CN101518242A - 一种甲氨基阿维菌素氟铃脲水分散粒剂及其制备方法 - Google Patents
一种甲氨基阿维菌素氟铃脲水分散粒剂及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种农药制剂，特别涉及一种甲氨基阿维菌素氟铃脲水分散粒剂及其制备方法。该发明的特征在于以下几个步骤：甲维盐氟铃脲分散粒剂，重量百分比为：甲氨基阿维阿维菌素0.5～1％；氟铃脲5～10％；崩解剂1～30％；分散剂、润湿剂1％～20％；粘结剂0.5～2％；稳定剂0.1～0.5％；其余为载体。其制备方法是：按配比称量，混匀；加入有效成分、助剂、载体；将配方料超细粉碎后挤压方式造颗。本发明克服了乳油的环境危害和粉剂的缺点，润湿性更好、崩解速度更快、分散性更好、悬浮率更高、热储稳定性好，易于使用，对人类和环境安全，易于控制释放和定向。
Description
技术领域
本发明涉及一种农药制剂，特别涉及一种甲氨基阿维菌素氟铃脲水分散粒剂及其制备方法。其产品是一种用于防治小菜蛾的高效杀虫剂。
技术背景
在传统的农药的使用中，主要是乳油和粉剂，在过去生产力水平不是很高的情况下，为防治病虫害起了很大的作用，但是由于乳油都是原药和乳化剂溶解在有机溶剂中形成，在使用的过程中对环境造成了很大的负担。粉剂由于在使用过程中，很容易飘移，给使用者和周围环境带来不利的影响，开发一种新剂型，尤显重要。
水分散粒剂是20世纪80年代初在欧美发展起来的一种农药新剂型，也称干悬浮，国际农药工业协会联合会(GIFAR)将其定义为：在水中崩解和分散后使用的颗粒剂。水分散粒剂主要由农药有效成分、分散剂、润湿剂、粘结剂、崩解剂和填料组成，粒径200μm—5mm，入水后能迅速崩解，分散，形成高悬浮分散体系。水分散粒剂可以生产出高浓缩，无需溶解的杀虫剂配方；水分散粒剂很少甚至基本不会生成灰尘(使用时)，从而减少了操作过程中的毒性；水分散粒剂不会流动，使得计量更为方便。易于包装，这样处理起来更为容易。而且，不会沉淀。
甲胺基阿维菌素苯甲酸盐是农用抗生素阿维菌素B1结构修饰产物，其主要作用方式是胃毒作用，并兼有一定的触杀作用，不具有杀卵功能。作用机理是增强神经递质如谷氨酸盐和γ-氨基丁酸的作用，从而使大量的氯离子进入神经细胞，使细胞功能丧失，扰乱神经传导，幼虫在接触药剂后很快停止取食，发生不可逆转的麻痹。药剂可以渗透到目标作物的表皮，形成一个有效的贮存层，有长期的药效。同时由于用量小，易降解，因而对环境无污染、无残留，是一种高效、高选择、绿色、环保型、生物源杀虫剂。
氟铃脲属苯甲酰脲杀虫剂，是几丁质合成抑制剂，具有很高的杀虫和杀卵活性，而且速效，阻碍昆虫正常蜕皮生长，以胃毒作用为主，兼有触杀和拒食作用。对绝大多数动物和人类无毒害作用，且能被微生物所分解，成为当前调节剂类农药的主要品种。
在专利CN 1480040A中公开了甲氨基阿维菌素氟铃脲液体制剂组合互配，能有明显的增效作用，并没有做成水分散粒剂。甲氨基阿维阿维菌素氟铃脲分散粒剂没有添加有机溶剂、热储稳定，是一种环保的剂型。本发明就是根据这些问题提出的。
发明内容
本发明的目的是提供一种甲氨基阿维菌素氟铃脲水分散粒剂及其制备方法。
本发明另一个目的是在于克服现有技术的缺点，提供一种以甲氨基阿维阿维菌素氟铃脲为原药制备高效、低毒、对环境友好的无公害杀虫剂，可用于防治小菜蛾、棉铃虫、甜菜夜蛾等害虫。
本发明的目的通过如下技术方案实现：
一种甲氨基阿维阿维菌素氟铃脲水分散粒剂，配方中各组分的重量百分比为：甲氨基阿维阿维菌素0.5～2％，氟铃脲5～15％，分散剂3～15％，润湿剂3～5％，崩解剂10～20％，黏结剂0.1～0.5％，稳定剂0.1～0.5％，载体30～60％
所述的分散剂选自：苯乙基酚聚氧乙烯硫酸钠、烷基萘磺酸盐缩合物钠盐、木质素磺酸钙、木质素磺酸钠、烷基萘甲醛缩合物(NNO)、烷基苯磺酸盐(BX)、烷基酚聚氧乙烯醚甲醛缩合物中的一种或是多种。
所述的润湿剂选自：烷基硫酸钠(K12)、苄基萘磺酸盐、苄基萘磺酸盐甲醛缩合物、二烷基萘磺酸盐、脂肪酰胺N-甲基牛磺酸盐中的一种或是多种。
所述的崩解剂选自：硫酸铵、膨润土、PEG、变性淀粉、白碳黑、硅胶中的一种或是多种。
所述的黏结剂选自：聚丙烯酸钠、PEG、变性PVA、木钠、糊精、CMC(羧甲基纤维素钠及衍生物)、黄原胶中的一种或是多种。
所述的稳定剂选自：硫酸氢钠、甲醇钠、柠檬酸、碳酸氢铵、氢氧化钠中的一种或是多种。
所述的载体选自：高岭土、硅藻土、粘土、酸性白土、云母粉、膨润土、凹凸棒土、海泡石、碳酸钙、白炭黑、滑石粉中的一种或是多种。
所述甲氨基阿维阿维菌素氟铃脲水分散粒剂的制造工艺是：
1、将一组甲氨基阿维阿维菌素氟铃脲水分散粒剂配方料混合均匀；
2、配方料经超微气流粉碎机粉碎成母粉；
3、检验合格后将母粉在加入一定比例的去离子水混合均匀，然后转盘挤压式造粒；
4、造粒外形不合格则重新返回造粒，外形合格进入干燥器干燥；
5、干燥，筛分后经取样分析，合格即可进行包装。
6、包装好该水分散性粒剂进行入库。
本发明的配方加工的水分散性粒剂现有技术相比，具有悬浮率更高，热储更稳定、崩解速度更快、分散性更好；本发明的剂制剂对环境、人畜及其它有益生物安全，不易产生药害；制剂配制工艺较简单、使用方便、成本较低适宜于大面积推广应用。
具体实施方案
为了更好的理解本发明的实质，下面用实例说明本发明的技术内容。
实施例1
称取69.1％甲氨基阿维阿维菌素0.43kg、95％氟铃脲6.32kg、苯乙基酚聚氧乙烯硫酸钠12kg、烷基硫酸钠5kg、CMC 0.1kg、柠檬酸0.2kg、硫酸铵20kg、云母粉20kg、高岭土35.95kg。混合均匀后，经超微气流粉碎机粉碎成母粉，将母粉在加入一定比例的去离子水混合均匀，然后造粒，干燥，筛分后经取样分析，合格即可进行包装。经过检验有效成分含量甲氨基阿维阿维菌素0.31％，氟铃脲6.1％，水分<2％，PH值6.5，筛分(通过75μm)>99％，悬浮率>89％，持久起泡性(1min)<7ml，润湿性<40s，加速热储稳定性合格。
实施例2
称取69.1％甲氨基阿维阿维菌素0.72kg、95％氟铃脲10.5kg、烷基萘磺酸盐缩合物钠盐、10kg、烷基硫酸钠4kg、CMC 0.1kg、柠檬酸0.2kg、硫酸铵20kg、云母粉20kg、高岭土34.48kg。混合均匀后，经超微气流粉碎机粉碎成母粉，将母粉在加入一定比例的去离子水混合均匀，然后造粒，干燥，筛分后经取样分析，合格即可进行包装。经过检验有效成分含量甲氨基阿维阿维菌素0.51％，氟铃脲10.0％，水分<2％，PH值6.8，筛分(通过75μm)>99％，悬浮率>90％，持久起泡性(1min)<8ml，润湿性<40s，加速热储稳定性合格。
实施例3
称取69.1％甲氨基阿维阿维菌素1.1kg、95％氟铃脲15.8kg、烷基萘磺酸盐缩合物钠盐9.5kg、基萘磺酸盐甲醛缩合物4kg、CMC 0.1kg、柠檬酸0.2kg、硫酸铵20kg、云母粉20kg、高岭土29.3kg。混合均匀后，经超微气流粉碎机粉碎成母粉，将母粉在加入一定比例的去离子水混合均匀，然后造粒，干燥，筛分后经取样分析，合格即可进行包装。经过检验有效成分含量甲氨基阿维阿维菌素0.75％，氟铃脲15.2％，水分<2％，PH值7.0，筛分(通过75μm)>99％，悬浮率>90％，持久起泡性(1min)<8ml，润湿性<40s，加速热储稳定性合格。
Claims (7)
1、一种甲氨基阿维菌素氟铃脲水分散粒剂及其制备方法，其特征在于配方中各含量重量百分比为：甲氨基阿维阿维菌素0.5～2％，氟铃脲5～15％，分散剂3～15％，润湿剂3～5％，崩解剂10～20％，黏结剂0.1～0.5％，稳定剂0.1～0.5％，载体30～60％。
2、根据权利要求1所述的甲氨基阿维阿维菌素氟铃脲水分散粒剂，其特征在于所述的分散剂选自：苯乙基酚聚氧乙烯硫酸钠、木质素磺酸钙、木质素磺酸钠、烷基萘甲醛缩合物(NNO)、烷基苯磺酸盐(BX)、烷基酚聚氧乙烯醚甲醛缩合物中的一种或是多种。
3、根据权利要求1所述的甲氨基阿维阿维菌素氟铃脲水分散粒剂，其特征在于所述的润湿剂选自烷基硫酸钠(K12)、烷基萘磺酸盐缩合物钠盐、苄基萘磺酸盐、苄基萘磺酸盐甲醛缩合物、二烷基萘磺酸盐、脂肪酰胺N-甲基牛磺酸盐中的一种或多种。
4、根据权利要求1所述的甲氨基阿维阿维菌素氟铃脲水分散粒剂，其特征在于所述的崩解剂选自硫酸铵、膨润土、PEG、变性淀粉、白碳黑、硅胶中的一种或多种。
5、根据权利要求1所述的甲氨基阿维阿维菌素氟铃脲水分散粒剂，其特征在于所述的黏结剂选自聚丙烯酸钠、PEG、变性PVA、木钠、糊精、CMC(及纤维素衍生物)、黄原胶中的一种或多种。
6、根据权利要求1所述的甲氨基阿维阿维菌素氟铃脲水分散粒剂，其特征在于所述的稳定剂选自硫酸氢钠、甲醇钠、柠檬酸、碳酸氢铵、氢氧化钠中的一种或多种。
7、根据权利要求1所述的甲氨基阿维阿维菌素氟铃脲水分散粒剂，其特征在于所述的载体选自高岭土、硅藻土、粘土、酸性白土、云母粉、膨润土、凹凸棒土、海泡石、碳酸钙、白炭黑、滑石粉中的一种或多种。
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102273449A (zh) * | 2011-06-27 | 2011-12-14 | 上海师范大学 | 一种阿维菌素-蓝藻防紫外缓释微胶囊水分散粒剂及制备方法 |
| CN101773116B (zh) * | 2010-01-28 | 2012-02-01 | 惠州市银农科技有限公司 | 快速崩解甲维盐及氟铃脲水分散粒剂及其制造方法 |
| CN101911934B (zh) | 2010-01-28 | 2013-06-12 | 惠州市银农科技有限公司 | 快速崩解甲维盐水分散粒剂及其制造方法 |
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| CN1250081C (zh) * | 2003-07-23 | 2006-04-12 | 福建新农大正生物工程有限公司 | 甲氨基阿维菌素苯甲酸盐－氟铃脲混合杀虫剂 |
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| CN101773116B (zh) * | 2010-01-28 | 2012-02-01 | 惠州市银农科技有限公司 | 快速崩解甲维盐及氟铃脲水分散粒剂及其制造方法 |
| CN101911934B (zh) | 2010-01-28 | 2013-06-12 | 惠州市银农科技有限公司 | 快速崩解甲维盐水分散粒剂及其制造方法 |
| CN102273449A (zh) * | 2011-06-27 | 2011-12-14 | 上海师范大学 | 一种阿维菌素-蓝藻防紫外缓释微胶囊水分散粒剂及制备方法 |
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| CN106035356A (zh) * | 2016-06-06 | 2016-10-26 | 南通伟德动力电池研究所（普通合伙） | 一种防治松材线虫病的微胶囊注干农药制造方法 |
| CN113243382A (zh) * | 2021-05-18 | 2021-08-13 | 江苏东南植保有限公司 | 一种甲维·氟铃脲水分散粒剂及其制备方法和制备装置 |
| GB2625702A (en) * | 2022-09-22 | 2024-07-03 | Rotam Agrochem Int Co Ltd | Insecticidal composition comprising a macrolide active ingredient |
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Effective date of registration: 20180723 Address after: 100080, Zhongguancun building, No. 27 Zhongguancun street, Beijing, Haidian District, China, 14 floor Co-patentee after: HEBEI GREEN NONGHUA CROP TECHNOLOGY CO.,LTD. Patentee after: BEIJING GREEN AGROSINO CROP TECHNOLOGY CO.,LTD. Address before: 100080, Zhongguancun building, No. 27 Zhongguancun street, Beijing, Haidian District, China, 14 floor Co-patentee before: BEIJING DASHIFENG BIOTECHNOLOGY Co.,Ltd. Patentee before: BEIJING GREEN AGROSINO CROP TECHNOLOGY CO.,LTD. |