CN101617670A - Sterilization composite containing tetraconazole and tebuconazole - Google Patents
Sterilization composite containing tetraconazole and tebuconazole Download PDFInfo
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- CN101617670A CN101617670A CN200910023451A CN200910023451A CN101617670A CN 101617670 A CN101617670 A CN 101617670A CN 200910023451 A CN200910023451 A CN 200910023451A CN 200910023451 A CN200910023451 A CN 200910023451A CN 101617670 A CN101617670 A CN 101617670A
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- tebuconazole
- tetraconazole
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Abstract
The invention relates to a sterilization composite which contains tetraconazole and has a synergized effect; the effective activity components of the composite are tetraconazole and tebuconazole; auxiliary agent and excipient are added into the effective activity components to prepare into aqua resigen or microemulsion; wherein the weight ratio of tetraconazole and tebuconazole is 1-25:40-5. The compounded composite of tetraconazole and tebuconazole of the invention has obvious synergized effect and is mainly used for curing and preventing powdery mildew of vegetable and fruit trees.
Description
Technical field:
The invention belongs to technical field of pesticide, relate to the powdery mildew that a kind of bactericidal composition that contains tetraconazole and Tebuconazole is mainly used in control fruit tree or vegetables.
Technical background:
Tetraconazole, English name are tetraconazole, and chemical name is (RS)-2-(2,4 dichloro benzene base)-3-(1H-1,2,4-triazol-1-yl) propyl group 1,1,2,2-tetrafluoro ethyl ether,
Structural formula is:
Tetraconazole is that tetraconazole is a sterol demethylation inhibitor by the triazole bactericidal agent of Italian Yi Saige company research and development.Because absorption in having well, therefore can be promptly by plant absorbing, and in conducted inside; Have good protection and therapeutic activity, 6 weeks of lasting period.This medicine is used for cereal crop such as wheat, barley, oat, rye, fruit tree such as banana, grape, pears, apple, vegetables such as melon, beet, the control of various crop multiple diseases such as ornamental plants.
Tebuconazole: English name tebuconazole, chemical formula is: (RS)-and 1-is right-chlorphenyl-4, and 4-dimethyl-3 (1H-1,2,4-triazol-1-yl methyl) amylalcohol, molecular formula: C
16H
22ClN
3O.
Tebuconazole belongs to ergosterol biosynthesis inhibitor, can be is rapidly partially absorbed and mainly shifts to the top by plant is vegetative.Not only have bactericidal activity, also can promote plant growth, make it well developed root system, leaf look dark green, robust plant, thereby improve output.Tebuconazole is mainly used in the disease that control Erysiphe, Puccinia, nuclear cavity Pseudomonas etc. cause.
At present, to the restriction increasingly stringent of organic solvent use, some national dimethylbenzene has disabled trend, thereby the formulations of pesticide will be brought in constant renewal in and develop both at home and abroad, and wherein Water-borne modification is exactly one of dominant direction of formulations of pesticide development.Therefore, just arise at the historic moment, make it become novel form and be developed and applied with aqueous emulsion, the microemulsion of organic solvent in water section or the replacing whole missible oil.
Have not yet to see the relevant report of the composite product of tetraconazole and Tebuconazole.
Summary of the invention
The purpose of this invention is to provide a kind of efficient, low toxicity, low-residual,, the bactericidal composition that contain tetraconazole and Tebuconazole that cost low good to Environmental compatibility.
The present invention is achieved by the following technical solutions:
A kind of bactericidal composition that contains tetraconazole and Tebuconazole, wherein tetraconazole and Tebuconazole percentage by weight are 1～25: 40～5.
The described bactericidal composition that contains tetraconazole and Tebuconazole, wherein tetraconazole and Tebuconazole percentage by weight are 1～20: 30～5.
The described bactericidal composition that contains tetraconazole and Tebuconazole, wherein tetraconazole and Tebuconazole percentage by weight are 1～15: 25～10.
The described bactericidal composition active constituent content that contains tetraconazole and Tebuconazole is 6%～50%.
The described bactericidal composition that contains tetraconazole and Tebuconazole adds auxiliary agent and excipients is made aqueous emulsion or microemulsion.
Comprise following group component composition when making aqueous emulsion: tetraconazole 1%～25%, Tebuconazole 5%～40%, solvent 5%～40%, emulsifier 1%～10%, antifreezing agent 1%～5%, thickener 0.1%～1%, defoamer 0.1%～0.5%, deionized water surplus.
Above-mentioned formulation material is mixed, the former medicine of tetraconazole, the former medicine of Tebuconazole, solvent, emulsifier are added together, make and be dissolved into even oil phase; Deionized water, antifreeze, thickener, defoamer are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, can make the tetraconazole tebuconazole aqueous emulsion.
Comprise following group component composition when making microemulsion: tetraconazole 1%～25%, Tebuconazole 5%～40%, solvent 5%～40%, emulsifier 5%～20%, antifreezing agent 1%～5%, defoamer 0.1%～0.5%, deionized water surplus.
The compound method of microemulsion: be that the former medicine of tetraconazole, the former medicine of Tebuconazole are dissolved in the reactor that solvent and cosolvent are housed; Mix strongly after joining emulsifier, antifreeze, defoamer, deionized water in the reactor that above-mentioned solution is housed and homogenize, obtain the as clear as crystal tetraconazole tebuconazole microemulsion of outward appearance at last.
Described solvent is selected from: N, one or more in dinethylformamide, cyclohexanone, dimethyl sulfoxide (DMSO), 3-methyl cyclohexanol ketenes, N-octylpyrrolidone, N-pyrrolidones, propyl alcohol, butanols, ethylene glycol, ethylene glycol monomethyl ether, ethyl acetate, vegetable oil, the acetonitrile.
Described emulsifier is selected from: farming breast 500
#(alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600
#Phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, farming breast 400
#(benzyl dimethyl phenol polyoxy ethyl ether), farming breast 600
#(phenyl phenol polyoxy ethyl ether), Nongru-700
#(alkylphenol-formaldehyde resin polyoxy ethyl ether), farming breast 36
#(phenethyl fluosite polyoxy ethyl ether), farming breast 1600
#(phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), By series (castor oil polyoxyethylene ether), farming breast 33
#(alkylaryl polyoxyethylene polyoxypropylene ether), farming breast 34
#In (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), the AEO series (the pure APEO of fat) one or more.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthans, methylcellulose, Magnesiumaluminumsilicate, the polyvinyl alcohol.
The described bactericidal composition that contains tetraconazole and Tebuconazole is mainly used in the powdery mildew of control vegetables and fruit tree.
Tetraconazole and the composite bactericidal composition of Tebuconazole of containing of the present invention, with water is matrix, reduced the usage amount of organic solvent in the missible oil product, that the control that is used for vegetables and fruit tree powdery mildew has is effective, cost is low, the lasting period is long, environmental pollution is little, be difficult for producing the advantage of poisoning.
Embodiment
To further instruction of the present invention, but the present invention is not limited thereto below in conjunction with embodiment.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Pass through Toxicity Determination earlier, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Embodiment 1:50% tetraconazole tebuconazole aqueous emulsion
Tetraconazole 10%, Tebuconazole 40%, cyclohexanone 15%, ethyl acetate 13%, N, dinethylformamide 4%, farming breast 500
#2%, 600
#Phosphate 3%, farming breast 400
#3%, ethylene glycol 2%, silicone compound 0.4%, polyvinyl alcohol 0.1%, deionized water are mended to 100%, make 50% tetraconazole tebuconazole aqueous emulsion.
Embodiment 2:43% tetraconazole tebuconazole aqueous emulsion
Tetraconazole 20%, Tebuconazole 23%, 3-methyl cyclohexanol ketenes 10%, N-Methyl pyrrolidone 8%, farming breast 1600
#4%, triethanolamine salt 4%, ethylene glycol 4%, silicone compound 0.4%, polyethylene glycol 0.2%, deionized water are mended to 100%, make 43% tetraconazole tebuconazole aqueous emulsion.
Embodiment 3:27% tetraconazole tebuconazole aqueous emulsion
Tetraconazole 10%, Tebuconazole 17%, ethyl acetate 8%, cyclohexanone 5%, acetonitrile 5%, OP-102%, farming breast 500
#4%, propane diols 3%, silicone compound 0.4%, aluminium-magnesium silicate 0.5%, deionized water are mended to 100%, make 27% tetraconazole tebuconazole aqueous emulsion.
Embodiment 4:6% tetraconazole tebuconazole aqueous emulsion
Tetraconazole 1%, Tebuconazole 5%, N-pyrrolidones 4%, vegetable oil 8%, farming breast 1600
#3%, the farming breast 33
#2%, glycerine 3%, silicone compound 0.4%, xanthans 0.2%, deionized water are mended to 100%, make 6% tetraconazole tebuconazole aqueous emulsion.
Above-mentioned formulation material is mixed, the former medicine of tetraconazole, the former medicine of Tebuconazole, solvent, emulsifier are added together, make and be dissolved into even oil phase; Water, antifreeze, thickener, defoamer are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, can make the tetraconazole tebuconazole aqueous emulsion.
Embodiment 5:50% tetraconazole tebuconazole microemulsion
Tetraconazole 25%, Tebuconazole 25%, ethyl acetate 10%, N, dinethylformamide 15%, OP-105%, farming breast 500
#8%, ethylene glycol 3%, silicone compound 0.4%, deionized water are mended to 100%, and emulsifier and water are mixed and made into water, and the former medicine that will be dissolved in then in the solvent under agitation adds water, make 50% tetraconazole tebuconazole microemulsion.
Embodiment 6:36% tetraconazole tebuconazole microemulsion
Tetraconazole 6%, Tebuconazole 30%, N-pyrrolidones 13%, acetonitrile 8%, farming breast 1600
#6%, the farming breast 33
#8%, propane diols 4%, silicone compound 0.2%, deionized water are mended to 100%, and emulsifier and water are mixed and made into water, and the former medicine that will be dissolved in then in the solvent under agitation adds water, make 36% tetraconazole tebuconazole microemulsion.
Embodiment 7:20% tetraconazole tebuconazole microemulsion
Tetraconazole 5%, Tebuconazole 15%, cyclohexanone 7%, N, dinethylformamide 13%, OP series phosphate 9%, By series 5%, propane diols 4%, silicone oil 0.4%, deionized water supplies 100%, emulsifier and water are mixed and made into water, the former medicine that will be dissolved in then in the solvent under agitation adds water, makes 20% tetraconazole tebuconazole microemulsion.
Embodiment 8:12% tetraconazole tebuconazole microemulsion
Tetraconazole 2%, Tebuconazole 10%, vegetable oil 5%, dimethyl Asia 12%, sapn series 6%, farming breast 400
#5%, glycerine 4%, silicone oil 0.4%, deionized water supplies 100%, and emulsifier and water are mixed and made into water, and the former medicine that will be dissolved in then in the solvent under agitation adds water, makes 12% tetraconazole tebuconazole microemulsion.
Implementation of an application example one tetraconazole, Tebuconazole and composite to the powdery mildew of cucumber Toxicity Determination
Test medicine is by Shanxi Thompson Biological Technology Co., Ltd..
Test medicine is provided with 5 dose concentrations respectively to be handled, if there is not the medicine contrast, each concentration is handled and is repeated 4 times, carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", the incidence of routine observation inoculation blade and newborn blade, after treating that control treatment is fully fallen ill, begin to put down in writing the incidence that each is handled, and calculate disease index and protection effect thereof.Concentration-preventive effect is converted into corresponding logarithm-probit value, obtains virulence regression equation, calculate EC
50Value.
Result of the test is as shown in the table:
Table 1 tetraconazole, Tebuconazole and composite to the powdery mildew of cucumber toxicity test
As shown in Table 1, tetraconazole of the present invention, Tebuconazole and complex composition thereof are to the powdery mildew of cucumber toxicity test, the tetraconazole virulence is higher than the Tebuconazole virulence, when tetraconazole and Tebuconazole proportioning are all to show obvious synergistic effect in 2: 1,1: 1,1: 3,1: 5,1: 7, so tetraconazole and Tebuconazole percentage by weight were synergistic effect at 1: 1 to 1: 7 in the scope, wherein tetraconazole: Tebuconazole=synergistic effect in 1: 3 o'clock is the most outstanding.
Implementation of an application example two tetraconazoles, Tebuconazole and the composite powdery mildew of cucumber of preventing and treating thereof
This test arrangement is in area just outside a city gate town, Pucheng County, Shaanxi Province, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..Test and converted water April 28 by every mu of medication amount of formulation and carry out even spraying for 60 kilograms, dispenser is 2 times altogether, each dispenser 7 days at interval, and 7 days, 14 days control efficiency such as tables 2 after the 2nd dispenser:
Table 2 tetraconazole, Tebuconazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine |
| 50% tetraconazole tebuconazole aqueous emulsion | 8 gram/mus | ??82.37 | ??95.47 |
| 6% tetraconazole tebuconazole aqueous emulsion | 80 gram/mus | ??83.19 | ??96.26 |
| 36% tetraconazole tebuconazole microemulsion | 15 gram/mus | ??85.20 | ??95.74 |
| 20% tetraconazole tebuconazole microemulsion | 20 gram/mus | ??86.74 | ??95.84 |
| 4% tetraconazole aqueous emulsion | 50 gram/mus | ??80.26 | ??84.20 |
| 12.5% Tebuconazole wetting powder | 60 gram/mus | ??78.74 | ??82.19 |
Found out that by table 2 the composite bactericidal composition of tetraconazole of the present invention and Tebuconazole can effectively prevent powdery mildew of cucumber, control efficiency obviously is better than contrasting single agent, to crop safety, has no adverse effects in this experimental drug scope.
Implementation of an application example three tetraconazoles, Tebuconazole and composite control apple tree powdery mildew thereof
This test medicine provides by Shanxi Thompson Biological Technology Co., Ltd., begins dispenser in apple tree powdery mildew initial stage of origination, and altogether dispenser is 2 times, each dispenser 7 days at interval, and 7 days, 30 days investigation results and calculate preventive effect, result such as table 3 after the last dispenser:
Table 3 tetraconazole, Tebuconazole and the control apple tree powdery mildew test of pesticide effectiveness thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 43% tetraconazole tebuconazole aqueous emulsion | 8000 times | ??81.32 | ??94.55 |
| 27% tetraconazole tebuconazole aqueous emulsion | 5000 times | ??82.65 | ??92.03 |
| 50% tetraconazole tebuconazole microemulsion | 10000 times | ??80.22 | ??90.74 |
| 12% tetraconazole tebuconazole microemulsion | 1500 times | ??83.72 | ??89.58 |
| 4% tetraconazole aqueous emulsion | 1000 times | ??74.35 | ??79.00 |
| 25% Tebuconazole wetting powder | 2000 times | ??76.29 | ??78.37 |
Present composition energy effectively preventing and treating apple-tree powdery mildew, compare with the contrast medicament, has the advantage that preventive effect height, quick-acting are good, the lasting period is long, in the experimental drug scope to crop safety, in experimentation, the present composition pair also has fine control efficiency with the simultaneous spot defoliation of apple mildew, leaf spot, and control efficiency reaches more than 85% after 30 days.
In sum, the bactericidal composition that tetraconazole and Tebuconazole are composite has obvious synergistic function to the control of vegetables and fruit tree powdery mildew. Compare the advantage that have crop safety, environmental pollution is little, cost is low, quick-acting is good, the lasting period is long with single dose. So R﹠D and promotion tool of the present invention is of great significance.
Claims (5)
1, a kind of bactericidal composition that contains tetraconazole and Tebuconazole is characterized in that: effective active composition tetrafluoro imidazoles and Tebuconazole percentage by weight are 1～25: 40～5.
2, the bactericidal composition that contains tetraconazole and Tebuconazole according to claim 1 is characterized in that: tetrafluoro imidazoles and Tebuconazole percentage by weight are 1～20: 30～5.
3, the bactericidal composition that contains tetraconazole and Tebuconazole according to claim 1 is characterized in that: tetrafluoro imidazoles and Tebuconazole percentage by weight are 1～1 5: 25～1 0.
4, the bactericidal composition that contains tetraconazole and Tebuconazole according to claim 1 is characterized in that the active ingredient total content is 6%～50%.
5, according to the described bactericidal composition that contains tetraconazole and Tebuconazole of claim 1 to 4, it is characterized in that: composition can be made into aqueous emulsion or microemulsion.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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|---|---|---|---|
| CN 200910023451 CN101617670B (en) | 2009-07-28 | 2009-07-28 | Sterilization composition containing tetraconazole and tebuconazole |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102150660A (en) * | 2010-12-16 | 2011-08-17 | 陕西韦尔奇作物保护有限公司 | Sterilization composition containing tetraconazole |
| CN114051378A (en) * | 2019-07-31 | 2022-02-15 | 伊萨格罗股份公司 | Liquid agrochemical mixtures containing tetraconazole and related use thereof as fungicides in crops |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ508884A (en) * | 1998-06-17 | 2002-10-25 | Bayer Ag | synergistic mixture of fungicidal compounds |
| GB0418047D0 (en) * | 2004-08-12 | 2004-09-15 | Syngenta Participations Ag | Fungicidal compositions |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102150660A (en) * | 2010-12-16 | 2011-08-17 | 陕西韦尔奇作物保护有限公司 | Sterilization composition containing tetraconazole |
| CN102150660B (en) * | 2010-12-16 | 2013-08-14 | 陕西韦尔奇作物保护有限公司 | Sterilization composition containing tetraconazole |
| CN114051378A (en) * | 2019-07-31 | 2022-02-15 | 伊萨格罗股份公司 | Liquid agrochemical mixtures containing tetraconazole and related use thereof as fungicides in crops |
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| CN101617670B (en) | 2012-11-07 |
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