CN101541335A - Nutritional supplement - Google Patents
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- CN101541335A CN101541335A CNA2007800439074A CN200780043907A CN101541335A CN 101541335 A CN101541335 A CN 101541335A CN A2007800439074 A CNA2007800439074 A CN A2007800439074A CN 200780043907 A CN200780043907 A CN 200780043907A CN 101541335 A CN101541335 A CN 101541335A
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Abstract
A nutritional supplement derived from skeletal tissue found in bony and cartilaginous fish has been found to be useful in the treatment of mineral deficiencies, in particular calcium deficiency, and additionally, in the treatment of arthritis, kidney stones, and gout in animals, including humans. A nutritional supplement composition and a pharmaceutical composition containing the nutritional supplement are also provided. The nutritional supplement contains 300,000 to 400,000 mg/kg calcium, 100 to 150 mg/kg phosphorous, 10 to 20 mg/kg magnesium, and 1,500 to 2,000 mg/kg sodium.
Description
Invention field
The present invention relates to a kind of nutritional supplement (nutritional supplement), relate to particularly be used for the treatment of suffer from calcium deficiency, the patient's of arthritis, renal calculus and/or gout nutritional supplement.
Summary of the invention
The inventor finds that the skeletal tissue that finds in the fish can be used for treating the patient who suffers from calcium deficiency.Further, the inventor finds that the skeletal tissue that finds in the fish can be used for treating the patient who suffers from arthritis, renal calculus and/or gout.
Therefore, in a first aspect of the present invention, provide a kind of nutritional supplement who stems from the skeletal tissue that finds in the fish.
In a second aspect of the present invention, a kind of nutritional supplement composition is provided, this nutritional supplement composition comprises skeletal tissue and carrier and/or the excipient of finding in the fish.
In a third aspect of the present invention, a kind of pharmaceutical composition is provided, this pharmaceutical composition comprises skeletal tissue and pharmaceutically acceptable carrier and/or the excipient of finding in the fish.
Of the present invention further aspect, the method that provides a kind of treatment to suffer from the patient of calcium deficiency, described method comprise nutritional supplement as defined above, nutritional supplement composition or the pharmaceutical composition of using effective dose.
Of the present invention further aspect, the method that provides a kind of treatment to suffer from the patient of arthritis, renal calculus and/or gout, described method comprise nutritional supplement as defined above, nutritional supplement composition or the pharmaceutical composition of using effective dose.
In one embodiment of the invention, nutritional supplement, nutritional supplement composition or the pharmaceutical composition of using effective dose comprise, nutritional supplement, nutritional supplement composition or drug composition oral ground or the gastrointestinal other places of effective dose is applied to the patient.
In another aspect of the present invention, provide the skeletal tissue that finds in the fish to be used for the treatment of purposes in the patient's who suffers from calcium deficiency the medicine in preparation.
Of the present invention also on the other hand, provide the skeletal tissue that finds in the fish to be used for the treatment of to suffer from arthritis, the purposes in the patient's of renal calculus and/or gout the medicine in preparation.The detailed description of the preferred embodiment of the invention
The present invention relates to the nutritional supplement, relate to the nutritional supplement that stems from the skeletal tissue that finds in the fish particularly, relate to the nutritional supplement composition that contains described skeletal tissue, relate to the pharmaceutical composition that contains described skeletal tissue, and relate to such nutritional supplement and compositions be used for the treatment of suffer from mineral deficiency, the patient's of arthritis, renal calculus and/or gout purposes.
Usually, skeletal tissue finds in the skull of fish, is preferably shaped to a pair of little deposit that is present in the skull top.Skeletal tissue can be os osseum (bony) or cartilage.The illustrative examples of skeletal tissue includes but not limited to, at statocyst, promptly is arranged in the otolith that the chamber of the skull below the brain is found.Otolith is formed by polycrystalline calcium carbonate such as aragonite.Should be understood that in other embodiments of the present invention skeletal tissue also can be formed by the polycrystalline calcium carbonate.
In one embodiment of the invention, skeletal tissue can find in bony fish (bony fish).Preferably, skeletal tissue finds in from gadidae (Gadidae family) the teleostean skull of (more generally being called morrhua section (cod family)).The illustrative examples of alternative section that wherein can find the fish of the morrhua of skeletal tissue or morrhua sample includes but not limited to, coalfish section (Melanonidae), wry tail gadidae (Euclichthyidae), need not gadidae (Merlucciidae), Stindachneriidae and Macrouridae (Macrouridae).
In optional embodiment of the present invention, skeletal tissue finds in the selachian such as shark, ray (ray), bluet (skate).
The illustrative examples of the section of the wherein known bony fish of having found skeletal tissue or selachian includes but not limited to: Rhincodontidae (Rhiniodontidae), Stegostimatidae, strand mouthful shark section (Ginglymostomatidae), Carchariidae (Odontaspididae), Alopiidae (Alopiidae), Heterodontidae (Heterodontidae), Lamnidae (Lamnidae), Hexanchiade (Hexanchidae), India shark section (Hemiscyllidae), Scylliorhinidae (Scyliorhinidae), Orectolobidae (Orectolobidae), Carcharhinidae (Carcharhinidae), hammerhead section (Spyrnidae), Pristidae (Pristidae), point Rhinobatidae (Rhynchobatidae), Rhinobatidae (Rhinobatidae), Squatinidae (Squatinidae), flat ray section (Urolophidae), Torpedinidae (Torpedinidae), Rajidae (Rajidae), ray section (Dasyatididae), Mobulidae (Mobulidae), swallow ray section (Gymnuridae), eagle ray section (Myliobatidae), Ratfishes (Chimaeridae), Elopidae (Elopidae), ladyfish section (Albulidae), Chanidae (Chanidae), Meglopidae, valued knife Gyrinocheilidae (Chirocentridae), clupeidae (clupeidae) Anchovies section (Engraulidae), moray section (Muraenidae), Congridaw, Serpentis eel section (Ophichthidae), sea Nian section (Ariidae), eel cat section (Plotosidae), Lizardfiss section (Synodotidae), bombay duct (Harpodontidae), scorpion fish section (Batrachoididae), Gobiesocidae (Gobiescosidae) lame Gyrinocheilidae (Antennariidae), weasel Blenniidae section (Ophidiidae), Carapidae (Carapidae), tire weasel Blenniidae section (Bythitidae), Exocoetidae (Exocoetidae);
Section (Hemirhamphidae), needlefish section (Belonidae), Atherinidae (Atherinidae), Wei section (Holocentridae), Strobilus Pini Gyrinocheilidae (Monocentridae), Zeidae (Zeidae), Pedicellus et Pericarpium Trapae Channa argus section (Caproidae), flag Lamripdae (Veliferidae), smoke pipe Gyrinocheilidae (Fistularidae), mouth of pipe Gyrinocheilidae (Aulostomidae), Bao Fang Fu section of pin Yong section (Hoplichthidae) (Dactylopteridae), Pegasidae (Pegasidae), augitite shrimpfish section (Centriscidae), razor Gyrinocheilidae (Solenostomidae), Syngnathidae (Syngnathidae), Syngnathidae, Rockfish section (Scorpaenidae), Fang Fu section of velour leather Rockfish section (Aploactinidae) (Triglidae), Yong section (Platycephalidae), purport section (Serrandae), Dong section of strain line Gyrinocheilidae (Grammistidae) Ji Dong section (Acanthoclinidae) (Plesiopidae), intend Pomacentridae (Pseudochromidae), snook section (Centropomidae), bilateral Gyrinocheilidae (Ambassidae), Xi section of La section of leaf Channa argus section (Glaucosomidae) (Teraponidae) (Sillaginidae), a big Channa argus section (Priacanthidae), Apogonidae (Apogonidae), Scad section (Carangidae), Mahi Cobitidae (Coryphaenidae), Malacanthidae (Malacanthidae) Bluefish section (Pomatomidae), Yin section of Rachycentron canadum section (Rachycentridae) (Echeneidae), glasses Gyrinocheilidae (Menidae), Bi section (Leiognathidae), tripletail section (Lobotidae), Lutjanidae (Lutjanidae), Pomadasyidae (Haemulidae), prunus mume (sieb.) sieb.et zucc. Channa argus section (Caesionidae), longevity Gyrinocheilidae (Banjosidae), naked cheek Channa argus section (Lethrinidae), Channa argus section (Sparidae), Menipteridae, broad shad section (Gerreidae), Mullidae (Mullidae), Sciaenidae (Scianidae), a big silvery pomfret section (Monodactylidae), fat eye triangular bream section (Leptobramidae), Haplolepidae (Pempheridae), rudder Gyrinocheilidae (Kyphosidae), Scorpidadae, Toxotidae (Toxotidae), money Gyrinocheilidae (Scatophagidae), orbfish section (Ephippididae), silk fin silvery pomfret section (Rhinoprenidae), Chaetodontidae (Chaetodontidae), indianfish section (Pomacanthidae), Pomacentridae (Pomacentridae), Pentaceros section (Pentacerotidae), fish father-in-law section (Cirrhitidae), gram Callichthyidae (Creediidae), Bandfishes (Cepolidae), eel Blenniidae section (Congrodadidae), palpus eel Blenniidae section (Notograptidae), Mugilidae (Mugilidae), Polynemidae (Polynemidae), Yu section (Sphyraenidae), Labridae (Labridae), Scaridae (Scaridae), mullet shape Teng section (Mugiloididae), back jaw
Section (Opistognathidae),
Section (Uranoscopidae), Blenniidae section (Blenniidae), three fin Blenniidae sections (Tripterygiidae), of fish rank section (Callionumidae) Acenthogobius flavimanus section (Gobiidae), Eleotridae (Eleotridae), Gobiodae, Moorish idol section (Zanclidae), Siganidae (Siganidae), Acanthuridae (Acanthuridae), Istiophoridae (Istiophoridae), Xiphiidae (Xiphiidae), mackerel section (Scombridae), Qian section (Psetodidae), Bothidae (Bothidae), Pangasiidae (Pleuronectidae), Soleidae (Soleidae), Cynoglossidae (Cynoglossidae), perch Teng Ke (Percophididae), blackfish section (Centrolophidae), Nomeidae (Nomeidae), Ariomma section (Ariommatidae), three tooth Molidaes (Triodontidae), Hollardia section (Triacanthodidae), three thorn Molidaes (Triacanthidae), squama Molidae (Balistidae), Monacanthus section (Monacanthidae), case Molidae (Ostraciidae), Molidae (Tetraodontidae), thorn Molidae (Diodontidae).
Nutritional supplement of the present invention removes skeletal tissue by the skull from fish and skeletal tissue is cleaned and be ground to fine powder and prepares.Usually, skeletal tissue has translucent milky white appearance, has the hardness in about 5 units of Mohs' hardness scale (Mohr scale).The average weight of skeletal tissue is about 230mg.
Resulting nutritional supplement contains 300,000 to 400, the calcium of 000mg/kg, 100 to 150mg/kg phosphorus, 10 to 20mg/kg magnesium and 1,500 to 2, and the sodium of 000mg/kg, and suitable mammal (comprising the people) consumes.
Specifically, the above-mentioned concentration of calcium, phosphorus and magnesium makes nutritional supplement of the present invention be suitable for treating mineral deficiency, especially calcium deficiency in mammal (comprising the people), house pet (as Canis familiaris L. and cat), domestic animal (as horse, cattle and sheep) or the zoo animal (as felid, Canis animals, bovid and ungulate).
The nutritional supplement can dry powder form directly absorb or with solid food or liquid food or beverage blends picked-up.
In addition, the nutritional supplement can with carrier and/or excipient composition to produce nutritional supplement composition.Many acceptable carriers are known in the nutritional supplement field, and carrier can be any suitable carriers.Carrier only need be fit to be applied to animal (comprising the people), and can not influence nutritional supplement's expectation activity as carrier basically.Also can select carrier based on the dosage form of required route of administration and compositions.For example, nutritional supplement composition according to the present invention is suitable for using with multiple dosage form, as liquid dosage form and solid dosage forms.
Further, pharmaceutical composition can prepare with pharmaceutically acceptable carrier and/or mixed with excipients by the skeletal tissue that will find in the fish.
As used herein term " pharmaceutically acceptable " refer to be suitable for animal (comprising the people) absorb, do not have undue toxicity, incompatibility, unstability, zest, anaphylaxis and similar reaction, with rational benefit/risk than forms of pharmacologically active agents that matches or inert fraction.
Compositions of the present invention can combine existence with one or more pharmaceutically acceptable carriers and/or excipient and/or diluent and/or adjuvant and other active component (if desired).
The compositions that is used to orally use can prepare according to any method that is used for pharmaceutical compositions known in the art, and this compositions can contain one or more sweeting agents, flavoring agent, coloring agent, antiseptic, stabilizing agent, buffer agent, dispersant, thickening agent, solubilizing agent and analog, and vitamin, mineral, coenzyme, organic oxidation-resistant agent or inorganic anti oxidant or its precursor, other nutritional supplement and/or plant extract and other active component.
The illustrative examples that can be used on the sweeting agent in the present composition includes but not limited to, fructose, sucrose, saccharide, dextrose, lactose, maltose, maltodextrin, corn-syrup solids (corn syrupsolid), solid honey (honey solid), mannitol, Sorbitol, xylitol, glucide, aspartame, cyclohexyl-n-sulfonate (cyclamate), acesulfame potassium (acesulfame K), neohesperidin dihydrochalcone, other super sweeteners and composition thereof, they can enough low amount be added in the carrier, thus not can with nutritional supplement's chemically reactive.
The illustrative examples that can be used on the flavoring agent in the present composition includes but not limited to, Herba Menthae (peppermint), Herba Menthae-menthol, eucalyptole, Ilicis Purpureae, Radix Glycyrrhizae, Flos Caryophylli, Cortex Cinnamomi, Herba Menthae Rotundifoliae, Fructus Pruni pseudocerasi, Fructus Citri Limoniae, orange, Citrus aurantium Linn., menthol and various combination thereof.
The mode that compositions of the present invention can be suitable for orally using is prepared, for example as tablet, buccal tablet, lozenge, water slurry or oil suspension, dispersible powders (dispersible powder) or granule, Emulsion, hard capsule or soft capsule or syrup or elixir.
Tablet contains and is suitable for making the nutritional supplement of the nontoxic pharmaceutically acceptable mixed with excipients of tablet.These excipient can be inert diluents for example, as calcium carbonate, sodium carbonate, sodium citrate, lactose, calcium phosphate, sodium phosphate, microcrystalline Cellulose, corn starch, potato starch and cellulose esters (as cellulose acetate, ethyl cellulose); Granulating agent and disintegrating agent, for example corn starch or alginic acid or composition silicate; Binding agent, for example starch, polyvinylpyrrolidone, PEG-8000, gelatin or Radix Acaciae senegalis; And lubricant, for example magnesium stearate, stearic acid, sodium lauryl sulfate or Talcum.Tablet can not come coating by known technology by coating or they.In some cases, such coating can prepare by known technology, postponing in gastrointestinal disintegrate and absorption, and therefore provides the continuous action of longer time.For example, can adopt time-delay material (time delay material) such as glyceryl monostearate or distearin.
The preparation that is used to orally use also can be used as hard gelatin capsule and provides, wherein the nutritional supplement for example calcium carbonate, calcium phosphate or Kaolin mix with inert solid diluent, or provide for example Oleum Arachidis hypogaeae semen, liquid paraffin or mixed with olive oil of nutritional supplement and water or oily medium wherein as Perle.
Water slurry contains and is suitable for making the nutritional supplement of the mixed with excipients of water slurry.Such excipient is a suspending agent, for example sodium carboxymethyl cellulose, methylcellulose, hydroxypropyl-methylcellulose (hydropropyl-methylcellulose), sodium alginate, polyvinylpyrrolidone, Tragacanth and Radix Acaciae senegalis; Dispersant or wetting agent can be naturally occurring phospholipid such as lecithin, or 1, the condensation product of 2-epoxyalkane and fatty acid such as Myrj 45, or the condensation product of oxirane and long-chain fatty alcohol such as heptadecane ethoxy thiazolinyl spermol (heptadecaethyleneoxycetanol), or oxirane and derived from the condensation product such as the polyoxyethylene sorbitan monoleate of the partial ester of fatty acid and hexitol, or oxirane and derived from the condensation product such as the polyethylene dehydrated sorbitol mono-fatty acid ester (polyethylene sorbitanmonooleate) of the partial ester of fatty acid and hexitan mixture.Aqueous suspension agent also can contain one or more antiseptic such as ethylparaben or P-hydroxybenzoic acid n-propyl, one or more coloring agent, one or more flavoring agents and one or more sweeting agents such as sucrose or glucide.
Oil suspension can by the nutritional supplement is suspended in vegetable oil such as Oleum Arachidis hypogaeae semen, olive oil, Oleum sesami or Oleum Cocois or be suspended in mineral oil such as liquid paraffin in prepare.Oil suspension can contain thickening agent, for example Cera Flava, hard paraffin or acetyl alcohol (acetyl alcohol).Can add sweeting agent and flavoring agent good to eat oral formulations is provided.Can preserve these compositionss such as the antioxidant of ascorbic acid by adding.
Be suitable for providing and dispersant or wetting agent, suspending agent and the blended nutritional supplement of one or more antiseptic by adding dispersible powders and the granule that water prepares water slurry.Suitable dispersant or wetting agent or suspending agent are by already mentioned those examples above.Also can there be other excipient, for example sweeting agent, flavoring agent and coloring agent.
Pharmaceutical composition of the present invention can also be the form with oil in water emulsion.Oil phase can be vegetable oil or mineral oil or these oily mixture.Suitable emulsifying agent can be naturally occurring natural gum such as Radix Acaciae senegalis or Tragacanth, naturally occurring phospholipid such as soybean lecithin (soy bean, lecithin) and derived from fatty acid and hexitan mixture (hexitol, ester anhydride) or partial ester as dehydrated sorbitol mono-fatty acid ester and as described in the condensation product such as the polyoxyethylene sorbitan monoleate of partial ester and oxirane.Emulsion also can contain sweeting agent and flavoring agent.
Syrup and elixir can be prepared with sweeting agent such as glycerol, propylene glycol, Sorbitol, glucose or sucrose.Such preparation also can contain demulcent, antiseptic, flavoring agent and coloring agent.
Pharmaceutical composition can be the form with sterile injectable aqueous or oleagenous suspension.Can use those suitable dispersants or wetting agent and the suspending agent above mentioned, prepare this suspension according to known technology.Sterile injectable preparation can also be nontoxic parent's (parentally) acceptable diluent or sterile injectable solution or the suspension in the solvent, for example as the solution in the 1,3 butylene glycol.Adoptable acceptable carrier and solvent are water, Ringer's mixture and isotonic sodium chlorrde solution.In addition, aseptic, fixed oil is usually as solvent or suspension media.For this purpose, can adopt the fixed oil of any gentleness, comprise synthetic monoglycceride or diglyceride.In addition, find to can be used for preparing the injectable agent such as oleic fatty acid.
Also find surprisingly, absorb nutritional supplement of the present invention or comprise the nutritional supplement and the compositions of one or more carriers and/or excipient treatment is suffered from renal calculus, gout and arthritic patient is useful.
Can change with host who is treated and specific mode of administration with carrier and/or excipient composition effective dose with the nutritional supplement that produces the single dose form.Dosage unit form generally contains from about 5mg to the nutritional supplement between about 5000mg.The dosage that reaches 1000-5000mg is suitable for consuming every day.Term " effective dose " refers to respect to patient's symptom of using before the nutritional supplement as used herein, is enough to alleviate or reduce the mineral deficiency nutritional supplement's of the symptom of the symptom of calcium deficiency or arthritis, renal calculus and/or gout the amount especially of being treated patient (subject patient).Should understand, effective dose to any particular patient or curee depends on various factors, and described factor comprises age, body weight, general health, sex, diet, time of application, route of administration, discharge rate and the seriousness of the particular condition that stands to treat.
In the treatment of renal calculus, preferred dosage is the 230mg nutritional supplement, and take every day, continues 3 day time.To the treatment of other diseases, preferred dosage is 800mg, and take 2-3 every day.
The nutritional supplement independent or that be formulated as the present composition that oral or parenteral is used effective dose has alleviated the symptom of the individuality of suffering from above-mentioned disease.Usually, the clinical patients of suffering from renal calculus shows alleviating of symptom in 24 hours after oral or parenteral are used compositions, and seldom or do not have an adverse side effect.It is believed that compositions has realized dissolving renal calculus, it is discharged by the patient then in a usual manner.
Provide following embodiment with further illustration several embodiments of the present invention.
Embodiment 1.
Shift out the sclerotin deposit, clean and grind to form tenderly white powder (fine whit powder) from morrhua skull.Analysed for powder, and find that it has the composition that shows as following table.
| Analyze | 1. result | 2. adult's dosage 1 230mg takes every day | 3. dosage 2 400mg (taking every day 3 times) are grown up | X3 | Food standard standard (Food Standards Code) maximum to " not containing not the food of standardized food separately " |
| Calcium, Camg/kg | 347,000 | 79.8 | 138.8 | 416 | - |
| Phosphorus, P ppm | 120 | 0.03 | 0.05 | 0.14 | - |
| Sodium, Na ppm | 1850 | 0.43 | 0.7 | 2.2 | - |
| Magnesium, Mg mg/kg | 14 | 0.0003 | 0.0006 | 0.02 | - |
| Cadmium, Cd ppm | ＜0.05 | Trace | Trace | Trace | 0.05 |
| Hydrargyrum, Hg ppb lead, pb ppm | ＜10 | ＜0.002 | ＜0.004 | ＜0.012 | 0.03 |
| Zinc, Zn ppm | ＜1 | Trace | Trace | ＜0.001 | 1.5 |
| Chromium, Cr ppm | 3 | Trace | ＜0.001 | 0.004 | 150 |
| Copper, Cu ppm | ＜5 | ＜0.001 | ＜0.002 | ＜0.006 | Can't obtain |
| 1.5 | Trace | Trace | ＜0.002 | 10 |
Be apparent that from table nutritional supplement's first recommended dose (referring to the 2nd row) is 230 milligrams, take every day, continues 3 day time.Second recommended dose is the consumption of 400mg, takes every day 3 times (referring to the 3rd row).On these levels, the patient absorbs the calcium of useful amount every day.
On the other hand, other components especially the intake of lead, cadmium, hydrargyrum, chromium, zinc and copper far below the minimum flow of food standard specification recommends, shown in the 4th row.
Although should be understood that this paper can be with reference to the use and the publication of prior art, this reference does not constitute admits that any in these forms the part of this area common sense in Australia or any other are national.
In description of the present invention, except since representation language or necessary implication the place that context requires in addition, speech " comprises (comprise) " or uses with the meaning that comprises such as the variant that " comprising (comprises) " " comprises (comprising) ", promptly in each embodiment of the present invention, specify the existence of described feature, but do not get rid of the existence or the increase of further feature.
Except described those, many variations and change will be presented on various equivalent modifications at the moment, and not depart from basic inventive concept.All these type of variations and change will be considered within the scope of the invention, and character of the present invention will be determined by above-mentioned description.
Claims (18)
1. nutritional supplement, it stems from the skeletal tissue that finds in the fish.
2. nutritional supplement as claimed in claim 1, wherein said skeletal tissue be os osseum or cartilage.
3. as claim 1 or the described nutritional supplement of claim 2, wherein said skeletal tissue finds in the skull of fish.
4. nutritional supplement as claimed in claim 3, wherein said skeletal tissue are configured as a pair of little deposit that is present in described skull top.
5. nutritional supplement as claimed in claim 4, wherein said skeletal tissue is an otolith.
6. as claim 3 each described nutritional supplement to the claim 5, wherein said skeletal tissue finds in the teleostean skull from gadidae.
7. as claim 3 each described nutritional supplement to the claim 5, wherein said skeletal tissue in the group of the section that comprises following section bony fish or selachian in find: Rhincodontidae, Stegostimatidae, strand mouthful shark section, Carchariidae, Alopiidae, Heterodontidae, Lamnidae, Hexanchiade, India shark section, Scylliorhinidae, Orectolobidae, Carcharhinidae, hammerhead section, Pristidae, the point Rhinobatidae, Rhinobatidae, Squatinidae, flat ray section, Torpedinidae, Rajidae, ray section, Mobulidae, swallow ray section, eagle ray section, Ratfishes, Elopidae, ladyfish section, Chanidae, Meglopidae, the valued knife Gyrinocheilidae, clupeidae Anchovies section, moray section, Congridaw, Serpentis eel section, sea Nian section, eel cat section, Lizardfiss section, bombay duct, scorpion fish section, Gobiesocidae lame Gyrinocheilidae, weasel Blenniidae section, Carapidae, tire weasel Blenniidae section, Exocoetidae Zhen section, needlefish section, Atherinidae, Wei section, Strobilus Pini Gyrinocheilidae, Zeidae, Pedicellus et Pericarpium Trapae Channa argus section, the flag Lamripdae, the smoke pipe Gyrinocheilidae, mouth of pipe Gyrinocheilidae, Bao Fang Fu section of pin Yong section, Pegasidae, augitite shrimpfish section, the razor Gyrinocheilidae, Syngnathidae, Syngnathidae, Rockfish section, Fang Fu section of velour leather Rockfish section, Yong section, purport section, Dong section of strain line Gyrinocheilidae Ji Dong section, intend Pomacentridae, snook section, bilateral Gyrinocheilidae, Xi section of La section of leaf Channa argus section, big Channa argus section, Apogonidae, Scad section, the Mahi Cobitidae, Malacanthidae Bluefish section, Yin section of Rachycentron canadum section, the glasses Gyrinocheilidae, Bi section, tripletail section, Lutjanidae, Pomadasyidae, prunus mume (sieb.) sieb.et zucc. Channa argus section, longevity Gyrinocheilidae, naked cheek Channa argus section, Channa argus section, Menipteridae, broad shad section, Mullidae, Sciaenidae, big silvery pomfret section, fat eye triangular bream section, Haplolepidae, the rudder Gyrinocheilidae, Scorpidadae, Toxotidae, the money Gyrinocheilidae, orbfish section, silk fin silvery pomfret section, Chaetodontidae, indianfish section, Pomacentridae, Pentaceros section, fish father-in-law section, the gram Callichthyidae, Bandfishes, eel Blenniidae section, palpus eel Blenniidae section, Mugilidae, Polynemidae, Yu section, Labridae, Scaridae, mullet shape Teng section, back jaw
Section,
Section, Blenniidae section, three fin Blenniidae sections, fish rank section, Acenthogobius flavimanus section, Eleotridae, Gobiodae, Moorish idol section, Siganidae, Acanthuridae, Istiophoridae, Xiphiidae, mackerel section, Qian section, Bothidae, Pangasiidae, Soleidae, Cynoglossidae, perch Teng Ke, blackfish section, Nomeidae, Ariomma section, three tooth Molidaes, Hollardia section, three thorn Molidaes, squama Molidae, Monacanthus section, case Molidae, Molidae, thorn Molidae.
8. as each described nutritional supplement in the claim 1 to 7, wherein said nutritional supplement prepares by described skeletal tissue is cleaned and is ground to fine powder.
9. as each described nutritional supplement in the claim 1 to 8, wherein said nutritional supplement contains 300,000 to 400, the calcium of 000mg/kg, 100 to 150mg/kg phosphorus, 10 to 20mg/kg magnesium and 1,500 to 2, the sodium of 000mg/kg.
10. nutritional supplement composition, it comprises as each described nutritional supplement and carrier and/or excipient in the claim 1 to 9.
11. a pharmaceutical composition, it comprises as each described nutritional supplement and pharmaceutically acceptable carrier and/or excipient in the claim 1 to 9.
12. a treatment suffers from the patient's of calcium deficiency method, described method comprises effective dose is applied to the patient of this treatment of needs as each described nutritional supplement, nutritional supplement composition as claimed in claim 10 or pharmaceutical composition as claimed in claim 11 in the claim 1 to 9.
13. a treatment suffers from the patient's of arthritis, renal calculus and/or gout method, described method comprises effective dose is applied to the patient of this treatment of needs as each described nutritional supplement, nutritional supplement composition as claimed in claim 10 or pharmaceutical composition as claimed in claim 11 in the claim 1 to 9.
14. as claim 12 or 13 described methods, wherein use the described nutritional supplement of effective dose, described nutritional supplement composition or described pharmaceutical composition and comprise, the described nutritional supplement of effective dose, described nutritional supplement composition or described drug composition oral ground or gastrointestinal other places are applied to described patient.
15. as each described method in the claim 12 to 14, wherein the patient be applied every day dosage from about 5mg to the scope of about 5000mg.
16. method as claimed in claim 15, wherein said dosage every day that is applied reaches 1000mg-5000mg.
17. be used for the treatment of purposes in the patient's who suffers from calcium deficiency the medicine in preparation as each described nutritional supplement in the claim 1 to 9.
18. be used for the treatment of in preparation as each described nutritional supplement in the claim 1 to 9 suffer from arthritis, the purposes of the patient's of renal calculus and/or gout medicine.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2006906674A AU2006906674A0 (en) | 2006-11-29 | Composition food supplement for the treatment of patients suffering from kidney stone, gout & arthritis | |
| AU2006906674 | 2006-11-29 | ||
| AU2007201520 | 2007-04-05 |
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| Publication Number | Publication Date |
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| CN101541335A true CN101541335A (en) | 2009-09-23 |
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| CNA2007800439074A Pending CN101541335A (en) | 2006-11-29 | 2007-11-28 | Nutritional supplement |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773249A (en) * | 2010-03-01 | 2010-07-14 | 宋艳 | Method for preparing active peptide calcium from loach and eel bone and sheep placenta |
| CN103689597A (en) * | 2013-12-24 | 2014-04-02 | 南京中医药大学 | Application of inimicus japonicus or liver extract thereof in preparation of healthcare product or medicine for improving immunity |
| CN110024725A (en) * | 2019-05-27 | 2019-07-19 | 海南晨海水产有限公司 | A kind of artificial raise seedling method of scavenger |
-
2007
- 2007-11-28 CN CNA2007800439074A patent/CN101541335A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773249A (en) * | 2010-03-01 | 2010-07-14 | 宋艳 | Method for preparing active peptide calcium from loach and eel bone and sheep placenta |
| CN101773249B (en) * | 2010-03-01 | 2012-05-23 | 宋艳 | Method for preparing active peptide calcium from loach and eel bone and sheep placenta |
| CN103689597A (en) * | 2013-12-24 | 2014-04-02 | 南京中医药大学 | Application of inimicus japonicus or liver extract thereof in preparation of healthcare product or medicine for improving immunity |
| CN103689597B (en) * | 2013-12-24 | 2015-04-22 | 南京中医药大学 | Application of inimicus japonicus or liver extract thereof in preparation of healthcare product or medicine for improving immunity |
| CN110024725A (en) * | 2019-05-27 | 2019-07-19 | 海南晨海水产有限公司 | A kind of artificial raise seedling method of scavenger |
| CN110024725B (en) * | 2019-05-27 | 2022-02-18 | 海南晨海水产有限公司 | Artificial breeding method of acanthopagrus schlegelii |
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