CN101595876A - A kind of bactericidal composition that contains bromothalonil and Fluoxastrobin - Google Patents
A kind of bactericidal composition that contains bromothalonil and Fluoxastrobin Download PDFInfo
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- CN101595876A CN101595876A CNA2009100233119A CN200910023311A CN101595876A CN 101595876 A CN101595876 A CN 101595876A CN A2009100233119 A CNA2009100233119 A CN A2009100233119A CN 200910023311 A CN200910023311 A CN 200910023311A CN 101595876 A CN101595876 A CN 101595876A
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- bromothalonil
- fluoxastrobin
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Abstract
The present invention relates to a kind of microbicide compositions, its active ingredient contains bromothalonil and Fluoxastrobin, wherein the percentage by weight of bromothalonil and Fluoxastrobin is 1～40: 1～20, composition is used to prevent and treat the multiple diseases on fruit tree and the vegetable crop, be particularly useful for preventing and treating anthracnose, its preventive effect obviously is better than its single agent and uses.
Description
Technical field:
The invention belongs to technical field of pesticide, relate to the control that a kind of bactericidal composition that contains bromothalonil and Fluoxastrobin is used for disease on fruit tree or the vegetables.
Technical background:
Bromothalonil, English name are (bromothalonil), and chemical name is 2-bromo-2 bromomethyl glutaronitriles, and structural formula is:
The former medicine of bromothalonil belongs to the low toxicity bactericide by Chinese pesticide toxicity grading criteria, is a kind of wide spectrum, bactericide efficiently, can suppress and root out fungi, bacterium, algae grows, and corps diseases is had the better prevention effect, and anthracnose is had special efficacy.Be widely used in various crop such as fruit tree, grape, vegetables, cotton, peanut, watermelon, tobacco, tea tree, flowers, prevent and treat multiple fungoid, bacteroidal diseases such as anthracnose, scab, shot hole, powdery mildew, rust, damping off, damping off, root stem rot, canker, bacterial wilt, angular leaf spot.Application mode is flexible, and foliar spray, seed treatment and soil are irritated root, all show preventive effect preferably.
Fluoxastrobin English name (azoxystrobin), chemical formula is: (E)-and 2-{2-[6 (2-cyano-benzene oxygen) pyrimidine-4-base oxygen] phenyl }-the 3-methoxy acrylate, molecular formula: C
22H
17N
3O
5
Structural formula is:
Fluoxastrobin is new and effective bactericide, has protection, treats, roots out, infiltration, systemic activity.Be the methoxy acrylic bactericide of Syngenta Co.,Ltd's exploitation, belong to the mitochondrial respiratory inhibitor, promptly pass through at cytochrome b and c
1Between electronics shift to suppress mitochondrial breathing.Extranuclear mitochondria mainly by breathing to cell provides energy (ATP), if mitochondrial respiratory is obstructed, can not produce ATP, and cell will be dead.The bactericide that acts on mitochondrial respiratory is more, but the position of methoxy acrylic ester compounds effect was with all bactericide were all different in the past, and the bacterial strain of therefore preventing and treating sterol inhibitor, phenylamide, dicarboxylic dihydrazides amine and benzimidazole generation resistance is effective.
On the one hand, the use of organic solvent on agricultural chemicals is restricted day by day, and need not or lack with organic solvent has been the inexorable trend of agricultural chemicals development as far as possible.The formulation of agricultural chemicals needs constantly to upgrade, thereby impels agricultural chemicals to develop along the good direction of efficient, low toxicity, safety and Environmental compatibility.The formulation of the present composition is micro-emulsion type or emulsion type, can effectively overcome existing problem, has become one of dominant direction of formulations of pesticide development.On the other hand, the single agent of long-term use makes plant disease develop immunity to drugs easily and can not reach therapeutic purposes, adopts composite bactericidal composition can obviously improve control and result of treatment, has reduced the usage amount of agricultural chemicals, reduce cost, become the important means of the various diseases of integrated control.
Have not yet to see the relevant report of the composite product of bromothalonil and Fluoxastrobin.
Summary of the invention
The present invention has overcome prior art cost height, big for environment pollution, problems such as safety is unsecured, storing inconvenience, research and develop a kind of formulations of pesticide developing direction of complying with, microemulsion or aqueous emulsion that cost is low, be difficult for producing poisoning, have no adverse effects to people, animal, environment.
Another object of the present invention is to propose the bactericidal composition that contains bromothalonil and Fluoxastrobin that a kind of antagonism disease has synergistic effect.
In order to reach the above object, the present invention is achieved by the following technical solutions.
A kind of bactericidal composition that contains bromothalonil and Fluoxastrobin.Said composition effective active composition bromothalonil and Fluoxastrobin percentage by weight are 1～40: 1～20.
Described bactericidal composition effective active composition bromothalonil and the Fluoxastrobin percentage by weight that contains bromothalonil and Fluoxastrobin is 5～30: 1～15.
Described bactericidal composition effective active composition bromothalonil and the Fluoxastrobin percentage by weight that contains bromothalonil and Fluoxastrobin is 10～25: 5～10.
The described bactericidal composition that contains bromothalonil and Fluoxastrobin adds auxiliary agent and excipients is made aqueous emulsion or microemulsion.
The described bactericidal composition active constituent content that contains bromothalonil and nitrile bacterium azoles is 2～50%.
Comprise following group component composition when making aqueous emulsion: bromothalonil 1%～40%, Fluoxastrobin 1%～20%, solvent and cosolvent 5%～40%, emulsifier 1%～10%, antifreezing agent 0%～5%, thickener 0.1%～1%, defoamer 0.1%～0.5%, deionized water surplus.
Above-mentioned formulation material is mixed, the former medicine of bromothalonil, the former medicine of Fluoxastrobin, solvent, emulsifier are added together, make and be dissolved into even oil phase; Deionized water, antifreeze, thickener, defoamer are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, can make the bromothalonil azoxystrobin water emulsion.
Comprise following group component composition when making microemulsion: bromothalonil 1%～40%, Fluoxastrobin 1%～20%, solvent and cosolvent 5%～40%, emulsifier 10%～20%, antifreezing agent 0%～5%, defoamer 0.1%～0.5%, deionized water surplus.
The compound method of microemulsion: be that the former medicine of bromothalonil, the former medicine of Fluoxastrobin are dissolved in the reactor that solvent and cosolvent are housed; Mix strongly after joining emulsifier, antifreeze, defoamer, deionized water in the reactor that above-mentioned solution is housed and homogenize, obtain the as clear as crystal bromothalonil Fluoxastrobin microemulsion of outward appearance at last.
Described solvent and cosolvent are selected from acetonitrile, N, one or more of N dimethyl formamide, ethylene glycol, propane diols, ethanol, cyclohexanone, vegetable oil, ethyl acetate, N-Methyl pyrrolidone.
Described emulsifier is selected from alkyl benzene calcium sulfonate, the polyoxyethylene nonylphenol ether phosphate, phenyl phenol polyoxy ethyl ether phosphate, styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, benzyl dimethyl phenol polyoxy ethyl ether, phenyl phenol polyoxy ethyl ether, alkylphenol-formaldehyde resin polyoxy ethyl ether, phenethyl fluosite polyoxy ethyl ether, phenethyl phenol polyoxy ethyl polypropylene-base ether, ethylene oxide-propylene oxide block copolymer, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, alkylaryl polyoxyethylene polyoxypropylene ether, the alkylaryl polyoxyethylene poly-oxygen propylene aether, sorbitan monostearate, the sorbitan fatty acid ester APEO, in the pure APEO of fat one or more.
Described frost resistance is selected from one or more in ethylene glycol, glycerine, propane diols, glycerine, polyethylene glycol or sorbierite, uses that total consumption is no more than when multiple.
Described thickener is selected from: one or more in xanthans, Magnesiumaluminumsilicate, the polyvinyl alcohol.
Described defoamer is selected from one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
The described bactericidal composition that contains the bromothalonil Fluoxastrobin is used to prevent and treat the control of fruit tree and vegetable disease.
Advantage of the present invention: being used in combination of (1) two kind of bactericide enlarged fungicidal spectrum; (2) reduced the organic solvent usage amount, to target crop, people and animals, Environmental security; (3) reduce formulation rate, minimizing application times, easy to use, reduction use cost has advantage efficient, quick-acting, that the lasting period is long; (4) production method is simple, storing safety, and the water-base preparation type is little to environmental influence.
Embodiment
To further instruction of the present invention, but the present invention is not limited thereto below in conjunction with embodiment.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.Pass through Toxicity Determination earlier, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Embodiment 1:5% bromothalonil azoxystrobin water emulsion
3g bromothalonil, 2g Fluoxastrobin, 3g acetonitrile, 2g ethylene glycol, 2g sorbitan monostearate, 3g phenethyl fluosite polyoxy ethyl ether, 0.4g silicone compound, 0.1g xanthans, 0.1g xanthans, deionized water are mended to 100g, make 5% bromothalonil azoxystrobin water emulsion.
Embodiment 2:25% bromothalonil azoxystrobin water emulsion
18g bromothalonil, 7g Fluoxastrobin, 10g ethyl acetate, 8g cyclohexanone, 2g phenyl phenol polyoxy ethyl ether phosphate, 4g alkyl benzene calcium sulfonate, 3g propane diols, 0.4g silicone compound, 0.3g polyvinyl alcohol, deionized water are mended to 100g, make 25% bromothalonil azoxystrobin water emulsion.
Embodiment 3:45% bromothalonil azoxystrobin water emulsion
30g bromothalonil, 15g Fluoxastrobin, 15g ethyl acetate, 10g acetonitrile, 5g cyclohexanone, 3g triethanolamine salt, 4g polyoxyethylene nonylphenol ether phosphate, 2g castor oil polyoxyethylene ether, 4g glycerine, 0.4g silicone compound, 0.2g xanthans, deionized water are mended to 100g, make 45% bromothalonil azoxystrobin water emulsion.
Embodiment 4:10% bromothalonil Fluoxastrobin microemulsion
7g bromothalonil, 3g Fluoxastrobin, 8g acetonitrile, 3gN-methyl pyrrolidone, 7g phenyl phenol polyoxy ethyl ether phosphate, 6g styrene polyoxyethylene ether ammonium sulfate salt, 3g ethylene glycol, 0.4g silicone compound, deionized water are mended to 100g, make 10% bromothalonil Fluoxastrobin microemulsion.
Embodiment 5:35% bromothalonil Fluoxastrobin microemulsion
25g bromothalonil, 10g Fluoxastrobin, 15g ethyl acetate, 3g acetonitrile, 5g vegetable oil, 7g polyoxyethylene nonylphenol ether, 7g triethanolamine salt, 2g ethylene glycol, 0.2g silicone compound, deionized water are mended to 100g, make 35% bromothalonil Fluoxastrobin microemulsion.
Embodiment 6:50% bromothalonil Fluoxastrobin microemulsion
30g bromothalonil, 20g Fluoxastrobin, 5g acetonitrile, 3g cyclohexanone, 19g ethyl acetate, 6g alkyl benzene calcium sulfonate, 4g triethanolamine salt, the pure APEO of 4g fat, 0.4g silicone oil, deionized water is supplied 100g, makes 50% bromothalonil Fluoxastrobin microemulsion.
Implementation of an application example one: bromothalonil, Fluoxastrobin and composite to the apple anthracnose toxicity test
This experimental establishment is in one apple orchard, suburb, Dali County, Shaanxi Province, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..Result of the test is as follows:
Table 1 bromothalonil, Fluoxastrobin and composite to the apple anthracnose toxicity test
By test as can be known, the bactericidal composition of bromothalonil and Fluoxastrobin has higher synergistic effect to apple anthracnose, bromothalonil and Fluoxastrobin proportioning are to have synergistic effect in 1: 1,2: 1,3: 1,4: 1, wherein when bromothalonil: during Fluoxastrobin=2: 1 synergistic effect the most outstanding, can be used as best proportioning.
Implementation of an application example two: bromothalonil, Fluoxastrobin and composite to the apple anthracnose field trial
This experimental establishment is in orchard, one suburb, Dali County, Shaanxi Province, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and the contrast medicament is commercial.
This is tested in the apple anthracnose initial stage of origination and begins dispenser, and dispenser in per 7 days once is total to dispenser 6 times, investigates disease indexs in 7 days, 20 days, 50 days after the last dispenser and calculates preventive effect, result of the test such as table 2:
Table 2 bromothalonil, Fluoxastrobin and composite control apple anthracnose field control effectiveness test thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 20 days preventive effects (%) behind the last medicine | 50 days preventive effects (%) behind the last medicine |
| 5% bromothalonil azoxystrobin water emulsion | 200 times | 77.02 | 86.42 | 89.61 |
| 25% bromothalonil azoxystrobin water emulsion | 800 times | 81.00 | 88.33 | 93.72 |
| 45% bromothalonil azoxystrobin water emulsion | 1500 times | 79.52 | 87.44 | 91.06 |
| 10% bromothalonil Fluoxastrobin microemulsion | 300 times | 78.46 | 88.39 | 92.55 |
| 35% bromothalonil Fluoxastrobin microemulsion | 1000 times | 80.33 | 86.17 | 90.36 |
| 50% bromothalonil Fluoxastrobin microemulsion | 2000 times | 81.60 | 89.75 | 91.42 |
| 25% bromothalonil missible oil | 500 times | 67.15 | 79.87 | 74.99 |
| 25% Fluoxastrobin suspending agent | 1000 times | 67.42 | 77.66 | 74.18 |
As seen from Table 2, composition is all remarkable to the control efficiency of apple anthracnose, and preventive effect is apparently higher than the contrast medicament, and the lasting period is long, and to fruit tree safety, bad reaction is not found in the field.
Implementation of an application example three: bromothalonil, Fluoxastrobin and composite control cucumber anthracnose thereof
This experimental establishment is in area just outside a city gate town, Pucheng County, Shaanxi Province, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and the contrast medicament is commercial.
Test of the present invention and the dispenser of cucumber anthracnose initial stage of origination, dispenser in per 7 days once are total to dispenser 3 times, investigate disease indexs in 3 days, 7 days, 20 days after the 3rd dispenser and calculate preventive effect, result of the test such as table 3:
Table 3 bromothalonil, Fluoxastrobin and the composite control cucumber anthracnose test of pesticide effectiveness thereof
| Handle medicament | The preparation dosage | 3 days preventive effects (%) behind the last medicine | 7 days preventive effects (%) behind the last medicine | 20 days preventive effects (%) behind the last medicine |
| 5% bromothalonil azoxystrobin water emulsion | 400 gram/mus | 75.39 | 82.32 | 87.78 |
| 25% bromothalonil azoxystrobin water emulsion | 100 gram/mus | 76.45 | 84.91 | 91.34 |
| 45% bromothalonil azoxystrobin water emulsion | 50 gram/mus | 78.42 | 83.26 | 92.05 |
| 10% bromothalonil Fluoxastrobin microemulsion | 200 gram/mus | 77.32 | 79.39 | 90.75 |
| 35% bromothalonil Fluoxastrobin microemulsion | 80 gram/mus | 78.01 | 82.06 | 92.86 |
| 50% bromothalonil Fluoxastrobin microemulsion | 50 gram/mus | 78.64 | 84.00 | 91.76 |
| 25% bromothalonil missible oil | 120 gram/mus | 62.85 | 78.56 | 75.64 |
| 25% Fluoxastrobin suspending agent | 80 gram/mus | 65.76 | 80.19 | 76.29 |
The present composition has good prevention effect to cucumber anthracnose, and preventive effect all is higher than the contrast medicament, to crop safety, has the advantage that quick-acting is good, the lasting period is long, and powdery mildew of cucumber is had certain preventive effect in test dosage scope.
In sum, the bactericidal composition of bromothalonil and azoxystrobin compound is compared with single dose, and to crop safety, quick-acting is good, the lasting period is long, the present invention is take water as matrix, and is environmentally safe, and cost is low. So R﹠D and promotion tool of the present invention is of great significance.
Claims (5)
1, the present invention relates to a kind of bactericidal composition that contains bromothalonil and Fluoxastrobin, wherein effective active composition bromothalonil and Fluoxastrobin percentage by weight are 1～40: 1～20.
2, the bactericidal composition that contains bromothalonil and Fluoxastrobin according to claim 1 is characterized in that bromothalonil and Fluoxastrobin percentage by weight are 5～30: 1～15.
3, the bactericidal composition that contains bromothalonil and Fluoxastrobin according to claim 1 is characterized in that bromothalonil and Fluoxastrobin percentage by weight are 10～25: 5～10.
4, the bactericidal composition that contains bromothalonil and Fluoxastrobin according to claim 1 is characterized in that: the effective active composition adds conventional auxiliary agent and excipients and makes aqueous emulsion or microemulsion.
5, be 2～50% according to the described bactericidal composition active constituent content that contains bromothalonil and Fluoxastrobin of claim 1 to 4.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910023311 CN101595876B (en) | 2009-07-13 | 2009-07-13 | Bromothalonil and azoxystrobin containing sterilizing composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910023311 CN101595876B (en) | 2009-07-13 | 2009-07-13 | Bromothalonil and azoxystrobin containing sterilizing composition |
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| CN101595876B CN101595876B (en) | 2013-06-05 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101755779B (en) * | 2010-01-07 | 2013-12-25 | 青岛星牌作物科学有限公司 | Fungicidal composition containing bromothalonil and propineb and application thereof |
| CN106689128A (en) * | 2016-12-11 | 2017-05-24 | 广东中迅农科股份有限公司 | Antiseptic composition containing bromothalonil and phenamacri |
| CN109953025A (en) * | 2017-12-25 | 2019-07-02 | 江苏托球农化股份有限公司 | A kind of bactericidal composition containing bromothalonil and pentachloronitrobenzene |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1518876A (en) * | 2003-01-23 | 2004-08-11 | 王玉万 | Bactericide and insecticide in agricultural use containing albendazole sulfoxide and its salt |
-
2009
- 2009-07-13 CN CN 200910023311 patent/CN101595876B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101755779B (en) * | 2010-01-07 | 2013-12-25 | 青岛星牌作物科学有限公司 | Fungicidal composition containing bromothalonil and propineb and application thereof |
| CN106689128A (en) * | 2016-12-11 | 2017-05-24 | 广东中迅农科股份有限公司 | Antiseptic composition containing bromothalonil and phenamacri |
| CN109953025A (en) * | 2017-12-25 | 2019-07-02 | 江苏托球农化股份有限公司 | A kind of bactericidal composition containing bromothalonil and pentachloronitrobenzene |
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| CN101595876B (en) | 2013-06-05 |
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