CN101496577B - Special diet and foodstuffs formula containing small peptide for patient with kidney disease - Google Patents
Special diet and foodstuffs formula containing small peptide for patient with kidney disease Download PDFInfo
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Abstract
The invention provides a formulation for a special prandial food, which contains short peptides and is provided for nephritic sufferers to eat. The food uses food-originated short peptides as raw materials which are added with extracts of medical-edible Chinese herbal medicines such as medlar, yams, black bean husks, rhizoma polygonati, mulberries, and the like, and are supplemented with oligosaccharides, vitamins and minerals to form a compound formulation. With the food formulation, powdered or granular foods can be prepared and are dissolved with warm water to eat. The food prepared according to the formulation is easy to dissolve, can be absorbed and utilized quickly, provides a high quality nitrogen source, various vitamins and minerals for organisms, improves the nutritional status of the nephritic sufferers, and can improve the organism immunity in an assisted mode and play a role in deferring kidney damages and protecting the kidney through the combined action of various factors such as bioactive components, the oligosaccharides, and the like in the food-originated short peptides and the extracts of the and the medical-edible Chinese herbal medicines, thus the food is suitable for the nephritic sufferers to eat.
Description
Technical field:
The present invention relates to a kind of prescription of food, especially relate to a kind of with the additional protein of small peptide, replenishing vitamins and mineral matter, and utilize the function factor in the medicine-food two-purpose Chinese herbal medicine to regulate body function, the prescription of the food for special foods that suitable nephrotic eats.
Background technology:
Acute and chronic ephrosis is a class common disease, frequently-occurring disease.Injury of kidney due to a variety of causes causes renal function to go down, thereby causes that power and water separates matter metabolic disorder, acid-base imbalance, and the metabolite of protein such as urea, creatinine, phenol, guanidine class material increase, and forms azotemia and uremia.Nephrotic's enteron aisle descends to the absorbability of vitamin and mineral matter, is easy to cause malnutrition, increases the weight of the deterioration of the state of an illness.
Implementing necessary nutritional supplementation for the nephrotic, especially select and the protein of additional high-quality, is the key of the nephrotic being carried out nutritional support.Nitrogen balance and normal nutritional status that it helps keeping the nephrotic improve the body functional condition, alleviate the kidney burden.
Now, all advocate both at home and abroad and adopt food of special nutrients, specific crowds such as nephrotic are carried out nutritional supplementation and improvement.This is in the existing development and application of developed countries such as the U.S., European Union.U.S. food Drug Administration (FDA) is defined as food of special nutrients " dietetic food (medicalfoods) ".Committee's promulgation instruction (COMMISSION DIRECTIVE 1999/21/EC of 25 March 1999) of European Union's special diet is defined as food of special nutrients " being the special diet of purpose with the medical treatment ".China is with food of special nutrients called after " food for special foods ", and " the packing food for special foods label general rule in advance " of China (GB13432-2004) in regulation, food for special foods is for satisfying the physiological requirements of some special population, or some disease patient's nutritional need, press special formulation and the food of special processing.Therefore, according to nephrotic's metabolic characteristic and nutritional need, select suitable food material and nutrient, preparation is used to improve nephrotic's nutrition condition for the food of special nutrients that the nephrotic eats, and meets the policy guidance and the standard-required of country.
The selection of nitrogenous source is the key of nephrotic's food.Scientific research confirms that the small peptide that utilizes biological enzyme digestion method to extract is a small molecule protein from protein, it need not digest and can absorb, and in absorption process, carrier is difficult for saturated, and power consumption is few, speed is fast, is better than amino acid and complete protein, is the high-quality nitrogenous source of body.
Integration of drinking and medicinal herbs food is with a long history in China, is widely used.This group food not only can be used as food, for human body provides trophic function, but also has very high medical value, and certain therapeutic action is provided.Health ministry has been issued " be food be again the article list (defending the method prison sends out [2002] No. 51) of medicine " in 2002, the foundation that provides in Application in Food for traditional Chinese herbal medicine.
In patent documentation, some are also arranged specially at nephrotic's medicine or health food, as " patent No. 02139402.4 ephrosis oral liquid ", " medicine of the patent No. 03111869.0 treatment ephrosis ", " patent No. is treated Chinese medicine preparation of ephrosis and preparation method thereof for 03105362.9 1 kinds " etc., but, do not find that also according to nephrotic's metabolic characteristic and nutritional need, with food source property small peptide and traditional medicine food homogenous foodstuff be the special small peptide food of special nutrients that eats for the nephrotic that primary raw material prepares according to patent documentation and non-patent literature.
Summary of the invention:
The objective of the invention is metabolic characteristic and nutritional need according to the nephrotic, in conjunction with the principle of nephrotic's nutritional support, provide a kind of food formula of special diet that comprises food source inhibition biological active small peptide, traditional medicine-food two-purpose Chinese herbal medicine, compound sugar, vitamin and mineral matter.This small peptide food formula of special diet not only can replenish good protein, vitamin, the mineral matter that the nephrotic needs; do not increase the kidney burden; simultaneously can the auxiliary protection kidney, keep the body function of intestinal canal; not fatty and cholesterol can not increase the danger of cardiovascular and cerebrovascular disease after edible.It is edible that the small peptide food for special foods that the present invention proposes is fit to the nephrotic.
The food for special foods that the present invention proposes is to be primary raw material with the small peptide, adds traditional medicine-food two-purpose Chinese herbal medicine extract, compound sugar, vitamin, mineral matter again, the compound prescription that is combined into.
The main component of the present invention's prescription is:
Small peptide:
Small peptide of the present invention is oligopeptide, is meant the small molecule protein that utilizes bio-enzyme engineering technology separation and Extraction from animal or vegetable protein.Its mean molecule quantity is below 1000Dalton, and is soluble in water, to acid, thermally-stabilised, can not need directly absorb through digestion, the bioavailability height, amino acid that is better than dissociating in absorption and utilization and complete protein can be applicable in the protein supplement.Especially for the crowd who digests and absorbability weakens, small peptide is splendid nitrogenous source.
Except that trophic function, small peptide also has a series of physiological active functions:
1. improve the digestion and absorption function of small intestine.Small peptide can improve mucous membrane of small intestine tissue morphology structure, increases the height and the surface area of intestinal villi, deepens the degree of depth of crypts, improves and keep the integrality of intestines wall mucomembranous cell 26S Proteasome Structure and Function.
2. enhancing immunity of organisms.Small peptide can increase the phagocytic rate and the phagocytic index of macrophage, strengthens lymphocytic multiplication capacity, and enhancing antibody forms cell quantity and increases, and improves the immune level of body.
3. anti-oxidant.Small peptide can increase the activity of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), reduces the level of MDA MDA (MAD), thus the performance anti-oxidation function.
4. auxiliary adjustment blood sugar.Zoopery shows that small peptide has the trend that reduces the diabetes rat fasting blood glucose level, but the fasting blood glucose level of normal rat is not had obvious influence.
5. auxiliary adjustment of blood fat.Small peptide can reduce the level of serum total cholesterol and LDL-C.
6. aided blood pressure-lowering.
7. radioresistance.Small peptide helps to keep the integrality of body Skin Cell 26S Proteasome Structure and Function, alleviates radiation injury.
8. promote that mineral matter absorbs.Small peptide in enteron aisle by with the chelating of mineral matter such as calcium, iron, zinc etc., improve the transhipment ratio of mineral matter, increase the absorptivity of mineral matter.
9. strengthen the action effect of function factor in the medicine-food two-purpose Chinese herbal medicine.Function factor in small peptide and the Chinese herbal medicine such as active polysaccharide etc. have synergy, can improve it and strengthen immunity of organisms, radiation-resistant effect.
Small peptide of the present invention is meant marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, wherein a kind of, several or whole mixing of ovalbumin peptide.
Marine collagen peptide of the present invention is meant that the fish-skin with deep-sea fish (as salmon etc.) is a raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
Sea bone peptide of the present invention is meant that the fish-bone with deep-sea fish (as cod, anglerfish etc.) is a raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
It is raw material that Soyprotein peptide of the present invention is meant with the soybean protein, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
Whey protein peptide of the present invention is meant that the lactalbumin with cow's milk is a raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
Ovalbumin peptide of the present invention is meant that with egg protein (as egg albumen) be raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
The medicine-food two-purpose Chinese herbal medicine extract:
Fructus lycii P.E:
The fruit of Chinese wolfberry is that former, the antidotal medicine-food two-purpose article of training are reinforced the kidney, consolidated to strong essence.According to modern medicine study, the fruit of Chinese wolfberry contains multiple necessary amino acid, can make in vigorous health.Nourishing the essence and strengthening QI for oral administration, prosperous and powerful Yang Dao.It is sweet to distinguish the flavor of, and property is flat, returns liver, kidney channel.The fruit of Chinese wolfberry has filling liver kidney, makes eye bright, the effect of moistening lung.
Modern pharmacological research confirms that the LBP-X in the matrimony vine has very strong antioxidation activity and kidney defencive function.LBP-X can make kidney superoxide dismutase (SOD) raise, MDA in the serum (MDA) reduces, and SOD/MDA raises, and renal function is clearly better, LBP-X can improve the oxidative stress status of diabetes rat kidney, delays diabetic nephropathy and takes place.It is existing to also have research to refer to, LBP-X has the effect that delays the kidney aging, and with the increase of dosage, protective effect also strengthens. and its mechanism may be by strengthening cell viability, improve SOD activity in the body, improving the glomerular filtration barrier function and realize.
Yam extract:
Shennong's Herbal meaning Chinese yam " sweet, warm, the main strong China and foreign countries that distinguish the flavor of are empty, remove the fever and chills perverse trend, tonifying middle-Jiao and Qi power, and longue meat is obeyed normal hearing and eyesight for a long time." " Japan hanako materia medica " say Chinese yam " help the five internal organs, strengthening the bones and muscles, long will is calmed the nerves, main let out smart forgetful." Compendium of Material Medica record, Chinese yam can " strengthening the bones and muscles, the main essence, forgetful, kidney-nourishing gas of letting out ".Therefore the many mucus of Chinese yam can " kidney tonifying and replenishing essence, smart foot is reinforcing yin essence then ".Modern medicine study confirms that Chinese yam has multiple bioactive ingredients, as Chinese yam polysaccharide, saponin, mucus protein, choline, protamine, amino acid, polyphenol oxidase etc., is of value to the recovery of kidney and allomeric function.
Black bean extract:
Traditional medicine thinks that black soya bean has the heat extraction of dispeling the wind for going into the paddy of kidney, invigorating spleen for diuresis, the detumescence therapeutic method to keep the adverse qi flowing downward, kidney-replenishing blood-nourishing, the function of promoting longevity.Contain compositions such as anthocyanidin, flavones in the Testa sojae atricolor, can significantly increase the activity of hepatocuprein in the serum (SOD), glutathione peroxidase (GSH-Px), can remove interior free yl, have stronger antioxidation activity, to certain help that delays senility.
Rhizoma Polygonati extract:
The sealwort flavor is sweet, and property is flat, returns spleen, lung, kidney channel.Can boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.Put down in writing in the Compendium of Material Medica, sealwort " is mended all void, the replenishing essence marrow ".Be used for weakness of the spleen and the stomach, fatigue and asthenia, dry food is few, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, interior heat is quenched one's thirst.Modern pharmacological research shows that sealwort can be hypotensive, also can prevent atherosclerotic and fatty liver.Sealwort is gone into the spleen channel can beneficial gas, goes into lung channel and can moisturize, but go into the kidney channel nourishing kidney yin.Contain various active compositions such as Siberian solomonseal rhizome polysaccharide, steroid saponin, flavones, anthraquinone analog compound in the sealwort, help to improve immunity of organisms.
Fructus Mori extract:
Mulberry fruit is cold in nature, and it is sweet to distinguish the flavor of, and the effect of tonifying liver, kidney-nourishing, enriching yin is arranged, and is usually used in curing the deficiency of liver-yin and kidney-yin, insomnia tinnitus, disease such as body fluid deficiency." the southern regions of the Yunnan Province book on Chinese herbal medicine " cloud: " the dirty and controlling nocturnal emission with astringent drugs of mulberry fruit kidney-nourishing, the black invention order of clothes for a long time." people, the especially deficiency of the kidney yin person that suffer from a deficiency of the kidney, food the most suitable.
Medicine-food two-purpose Chinese herbal medicine extract of the present invention is a kind of, two kinds or all mixing wherein of Fructus lycii P.E, yam extract, black bean extract, Rhizoma Polygonati extract.
Fructus lycii P.E of the present invention be meant fruit of Chinese wolfberry dry powder water is carried concentrated, the flour that the concentrate spray-drying is prepared.
Yam extract of the present invention be meant Chinese yam dry powder water is carried concentrated, the flour that the concentrate spray-drying is prepared.
Black bean extract of the present invention be meant Testa sojae atricolor dry powder water is carried concentrated, the flour that the concentrate spray-drying is prepared.
Rhizoma Polygonati extract of the present invention be meant sealwort dry powder water is carried concentrated, the flour that the concentrate spray-drying is prepared.
Fructus Mori extract of the present invention be meant mulberry fruit dry powder water is carried concentrated, the flour that the concentrate spray-drying is prepared.
Compound sugar:
Compound sugar claims oligosaccharides again, is meant the low polymerization sugar of the straight or branched that is connected to form by glycosidic bond by 2～10 monose.Functional oligose is not absorbed by human consumption, is not utilized by most enteron aisle spoilage organisms yet, but can promote beneficial bacteria---the growth and breeding of Bifidobacterium in the human body, thereby can suppress the spoilage organisms growth, helps to improve and keep the enteron aisle normal function.Long-term edible can delay senility, defaecation, raising immunity, alleviate burden of liver, improve the nutrient absorption rate, particularly can improve the absorption of body calcium, iron, zinc ion.
Compound sugar of the present invention is an oligoisomaltose. a kind of, several or whole mixing wherein of FOS, soyabean oligosaccharides, xylo-oligosaccharide.
Vitamin and mineral matter:
Vitamin and mineral matter are the nutrients of needed by human.The vitamin that adds among the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin C, Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, nicotinic acid, folic acid, pantothenic acid, choline, biotin a kind of, several or whole mixing wherein.
The mineral matter that adds among the present invention is a kind of, several or whole mixing wherein of calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum.Mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter.
The addition of vitamin and minerals (GB14880-1994) is carried out with reference to " DRIs " and " food enrichment use sanitary standard " of Chinese Soclety of Nutrition's promulgation in 2000 among the present invention.
Above-mentioned various batch mixes is even, can keep its powdery, or through granulation, makes powdery or granule state food.
Technological merit of the present invention:
The present invention combines modern nutriology achievement in research and the traditional methods to keep in good health theory that keeps healthy, and has developed a kind of food for special foods that adopts mixed preparing such as food source property bioactive peptide, medicine-food two-purpose Chinese herbal medicine extract, compound sugar, vitamin and mineral matter.By the organic assembling of various batchings, various functions are merged, and by the synergy between the active ingredient, humidification effect.Can effectively replenish nephrotic's desired nutritional, enhancing nephrotic's resistance by the present invention's food of making of filling a prescription.
The characteristic of this formula food and the effect of body mainly shown the following aspects:
1) food has isotonicity
Utilize prescription of the present invention, various components adopt the food of suitable ratio collocation preparation, are to wait after a certain amount of water-soluble separating and ooze state, can arrive small intestine by stomach fast, absorb soon, and no residue does not increase stomach and intestine and burden of liver.Contained nitrogenous source is easy to absorption and is beneficial to from small peptide, does not increase the kidney burden.
2) bring into play better nutritive validity
Formula food of the present invention is a nitrogenous source with the small peptide in multiple source, can not absorb because small peptide need not digest, and multiple small peptide forms the amino acid pattern of balance, more helps the utilization of body.Can improve nephrotic's negative nitrogen balance to a certain extent.
Formula food of the present invention contains multivitamin and mineral matter, can replenish nephrotic's desired nutritional rapidly.Small peptide by with the chelating of calcium, iron, zinc etc. after, more increased the absorptivity of mineral matter element.
3) improve immunity of organisms
Physiological activator in the fruit of Chinese wolfberry of formula food of the present invention, Chinese yam, Testa sojae atricolor, the sealwort has effect, the small peptide of building up resistance and can improve immunity of organisms, compound sugar and also can strengthen immunity of organisms, small peptide and active polysaccharide class material by the growth and breeding that promotes beneficial bacteria of intestinal tract and have synergy.The associating of the factor of many aspects can obviously strengthen the resistivity of body, and the protection kidney delays or reduces kidney damage.
4) improve gastrointestinal function
Small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, improves the absorbability of intestinal mucosa.Compound sugar suppresses the growth of spoilage organisms by promoting the growth and breeding of probio in the intestines, forms on the intestinal mucosa surface simultaneously and protects barrier together, can resist the damage of enteron aisle spoilage organisms to intestinal mucosa, reduces the absorption of intestinal toxic material.Compound sugar can promote intestines peristalsis, quickens the discharge of residuals in the intestines, helps preventing constipation.
5) not fatty and cholesterol in the present invention prescription has been avoided taking in the adverse effect that fat, hypercholesterolia cause body because of feed meat, egg protein matter.
6) strengthen anti-oxidant, the capability of resistance to radiation etc. of body.
7) adopt the extract of various medicine-food two-purpose Chinese herbal medicines during the present invention fills a prescription, improved the concentration of function factor, reduce the absorption of various impurity, help to alleviate liver kidney burden.
The specific embodiment:
The invention will be further described by the following examples.
The small peptide food for special foods (powdery) that embodiment 1 preparation eats for the nephrotic
Present embodiment is selected marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide, Fructus lycii P.E, yam extract, black bean extract, Fructus Mori extract, isomalto-oligosaccharide and the various vitamin and the mineral matter of powdery, fills a prescription by following raw material and consumption thereof.
Marine collagen peptide 3.0g sea bone peptide 0.5g Soyprotein peptide 0.5g whey protein peptide 0.5g ovalbumin peptide 0.5g
Fructus lycii P.E 0.5g yam extract 0.5g black bean extract 0.5g Fructus Mori extract 0.5g
Isomalto-oligosaccharide 3.0g
Vitamin A 0.2mg, vitamin E 3mg, vitamin C 30mg, Cobastab
10.5mg, Cobastab
20.5mg, Cobastab
60.5mg, Cobastab
120.5mg, nicotinic acid 0.5mg, folic acid 0.1mg, pantothenic acid 1mg, choline 50mg
Calcium 200mg, potassium 100mg, magnesium 100, iron 5mg, zinc 5mg, selenium 0.01mg, manganese 1mg
Above-mentioned raw materials is mixed, stir,, make powdered food through super-dry.After about 150ml temperature dissolved in boiled water, directly drink or take in through nasal feeding.
The small peptide food for special foods (graininess) that embodiment 2 preparations eat for the nephrotic
Present embodiment is selected marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide, Fructus lycii P.E, black bean extract, isomalto-oligosaccharide and the various vitamin and the mineral matter of powdery, fills a prescription by following raw material and consumption thereof.
Marine collagen peptide 3.0g Soyprotein peptide 1.5g ovalbumin peptide 0.5g
Fructus lycii P.E 1.0g black bean extract 1.0g
Isomalto-oligosaccharide 3.0g
Vitamin A 0.2mg, vitamin E 3mg, vitamin C 30mg, Cobastab
10.5mg, Cobastab
20.5mg, Cobastab
60.5mg, Cobastab
120.5mg, nicotinic acid 0.5mg, folic acid 0.1mg, pantothenic acid 1mg, choline 50mg
Calcium 200mg, potassium 100mg, magnesium 100, iron 5mg, zinc 5mg, selenium 0.01mg, manganese 1mg
Above-mentioned raw materials is mixed, stir, through granulation, drying, whole grain is made graininess.After about 150ml temperature dissolved in boiled water, directly drink or take in through nasal feeding.
Claims (6)
1. dietary food product that eats for the nephrotic, it is by food source inhibition biological active small peptide, medicine-food two-purpose Chinese herbal medicine extract, compound sugar, vitamin and mineral matter, through being mixed and made into; Wherein, food source inhibition biological active small peptide is the mixture of marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide and ovalbumin peptide, and the medicine-food two-purpose Chinese herbal medicine extract is the mixture of fruit of Chinese wolfberry water extract and Testa sojae atricolor water extract.
2. dietary food product that eats for the nephrotic, it is by food source inhibition biological active small peptide, medicine-food two-purpose Chinese herbal medicine extract, compound sugar, vitamin and mineral matter, through being mixed and made into; Wherein, food source inhibition biological active small peptide is the mixture of marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide and ovalbumin peptide, and the medicine-food two-purpose Chinese herbal medicine extract is the mixture of fruit of Chinese wolfberry water extract, Chinese yam water extract, Testa sojae atricolor water extract and mulberry fruit water extract.
3. the dietary food product that supplies the nephrotic to eat according to claim 1 and 2 is characterized in that described compound sugar is a kind of, several or whole mixing wherein of oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide.
4. the dietary food product that supplies the nephrotic to eat according to claim 1 and 2 is characterized in that described vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin C, Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, a kind of, several or whole mixing in the nicotinic acid, folic acid, pantothenic acid, choline, biotin.
5. the dietary food product that supplies the nephrotic to eat according to claim 1 and 2 is characterized in that described mineral matter is a kind of, several or whole mixing in calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, the molybdenum.
6. the dietary food product that supplies the nephrotic to eat according to claim 1 and 2 is characterized in that described food preparation powdering or granule state food.
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| CN1729875A (en) * | 2005-08-18 | 2006-02-08 | 北京康比特威创体育新技术发展有限公司 | Sports drink |
| CN1742605A (en) * | 2005-09-30 | 2006-03-08 | 北京康比特威创体育新技术发展有限公司 | Soy-bean peptide |
| CN101091571A (en) * | 2006-06-20 | 2007-12-26 | 黄宪超 | Nutrition peptide for full day |
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| CN101496577A (en) | 2009-08-05 |
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Assignee: China CF Haishi (Beijing) Biotech Co., Ltd. Assignor: China Food Fermentation Industry Research Institute|China Food Yue Tai (Beijing) health science and Technology Co., Ltd. Contract record no.: 2010110000194 Denomination of invention: Special diet and foodstuffs formula containing small peptide for patient with kidney disease Granted publication date: 20101013 License type: Exclusive License Open date: 20090805 Record date: 20101110 |
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