CN101500424B - 抑制年龄相关能力减退和食欲的佐餐补充剂 - Google Patents
抑制年龄相关能力减退和食欲的佐餐补充剂 Download PDFInfo
- Publication number
- CN101500424B CN101500424B CN2006800503733A CN200680050373A CN101500424B CN 101500424 B CN101500424 B CN 101500424B CN 2006800503733 A CN2006800503733 A CN 2006800503733A CN 200680050373 A CN200680050373 A CN 200680050373A CN 101500424 B CN101500424 B CN 101500424B
- Authority
- CN
- China
- Prior art keywords
- vitamin
- nutritional supplementation
- pulverizes
- 400mcg
- cobastab
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 235000019789 appetite Nutrition 0.000 title abstract description 11
- 230000036528 appetite Effects 0.000 title abstract description 11
- 230000007423 decrease Effects 0.000 title 1
- 239000013589 supplement Substances 0.000 title 1
- 235000013570 smoothie Nutrition 0.000 claims abstract description 7
- 235000013361 beverage Nutrition 0.000 claims abstract description 5
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 5
- 235000008935 nutritious Nutrition 0.000 claims description 24
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 14
- 241000758789 Juglans Species 0.000 claims description 13
- 235000009496 Juglans regia Nutrition 0.000 claims description 13
- 235000020234 walnut Nutrition 0.000 claims description 13
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 12
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 12
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 12
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 12
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims description 12
- 235000016709 nutrition Nutrition 0.000 claims description 11
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 claims description 10
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 10
- 235000013736 caramel Nutrition 0.000 claims description 10
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 10
- 239000000835 fiber Substances 0.000 claims description 9
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 235000019221 dark chocolate Nutrition 0.000 claims description 8
- 239000000945 filler Substances 0.000 claims description 8
- 235000019152 folic acid Nutrition 0.000 claims description 8
- 239000011724 folic acid Substances 0.000 claims description 8
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 7
- 244000269722 Thea sinensis Species 0.000 claims description 7
- 229930003268 Vitamin C Natural products 0.000 claims description 7
- 229930003427 Vitamin E Natural products 0.000 claims description 7
- 150000001765 catechin Chemical class 0.000 claims description 7
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims description 7
- 235000005487 catechin Nutrition 0.000 claims description 7
- 229940014144 folate Drugs 0.000 claims description 7
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 7
- 235000009569 green tea Nutrition 0.000 claims description 7
- 235000019154 vitamin C Nutrition 0.000 claims description 7
- 239000011718 vitamin C Substances 0.000 claims description 7
- 235000019165 vitamin E Nutrition 0.000 claims description 7
- 239000011709 vitamin E Substances 0.000 claims description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 6
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 6
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims description 6
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims description 6
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 6
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims description 6
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 6
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 6
- 229960002685 biotin Drugs 0.000 claims description 6
- 235000020958 biotin Nutrition 0.000 claims description 6
- 239000011616 biotin Substances 0.000 claims description 6
- 239000011575 calcium Substances 0.000 claims description 6
- 229910052791 calcium Inorganic materials 0.000 claims description 6
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 6
- 235000019136 lipoic acid Nutrition 0.000 claims description 6
- 235000012661 lycopene Nutrition 0.000 claims description 6
- 239000001751 lycopene Substances 0.000 claims description 6
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims description 6
- 229960004999 lycopene Drugs 0.000 claims description 6
- 239000011777 magnesium Substances 0.000 claims description 6
- 229910052749 magnesium Inorganic materials 0.000 claims description 6
- 229960003512 nicotinic acid Drugs 0.000 claims description 6
- 235000001968 nicotinic acid Nutrition 0.000 claims description 6
- 239000011664 nicotinic acid Substances 0.000 claims description 6
- 229940055726 pantothenic acid Drugs 0.000 claims description 6
- 235000019161 pantothenic acid Nutrition 0.000 claims description 6
- 239000011713 pantothenic acid Substances 0.000 claims description 6
- 235000019192 riboflavin Nutrition 0.000 claims description 6
- 239000002151 riboflavin Substances 0.000 claims description 6
- 229960002477 riboflavin Drugs 0.000 claims description 6
- 229910052711 selenium Inorganic materials 0.000 claims description 6
- 239000011669 selenium Substances 0.000 claims description 6
- 235000019157 thiamine Nutrition 0.000 claims description 6
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims description 6
- 229960003495 thiamine Drugs 0.000 claims description 6
- 239000011721 thiamine Substances 0.000 claims description 6
- 229960002663 thioctic acid Drugs 0.000 claims description 6
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims description 6
- 239000011701 zinc Substances 0.000 claims description 6
- 229910052725 zinc Inorganic materials 0.000 claims description 6
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 5
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 5
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 5
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 5
- 229930003316 Vitamin D Natural products 0.000 claims description 5
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 5
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 5
- 229960001948 caffeine Drugs 0.000 claims description 5
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 5
- 235000012680 lutein Nutrition 0.000 claims description 5
- 239000001656 lutein Substances 0.000 claims description 5
- 229960005375 lutein Drugs 0.000 claims description 5
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims description 5
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims description 5
- 229960003080 taurine Drugs 0.000 claims description 5
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims description 5
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 5
- 235000019155 vitamin A Nutrition 0.000 claims description 5
- 239000011719 vitamin A Substances 0.000 claims description 5
- 235000019166 vitamin D Nutrition 0.000 claims description 5
- 239000011710 vitamin D Substances 0.000 claims description 5
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 5
- 229940046009 vitamin E Drugs 0.000 claims description 5
- 229940045997 vitamin a Drugs 0.000 claims description 5
- 229940046008 vitamin d Drugs 0.000 claims description 5
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims description 2
- 244000078534 Vaccinium myrtillus Species 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 230000009469 supplementation Effects 0.000 claims 10
- 239000004475 Arginine Substances 0.000 claims 2
- 235000009508 confectionery Nutrition 0.000 claims 1
- 230000036541 health Effects 0.000 abstract description 15
- 229940088594 vitamin Drugs 0.000 abstract description 13
- 229930003231 vitamin Natural products 0.000 abstract description 13
- 235000013343 vitamin Nutrition 0.000 abstract description 13
- 239000011782 vitamin Substances 0.000 abstract description 13
- 230000032683 aging Effects 0.000 abstract description 12
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 11
- 239000011707 mineral Substances 0.000 abstract description 11
- 235000010755 mineral Nutrition 0.000 abstract description 11
- 238000000034 method Methods 0.000 abstract description 10
- 239000011785 micronutrient Substances 0.000 abstract description 9
- 235000013369 micronutrients Nutrition 0.000 abstract description 9
- 235000013305 food Nutrition 0.000 abstract description 8
- 235000004626 essential fatty acids Nutrition 0.000 abstract description 6
- 235000015243 ice cream Nutrition 0.000 abstract description 3
- 235000013618 yogurt Nutrition 0.000 abstract description 3
- 235000003363 Cornus mas Nutrition 0.000 abstract 1
- 240000006766 Cornus mas Species 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 14
- 241000209094 Oryza Species 0.000 description 12
- 235000007164 Oryza sativa Nutrition 0.000 description 12
- 235000008429 bread Nutrition 0.000 description 12
- 235000009566 rice Nutrition 0.000 description 12
- 150000003722 vitamin derivatives Chemical class 0.000 description 12
- 239000000463 material Substances 0.000 description 9
- 230000003203 everyday effect Effects 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 235000012054 meals Nutrition 0.000 description 5
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 210000001186 vagus nerve Anatomy 0.000 description 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 3
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 3
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 3
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 3
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 206010042434 Sudden death Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 230000030136 gastric emptying Effects 0.000 description 2
- 235000004280 healthy diet Nutrition 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 229960004488 linolenic acid Drugs 0.000 description 2
- 230000007383 nerve stimulation Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 1
- LSHVYAFMTMFKBA-TZIWHRDSSA-N (-)-epicatechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-TZIWHRDSSA-N 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 230000007849 functional defect Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 231100000863 loss of memory Toxicity 0.000 description 1
- 229940070533 lutein 20 mg Drugs 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000002346 musculoskeletal system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L25/00—Food consisting mainly of nutmeat or seeds; Preparation or treatment thereof
- A23L25/30—Mashed or comminuted products, e.g. pulp, pastes, meal, powders; Products made therefrom, e.g. blocks, flakes, snacks; Liquid or semi-liquid products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Dairy Products (AREA)
Abstract
本申请涉及施用包括维生素,矿物质和必需脂肪酸,目标在于降低食欲和/或老化相关风险的每日所需微量营养素(DMRs)的方法。DMRs通过食品施用给个体。在本发明的实施方案中,DMRs以健康棒(health bar)的形式提供。DMRs可以在不超出本发明的范围的条件下加入到其他形式中。例如但不限于,组分可以加入到水果或酸乳酪“思慕雪(smoothie)”,冰冻甜点(frozen desert),如冰淇淋或果汁冰糕,以及饮料中。
Description
发明领域
本申请广泛涉及营养补充剂。
背景技术
老化影响着人类身体系统的所有部位。骨骼可以变得更细,密度更小,关节可能由于软骨流失而衰退,循环系统可能变得阻塞,心脏可能丧失肌肉或收缩强度(甚至衰竭),心理加工(mental processing)速度或能力可能减退。然而,并不是所有具有相同实足年龄的个体都表现出同样的“生理”年龄。因此,尽管老化不可阻止,但由老化引起的风险却不是预先注定的。
现已证实,健康的饮食,有规律的运动计划和积极的心态有助于延缓许多与老化有关的变化的发作,并减慢其进展。什么构成“健康”饮食是经常讨论的话题和书籍及脱口秀节目的主题。人们普遍公认的是,个体并不能一直容易地维持健康的饮食或获得有益健康的营养素。
对许多个体而言,方便食品是代替购买新鲜食品并做饭的具有吸引力的选择。然而,方便食品通常热量高,而营养素和纤维含量低。丸剂或片剂形式的营养补充剂可能有益,但必须有规律地摄取,并且,即使有任何烹饪满足感的话,也只能提供一点点。
合乎需要的是包括特定部分的目标在于降低与老化相关风险的每日所需微量营养素(例如,维生素,矿物质,必需脂肪酸)的佐餐(appetizer)营养补充剂(ANS),其以美味可口的形式,在例如进餐前食用。这样的ANS还可以提供食欲抑制作用。
发明内容
本申请的一个实施方案提供了施用由维生素,矿物质和必需脂肪酸组成的目标在于降低与老化相关的风险和/或减慢老化速度的每日所需微量营养素(DMRs)的方法。DMRs通过食品施用给个体。根据一个实施方案,DMRs以健康棒的形式提供。一般而言,DMRs可以在不超出本发明的范围的条件下体现为具有其它形式因素(form factor)的食品。例如但不限于,组分可以加入到“思慕雪(smoothie)”(基于水果,蔬菜,坚果油或酸乳酪),冰冻甜点(例如,冰淇淋或果汁冰糕),以及饮料中。
在例示性实施方案中,DMRs与其它成分组合,形成进餐前食用的佐餐营养补充剂(ANS)。以这种方式使用时,ANS还通过释放胆囊收缩素和/或刺激迷走神经传入的两种具体的手段或迄今仍未确定的机制起到抑制食欲的作用。体现为ANS的DMRs的组成可以改变,以适合特定群体,例如但不限于他汀使用者,非他汀使用者,男人和女人的需要。
因此,实施本发明的一种方式是提供含有每日所需微量营养素的佐餐营养补充剂(ANS),所述每日所需微量营养素包括维生素,矿物质和必需脂肪酸,其目标在于降低与老化相关风险,并且,其可以风味,质地和稠度均令人愉悦的形式在例如进餐前食用。
本申请的另一实施方案提供了抑制食欲的佐餐营养补充剂。
本申请的另一实施方案提供了通过释放胆囊收缩素和/或刺激迷走神经或其它神经的传入或传出抑制食欲的佐餐营养补充剂。
本申请的另一实施方案调整佐餐营养补充剂的内含物使其适应特定人群的需要。
本申请的另一实施方案提供了健康棒形式的佐餐营养补充剂。
本申请的另一实施方案提供了冰冻甜点形式的佐餐营养补充剂。
本申请的另一实施方案提供了饮料形式的佐餐营养补充剂。
实施本发明的另一方式是提供“思慕雪”型产品形式的佐餐营养补充剂。
根据至少某些实施方案的补充剂可以涉及降低与年龄相关疾病,如癌症和动脉老化病,包括心脏病,心律失常导致的猝死,中风,记忆丧失,阳萎甚至皮肤起皱,和/或与年龄相关心血管或神经或免疫或肌肉骨骼系统功能能力减退的风险。
这些实施方式以及所讨论的各种实施方案在关于本申请的详细且全面的描述的综述中将变得更加显而易见。
发明详述
本发明的一个实施方案提供了施用由维生素,矿物质和必需脂肪酸组成的,目标在于降低与老化相关风险的每日所需微量营养素(DMRs)的方法。DMRs通过食品施用给个体。在一个实施方案中,DMRs以健康棒的形式提供。DMRs可以在不超出本发明的范围的条件下加入到其它形式中。例如但不限于,DMRs可以加入到水果或酸乳酪“思慕雪”,冰冻甜点,如冰淇淋或果汁冰糕,以及饮料中。
根据另一实施方案,DMRs与其它成分组合,形成进餐前食用的佐餐营养补充剂(ANS)。以这种方式,ANS还通过直接作用或间接地,如释放胆囊收缩素或通过营养方法刺激传入迷走神经或通过其它神经或内分泌机制起到抑制食欲的作用。
本发明提供了他汀使用者的营养补充剂,所述营养补充剂包括:
碾碎的核桃;
三小片碾碎的黑巧克力;
碾碎的无卡路里焦糖;
高纤维填充剂;
高至2500IU的维生素A;
2mg维生素B6;
400mcg维生素B12;
50mg维生素C;
高至1000IU的维生素D;
50IU维生素E;
400mcg叶酸盐;
12.5mg硫胺素;
12.5mg核黄素;
15mg烟酸;
150mg生物素;
150mg泛酸;
高至1600mg的钙;
高至400mg的镁;
100mcg硒;
7.5mg锌;
30mg番茄红素;
20mg叶黄素;
高至200mg的α硫辛酸;
高至1500mg的乙酰基-L-肉碱;
高至400mg的辅酶Q10;
高至70mg的l-精氨酸;
高至180mg的酪氨酸;
高至70mg的牛磺酸;
高至120mg的绿茶儿茶素;
高至20mg的咖啡因;和
高至10mg的栎素。
本发明还提供了非他汀使用者的营养补充剂,所述营养补充剂包括:
碾碎的核桃;
碾碎的黑巧克力;
碾碎的无卡路里焦糖;
高纤维填充剂;
高至2500IU的维生素A;
2mg维生素B6;
400mcg维生素B12;
500mg维生素C;
高至1000IU的维生素D;
500IU的维生素E;
400mcg叶酸盐;
12.5mg硫胺素;
12.5mg核黄素;
15mg烟酸;
150mg生物素;
150mg泛酸;
高至1600mg的钙;
高至400mg的镁;
100mcg硒;
7.5mg锌;
30mg番茄红素;
20mg叶黄素;
高至200mg的α硫辛酸;
高至1500mg的乙酰基-L-肉碱;
高至400mg的辅酶Q10;
高至70mg的l-精氨酸;
高至180mg的酪氨酸;
高至70mg的牛磺酸;
高至120mg的绿茶儿茶素;
高至20mg的咖啡因;和
高至10mg的栎素。
实施例1
可以改变加入到ANS中的DMRs,来适合特定群体的需要。在第一实施例中,他汀使用者的健康棒形式的ANS包括1/2盎司的核桃,3块碾碎的黑巧克力小片,碾碎的无卡路里焦糖(carmel),高纤维填充剂。包括在本实施例的健康棒中的DMRs有下表1中所列维生素。注意,叶酸盐通常被称作“维生素F”(或者被某些专家称作B维生素),它是叶酸的阴离子形式。
维生素 | 近似量 |
A | 高至2500IU |
B6 | 2mg |
B12 | 400mcg |
C | 50mg |
D | 高至1000IU |
E | 50IU |
F(叶酸盐) | 400mcg |
硫胺素 | 12.5mg |
核黄素 | 12.5mg |
烟酸 | 15mg |
生物素 | 150mg |
泛酸 | 150mg |
表1第1实施例的维生素
第一实施例的健康棒的DMRs还包括下表2中所列的矿物质。
矿物质 | 近似量 |
钙 | 高至1600mg |
镁 | 高至400mg |
硒 | 100mcg |
锌 | 7.5mg |
钾 | 0mg |
表2第1实施例的矿物质
第一实施例的健康棒的DMRs还包括下表3中所列类维生素物质。
类维生素物质 | 近似量 |
番茄红素 | 30mg |
叶黄素 | 20mg |
α-硫辛酸 | 高至200mg |
乙酰基-L-肉碱 | 高至1500mg/天 |
表3第1实施例的类维生素物质
实施例2
根据本发明的第二实施例,除上文所列第一实施例的成分外,他汀使用者的ANS还包括高至1200mg的作为成分的辅酶Q10。
实施例3
根据本发明的第三实施例,ANS包括第一实施例中所述成分,对每一DMR而言,鉴定的各DMRs均在由政府(例如,美国食品药品监督管理局)制定的每日最低需要量的25-100%的范围内。
实施例4
根据本发明的第四实施例,ANS包括第一实施例中所述成分,但用其它组成代替了1/2盎司的核桃。具体地,用高至克级的三种脂肪酸(单独或组合)替代了核桃。这三种脂肪酸是二十二碳六烯酸(DHA),二十碳五烯酸(EPA)和α-亚麻酸(ALA)。ALA在核桃中存在,DHA和EPA与ALA相关,并已证实对心脏健康有益。
实施例5
根据本发明的第五实施例,ANS包括第一实施例中所述成分,只是用越橘提取物代替了焦糖(carmel)。
实施例6
根据本发明的第六实施例,ANS包括第一实施例中所述成分,只是用覆盆子提取物代替了焦糖。
实施例7
根据本发明的第七实施例,ANS包括第一实施例中所述成分,除维生素C和E之外,鉴定的各DMRs基本相同。对于第七实施例,维生素C和E的量如下表4中所列被提高了。
维生素 | 近似量 |
C | 500mg |
E | 500IU |
表4第七实施例的维生素的量
实施例8
根据本发明的第八实施例,ANS包括第一实施例中所述成分,鉴定的各DMRs基本相同,并进一步包括下表5中所列其它鉴定的DMRs。
类维生素物质 | 近似量 |
L-精氨酸 | 高至70mg |
酪氨酸 | 高至180mg |
牛磺酸 | 高至70mg |
绿茶儿茶素 | 高至120mg |
咖啡因 | 高至20mg |
栎素(querecin) | 高至10mg |
表5第八实施例的类维生素物质
如本实施例中所列,作为一类物质的绿茶儿茶素可以用作ANS中的成分。绿茶儿茶素中,表儿茶素没食子酸酯(EGCG)目前被确认为特别有用的抗氧化剂。
现已证实,进餐前食用上述某些实施例所示水平的核桃抑制胃排空,并抑制食欲,食用的该物质及其它物质可以刺激胆囊收缩素的释放和/或抑制胃排空和/或饥饿的迷走神经或其它神经冲动。
一个实施方案提供了降低食欲的方法,其中在进餐前8-30分钟食用包括作为成分的核桃,碾碎的黑巧克力小片,碾碎的无卡路里焦糖(carmel),高纤维填充剂和DMRs的ANS。食欲抑制作用,尤其是ANS的核桃内容物的食欲抑制作用有效减少了进餐期间食用的食物的量。应该了解的是,使食欲降低的作用机制是诱导释放内源性激素或肠多肽或其它降低食欲的物质。
根据降低食欲的方法,ANS的持续使用有效支持体重减轻和腰部尺寸缩小。
研究显示,维生素和矿物质以及微量营养素的组合减少了猝死,并延缓了动脉老化。研究进一步表明,维生素和矿物质以及微量营养素的组合还提供了对特定癌症一定程度的防护作用。
因此,本发明的另一方面是通过施予佐餐棒形式的含有包括目标维生素,矿物质和必需脂肪酸的每日所需微量营养素的营养补充剂(或其它递送机制),所述营养补充剂在降低与老化相关的风险和/或过程方面的应用。为降低与老化相关的风险,根据多种实施方案的ANS支持心脏功能,支持动脉健康,支持受试者免疫系统健康,并支持线粒体功能缺陷的减少。
递送机制选自多种不同的选择,由此,至少有一种机制在风味,质地和稠度方面将对大多数受试者而言是令人愉悦的。思慕雪,冰冻甜点或饮料都是战略上可采用的根据本发明的实施方案递送的营养补充剂的递送机制。
另一实施方案提供了包装目标在于降低与老化相关的风险和/或过程的食品补充剂的方法。在该实施方案中,健康棒形式的ANS包括核桃,碾碎的黑巧克力小片,碾碎的无卡路里焦糖(carmel),高纤维填充剂和DMRs。健康棒包装在密封容器中。例如但不限于,健康棒在氮气存在下包装于铝化的聚酯膜中,并注明货架期。干燥氮气(即,无水汽)对实施该实施方案尤其有效。尽管提到了氮气作为例子,但其它相对无活性的气体也是适宜的。作为进一步的说明而不是限制,健康棒包装在密封容器中,该棒添加有防腐物质,以保存棒中的脂肪。
已经显示了抑制年龄相关疾病和食欲的佐餐棒。本领域技术人员将了解,本发明可以在不超出所公开的本发明的范围的条件下以其它具体的形式体现,本文所述实施例和实施方案在各方面都是说明性的而非限制性的。本领域技术人员将认识到,使用本文所述概念的其它实施方案也是可行的。此外,单数形式的对要求要素的引用均不应被理解为将该要素限制为单数。
Claims (8)
1.他汀使用者的营养补充棒,包括:
二分之一盎司的碾碎的核桃;
三小片碾碎的黑巧克力;
高纤维填充剂
碾碎的无卡路里焦糖、越橘提取物或覆盆子提取物;
高至2500IU的维生素A;
2mg维生素B6;
400mcg维生素B12;
50mg的维生素C;
高至1000IU的维生素D;
50IU的维生素E;
400mcg叶酸盐;
12.5mg硫胺素;
12.5mg核黄素;
15mg烟酸;
150mg生物素;
150mg泛酸;
高至1600mg的钙;
高至400mg的镁;
100mcg硒;
7.5mg锌;
30mg番茄红素;
20mg叶黄素;
高至200mg的α硫辛酸;和
高至1500mg的乙酰基-L-肉碱。
2.营养补充产品,其包含权利要求1的营养补充棒和为了保存营养补充棒而将所述棒和防腐物质进行密封式包装的包装。
3.根据权利要求2的营养补充产品,其中营养补充棒还包括高至1200mg的辅酶Q10。
4.根据权利要求2的营养补充产品,其中防腐物质是氮气。
5.根据权利要求2的营养补充产品,其中防腐物质被添加至营养补充棒中。
6.他汀使用者的营养补充剂,所述营养补充剂包括:
碾碎的核桃;
碾碎的黑巧克力;
碾碎的无卡路里焦糖;
高纤维填充剂;
高至2500IU的维生素A;
2mg维生素B6;
400mcg维生素B12;
50mg维生素C;
高至1000IU的维生素D;
50IU维生素E;
400mcg叶酸盐;
12.5mg硫胺素;
12.5mg核黄素;
15mg烟酸;
150mg生物素;
150mg泛酸;
高至1600mg的钙;
高至400mg的镁;
100mcg硒;
7.5mg锌;
30mg番茄红素;
20mg叶黄素;
高至200mg的α硫辛酸;
高至1500mg的乙酰基-L-肉碱;
高至400mg的辅酶Q10;
高至70mg的1-精氨酸;
高至180mg的酪氨酸;
高至70mg的牛磺酸;
高至120mg的绿茶儿茶素;
高至20mg的咖啡因;和
高至10mg的栎素。
7.非他汀使用者的营养补充剂,所述营养补充剂包括:
碾碎的核桃;
碾碎的黑巧克力;
碾碎的无卡路里焦糖;
高纤维填充剂;
高至2500IU的维生素A;
2mg维生素B6;
400mcg维生素B12;
500mg维生素C;
高至1000IU的维生素D;
500IU的维生素E;
400mcg叶酸盐;
12.5mg硫胺素;
12.5mg核黄素;
15mg烟酸;
150mg生物素;
150mg泛酸;
高至1600mg的钙;
高至400mg的镁;
100mcg硒;
7.5mg锌;
30mg番茄红素;
20mg叶黄素;
高至200mg的α硫辛酸;
高至1500mg的乙酰基-L-肉碱;
高至400mg的辅酶Q10;
高至70mg的1-精氨酸;
高至180mg的酪氨酸;
高至70mg的牛磺酸;
高至120mg的绿茶儿茶素;
高至20mg的咖啡因;和
高至10mg的栎素。
8.权利要求2的营养补充产品,其以选自棒,思慕雪,冰冻甜品和饮料的形式提供。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73339405P | 2005-11-04 | 2005-11-04 | |
US60/733,394 | 2005-11-04 | ||
US11/592,050 | 2006-11-02 | ||
US11/592,050 US20070104762A1 (en) | 2005-11-04 | 2006-11-02 | Appetizer supplement to suppress age-related decline in capacity and appetite |
PCT/US2006/043229 WO2007056307A2 (en) | 2005-11-04 | 2006-11-03 | Appetizer supplement to suppress age-related decline in capacity and appetite |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101500424A CN101500424A (zh) | 2009-08-05 |
CN101500424B true CN101500424B (zh) | 2012-11-28 |
Family
ID=38004013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800503733A Expired - Fee Related CN101500424B (zh) | 2005-11-04 | 2006-11-03 | 抑制年龄相关能力减退和食欲的佐餐补充剂 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20070104762A1 (zh) |
EP (1) | EP1951310A4 (zh) |
CN (1) | CN101500424B (zh) |
WO (1) | WO2007056307A2 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8962678B2 (en) | 2006-07-05 | 2015-02-24 | Kao Corporation | Senescence inhibitor |
US20100055205A1 (en) * | 2008-08-29 | 2010-03-04 | Kristina Mains | Functional consumable compositions for promoting skin health and methods for using the same |
ES2587977T3 (es) | 2009-05-01 | 2016-10-28 | Celloxess Llc | Tratamiento de la infertilidad masculina secundaria al estrés oxidativo de esperma |
WO2010143053A1 (en) * | 2009-06-10 | 2010-12-16 | Energy4Life Ag | Methods and compositions for treating insulin resistance, diabetes mellitus type 2, metabolic syndrome and related disorders |
US9549982B2 (en) * | 2009-11-23 | 2017-01-24 | Foundational Biosystems, Llc | Ultra low dose nutraceutical compositions for enhancing sleep quality and treating sleep disorders |
US10238684B2 (en) | 2010-11-18 | 2019-03-26 | Foundational Biosystems, Llc | Micro- and nano-quantity sleep enhancing nutrient composition and method of enhancing central nervous system protein clearance using same |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1315859A (zh) * | 1998-09-01 | 2001-10-03 | Jan食品和饲料技术公司 | 抗肥胖和降低内脏脂肪蓄积的物质及其用途 |
WO2002094035A1 (en) * | 2001-05-23 | 2002-11-28 | Nutricopia, Inc. | Nutritional frozen dessert and methods of manufacture |
EP1302111A1 (en) * | 2001-10-09 | 2003-04-16 | Bariatrix Products International, Inc. | Dietary composition and method |
CN1493208A (zh) * | 2003-08-28 | 2004-05-05 | 彪 赵 | 一种膳食纤维冲食粉 |
US20050101660A1 (en) * | 2003-11-11 | 2005-05-12 | The Skinny Drink Company | Composition for prevention and treatment of obesity, cardiovascular and coronary artery disease |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4888187A (en) * | 1988-07-06 | 1989-12-19 | Nabisco Brands, Inc. | Fruit-containing confectionery bar |
US5480865A (en) * | 1994-02-25 | 1996-01-02 | Parkinson's Charitable Trust | Nutritional composition |
US6352713B1 (en) * | 1999-12-01 | 2002-03-05 | Drugtech Corporation | Nutritional composition |
US6391310B1 (en) * | 1996-03-13 | 2002-05-21 | Archer Daniels Midland Company | Method of preparing and using isoflavones for the treatment of neurological symptoms |
US6642259B1 (en) * | 1999-05-07 | 2003-11-04 | Trustees Of Tufts College | Immune stimulating dietary supplement and method of use thereof |
US6641847B1 (en) * | 1999-06-01 | 2003-11-04 | Ocean Spray Cranberries, Inc. | Cranberry seed oil extract and compositions containing components thereof |
AU2001239968A1 (en) * | 2000-03-02 | 2001-09-12 | Warner Lambert Company | Nutritional food bar for sustained energy |
IL152175A (en) * | 2000-04-14 | 2005-08-31 | Mars Inc | Compositions and methods for improving vascular health |
ES2210179T3 (es) * | 2000-07-12 | 2004-07-01 | Koninklijke Philips Electronics N.V. | Soporte optico de informacion con distintas capas de grabacion. |
US6576253B2 (en) * | 2000-12-05 | 2003-06-10 | Pbm Pharmaceuticals, Inc. | Food bars containing nutritional supplements |
US20050002992A1 (en) * | 2003-06-17 | 2005-01-06 | Mccleary Edward Larry | Foods, beverages, condiments, spices and salad dressings with specialized supplements |
US7030092B1 (en) * | 2001-08-24 | 2006-04-18 | Small Giant L.L.C. | Ultra-high fiber supplement and method of reducing weight cardiovascular risks and ingested toxins. |
US7033629B2 (en) * | 2001-08-31 | 2006-04-25 | Nutricopia Inc. | Nutritional frozen dessert and methods of manufacture |
US7022356B2 (en) * | 2003-05-14 | 2006-04-04 | Rcd Holdings, Inc. | Protein enhanced low carbohydrate snack food |
US20050186306A1 (en) * | 2004-02-19 | 2005-08-25 | Susanne Sonneveld | Low carbohydrate cereal-like food product |
US7901710B2 (en) * | 2005-08-04 | 2011-03-08 | Vertical Pharmaceuticals, Inc. | Nutritional supplement for use under physiologically stressful conditions |
US8486469B2 (en) * | 2005-10-17 | 2013-07-16 | Intercontinental Great Brands Llc | Low-calorie food bar |
-
2006
- 2006-11-02 US US11/592,050 patent/US20070104762A1/en not_active Abandoned
- 2006-11-03 WO PCT/US2006/043229 patent/WO2007056307A2/en active Application Filing
- 2006-11-03 CN CN2006800503733A patent/CN101500424B/zh not_active Expired - Fee Related
- 2006-11-03 EP EP06836991A patent/EP1951310A4/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1315859A (zh) * | 1998-09-01 | 2001-10-03 | Jan食品和饲料技术公司 | 抗肥胖和降低内脏脂肪蓄积的物质及其用途 |
WO2002094035A1 (en) * | 2001-05-23 | 2002-11-28 | Nutricopia, Inc. | Nutritional frozen dessert and methods of manufacture |
EP1302111A1 (en) * | 2001-10-09 | 2003-04-16 | Bariatrix Products International, Inc. | Dietary composition and method |
CN1493208A (zh) * | 2003-08-28 | 2004-05-05 | 彪 赵 | 一种膳食纤维冲食粉 |
US20050101660A1 (en) * | 2003-11-11 | 2005-05-12 | The Skinny Drink Company | Composition for prevention and treatment of obesity, cardiovascular and coronary artery disease |
Also Published As
Publication number | Publication date |
---|---|
WO2007056307A2 (en) | 2007-05-18 |
EP1951310A4 (en) | 2010-03-31 |
CN101500424A (zh) | 2009-08-05 |
US20070104762A1 (en) | 2007-05-10 |
WO2007056307A3 (en) | 2009-04-23 |
EP1951310A2 (en) | 2008-08-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Awuchi et al. | Nutritional diseases and nutrient toxicities: A systematic review of the diets and nutrition for prevention and treatment | |
US6866873B2 (en) | Nutritional dietary system, formulation, kit and method for use in preparing an individual for a predetermined activity | |
CN102687750B (zh) | 一种减肥代餐蛋白型固体饮料 | |
US7976879B2 (en) | Nutritional supplement product to suppress age-related decline in cognitive capacity and other aging functions | |
US20030143287A1 (en) | Nutritional supplement for the management of weight | |
JP5537438B2 (ja) | 卵黄に基づく機能性食物製品の生産方法およびこれによって得られる製品 | |
US20060159724A1 (en) | Nutritional supplement for the management of weight | |
JP3512198B2 (ja) | 2相調合剤 | |
JP2006223293A (ja) | ダイエット食品組成物 | |
TW200812503A (en) | Compositions, methods and kits for enhancing weight loss while inhibiting loss of lean body mass | |
CN101500424B (zh) | 抑制年龄相关能力减退和食欲的佐餐补充剂 | |
JP2013538185A (ja) | 経管栄養パッケージ及びそれを使用する方法 | |
JP2024009190A (ja) | 骨強化剤 | |
US6455095B2 (en) | Thermogenic, appetite suppressing, gas suppressing, complete legume protein formulae; thermobean™ | |
EP1605958B1 (en) | Compositions of natural products and use thereof | |
JPWO2007132714A1 (ja) | 骨密度増加剤 | |
WO2015190682A1 (ko) | 쿠마린산을 유효성분으로 포함하는 성장 촉진용 조성물 | |
JP2008156292A (ja) | 末梢血流改善剤および抹消血流改善作用を有する食品組成物 | |
Wahlqvist et al. | Vitamins and vitamin like compounds | |
JP2022173468A (ja) | 血流改善組成物 | |
Bippen | Collagen: Self-Care Secrets to Eat, Drink, and Glow | |
KR20160084091A (ko) | 찹쌀을 주원료로 하는 기능성 식품 제조방법 | |
KR20160010027A (ko) | 가르시아캄보지아(hca)를 유효성분으로 함유하는 체지방 감소를 위한 조성물 | |
Wilder | Nutrition and weight control for longevity | |
Karvandi | Eat Fat, Get Fit: How to Create Your Perfect Diet to Lose Weight, Heal Your Gut, and Have More Energy |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121128 Termination date: 20131103 |