CN101549144A - Oral preparation for treating vitiligo - Google Patents
Oral preparation for treating vitiligo Download PDFInfo
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- CN101549144A CN101549144A CNA2009101133194A CN200910113319A CN101549144A CN 101549144 A CN101549144 A CN 101549144A CN A2009101133194 A CNA2009101133194 A CN A2009101133194A CN 200910113319 A CN200910113319 A CN 200910113319A CN 101549144 A CN101549144 A CN 101549144A
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Abstract
The invention relates to an oral preparation for treating vitiligo, the preparation is prepared by the ana roots, cloves, dried ginger, aniseed, nigella seed, vegetable seedsf, west fruit, acid vine fruit, deworming Vernonia, psoralen, yellow myrobalan skin, belleric terminalia fruit, emblic leafflower fruit, and saffron. The clinical data indicate that 286 cases of patients is inspected and treated, after they takes the preparation 15-20 days, have obvious effect, the white spot area becomes red, continue taking 45 days, 92% of the patients return to normal local pigment, the pigment recovery area is more than 85%, after continued three courses of treatment, the disease will not relapse. The preparation is capable of regulating abnormal phlegm, promoting blood-circulation and removing blood stasis, catalyzing the synthesizing of melanin cell, having remarkable effect of treating vitiligo, short curative effect, high curability, is not liable to relapse, no toxic effect deputy to make up the lack of other drugs.
Description
Technical field
The present invention relates to a kind ofly has dysregulation phlegmatic temperament, activating blood circulation to dissipate blood stasis, catalysis melanocyte synthetic, is used for the treatment of leukodermic oral formulations and preparation method thereof.
Background technology
Vitiligo is owing to the melanocyte hypofunction of skin and hair follicle, loses cause a kind of with limitation or general the mucocutaneous disease that the property depigmentation is a feature.Clinical easy diagnosis, but the cause of disease and pathogeny are still not fully aware of, and the treatment difficulty.Secular clinical practice proves, Uygur medicine treatment vitiligo has one's own knack and the characteristic advantage, accumulated rich practice experience and achievement, having formed dietetic therapy, ripe therapy, having removed therapy, pharmacotherapy and non-drug therapy is the comprehensive treatment and the technology of one.
The Uygur medicine pathology think that under the effect of internal and external factor, the metering of body fluid changes and causes the unusual of body fluid quality gradually, and exceeds the envelop of function of human body self regulation.The unusual body fluid that generates is that disease takes place, the main cause of development.Be be in the normal phase raw environment, because of natural agent descend due to liver generate the physiological function disorder of normal body fluid, make phlegmatic temperament generation ANOMALOUS VARIATIONS generate unusual phlegmatic temperament.It is excessive moist and excessively cold that unusual phlegmatic temperament contains, infringement digestion first and second and third time digestion (normal physiological functions of organs such as stomach, small intestinal, liver, blood circulation), form vicious cycle, weaken required energy of material circulation process and natural agent, the colouring function of weak blood matter further promotes the generation of unusual body fluid.Cross the unusual phlegmatic temperament of containing in the body and be deposited in the skin bottom, hinder the normal blood circulation of skin, make nutritional labeling can't be transported to the 4th digestion (skin position), cause trophicity, (absorbing power, pinch power, eupepsy, drainage power) growing power, (transformation power, formation power) dysfunction of skin, melanocyte can not be grown by normal growth, thereby the vitiligo kitchen range appears in skin depigmentation.Modern medicine thinks because of the tryrosinase system destruction in the melanocyte of skin, and can not form melanin, is to occur the posteriority pigment on a kind of skin to lose speckle be curing the disease of feature.May be relevant with Nervous and Mental Factors, delayed ischemic neurological deficits, immunologic function and endocrine disturbance.Dimension medicine treatment vitiligo with microcirculation improvement, makes melanin new life by diet dieting, adjusting makings, the leukodermic medicine of application of treatment, controls suitable dysregulation phlegmatic temperament, activating blood circulation to dissipate blood stasis.
Summary of the invention
The object of the invention is, provide a kind of treatment leukodermic oral formulations, said preparation is to be made by dry root of Anacyclus pyrethrum(L.)DC., Flos Caryophylli, Rhizoma Zingiberis, anisum fruit, Semen Nigellae, colza, FRUCTUS TERMINALIAE IMMATURUS, Fructus embeliae laetae, Caulis Vernoniae andersonii, Fructus Psoraleae, HUANGKEZIPI, Fructus Terminaliae Billericae, Fructus Phyllanthi, Stigma Croci, clinical data shows: 286 routine patients are observed treatment, after taking said preparation 15-20 days, effect is obvious, the white macula district becomes redness, after continuing to take 45 days, have the local pigment of 92% patient to recover normal, the area that pigment recovers surpasses more than 85%.Serve on three courses of treatment, strengthen consolidating, its disease is no longer recurred.Said preparation has the dysregulation phlegmatic temperament, activating blood circulation to dissipate blood stasis, and the catalysis melanocyte is synthetic, and treatment vitiligo effect is remarkable, and curative effect is short, cure rate is high, be difficult for recurrence, do not have secondary toxic action, to remedy the deficiency of other drug.
The leukodermic oral formulations of a kind of treatment of the present invention, the content of the per 1 part of each component of said preparation is: dry root of Anacyclus pyrethrum(L.)DC. 20-150 gram, Flos Caryophylli 40-180 gram, Rhizoma Zingiberis 30-190 gram, anisum fruit 20-160 gram, Semen Nigellae 25-210 gram, colza 40-120 gram, FRUCTUS TERMINALIAE IMMATURUS 45-130 gram, Fructus embeliae laetae 5-70 gram, Caulis Vernoniae andersonii 15-90 gram, Fructus Psoraleae 20-160 gram, HUANGKEZIPI 30-210 gram, Fructus Terminaliae Billericae 50-200 gram, Fructus Phyllanthi 20-100 gram, Stigma Croci 2-30 gram.
The preparation method of the leukodermic oral formulations of described treatment, dry root of Anacyclus pyrethrum(L.)DC. 20-150 is restrained, Flos Caryophylli 40-180 gram, Rhizoma Zingiberis 30-190 gram, anisum fruit 20-160 gram, Semen Nigellae 25-210 gram, colza 40-120 gram, FRUCTUS TERMINALIAE IMMATURUS 45-130 gram, Fructus embeliae laetae 5-70 gram, Caulis Vernoniae andersonii 15-90 gram, Fructus Psoraleae 20-160 gram, HUANGKEZIPI 30-210 gram, Fructus Terminaliae Billericae 50-200 gram, Fructus Phyllanthi 20-100 gram, Stigma Croci 2-30 gram is got the raw materials ready by the prescription proportioning, mix, stir, grind to form fine powder, with medicated powder with disinfection by ultraviolet light after, cross the 100-160 mesh sieve, fully behind the mix homogeneously, pharmaceutical methods is made oral formulations and is got final product routinely.
Described leukodermic oral formulations is as the purposes of the leukodermic medicine of preparation control.
The leukodermic oral formulations of a kind of treatment of the present invention, each medicine cooperation has the dysregulation phlegmatic temperament in the said preparation, activating blood circulation to dissipate blood stasis, the catalysis melanocyte is synthetic, experimental study in recent years shows that anthelmintic turtledove chrysanthemum, benefit sclerotin etc. are to the key enzyme in the dermal melanin biosynthetic process---tryrosinase has activation, and the catalysis melanocyte is synthetic.All medicines cooperate, and the pathogenesis that hits can play the purpose for the treatment of primary disease.Principal agent wherein: anthelmintic turtledove chrysanthemum, dry root of Anacyclus pyrethrum(L.)DC., benefit sclerotin.Secondary principal agent: Flos Caryophylli, Rhizoma Zingiberis, anisum fruit, Semen Nigellae, colza, Stigma Croci.Regulate medicine: FRUCTUS TERMINALIAE IMMATURUS, Fructus embeliae laetae, HUANGKEZIPI, Fructus Terminaliae Billericae, Fructus Phyllanthi.Major function dysregulation phlegmatic temperament, blood circulation promoting and blood stasis dispelling, open retardance, tonneau through water, promote pigmentation, recover skin color, the strong muscle of cold relieving, warm-up tonifying YANG, regulating stomach, liver, intestinal digestion function.
The present invention can be made into any regular dosage form, and adult's dose is generally every day 2～3 times, each 10-15 gram.
The present invention treats leukodermic dimension medicine oral formulations and is based on Uygur's traditional medicine to pathogenetic understanding of vitiligo and Therapeutic Principle, and according to clinical experience for many years, all medicines cooperate, and the pathogenesis that hits can play the order of treatment primary disease.
The specific embodiment
Embodiment 1 (is radix with 1 part)
With dry root of Anacyclus pyrethrum(L.)DC. 20 grams, Flos Caryophylli 40 grams, Rhizoma Zingiberis 30 grams, anisum fruit 20 grams, Semen Nigellae 25 grams, colza 40 grams, FRUCTUS TERMINALIAE IMMATURUS 45 grams, Fructus embeliae laetae 5 grams, Caulis Vernoniae andersonii 15 grams, Fructus Psoraleae 20 grams, HUANGKEZIPI 30 grams, Fructus Terminaliae Billericae 50 grams, Fructus Phyllanthi 20 grams, Stigma Croci 2 grams, mix, stir, grind to form fine powder, fully behind the mix homogeneously, with medicated powder with disinfection by ultraviolet light after, cross 100 mesh sieves, fully behind the mix homogeneously, pharmaceutical methods is made oral formulations routinely.Adult's dose is every day 2-3 time, and each 10-15 restrains.
Described leukodermic oral formulations is as the purposes of the leukodermic medicine of preparation control.
Embodiment 2 (is radix with 1 part)
With dry root of Anacyclus pyrethrum(L.)DC. 80 grams, Flos Caryophylli 100 grams, Rhizoma Zingiberis 110 grams, anisum fruit 80 grams, Semen Nigellae 150-210 gram, colza 80 grams, FRUCTUS TERMINALIAE IMMATURUS 85 grams, Fructus embeliae laetae 35 grams, Caulis Vernoniae andersonii 55 grams, Fructus Psoraleae 80 grams, HUANGKEZIPI 110 grams, Fructus Terminaliae Billericae 120 grams, Fructus Phyllanthi 60 grams, Stigma Croci 15 grams, mix, stir, grind to form fine powder, with medicated powder with disinfection by ultraviolet light after, cross 120 mesh sieves, fully behind the mix homogeneously, pharmaceutical methods is made oral formulations routinely.Adult's dose is every day 2～3 times, each 10-15 gram.
Described leukodermic oral formulations is as the purposes of the leukodermic medicine of preparation control.
Embodiment 3 (is radix with 1 part)
With dry root of Anacyclus pyrethrum(L.)DC. 150 grams, Flos Caryophylli 180 grams, Rhizoma Zingiberis 190 grams, anisum fruit 160 grams, Semen Nigellae 210 grams, colza 120 grams, FRUCTUS TERMINALIAE IMMATURUS 130 grams, Fructus embeliae laetae 70 grams, Caulis Vernoniae andersonii 90 grams, Fructus Psoraleae 160 grams, HUANGKEZIPI 210 grams, Fructus Terminaliae Billericae 200 grams, Fructus Phyllanthi 100 grams, Stigma Croci 30 grams, mix, stir, grind to form fine powder, with medicated powder with disinfection by ultraviolet light after, cross 160 mesh sieves, pharmaceutical methods is made oral formulations routinely.Adult's dose is every day 2～3 times, each 10-15 gram.
Described leukodermic oral formulations is as the purposes of the leukodermic medicine of preparation control.
Claims (3)
1, the leukodermic oral formulations of a kind of treatment is characterized in that the per 1 part each component content of said preparation is: dry root of Anacyclus pyrethrum(L.)DC. 20-150 gram, Flos Caryophylli 40-180 gram, Rhizoma Zingiberis 30-190 gram, anisum fruit 20-160 gram, Semen Nigellae 25-210 gram, colza 40-120 gram, FRUCTUS TERMINALIAE IMMATURUS 45-130 gram, Fructus embeliae laetae 5-70 gram, Caulis Vernoniae andersonii 15-90 gram, Fructus Psoraleae 20-160 gram, HUANGKEZIPI 30-210 gram, Fructus Terminaliae Billericae 50-200 gram, Fructus Phyllanthi 20-100 gram, Stigma Croci 2-30 gram.
2, the preparation method of the leukodermic oral formulations of treatment according to claim 1, it is characterized in that: dry root of Anacyclus pyrethrum(L.)DC. 20-150 is restrained, Flos Caryophylli 40-180 gram, Rhizoma Zingiberis 30-190 gram, anisum fruit 20-160 gram, Semen Nigellae 25-210 gram, colza 40-120 gram, FRUCTUS TERMINALIAE IMMATURUS 45-130 gram, Fructus embeliae laetae 5-70 gram, Caulis Vernoniae andersonii 15-90 gram, Fructus Psoraleae 20-160 gram, HUANGKEZIPI 30-210 gram, Fructus Terminaliae Billericae 50-200 gram, Fructus Phyllanthi 20-100 gram, Stigma Croci 2-30 restrains mixing, stir, grind to form fine powder, with the medicated powder disinfection by ultraviolet light, cross the 100-160 mesh sieve, fully behind the mix homogeneously, pharmaceutical methods is made oral formulations and is got final product routinely.
3, leukodermic oral formulations according to claim 1 is in the purposes of the leukodermic medicine of preparation control.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101133194A CN101549144B (en) | 2009-05-14 | 2009-05-14 | Oral preparation for treating vitiligo |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101133194A CN101549144B (en) | 2009-05-14 | 2009-05-14 | Oral preparation for treating vitiligo |
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| Publication Number | Publication Date |
|---|---|
| CN101549144A true CN101549144A (en) | 2009-10-07 |
| CN101549144B CN101549144B (en) | 2011-06-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009101133194A Expired - Fee Related CN101549144B (en) | 2009-05-14 | 2009-05-14 | Oral preparation for treating vitiligo |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251847A (en) * | 2013-06-05 | 2013-08-21 | 高忠青 | Traditional Chinese medicine for treating leucoderma |
| CN106421717A (en) * | 2016-11-26 | 2017-02-22 | 新疆维吾尔自治区维吾尔医药研究所 | Uighur medicine compound effective parts and effective part group for treating leucoderma and preparation method thereof |
| CN109512996A (en) * | 2019-01-24 | 2019-03-26 | 依力扎提·阿布都哈克 | A kind of leucoderma electuary and preparation method thereof for treating leucoderma |
| KR102282727B1 (en) * | 2021-02-18 | 2021-07-30 | 노정동 | A composition for preventing and treating vitiligo comprising the natural materials |
-
2009
- 2009-05-14 CN CN2009101133194A patent/CN101549144B/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251847A (en) * | 2013-06-05 | 2013-08-21 | 高忠青 | Traditional Chinese medicine for treating leucoderma |
| CN103251847B (en) * | 2013-06-05 | 2014-10-22 | 河北工程大学 | Traditional Chinese medicine for treating leucoderma |
| CN106421717A (en) * | 2016-11-26 | 2017-02-22 | 新疆维吾尔自治区维吾尔医药研究所 | Uighur medicine compound effective parts and effective part group for treating leucoderma and preparation method thereof |
| CN109512996A (en) * | 2019-01-24 | 2019-03-26 | 依力扎提·阿布都哈克 | A kind of leucoderma electuary and preparation method thereof for treating leucoderma |
| KR102282727B1 (en) * | 2021-02-18 | 2021-07-30 | 노정동 | A composition for preventing and treating vitiligo comprising the natural materials |
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| Publication number | Publication date |
|---|---|
| CN101549144B (en) | 2011-06-22 |
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Granted publication date: 20110622 Termination date: 20180514 |