CN101617670B - Sterilization composition containing tetraconazole and tebuconazole - Google Patents
Sterilization composition containing tetraconazole and tebuconazole Download PDFInfo
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- CN101617670B CN101617670B CN 200910023451 CN200910023451A CN101617670B CN 101617670 B CN101617670 B CN 101617670B CN 200910023451 CN200910023451 CN 200910023451 CN 200910023451 A CN200910023451 A CN 200910023451A CN 101617670 B CN101617670 B CN 101617670B
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- tebuconazole
- tetraconazole
- microemulsion
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Abstract
The invention relates to a sterilization composite which contains tetraconazole and has a synergized effect; the effective activity components of the composite are tetraconazole and tebuconazole; auxiliary agent and excipient are added into the effective activity components to prepare into aqua resigen or microemulsion; wherein the weight ratio of tetraconazole and tebuconazole is 1-25:40-5. The compounded composite of tetraconazole and tebuconazole of the invention has obvious synergized effect and is mainly used for curing and preventing powdery mildew of vegetable and fruit trees.
Description
Technical field:
The invention belongs to technical field of pesticide, relate to the powdery mildew that a kind of bactericidal composition that contains tetraconazole and Tebuconazole is mainly used in control fruit tree or vegetables.
Technical background:
Tetraconazole, English name are tetraconazole, and chemical name is (RS)-2-(2,4 dichloro benzene base)-3-(1H-1,2,4-triazol-1-yl) propyl group 1,1,2,2-tetrafluoro ethyl ether,
Structural formula is:
Tetraconazole is that tetraconazole is a sterol demethylation inhibitor by the triazole bactericidal agent of Italian Yi Saige company research and development.Because absorption in having well, therefore can be promptly by plant absorbing, and in conducted inside; Have good protection and therapeutic activity, 6 weeks of lasting period.This medicine is used for cereal crop such as wheat, barley, oat, rye, fruit tree such as banana, grape, pears, apple, vegetables such as melon, beet, the control of various crop multiple diseases such as ornamental plants.
Tebuconazole: English name tebuconazole, chemical formula is: (RS)-and 1-is right-chlorphenyl-4, and 4-dimethyl-3 (1H-1,2,4-triazol-1-yl methyl) amylalcohol, molecular formula: C
16H
22ClN
3O.
Tebuconazole belongs to ergosterol biosynthesis inhibitor, can be is rapidly partially absorbed and mainly shifts to the top by plant is vegetative.Not only have bactericidal activity, also can promote plant growth, make it well developed root system, leaf look dark green, robust plant, thereby improve output.Tebuconazole is mainly used in the disease that control Erysiphe, Puccinia, nuclear cavity Pseudomonas etc. cause.
At present, the restriction increasingly stringent that both at home and abroad organic solvent is used, some national xylol has disabled trend, thereby the formulations of pesticide will be brought in constant renewal in and develop, and wherein Water-borne modification is exactly one of dominant direction of formulations of pesticide development.Therefore, just arise at the historic moment, make it become novel form and be developed and applied with aqueous emulsion, the microemulsion of organic solvent in water section or the replacing whole missible oil.
The relevant report of not seeing the composite product of tetraconazole and Tebuconazole as yet at present.
Summary of the invention
The purpose of this invention is to provide a kind of efficient, low toxicity, low-residual,, the bactericidal composition that contain tetraconazole and Tebuconazole that cost low good to Environmental compatibility.
The present invention realizes through following technical scheme:
A kind of bactericidal composition that contains tetraconazole and Tebuconazole, wherein tetraconazole and Tebuconazole percentage by weight are 1～25: 40～5.
The described bactericidal composition that contains tetraconazole and Tebuconazole, wherein tetraconazole and Tebuconazole percentage by weight are 1～20: 30～5.
The described bactericidal composition that contains tetraconazole and Tebuconazole, wherein tetraconazole and Tebuconazole percentage by weight are 1～15: 25～10.
The described bactericidal composition active constituent content that contains tetraconazole and Tebuconazole is 6%～50%.
The described bactericidal composition that contains tetraconazole and Tebuconazole adds auxiliary agent and excipients is processed aqueous emulsion or microemulsion.
Comprise following group component composition when processing aqueous emulsion: tetraconazole 1%～25%, Tebuconazole 5%～40%, solvent 5%～40%, emulsifier 1%～10%, antifreezing agent 1%～5%, thickener 0.1%～1%, antifoaming agent 0.1%～0.5%, deionized water surplus.
Above-mentioned formulation material is mixed, the former medicine of tetraconazole, the former medicine of Tebuconazole, solvent, emulsifier are added together, make and be dissolved into even oil phase; Deionized water, antifreeze, thickener, antifoaming agent are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, can make the tetraconazole tebuconazole aqueous emulsion.
Comprise following group component composition when processing microemulsion: tetraconazole 1%～25%, Tebuconazole 5%～40%, solvent 5%～40%, emulsifier 5%～20%, antifreezing agent 1%～5%, antifoaming agent 0.1%～0.5%, deionized water surplus.
The compound method of microemulsion: be that the former medicine of tetraconazole, the former medicine of Tebuconazole are dissolved in the agitated reactor that solvent and cosolvent are housed; Give intense mixing and homogenize after joining emulsifier, antifreeze, antifoaming agent, deionized water in the agitated reactor that above-mentioned solution is housed, obtain the as clear as crystal tetraconazole tebuconazole microemulsion of outward appearance at last.
Described solvent is selected from: N, one or more in dinethylformamide, cyclohexanone, dimethyl sulfoxide (DMSO), 3-methyl cyclohexanol ketenes, N-octylpyrrolidone, N-pyrrolidones, propyl alcohol, butanols, ethylene glycol, EGME, ethyl acetate, vegetable oil, the acetonitrile.
Described emulsifier is selected from: farming breast 500
#(alkyl benzene calcium sulfonate), OP series phosphate (NPE phosphate), 600
#Phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, farming breast 400
#(benzyl dimethyl phenol polyoxy ethyl ether), farming breast 600
#(phenyl phenol polyoxy ethyl ether), Nongru-700
#(alkylphenol-formaldehyde resin polyoxy ethyl ether), farming breast 36
#(phenethyl fluosite polyoxy ethyl ether), farming breast 1600
#(phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (NPE), By series (castor oil polyoxyethylene ether), farming breast 33
#(alkylaryl polyoxyethylene polyoxypropylene ether), farming breast 34
#In (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), the AEO series (the pure APEO of fat) one or more.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described antifoaming agent is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthans, methylcellulose, Magnesiumaluminumsilicate, the polyvinyl alcohol.
The described bactericidal composition that contains tetraconazole and Tebuconazole is mainly used in the powdery mildew of control vegetables and fruit tree.
Tetraconazole and the composite bactericidal composition of Tebuconazole of containing of the present invention; With water is matrix; Reduced the usage amount of organic solvent in the missible oil product, that the control that is used for vegetables and fruit tree powdery mildew has is effective, cost is low, the lasting period is long, environmental pollution is little, be difficult for producing the advantage of poisoning.
Embodiment
Below in conjunction with embodiment the present invention is further explained, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Pass through Toxicity Determination earlier, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Embodiment 1:50% tetraconazole tebuconazole aqueous emulsion
Tetraconazole 10%, Tebuconazole 40%, cyclohexanone 15%, ethyl acetate 13%, N, dinethylformamide 4%, farming breast 500
#2%, 600
#Phosphate 3%, farming breast 400
#3%, ethylene glycol 2%, silicone compound 0.4%, polyvinyl alcohol 0.1%, deionized water are mended to 100%, make 50% tetraconazole tebuconazole aqueous emulsion.
Embodiment 2:43% tetraconazole tebuconazole aqueous emulsion
Tetraconazole 20%, Tebuconazole 23%, 3-methyl cyclohexanol ketenes 10%, N-Methyl pyrrolidone 8%, farming breast 1600
#4%, triethanolamine salt 4%, ethylene glycol 4%, silicone compound 0.4%, polyethylene glycol 0.2%, deionized water are mended to 100%, make 43% tetraconazole tebuconazole aqueous emulsion.
Embodiment 3:27% tetraconazole tebuconazole aqueous emulsion
Tetraconazole 10%, Tebuconazole 17%, ethyl acetate 8%, cyclohexanone 5%, acetonitrile 5%, OP-102%, farming breast 500
#4%, propane diols 3%, silicone compound 0.4%, aluminium-magnesium silicate 0.5%, deionized water are mended to 100%, make 27% tetraconazole tebuconazole aqueous emulsion.
Embodiment 4:6% tetraconazole tebuconazole aqueous emulsion
Tetraconazole 1%, Tebuconazole 5%, N-pyrrolidones 4%, vegetable oil 8%, farming breast 1600
#3%, the farming breast 33
#2%, glycerine 3%, silicone compound 0.4%, xanthans 0.2%, deionized water are mended to 100%, make 6% tetraconazole tebuconazole aqueous emulsion.
Above-mentioned formulation material is mixed, the former medicine of tetraconazole, the former medicine of Tebuconazole, solvent, emulsifier are added together, make and be dissolved into even oil phase; Water, antifreeze, thickener, antifoaming agent are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, can make the tetraconazole tebuconazole aqueous emulsion.
Embodiment 5:50% tetraconazole tebuconazole microemulsion
Tetraconazole 25%, Tebuconazole 25%, ethyl acetate 10%, N, dinethylformamide 15%, OP-105%, farming breast 500
#8%, ethylene glycol 3%, silicone compound 0.4%, deionized water are mended to 100%, and emulsifier and water are mixed and made into water, and the former medicine that will be dissolved in then in the solvent under agitation adds water, process 50% tetraconazole tebuconazole microemulsion.
Embodiment 6:36% tetraconazole tebuconazole microemulsion
Tetraconazole 6%, Tebuconazole 30%, N-pyrrolidones 13%, acetonitrile 8%, farming breast 1600
#6%, the farming breast 33
#8%, propane diols 4%, silicone compound 0.2%, deionized water are mended to 100%, and emulsifier and water are mixed and made into water, and the former medicine that will be dissolved in then in the solvent under agitation adds water, process 36% tetraconazole tebuconazole microemulsion.
Embodiment 7:20% tetraconazole tebuconazole microemulsion
Tetraconazole 5%, Tebuconazole 15%, cyclohexanone 7%, N; Dinethylformamide 13%, OP series phosphate 9%, By series 5%, propane diols 4%, silicone oil 0.4%; Deionized water supplies 100%; Emulsifier and water are mixed and made into water, and the former medicine that will be dissolved in then in the solvent under agitation adds water, processes 20% tetraconazole tebuconazole microemulsion.
Embodiment 8:12% tetraconazole tebuconazole microemulsion
Tetraconazole 2%, Tebuconazole 10%, vegetable oil 5%, dimethyl Asia 12%, sapn series 6%, farming breast 400
#5%, glycerine 4%, silicone oil 0.4%, deionized water supplies 100%, and emulsifier and water are mixed and made into water, and the former medicine that will be dissolved in then in the solvent under agitation adds water, processes 12% tetraconazole tebuconazole microemulsion.
Practice a routine tetraconazole, Tebuconazole and composite to the powdery mildew of cucumber Toxicity Determination
Test medicine is by Shanxi Thompson Biological Technology Co., Ltd..
Test medicine is provided with 5 dose concentrations respectively to be handled; If there is not the medicine contrast, each concentration is handled repetition 4 times, carries out with reference to " agricultural chemicals indoor bioassay test rule bactericide "; The incidence of routine observation inoculation blade and newborn blade; After treating that control treatment is fully fallen ill, begin to put down in writing the incidence that each is handled, and calculate disease index and protection effect thereof.Concentration-preventive effect is converted into corresponding logarithm-probit value, obtains virulence regression equation, calculate EC
50Value.
Result of the test is as shown in the table:
Table 1 tetraconazole, Tebuconazole and composite to the powdery mildew of cucumber toxicity test
Can know by table 1; Tetraconazole of the present invention, Tebuconazole and complex composition thereof are to the powdery mildew of cucumber toxicity test; The tetraconazole virulence is higher than the Tebuconazole virulence; When tetraconazole and Tebuconazole proportioning are all to show obvious synergistic effect in 2: 1,1: 1,1: 3,1: 5,1: 7, so tetraconazole and Tebuconazole percentage by weight were synergistic effect at 1: 1 to 1: 7 in the scope, tetraconazole wherein: Tebuconazole=synergistic effect in 1: 3 o'clock is the most outstanding.
Practice routine two tetraconazoles, Tebuconazole and the composite powdery mildew of cucumber of preventing and treating thereof
This test arrangement is in area just outside a city gate town, Pucheng County, Shaanxi Province, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..Test and converted water April 28 by every mu of medication amount of formulation and carry out even spraying for 60 kilograms, dispenser is 2 times altogether, each dispenser 7 days at interval, and 7 days, 14 days control efficiency such as tables 2 after the 2nd dispenser:
Table 2 tetraconazole, Tebuconazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine |
| 50% tetraconazole tebuconazole aqueous emulsion | 8 gram/mus | 82.37 | 95.47 |
| 6% tetraconazole tebuconazole aqueous emulsion | 80 gram/mus | 83.19 | 96.26 |
| 36% tetraconazole tebuconazole microemulsion | 15 gram/mus | 85.20 | 95.74 |
| 20% tetraconazole tebuconazole microemulsion | 20 gram/mus | 86.74 | 95.84 |
| 4% tetraconazole aqueous emulsion | 50 gram/mus | 80.26 | 84.20 |
| 12.5% Tebuconazole wetting powder | 60 gram/mus | 78.74 | 82.19 |
Found out that by table 2 the composite bactericidal composition of tetraconazole of the present invention and Tebuconazole can effectively prevent powdery mildew of cucumber, control efficiency obviously is superior to contrasting single agent, in this experimental drug scope, to crop safety, has no adverse effects.
Practice routine three tetraconazoles, Tebuconazole and composite control apple tree powdery mildew thereof
This test medicine provides by Shanxi Thompson Biological Technology Co., Ltd., begins dispenser in apple tree powdery mildew initial stage of origination, and altogether dispenser is 2 times, each dispenser 7 days at interval, and 7 days, 30 days investigation results and calculate preventive effect, result such as table 3 after the last dispenser:
Table 3 tetraconazole, Tebuconazole and the control apple tree powdery mildew test of pesticide effectiveness thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 43% tetraconazole tebuconazole aqueous emulsion | 8000 times | 81.32 | 94.55 |
| 27% tetraconazole tebuconazole aqueous emulsion | 5000 times | 82.65 | 92.03 |
| 50% tetraconazole tebuconazole microemulsion | 10000 times | 80.22 | 90.74 |
| 12% tetraconazole tebuconazole microemulsion | 1500 times | 83.72 | 89.58 |
| 4% tetraconazole aqueous emulsion | 1000 times | 74.35 | 79.00 |
| 25% Tebuconazole wetting powder | 2000 times | 76.29 | 78.37 |
Present composition ability effectively preventing and treating apple-tree powdery mildew; Compare with the contrast medicament; Have the advantage that preventive effect height, quick-acting are good, the lasting period is long, in the experimental drug scope to crop safety, in experimentation; The present composition pair also has fine control efficiency with the simultaneous spot defoliation of apple mildew, leaf spot, and control efficiency reaches more than 85% after 30 days.
In sum, the bactericidal composition that tetraconazole and Tebuconazole are composite has obvious role in synergism to the control of vegetables and fruit tree powdery mildew.Compare the advantage that have crop safety, environmental pollution is little, cost is low, quick-acting is good, the lasting period is long with single agent.So R&D and promotion of the present invention has crucial meaning.
Claims (5)
1. bactericidal composition that contains tetraconazole and Tebuconazole, its effective active composition is tetraconazole and Tebuconazole, by weight percentage, contains tetraconazole 1～25%, Tebuconazole 5～40%.
2. the bactericidal composition that contains tetraconazole and Tebuconazole according to claim 1 is characterized in that: by weight percentage, contain tetraconazole 1～20%, Tebuconazole 5～30%.
3. the bactericidal composition that contains tetraconazole and Tebuconazole according to claim 1 is characterized in that: by weight percentage, contain tetraconazole 1～15%, Tebuconazole 10～25%.
4. according to each described bactericidal composition that contains tetraconazole and Tebuconazole in the claim 1 to 3, it is characterized in that the active ingredient total content is 6%～50%.
5. can be made into aqueous emulsion or microemulsion according to each described bactericidal composition that contains tetraconazole and Tebuconazole in the claim 1 to 4.
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| IT201900013446A1 (en) * | 2019-07-31 | 2021-01-31 | Isagro Spa | LIQUID AGROCHEMICAL MIXTURE CONTAINING TETRACONAZOLE AND RELATIVE USE AS FUNGICIDE IN AGRICULTURAL CROPS. |
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| CN102150660B (en) * | 2010-12-16 | 2013-08-14 | 陕西韦尔奇作物保护有限公司 | Sterilization composition containing tetraconazole |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1566113A (en) * | 1998-06-17 | 2005-01-19 | 拜尔公司 | Agents for controlling plant pests |
| WO2006015865A1 (en) * | 2004-08-12 | 2006-02-16 | Syngenta Participations Ag | Fungicidal compositions |
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2009
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1566113A (en) * | 1998-06-17 | 2005-01-19 | 拜尔公司 | Agents for controlling plant pests |
| WO2006015865A1 (en) * | 2004-08-12 | 2006-02-16 | Syngenta Participations Ag | Fungicidal compositions |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201900013446A1 (en) * | 2019-07-31 | 2021-01-31 | Isagro Spa | LIQUID AGROCHEMICAL MIXTURE CONTAINING TETRACONAZOLE AND RELATIVE USE AS FUNGICIDE IN AGRICULTURAL CROPS. |
| WO2021019452A1 (en) * | 2019-07-31 | 2021-02-04 | Isagro S.P.A. | Agrochemical liquid mixture containing tetraconazole and relative use as fungicide in agricultural crops |
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