CN101530196B - Food formula of special diet containing oligopeptides for postoperative patient - Google Patents
Food formula of special diet containing oligopeptides for postoperative patient Download PDFInfo
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Abstract
The invention provides a food formula of a special diet containing oligopeptides for postoperative patients; the composite formula of the food is as follows: foodborne oligopeptides are used as main raw material, Chinese herbal extractives with physic and edible use such as Chinese yam, mulberry, Chinese date, Chinese wolfberry, longan, siberian solomonseal rhizome and the like are added, and oligosaccharide, vitamin and minerals are also added. By adopting the food formula, powdery or grainy food can be made, and is eaten after being dissolved in warm boiled water. The food prepared in accordance with the food formula of the invention is easy to be dissolved, provides small molecule protein, vitamins and minerals which can be quickly absorbed and utilized for human body, and meets the nutritional requirement of postoperative patients; by the combined action of a plurality of factors such as foodborne oligopeptides, biological active ingredients in Chinese herbal extractives with physic and edible use, oligosaccharide and the like, the food formula can benefit vital energy and nourish the blood and auxiliarily improve the immunity of the organism, recuperate intestinal function, and is suitable for postoperative patients.
Description
Technical field:
The present invention relates to a kind of food formula; Especially relate to and a kind ofly can replenish the needed by human nutrient; Help satisfying the body nutritional need, and utilize the function factor in the medicine-food two-purpose Chinese herbal medicine to regulate body function, be fit to the edible food formula of special diet that contains small peptide of postoperative patient.
Background technology:
Numerous disease itself often causes patient's organism metabolic disorder, physical deterioration, and can cause malnutrition in various degree.Though operation is a kind of treatment measure for disease, also is a kind of wound to body.Because the needs that stimulation and the wound tissue of operation repair, the catabolism enhancing of body, to the increase in demand of nutriments such as protein.Simultaneously, the resistance of postoperative patient descends, and postoperative patient usually has degradation symptom under heating, infection, metabolic disorder, anorexia, the digestion and absorption function, even severe complication takes place.Especially accept the patient of gastrointestinal procedures, because function of intestinal canal temporarily can not recover normally, daily diet is limited, has influenced the healing of wound and the recovery of physique.
Postoperative patient is because to the increase of protein requirement, and exists self to absorption of nutrient ingredients and the obstacle that utilizes the aspect such as protein, explains that all postoperative patient is carried out good protein to be replenished and be very important.
Food source property small peptide is one type of small protein that utilizes biological enzymolysis technology to extract.Scientific research confirms that food source property small peptide can not need digest, and directly absorbs; In the process of absorbing, carrier is difficult for saturated, and infiltration rate is fast, the transhipment consumes energy is low; And the competition and the height that also do not have amino acid absorption and transport process to produce ooze phenomenon, obviously are superior to amino acid and complete protein.Simultaneously, food source property small peptide is safe and reliable, is the rare high-quality nitrogenous source of body.
It is the medicine-food two-purpose Chinese herbal medicine that the medicine that comprises a lot of help classes in the traditional Chinese herbal medicine, center are divided into.Health ministry in 2002 has been issued and has been made " be food be again the article list (defending the method prison sends out [2002] No. 51) of medicine " application of Chinese herbal medicine food is had regulations to abide by.Chinese yam, date, mulberry fruit etc. are all at its row.These foods not only have trophic function, also have good medical value.
Small peptide and integration of drinking and medicinal herbs food respectively have application respectively.But through the retrieval of patent documentation and non-patent literature, also not have at present to find special supply postoperative patient edible, be the small peptide food for special foods that primary raw material prepares to eat source property small peptide and medicine-food two-purpose Chinese herbal medicine.
Summary of the invention:
The objective of the invention is nutritional need and the incomplete characteristics of pipe intestinal digesting absorption function, a kind of food formula of special diet that comprises food source inhibition biological active small peptide, medicine-food two-purpose Chinese herbal medicine extract, compound sugar, vitamin and mineral matter is provided to the postoperative patient organization restoration.Immunity of organisms, conditioning body function of intestinal canal enriched blood, improved to this small peptide food formula of special diet can also tonifying Qi when replenishing the required good protein of body, vitamin, mineral matter.It is edible that the small peptide food for special foods that the present invention proposes is fit to postoperative patient.
The food for special foods that the present invention proposes is to be primary raw material with the small peptide, adds traditional medicine-food two-purpose Chinese herbal medicine extract, compound sugar, vitamin, mineral matter again, the compound prescription that is combined into.
The main component of the present invention's prescription is:
Small peptide:
Small peptide of the present invention is oligopeptide, is meant the small molecule protein that utilizes bio-enzyme engineering technology separation and Extraction from animal or vegetable protein.Its mean molecule quantity is below 1000Dalton, and is soluble in water, to acid, thermally-stabilised; Can not need pass through digestion and directly absorption; Bioavailability is high, and amino acid that in absorption and utilization, is superior to dissociating and complete protein can be applicable in the protein supplement.Especially for the low crowd of the ability of digesting and assimilating, small peptide is splendid nitrogenous source.
Except that trophic function, small peptide also has a series of physiological active functions:
1. improve the digestion and absorption function of small intestine.Small peptide can improve mucous membrane of small intestine tissue morphology structure, increases the height and the surface of intestinal villi, deepens the degree of depth of crypts, improves and keep the integrality of intestines wall mucomembranous cell 26S Proteasome Structure and Function.
2. enhancing body immunity.Small peptide can increase the phagocytic rate and the phagocytic index of macrophage, strengthens lymphocytic multiplication capacity, and enhancing antibody forms cell quantity and increases, and improves the immune level of body.
3. anti-oxidant.Small peptide can increase glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalatic activity (CAT), reduces the level of MDA MDA (MAD), thus the performance anti-oxidation function.
4. auxiliary adjustment blood sugar.Zoopery shows that small peptide has the trend that reduces the diabetes rat fasting blood glucose level, but the fasting blood glucose level of normal rat is not had obvious influence.
5. auxiliary adjustment of blood fat.Small peptide can reduce the level of serum total cholesterol and LDL-C.
6. aided blood pressure-lowering.
7. radioresistance.Small peptide helps to keep the integrality of body Skin Cell 26S Proteasome Structure and Function, alleviates radiation injury.
8. promote that mineral matter absorbs.Small peptide in enteron aisle through with the chelating of mineral matter such as calcium, iron, zinc etc., improve the transhipment ratio of mineral matter, increase the absorptivity of mineral matter.
9. strengthen the action effect of function factor in the medicine-food two-purpose Chinese herbal medicine.Function factor in small peptide and the Chinese herbal medicine such as active polysaccharide etc. have synergy, can improve its enhancing body immunity, radiation-resistant effect.
Small peptide of the present invention is meant marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide wherein a kind of, several kinds or all mixing.
Marine collagen peptide of the present invention is meant that the fish-skin with deep-sea fish (like salmon etc.) is a raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
Sea bone peptide of the present invention is meant that the fish-bone with deep-sea fish (like cod, anglerfish etc.) is a raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
It is raw material that Soyprotein peptide of the present invention is meant with the soybean protein, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
Whey protein peptide of the present invention is meant that the lactalbumin with cow's milk is a raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
Ovalbumin peptide of the present invention is meant that with egg protein (like egg albumen) be raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
The medicine-food two-purpose Chinese herbal medicine extract:
Yam extract:
Chinese yam can be strengtheninged the spleen and tonifying the lung, and the benefit of reinforcing the kidney is smart, helps the five internal organs, strengthening the bones and muscles.The Compendium of Material Medica record, Chinese yam ability " kidney-nourishing gas, strengthening the spleen and stomach, antidiarrheal dysentery, the saliva that reduces phlegm, profit fur ".Modern medicine study shows that Chinese yam has multiple bioactivator, like Chinese yam polysaccharide, saponin, mucus protein, choline, protamine, polyphenol oxidase etc.Postoperative patient is in poor health, edible yam extract, and recovery helps invigorating health effectively.
Fructus Mori extract:
Mulberry fruit has nourishing yin and supplementing blood, liver-kidney tonifying, calms the nerves and nourish heart, walk with vigorous strides effects such as shoe, sharp joint.Modern study is found; Contain nutritional labelings such as rutin, glucose, fructose, malic acid, amino nitrogen, calcareous, anthocyanidin, carrotene, linoleic acid, vitamin B complex, vitamin C in the mulberry fruit; Can promote the hematopoietic cell growth, improve deficiency of blood state, can significantly increase spleen, thymus gland quality and serum carbon clearance speed; Can promote lymphocyte transformation, improve immunity of organisms.
Fructus Jujubae extract:
Put down in writing in the Compendium of Material Medica, " jujube be apt to tonifying yin sun, qi and blood, body fluid, train of thought, marrow, all decrease useless nihility unsuitable it ".The tonifying middle-Jiao and Qi of date ability, nourishing blood and tranquilization.Containing the various active composition in the date, like active polysaccharide and water-soluble saccharides, saponin, alkaloid, flavonoids, cyclic adenosine monophosphate, rutin etc., is traditional help good merchantable brand.
Fructus lycii P.E:
Matrimony vine is that former, the antidotal medicine-food two-purpose article of training are reinforced the kidney, consolidated to strong essence.It is sweet to distinguish the flavor of, and property is flat, returns liver, kidney channel, and matrimony vine has filling liver kidney, makes eye bright, the effect of moistening lung.
According to modern medicine study, the fruit of Chinese wolfberry contains the nutritional labeling and the bioactive ingredients of multiple needed by human.LBP-X has very strong antioxidation activity, can elevating blood in the content of superoxide dismutase (SOD), can strong cell membrane, to the attack of Green Tea Extract, and then can promote intercellular material Transfer and transhipment.LBP-X has enhancing human immune.
The longan extract:
Heart-spleen boosting fills blood, the will of calming the nerves.In motherland's medical science, be usually used in treating that consumptive disease is thin and weak, illness such as palpitaition is appointed sad, insomnia forgetfulness, insufficiency of the spleen diarrhoea, postpartum edema, lassitude, spontaneous sweating.Also be the edible good merchantable brands such as people that are suitable for postpartum weakness, insufficiency of vital energy and blood, malnutrition, anaemia.Longan contains abundant glucose, sucrose and protein etc., and iron-holder is also higher, can when improving heat energy, extra-nutrition, can promote hemoglobin regeneration to enrich blood again.Experimental study finds that dried longan pulp is except that whole body is had the benefiting action, and is useful especially to brain cell, and the ability enhance memory is eliminated tired.
Rhizoma Polygonati extract:
Traditional medicine thinks, the effect that sealwort has nourshing kidney moistening lung, nourishing Yin and promoting production of body fluid, invigorates the spleen and benefits qi has good improvement effect to diseases such as weakness of the spleen and the stomach, fatigue and asthenias.Be usually used in that insufficiency of the spleen weak, pale complexion, blood pressure are low, lassitude, diet do not have diseases such as appetite, menoxenia.Contain multiple steroid saponin constituents, active polysaccharide composition, Flavonoid substances in the sealwort, help the enhancing body resistance, recovery of invigorating health effectively and function are improved.
Medicine-food two-purpose Chinese herbal medicine extract of the present invention is a kind of, several kinds or all mixing wherein of yam extract, Fructus Mori extract, Fructus Jujubae extract, Fructus lycii P.E, longan extract, Rhizoma Polygonati extract.
Yam extract of the present invention be meant Chinese yam dry powder water is carried concentrated, the flour that the concentrate spray-drying is prepared.
Fructus Mori extract of the present invention be meant mulberry fruit dry powder water is carried concentrated, the flour that the concentrate spray-drying is prepared.
Fructus Jujubae extract of the present invention be meant date dry powder water is carried concentrated, the flour that the concentrate spray-drying is prepared.
Fructus lycii P.E of the present invention be meant matrimony vine dry powder water is carried concentrated, the flour that the concentrate spray-drying is prepared.
Longan extract of the present invention be meant longan dry powder water is carried concentrated, the flour that the concentrate spray-drying is prepared.
Rhizoma Polygonati extract of the present invention be meant sealwort dry powder water is carried concentrated, the flour that the concentrate spray-drying is prepared.
Compound sugar:
Compound sugar is claimed oligosaccharides again, is meant the low polymerization sugar of the straight or branched that is connected to form through glycosidic bond by 2～10 monose.Functional oligose is not absorbed by human consumption; Do not utilized by most enteron aisle spoilage organisms yet; But can promote beneficial bacteria---the growth and breeding of lactobacillus and Bifidobacterium in the human body, thereby can suppress the spoilage organisms growth, help to improve and keep the enteron aisle normal function.Long-term edible can delay senility, defaecation, raising immunity, alleviate burden of liver, improve the nutrient absorption rate, particularly can improve the absorption of body calcium, iron, zinc ion.
Compound sugar of the present invention is a kind of, several kinds or all mixing wherein of oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide.
Vitamin and mineral matter:
Vitamin and mineral matter are the nutrients of needed by human.The vitamin that adds among the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin C, Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, nicotinic acid, folic acid, pantothenic acid, choline, biotin wherein a kind of, several kinds or all mix.
The mineral matter that adds among the present invention is a kind of, several kinds or all mixing wherein of calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum.Mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter.
The addition of vitamin and minerals (GB14880-1994) is carried out with reference to " DRIs " and " food enrichment use sanitary standard " of Chinese Soclety of Nutrition's promulgation in 2000 among the present invention.
Above-mentioned various batch mixes is even, can keep its powdery, or through granulation, processes powdery or granule state food.
Technological merit of the present invention:
The present invention combines modern nutriology achievement in research and the traditional methods to keep in good health theory that keeps healthy, and has developed a kind of source property small peptide, medicine-food two-purpose Chinese herbal medicine extract, compound sugar, vitamin and mineral matter etc. will eaten and has mixed and the preparation food for special foods.Through the organic assembling of various batchings, various functions are merged, and through the synergy between the active ingredient, humidification effect.Can the desired nutritional composition be provided for postoperative patient by the present invention's food of making of filling a prescription, especially be easy to the protein that absorbed by body, can also strengthen patient's resistance, promote the rehabilitation of postoperative body help vim and vigour.
The characteristic of this formula food and the effect of body mainly shown the following aspects:
1) food has good absorbability, isotonicity and does not have slag property
Utilize prescription of the present invention, various components adopt the food of suitable ratio collocation preparation, the state that oozes such as after a certain amount of water-soluble separating, are; Can arrive small intestine through stomach fast; Need not digest direct absorption, and absorb fast, fully no residue; Not increasing stomach and intestine and burden of liver, is the nutrient supplement food of abdominal operation patient high-quality.
2) good trophism
Formula food of the present invention is a nitrogenous source with the small peptide in multiple source, can not absorb because small peptide need not digest, and multiple small peptide forms the amino acid pattern of balance, more helps the utilization of body.Can improve the postoperative patient negative nitrogen balance to a certain extent.
Formula food of the present invention contains multivitamin and mineral matter, can replenish the postoperative patient desired nutritional rapidly.Small peptide through with the chelating of calcium, iron, zinc etc. after, more increased the absorptivity of mineral matter element.
3) utilize the Chinese herbal medicine function factor, the recovery of invigorating health effectively
Physiological activator in the Chinese yam of formula food of the present invention, mulberry fruit, date, matrimony vine, sealwort, the longan have effect, the small peptide of building up resistance can improve immunity of organisms, the compound sugar growth and breeding through promoting beneficial bacteria of intestinal tract also can enhancing body immunity, small peptide and active polysaccharide class material have synergy.The factor of many aspects is united use, and obviously the resistivity of enhancing body promotes rehabilitation.
4) improve gastrointestinal function
Small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, improves the absorbability of intestinal mucosa.Compound sugar suppresses the growth of spoilage organisms through promoting the growth and breeding of probio in the intestines, forms on the intestinal mucosa surface simultaneously and protects barrier together, can resist the damage of enteron aisle spoilage organisms to intestinal mucosa, reduces the absorption of intestinal toxic material.Compound sugar can promote intestines peristalsis, quickens the discharge of residuals in the intestines, helps preventing constipation.
5) not fatty and cholesterol in the present invention prescription has been avoided taking in the adverse effect that fat, hypercholesterolia cause body because of feed meat, egg protein matter.
6) anti-oxidant, capability of resistance to radiation of enhancing body etc.
The specific embodiment:
Below through embodiment the present invention is described further.
Embodiment 1 preparation supplies the edible food for special foods (powdery) that contains small peptide of postoperative patient
Present embodiment is selected marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide, yam extract, Fructus Mori extract, Fructus Jujubae extract, Rhizoma Polygonati extract and isomalto-oligosaccharide, various vitamin and the mineral matter of powdery, fills a prescription by following raw material and consumption thereof.
Marine collagen peptide 2.5g sea bone peptide 0.5g Soyprotein peptide 0.5g whey protein peptide 1.0g ovalbumin peptide 0.5g
Yam extract 0.5g Fructus Mori extract 0.5g Fructus Jujubae extract 0.5g Rhizoma Polygonati extract 0.5g
Isomalto-oligosaccharide 3.0g
Vitamin A 0.2mg, vitamin E 3mg, vitamin C 30 mg, Cobastab
10.5mg, Cobastab
20.5mg, Cobastab
60.5mg, Cobastab
120.5mg, nicotinic acid 0.5mg, folic acid 0.1mg, pantothenic acid 1mg, choline 50mg
Calcium 200mg, potassium 100mg, magnesium 100, iron 5mg, zinc 5mg, selenium 0.01mg, manganese 1mg
Above-mentioned raw materials is mixed, stir,, process powdered food through super-dry.After a certain amount of temperature dissolved in boiled water, directly drink or take in through nasal feeding.
Embodiment 2 preparations supply the edible food for special foods (graininess) that contains small peptide of postoperative patient
Present embodiment is selected marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, yam extract, Fructus Jujubae extract, isomalto-oligosaccharide and the various vitamin and the mineral matter of powdery, fills a prescription by following raw material and consumption thereof.
Marine collagen peptide 3.0g Soyprotein peptide 1.5g whey protein peptide 0.5g
Yam extract 1.0g Fructus Jujubae extract 1.0g
Isomalto-oligosaccharide 2.0g
Vitamin A 0.2mg, vitamin E 3mg, vitamin C 30 mg, Cobastab
10.5mg, Cobastab
20.5mg, Cobastab
60.5mg, Cobastab
120.5mg, nicotinic acid 0.5mg, folic acid 0.1mg, pantothenic acid 1mg, choline 50mg
Calcium 200mg, potassium 100mg, magnesium 100, iron 5mg, zinc 5mg, selenium 0.01mg, manganese 1mg.
Above-mentioned raw materials is mixed, stir, through granulation, drying, whole grain is processed graininess.With after about 150ml temperature dissolved in boiled water, directly drink or take in through nasal feeding.
Claims (5)
1. one kind supplies the edible dietary food product of postoperative patient, and it is by food source inhibition biological active small peptide, medicine-food two-purpose Chinese herbal medicine extract, compound sugar, vitamin and mineral matter, through being mixed and made into; Wherein, Food source inhibition biological active small peptide is the mixture of marine collagen peptide, sea bone peptide, Soyprotein peptide and whey protein peptide and ovalbumin peptide, and the medicine-food two-purpose Chinese herbal medicine extract is the mixture of Chinese yam water extract, mulberry fruit water extract, date water extract, fruit of Chinese wolfberry water extract, longan water extract, sealwort water extract.
2. the dietary food product that confession tumor patient according to claim 1 is edible is characterized in that described compound sugar is a kind of, several kinds or all mixing wherein of oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide.
3. the dietary food product that confession tumor patient according to claim 1 and 2 is edible is characterized in that described vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin C, Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, in the nicotinic acid, folic acid, pantothenic acid, choline, biotin a kind of, several kinds or all mix.
4. the dietary food product that confession tumor patient according to claim 1 and 2 is edible is characterized in that described mineral matter is a kind of, several kinds or all mixing in calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, the molybdenum.
5. the dietary food product that confession tumor patient according to claim 1 and 2 is edible is characterized in that described food preparation powdering or granule state food.
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| CN102308940B (en) * | 2011-08-08 | 2012-08-08 | 山东鲁健生物医药科技有限公司 | Composition containing oligopeptide and oligosaccharide for postoperative group to eat |
| CN103005255A (en) * | 2011-09-23 | 2013-04-03 | 浙江海洋学院 | Chitosan oligosaccharide-collagen peptide compound health food and preparation method thereof |
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| CN108095072A (en) * | 2017-12-11 | 2018-06-01 | 重庆市生物技术研究所有限责任公司 | Small peptide spy's dietary seafood formula is eaten for long-term bed and muscle attenuation syndrome crowd |
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| CN109938337A (en) * | 2019-04-10 | 2019-06-28 | 吉林省九圣源生物科技有限公司 | A kind of herbal cuisine eaten for malignant tumour peri-operation period crowd |
| CN112772813A (en) * | 2020-02-05 | 2021-05-11 | 河北康平健康产业有限责任公司 | Compound peptide solid beverage capable of improving immunity and relieving fatigue and preparation method thereof |
| CN111357870A (en) * | 2020-03-23 | 2020-07-03 | 上海信元宠物食品有限公司 | Recovery period pet diet for wound healing |
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