implantation of cotton pellets hypertrophy of inhibition of capillary permeability, hyperfunction to the acute vascular permeability of phase that oozes out of inflammation, oozing out with edema and propagation phase inflammation all has antagonism.
Radix Glycyrrhizae is glycyrrhizic legume Glycyrrhiza uralensis Fisch., the root and rhizome of Glycyrrhiza inflata Bat. G.inflata Bat. or Glycyrrhiza glabra L. G.glabra L..Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription effect; Cure mainly diseases such as the anxious pain of weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, but cushion toxicity, strong also.The main compositions such as triterpene saponin, flavone, glycyrrhizin, glycyrrhizic acid, enoxolone that contain in the Radix Glycyrrhizae.Modern pharmacological research confirms that glycyrol extract and enoxolone, liquorice flavonoids compound are to having inhibitory action to staphylococcus aureus, bacillus subtilis, yeast, fungus, streptococcus etc.Radix Glycyrrhizae glucosan energy enhancing human body immunity function has the activationa and proliferation effect to mouse spleen lymphocyte, shows and causes the mitogen characteristic, has share synergism with ConA.Radix Glycyrrhizae has 17-hydroxy-11-dehydrocorticosterone sample antiinflammatory action, to mice chemical auricle edema, abdominal cavity capillary permeability increase, rat granuloma is swollen, formaldehyde rat paw edema, chondrus ocellatus Holmes colloidality rat arthritis etc. all have inhibitory action.
The psoriatic Chinese medicine composition of treatment of the present invention is based on traditional traditional Chinese medical science to psoriatic understanding and Therapeutic Principle, achieve with reference to modern pharmacological research, from motherland's medicine and pharmacology treasure-house, filter out have wind and heat dispersing, the medicament composing prescription of effect such as removing pathogenic heat from blood and toxic substance from the body, purging liver-fire, detoxifcation, nourishing YIN to lower pathogenic fire, nourishing blood to expel wind are moisturized forms, at the psoriatic cause of disease, the verification treatment, short term effect can not only be reached, and recurrence can also be prevented.
Through clinical practice for many years, show that the psoriatic Chinese medicine composition of treatment of the present invention has definite curative effect, cure rate height, relapse rate are low.
The specific embodiment
The present invention is described in further detail below in conjunction with specific embodiment.
Embodiment 1
The psoriatic Chinese medicine composition of the treatment of present embodiment, be the concentrated pill made by following bulk drugs thing (unit of material medicine: kg):
The Flos Sophorae Immaturus 4, Herba Spirodelae 4, Fructus Xanthii 3, Herba Taraxaci 3, Radix Scrophulariae 2.4, Radix Scutellariae 1.5, Fructus Gardeniae 1.5, Rhizoma Osmundae 1.5, Cortex Phellodendri 1.2, Radix Saposhnikoviae 1.5, Radix Angelicae Sinensis 1.2, Radix Arnebiae (Radix Lithospermi) 1.2, Radix Glycyrrhizae 0.6.
The psoriatic Chinese medicine composition of the described treatment of present embodiment is prepared in accordance with the following methods:
(1) weighting raw materials thing is by weight ratio pulverized together, crosses 80 mesh sieves, with 60% soak with ethanol of 5 times of injection volumes 30 minutes, and reflux, extract, effective ingredient 3 times, each 1 hour, merge extractive liquid,, filtration;
(2) step (1) effective ingredient of carrying is merged, adds starch, dextrin is made graininess, through screening, dry to moisture be not more than 9%, sterilization, packing get concentrated pill, the heavy 1g of per 78 balls.The instructions of taking of this concentrated pill is: oral, and a 1g, 3 times on the one.
Embodiment 2
The psoriatic Chinese medicine composition of the treatment of present embodiment, be the tablet made by following bulk drugs thing (unit of material medicine: kg):
The Flos Sophorae Immaturus 3, Herba Spirodelae 5, Fructus Xanthii 4, Herba Taraxaci 2, Radix Scrophulariae 1.8, Radix Scutellariae 1.2, Fructus Gardeniae 1.8, Rhizoma Osmundae 2, Cortex Phellodendri 0.9, Radix Saposhnikoviae 1, Radix Angelicae Sinensis 1.8, Radix Arnebiae (Radix Lithospermi) 0.9, Radix Glycyrrhizae 0.3.
The psoriatic Chinese medicine composition of the described treatment of present embodiment is prepared in accordance with the following methods:
(1) weighting raw materials thing is by weight ratio pulverized together, crosses 80 mesh sieves, with 60% soak with ethanol of 5 times of injection volumes 30 minutes, and reflux, extract, effective ingredient 3 times, each 1 hour, merge extractive liquid,, filtration;
(2) step (1) effective ingredient of carrying is merged, be condensed into thick paste, add starch, dextrin is made tablet, drying to moisture is not more than 9%, sterilization, packing get tablet, and every contains dry extract 0.5g.The instructions of taking of this tablet is: oral, and a 1g, 3 times on the one.
Embodiment 3
The psoriatic Chinese medicine composition of the treatment of present embodiment, be the capsule made by following bulk drugs thing (unit of material medicine: kg):
The Flos Sophorae Immaturus 5, Herba Spirodelae 3, Fructus Xanthii 2, Herba Taraxaci 4, Radix Scrophulariae 3, Radix Scutellariae 1.8, Fructus Gardeniae 1.2, Rhizoma Osmundae 1, Cortex Phellodendri 1.8, Radix Saposhnikoviae 2, Radix Angelicae Sinensis 0.9, Radix Arnebiae (Radix Lithospermi) 1.8, Radix Glycyrrhizae 0.9.
The psoriatic Chinese medicine composition of the described treatment of present embodiment is prepared in accordance with the following methods:
(1) weighting raw materials thing is by weight ratio pulverized together, crosses 80 mesh sieves, with the water logging bubble of 8 times of injection volumes 30 minutes, and reflux, extract, effective ingredient 3 times, each 1 hour, merge extractive liquid,, filtration;
(2) step (1) effective ingredient of carrying is merged, is condensed into thick paste, dry to moisture be not more than 9%, sterilization, fill capsule, packing get capsule, every contains dry extract 0.5g.The instructions of taking of this capsule is: oral, and a 1g, 3 times on the one.
The clinical observation example
Further specify beneficial effect of the present invention below in conjunction with the clinical observation example:
Selecting the age is that the 60 routine patients in 15-70 year carry out systematic observation, male's 35 examples wherein, women's 25 examples in the stadium 3-10 anniversary, have the inflammatory pimple or the maculopapule that come in every shape on most patient skins, the silvery white squama of surface-coated multilamellar, blush is arranged on every side, divest squama and can expose semitransparent thin film, erythra to be merged in flakes, the skin lichenization is with desquamation.The patient is conscious pruritus in various degree, goes into Night Watch very, and that scratches does not know pain, and during anxious state of mind, pruritus is aggravated thereupon.Take the psoriatic capsule of treatment of the embodiment of the invention 3 to the object of observation, instructions of taking is: 2g/ time, and day clothes 3 times, ante cibum, boiled water was taken after mixing it with water, and 1 month was 1 course of treatment, took 3 courses of treatment continuously.
Followed up a case by regular visits to 1 year through outpatient service after 3 months observation period, the statistical observation result, following up a case by regular visits to 1 year erythra all disappears, leave pigmentation spots or go down speckle for the recovery from illness, follow up a case by regular visits to deflorescence in a year and be produce effects more than 75%, following up a case by regular visits to deflorescence in a year is that effectively it is invalid following up a case by regular visits to 1 year deflorescence less than 50% and newborn erythra is arranged more than 50%.Through 1 year with examining statistics, 24 examples of fully recovering account for 40%; Produce effects 27 examples account for 45%; Effective 7 examples account for 11.6%; Invalid 2 examples account for 3.3%.Total effective rate reaches 96.6%.
Model case
Example 1
The king so-and-so, man 56 years old went to a doctor on May 7th, 2005, had during prescription on individual diagnosis surplus the psoriasis medical history 10 year, fail to respond to any medical treatment in many places, many places inflammatory pimple or maculopapule are arranged on the patient skin during prescription on individual diagnosis, and the silvery white squama of surface-coated multilamellar has blush on every side, divest squama and can expose semitransparent thin film, erythra to be merged in flakes, and the skin lichenization is with desquamation.The patient is conscious not degree pruritus, goes into Night Watch very, and that scratches does not know pain, and during anxious state of mind, pruritus is aggravated thereupon.
Example 2
High so-and-so, man 22 years old, suffer from psoriasis during prescription on individual diagnosis more than 3 years, come to go to a doctor, see general property proliferative psoriasis during prescription on individual diagnosis on June 10th, 2006, shank, forearm, after the large stretch of strong plumpness skin lesion of 30 * 40cm of having broken an agreement cover greasy scales, very itch, once took immunosuppressant, recurrence again behind the cured substances such as hormone.Take the psoriatic capsule of treatment to it, shared three courses of treatment, outpatient service is followed up a case by regular visits to, so far not recurrence.
Example 3
The marquis so-and-so, man 56 years old suffered from psoriasis nearly 10 years during prescription on individual diagnosis, examine on July 10th, 2007, disease is seen: extremity and trunk all have many places inflammatory pimple or maculopapule, and be big little of the monobasic coin as palm, get up morning from saying, can tremble white scales one crust from sheet, substrate is rubescent, and that scratches goes out purple dark blood, pruritus very not, in many ways seek medical advice, again and again, very painful.Take the psoriatic capsule of treatment to it, shared three courses of treatment, outpatient service is followed up a case by regular visits to, so far not recurrence.
Example 4
Deng, the man, 30 years old, it was surplus to suffer from psoriasis 2 years during prescription on individual diagnosis, examines on April 10th, 2007, and the conscious pruritus of patient is unbearably.Disease is seen: many places, extremity many places lichen sample pimple or maculopapule, and surface-coated squama has blush on every side, and the part has disturbs the blood crusts of grabbing friction.Take the psoriatic capsule of treatment to it, take the conscious pruritus in a week back and obviously alleviate the first of the white that drops after having a bath.Take after three months and do not itch fully, the red marking is only stayed at lichen sample maculopapule place.Take that redness slowly just reverts to the white marking after three months, the marking of last white also slowly disappears.Outpatient service is followed up a case by regular visits to, not recurrence in 2 years.
Claims (3)
1. treat psoriatic Chinese medicine composition for one kind, it is characterized in that it is the medicament of being made by following bulk drugs thing:
Flos Sophorae Immaturus 30-50, Herba Spirodelae 30-50, Fructus Xanthii 20-40, Herba Taraxaci 20-40, Radix Scrophulariae 18-30, Radix Scutellariae 12-18, Fructus Gardeniae 12-18, Rhizoma Osmundae 10-20, Cortex Phellodendri 9-18, Radix Saposhnikoviae 10-20, Radix Angelicae Sinensis 9-18, Radix Arnebiae (Radix Lithospermi) 9-18, Radix Glycyrrhizae 3-9.
2. the psoriatic Chinese medicine composition of treatment according to claim 1 is characterized in that it is the medicament of being made by following bulk drugs thing:
The Flos Sophorae Immaturus 40, Herba Spirodelae 40, Fructus Xanthii 30, Herba Taraxaci 30, Radix Scrophulariae 24, Radix Scutellariae 15, Fructus Gardeniae 15, Rhizoma Osmundae 15, Cortex Phellodendri 12, Radix Saposhnikoviae 15, Radix Angelicae Sinensis 12, Radix Arnebiae (Radix Lithospermi) 12, Radix Glycyrrhizae 6.
3. the psoriatic Chinese medicine composition of treatment according to claim 1 and 2 is characterized in that described medicament is capsule, pill, electuary or tablet.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579917A (en) * | 2012-03-16 | 2012-07-18 | 刘洪普 | Traditional Chinese medicine for treating psoriasis |
| CN114869902A (en) * | 2022-05-09 | 2022-08-09 | 黑龙江中医药大学 | Pharmaceutical composition containing tretinoin and geniposide for treating psoriasis |
-
2009
- 2009-05-21 CN CNA2009103025014A patent/CN101601783A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579917A (en) * | 2012-03-16 | 2012-07-18 | 刘洪普 | Traditional Chinese medicine for treating psoriasis |
| CN114869902A (en) * | 2022-05-09 | 2022-08-09 | 黑龙江中医药大学 | Pharmaceutical composition containing tretinoin and geniposide for treating psoriasis |
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