CN101537044A - Neem oil microemulsion and application thereof - Google Patents
Neem oil microemulsion and application thereof Download PDFInfo
- Publication number
- CN101537044A CN101537044A CN200910059057A CN200910059057A CN101537044A CN 101537044 A CN101537044 A CN 101537044A CN 200910059057 A CN200910059057 A CN 200910059057A CN 200910059057 A CN200910059057 A CN 200910059057A CN 101537044 A CN101537044 A CN 101537044A
- Authority
- CN
- China
- Prior art keywords
- neem oil
- oil microemulsion
- neem
- deionized water
- microemulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides neem oil microemulsion and a preparation method thereof which have the advantages of presenting high effect of killing vermin on the body surfaces of animals, overcoming the service durability of chemical drugs, reducing usage amount and drug cost and enhancing the insecticidal activity. The invention also has another purpose of providing the application of the neem oil microemulsion in controlling the verminosis which appears on the body surfaces of the animals. The invention adopts the following technical scheme to realize that seed oil prepared from the insecticidal plant, i.e. neem, is used as an insecticidal active component; and under the action of emulsifier and assistant emulsion, the neem seed oil is uniformly dispersed in deionized water to form the semitransparent or transparent nim oil microemulsion which is of oil-in-water type (O/W type).
Description
Technical field
The present invention relates to a kind of animal body surface insecticide, relate to a kind of animal body surface insecticidal activity microemulsion and application thereof that contains neem oil particularly.
Background technology
China is a breed big country in the world, and is annual because harm such as ectozoa such as Ticks, demodicid mite, fly, mosquito, flea have caused tremendous loss to aquaculture.At present, in the parasitic control of animal body surface,, caused the generation of problems such as person poultry toxicity, drug residue, drug resistance and environmental pollution owing to frequently use chemical synthetic drug in a large number.For this reason, exploitation wide spectrum, efficient, low-residual come into one's own gradually to environment and person poultry safety's plant source medicine.
The efficient insecticide plant that Azadirachta Indica A. is universally acknowledged, its Azadirachta Indica A. seed oil not only has multiple biological activity, but and safety natural degradation.But the report that is used for animal diseases control for neem oil is few, and Chinese invention patent discloses the ublic specification of application (patent No. 03117727.1) that a kind of name is called " with neem oil preparation control parasite in aquiculture preparation and preparation method thereof ".But do not see and be useful on the ectozoal control of poultry.And existing neem oil preparation is mainly emulsifiable concentrate and aqueous emulsion, this two kinds of preparations or have problem of environmental pollution, or be exactly lamination, and also dosage is bigger, has caused adverse consequences for ecological environment and product quality.
Summary of the invention
The objective of the invention is shortcoming, provide a kind of, overcome the ruggedness of chemical medicine, reduce use amount and drug cost, strengthen neem oil microemulsion of insecticidal activity and preparation method thereof animal body surface parasite insecticidal effect ideal at prior art.
Another object of the present invention provides the application of above-mentioned neem oil microemulsion in control animal body surface parasitic disease.
Purpose of the present invention is implemented by the following technical programs: with pesticide plant Azadirachta Indica A. seed oil is the insecticidal activity composition, by emulsifying agent and the effect that helps Emulsion, make it be scattered in the translucent or transparent neem oil microemulsion of formation in the deionized water equably, be oil-in-water type (O/W type) microemulsion.
Described neem oil microemulsion is made up of following percentage by weight:
Neem oil 0.1%～35% emulsifying agent 0.2%～50%,
Co-emulsifier 0.1%～20% deionized water 10%～90%
Described neem oil is Azadirachta Indica A. seed process squeezing, organic solvent extraction or CO
2The supercritical extraction gained.
Described emulsifying agent is C
8～C
20Alkyl benzene sulfonate calcium salt (or salt such as magnesium, zinc, sodium, barium, aluminum), C
8～C
18Alkylsurfuric acid sodium salt (or potassium, ammonium salt etc.), C
12～C
18One or more of polyoxyethylenated alcohol sodium sulfate salt (or salt such as potassium, ammonium), polyoxyethylene sorbitan fatty acid ester, phenethyl phenol polyethenoxy polyethenoxy ether, alkylphenol polyoxyethylene, alkylphenol polyoxyethylene formaldehyde condensation products etc.
The described Emulsion that helps is C
1～C
10In low chain alcohols, as methanol, ethanol, propylene glycol, glycerol, n-butyl alcohol, n-amyl alcohol, hexanol, n-heptanol etc.
The neem oil microemulsion method for producing insecticide is: the Azadirachta Indica A. seed is through squeezing, organic solvent extraction or CO
2Supercritical extraction gets neem oil; Earlier neem oil is mixed with emulsifying agent, co-emulsifier in proportion, add small amount of deionized water then gradually, be stirred well to transparently in 30～50 ℃ of heating, add the remaining abundant stirring and evenly mixing of deionized water at last and promptly get translucent or transparent neem oil microemulsion.
The purposes of neem oil microemulsion insecticide is a control animal body surface parasitic infection.
Advantage of the present invention is: to humans and animals and Environmental security; Good penetrability, the absorbance height; Help medicine and enter in the parasitic polypide, improved drug effect; Can with the deionized water infinite dilution, not stratified, the convenient use; With the deionized water is substrate, aboundresources, and product cost is low, and technology is simple, is convenient to suitability for industrialized production.
Below further specify the present invention by specific embodiment, but embodiment only be used for the explanation can not limit the scope of the invention.
The specific embodiment
Embodiment 1: the neem oil microemulsion insecticide by neem oil, emulsifying agent, help Emulsion and deionized water to form.Above-mentioned neem oil is CO
2Supercritical extraction gained, emulsifying agent are C
8～C
20Alkylbenzenesulfonate and polyoxyethylene sorbitan fatty acid ester, helping emulsifying is n-butyl alcohol, n-amyl alcohol, hexanol, n-heptanol.More than the percentage by weight of each composition: neem oil 0.1%, emulsifying agent 40% helps Emulsion 15%, deionized water 44.9%.Earlier neem oil is mixed with emulsifying agent, co-emulsifier in proportion during preparation, add small amount of deionized water then gradually, be stirred well to transparently in 30～50 ℃ of heating, add the remaining abundant stirring and evenly mixing of deionized water at last and promptly get translucent or transparent neem oil microemulsion.
Embodiment 2: the neem oil microemulsion insecticide by neem oil, emulsifying agent, help Emulsion and deionized water to form.Above-mentioned neem oil is CO
2Supercritical extraction gained, emulsifying agent are C
8～C
20Alkylbenzenesulfonate and polyoxyethylene sorbitan fatty acid ester, helping emulsifying is n-butyl alcohol, n-amyl alcohol, hexanol, n-heptanol.More than the percentage by weight of each composition: neem oil 10%, emulsifying agent 25% helps Emulsion 5%, deionized water 60%.Earlier neem oil is mixed with emulsifying agent, co-emulsifier in proportion during preparation, add small amount of deionized water then gradually, be stirred well to transparently in 30～50 ℃ of heating, add the remaining abundant stirring and evenly mixing of deionized water at last and promptly get translucent or transparent neem oil microemulsion.
Embodiment 3: the neem oil microemulsion insecticide by neem oil, emulsifying agent, help Emulsion and deionized water to form, neem oil is CO
2Supercritical extraction gained, emulsifying agent are C
8～C
18Alkylsurfuric acid sodium salt and polyoxyethylene sorbitan fatty acid ester, helping emulsifying is n-butyl alcohol, n-amyl alcohol, hexanol, n-heptanol.More than the percentage by weight neem oil 10% of each composition, emulsifying agent 20% helps Emulsion 10%, deionized water is 60%.Earlier neem oil is mixed with emulsifying agent, co-emulsifier in proportion during preparation, add small amount of deionized water then gradually, be stirred well to transparently in 30～50 ℃ of heating, add the remaining abundant stirring and evenly mixing of deionized water at last and promptly get translucent or transparent neem oil microemulsion.
Indoor insecticidal test result, product of the present invention is handled rabbit acaricide larva with 10% concentration, and in 4 hours, the kill ratio of the product of embodiment 2 reaches more than 97%, and the kill ratio of the product of embodiment 3 reaches more than 100%, and 10% Nim oil-water emulsion is 89%.Its half lethal time of 50 sees Table 1.
Table 1 neem oil microemulsion formulation is analyzed rabbit acaricide larva lethal time of 50 probability value
Embodiment 4: the neem oil microemulsion insecticide by neem oil, emulsifying agent, help Emulsion and deionized water to form.Above-mentioned neem oil is CO
2Supercritical extraction gained, emulsifying agent are C
8～C
20Alkylbenzenesulfonate and polyoxyethylene sorbitan fatty acid ester, helping emulsifying is n-butyl alcohol, n-amyl alcohol, hexanol, n-heptanol.More than the percentage by weight of each composition: neem oil 35%, emulsifying agent 15% helps Emulsion 10%, deionized water 40%.Earlier neem oil is mixed with emulsifying agent, co-emulsifier in proportion during preparation, add small amount of deionized water then gradually, be stirred well to transparently in 30～50 ℃ of heating, add the remaining abundant stirring and evenly mixing of deionized water at last and promptly get translucent or transparent neem oil microemulsion.
The percentage by weight of embodiment 5:20% neem oil microemulsion consists of neem oil 20%, emulsifying agent 30%, co-emulsifier 8.5%, deionized water 41.5%.
Test one: the biological activity test of doing the examination worm with phyllotreta striolata (Phyllotreta striolata) adult shows: 20% neem oil microemulsion is directly acted on the phyllotreta striolata adult, in 24 hours, the neem oil behind the microemulsified can reduce the phyllotreta striolata adult fall worm amount 13.4%, 47.8% and imago feeding area of egg laying amount 55.3%.Wherein to fall sustainable 96 hours of the minimizing of worm amount and egg laying amount of adult, can continue 168 hours at least to the minimizing of imago feeding area.
Test two: select 20 of Sichuan Agricultural University test cattle farms to infect the warble milch cow, wherein 10 are coated with 20% neem oil microemulsion at skin of back, other 10 compare test with 1% ivermectin injection subcutaneous injection, the result shows that 20% neem oil microemulsion is 100% to first and second phase larva killing rate of bomb fly, can make the infection rate of warble reduce to 0, not have 1 routine cattle in the control and poison by 30%.With 3 multiple doses 3 cattle are made toxicity test, do not see toxic reaction.In bomb fly control, this medicament is compared with 1% ivermectin injection, and killing rate improves 10%, has advantage easy and simple to handle, that safety range is big in the use, compares with 1% ivermectin injection, reduced cost, use easier.
200 times, 100 times of 20% neem oil microemulsions after behind the medicine 3 days to advanced age mulberry geometrid (Hemerophila atrilineata) proofread and correct preventive effect all 89.11%, 89.13% and 79.18, more than 88.18%, be significantly higher than 44.17%, 87.19% of 1000 times of 59.16% and 13.11% and 1000 times of phosmet treatment regions that opposes the horse treatment regions.400 times of treatment regions of 20% neem oil microemulsion 1 day, 3 days to low age, advanced age mulberry geometrid (Hemerophila atrilineata) the correction preventive effect be 45.13%, 60.13% and 76.10% and 72.14%, close with 1000 times of enemy horse treatment regions.But compare with phosmet etc., 20% neem oil microemulsion nontoxic residue-free, cost is low, more environmental protection.
Claims (5)
1, a kind of neem oil microemulsion is characterized in that being made up of following mass percent:
Neem oil 0.1%～35%, emulsifying agent 0.2%～50%, co-emulsifier 0.1%～20%, deionized water 10%～90%.
2, a kind of neem oil microemulsion according to claim 1 is characterized in that being made up of following mass percent:
Neem oil 10%～20%, emulsifying agent 5%～10%, co-emulsifier 20%～30%, deionized water 41.5%～60%.
3, according to claim 1 or the described a kind of neem oil microemulsion of claim 2, it is characterized in that: described emulsifying agent is C
8～C
20Alkyl benzene sulfonate calcium salt or magnesium, zinc, sodium, barium, aluminum salt, C
8～C
18Alkylsurfuric acid sodium salt or potassium, ammonium salt, C
12～C
18One or more of polyoxyethylenated alcohol sodium sulfate salt or potassium, ammonium salt, polyoxyethylene sorbitan fatty acid ester, phenethyl phenol polyethenoxy polyethenoxy ether, alkylphenol polyoxyethylene, alkylphenol polyoxyethylene formaldehyde condensation products.
4, according to claim 1 or the described a kind of neem oil microemulsion of claim 2, it is characterized in that: described co-emulsifier is C
1～C
10In low chain alcohols.
5, according to claim 1～4 application of described a kind of neem oil microemulsion in control animal body surface parasitic infection arbitrarily.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910059057A CN101537044A (en) | 2009-04-24 | 2009-04-24 | Neem oil microemulsion and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910059057A CN101537044A (en) | 2009-04-24 | 2009-04-24 | Neem oil microemulsion and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101537044A true CN101537044A (en) | 2009-09-23 |
Family
ID=41120585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910059057A Pending CN101537044A (en) | 2009-04-24 | 2009-04-24 | Neem oil microemulsion and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101537044A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103974621A (en) * | 2011-10-04 | 2014-08-06 | 0903608B.C.有限公司 | Pest control formulations and methods of making and using same |
| CN105724448A (en) * | 2016-04-29 | 2016-07-06 | 成都绿金生物科技有限责任公司 | Neem oil fly-repelling and fly-killing environment-friendly agent used in livestock farm and preparation method thereof |
| CN106491399A (en) * | 2016-11-07 | 2017-03-15 | 成都绿金生物科技有限责任公司 | A kind of removing lice drives demodicid mite spray and preparation method thereof |
| US9999218B2 (en) | 2011-10-04 | 2018-06-19 | 0903608 B.C. Ltd. | Pest control formulations and methods of making and using same |
| CN109805037A (en) * | 2019-02-27 | 2019-05-28 | 中国热带农业科学院环境与植物保护研究所 | A kind of print chinaberry mite killing, fungicide and its preparation method and application |
| CN111743916A (en) * | 2020-07-10 | 2020-10-09 | 广州迈高化学有限公司 | Pesticide for preventing and treating ectoparasites of livestock and poultry as well as preparation method and application thereof |
| CN113908082A (en) * | 2021-10-14 | 2022-01-11 | 上海应用技术大学 | Preparation method of soybean oil microemulsion capable of being infinitely diluted |
-
2009
- 2009-04-24 CN CN200910059057A patent/CN101537044A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103974621A (en) * | 2011-10-04 | 2014-08-06 | 0903608B.C.有限公司 | Pest control formulations and methods of making and using same |
| US9999218B2 (en) | 2011-10-04 | 2018-06-19 | 0903608 B.C. Ltd. | Pest control formulations and methods of making and using same |
| US9999227B2 (en) | 2011-10-04 | 2018-06-19 | 0903608 B.C. Ltd. | Pest control formulations and methods of making and using same |
| CN108633932A (en) * | 2011-10-04 | 2018-10-12 | 0903608 B.C.有限公司 | Injurious insect control formulation and manufacture and use its method |
| US10791744B2 (en) | 2011-10-04 | 2020-10-06 | 0903608 B.C. Ltd. | Pest control formulations and methods of making and using same |
| US10905114B2 (en) | 2011-10-04 | 2021-02-02 | 0903608 B.C. Ltd. | Pest control formulations and methods of making and using same |
| CN105724448A (en) * | 2016-04-29 | 2016-07-06 | 成都绿金生物科技有限责任公司 | Neem oil fly-repelling and fly-killing environment-friendly agent used in livestock farm and preparation method thereof |
| CN106491399A (en) * | 2016-11-07 | 2017-03-15 | 成都绿金生物科技有限责任公司 | A kind of removing lice drives demodicid mite spray and preparation method thereof |
| CN106491399B (en) * | 2016-11-07 | 2019-11-19 | 成都绿金生物科技有限责任公司 | One kind driving mite spray and preparation method thereof except lice |
| CN109805037A (en) * | 2019-02-27 | 2019-05-28 | 中国热带农业科学院环境与植物保护研究所 | A kind of print chinaberry mite killing, fungicide and its preparation method and application |
| CN111743916A (en) * | 2020-07-10 | 2020-10-09 | 广州迈高化学有限公司 | Pesticide for preventing and treating ectoparasites of livestock and poultry as well as preparation method and application thereof |
| CN113908082A (en) * | 2021-10-14 | 2022-01-11 | 上海应用技术大学 | Preparation method of soybean oil microemulsion capable of being infinitely diluted |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101537044A (en) | Neem oil microemulsion and application thereof | |
| CN102349539B (en) | Insecticidal composition containing lythidathion and antibiotic compound | |
| CN102599193A (en) | Food attractant of Bactrocera minax | |
| CN103636661A (en) | Insecticide composition containing bifenthrin and flonicamid | |
| CN101708005A (en) | Acaricidal composition containing bifenazate and application thereof | |
| CN104186514A (en) | Pesticide composition containing cyhalodiamide | |
| CN103651550A (en) | Microcapsule suspending agent prepared from carbosulfan, chlorpyrifos and abamectin by compounding | |
| CN102365958A (en) | Synergistic insecticidal composition containing rotenone and emamectin benzoate | |
| CN101278683A (en) | Pollution-free plant source pesticide rotenone emulsifiable solution formulation and method of preparing the same | |
| CN101406192A (en) | Compositional acaricide and uses thereof | |
| CN101406197B (en) | Compositional mite-killing composition containing spirodiclofen and ivermectin | |
| CN101015297A (en) | Biological insecticide with synergistic effect and preparing method thereof | |
| CN103798282A (en) | Insecticide composition containing pirimiphos-methyl and micro-capsule suspending agent thereof | |
| Bushland et al. | DEVELOPMENT OF SYSTEMIC INSECTICIDES FOR PESTS OF ANIMALS IN THE UNITED STATES1 | |
| CN103202314B (en) | Emulsion in water of pesticide composition for controlling cotton aphids and thrips | |
| CN102090406A (en) | Application of rotenone to preparation of termite insecticide capable of killing termites effectively | |
| CN105994275B (en) | A kind of composition pesticide of ring tebufenozide and biogenic substances | |
| CN104115850A (en) | Insect and mite killing composition containing etoxazole and spirotetramat | |
| CN102308841A (en) | Pesticide composition containing etoxazole | |
| CN106035364A (en) | Insecticide composition containing tefluthrin and cyromazine | |
| CN102988462B (en) | Chinese medicinal preparation for controlling parasites of aquatic animal as well as preparation method and application thereof | |
| CN102239858B (en) | Pesticide composition containing pyrimidifen and avermectins | |
| CN102687723B (en) | Insecticidal composition and purpose of insecticidal composition | |
| CN103371154B (en) | The composition pesticide of a kind of fluorine-containing lice sulfanilamide (SN) and biogenic substances | |
| CN103300033B (en) | Pesticide composition containing flutenzine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090923 |