CN101496773B - 一种含林蛙抗菌肽的抗菌洗剂及其制备方法 - Google Patents
一种含林蛙抗菌肽的抗菌洗剂及其制备方法 Download PDFInfo
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- CN101496773B CN101496773B CN2009100665678A CN200910066567A CN101496773B CN 101496773 B CN101496773 B CN 101496773B CN 2009100665678 A CN2009100665678 A CN 2009100665678A CN 200910066567 A CN200910066567 A CN 200910066567A CN 101496773 B CN101496773 B CN 101496773B
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- Prior art keywords
- antibacterial
- lotion
- antimicrobial
- wood frog
- mannitol
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- 239000006210 lotion Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 230000000845 anti-microbial effect Effects 0.000 title claims description 27
- 241000191896 Rana sylvatica Species 0.000 title claims description 16
- 239000003910 polypeptide antibiotic agent Substances 0.000 title description 4
- 108700042778 Antimicrobial Peptides Proteins 0.000 title 1
- 102000044503 Antimicrobial Peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 230000003115 biocidal effect Effects 0.000 claims abstract description 11
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 9
- 229930195725 Mannitol Natural products 0.000 claims abstract description 9
- 235000010355 mannitol Nutrition 0.000 claims abstract description 9
- 239000000594 mannitol Substances 0.000 claims abstract description 9
- 239000008363 phosphate buffer Substances 0.000 claims abstract description 8
- 239000003223 protective agent Substances 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 14
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 4
- 239000002917 insecticide Substances 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- 241000269435 Rana <genus> Species 0.000 abstract 2
- 210000004400 mucous membrane Anatomy 0.000 abstract 2
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 235000019606 astringent taste Nutrition 0.000 abstract 1
- 230000023597 hemostasis Effects 0.000 abstract 1
- 230000007803 itching Effects 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 description 12
- 229920001184 polypeptide Polymers 0.000 description 11
- 239000000243 solution Substances 0.000 description 9
- 239000000047 product Substances 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000008176 lyophilized powder Substances 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000013049 sediment Substances 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000019633 pungent taste Nutrition 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 241000255789 Bombyx mori Species 0.000 description 1
- 239000006137 Luria-Bertani broth Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- UZIQYAYUUNMDMU-UHFFFAOYSA-N N.[Br+] Chemical compound N.[Br+] UZIQYAYUUNMDMU-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229960002152 chlorhexidine acetate Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000000087 hemolymph Anatomy 0.000 description 1
- 230000007233 immunological mechanism Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000008921 jie er yin Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
| 名称 | pH值 | 杀菌时间/min | 杀灭效果/％ | 透明度 | 稀释倍数 | 刺激性 |
| 实施例1 | 4.5 | 3 | 100 | 淡黄色透明 | 50 | 无 |
| 实施例2 | 5.4 | 3 | 100 | 淡黄色透明 | 50 | 无 |
| 实施例3 | 6.4 | 3 | 100 | 淡黄色透明 | 50 | 无 |
| 妇康洁 | 5 | 未定 | 未定 | 灰黑色明显沉淀 | 5 | 轻度 |
| 舒洁 | 7.0 | 未定 | 未定 | 黑灰色明显沉淀 | 5-10 | 轻度 |
| 洁尔阴 | 4.5 | 未定 | 未定 | 黑灰色明显沉淀 | 10-20 | 轻度 |
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100665678A CN101496773B (zh) | 2009-02-25 | 2009-02-25 | 一种含林蛙抗菌肽的抗菌洗剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100665678A CN101496773B (zh) | 2009-02-25 | 2009-02-25 | 一种含林蛙抗菌肽的抗菌洗剂及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101496773A CN101496773A (zh) | 2009-08-05 |
| CN101496773B true CN101496773B (zh) | 2011-02-09 |
Family
ID=40944183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100665678A Active CN101496773B (zh) | 2009-02-25 | 2009-02-25 | 一种含林蛙抗菌肽的抗菌洗剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101496773B (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105749250A (zh) * | 2016-03-14 | 2016-07-13 | 吉林大学 | 林蛙抗菌肽在治疗灰指甲的药物制备中的用途 |
| CN113940895A (zh) * | 2020-07-15 | 2022-01-18 | 南京星银药业集团有限公司 | 一种抗菌肽洗手液及其制备方法 |
| WO2022155783A1 (zh) * | 2021-01-19 | 2022-07-28 | 江苏普莱医药生物技术有限公司 | 一种抗菌肽液体组合物及其制剂 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583165A (zh) * | 2004-05-25 | 2005-02-23 | 吉林大学 | 林蛙抗菌肽凝胶剂及其制备方法 |
-
2009
- 2009-02-25 CN CN2009100665678A patent/CN101496773B/zh active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583165A (zh) * | 2004-05-25 | 2005-02-23 | 吉林大学 | 林蛙抗菌肽凝胶剂及其制备方法 |
Non-Patent Citations (3)
| Title |
|---|
| 田晓乐等.林蛙抗菌肽体外抑菌活性研究.《2006年全国生化与生物技术药物学术年会论文集》.2006,第2006年卷第247至251页. * |
| 田晓乐等.林蛙抗菌肽凝胶剂的制备及抑菌试验.《吉林大学学报(工学版)》.2006,第36卷(第1期),第133至136页. * |
| 田晓乐等.林蛙抗菌肽喷雾剂的制备及体外抑菌活性研究.《中国药学杂志》.2006,第41卷(第21期),第1635至1637页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101496773A (zh) | 2009-08-05 |
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Denomination of invention: Antimicrobial lotion containing wood frog antimicrobial peptide and preparation method thereof Effective date of registration: 20191115 Granted publication date: 20110209 Pledgee: Tonghua Branch of China Everbright Bank Co.,Ltd. Pledgor: TONGHUA KANG YUAN BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: Y2019220000042 |
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Denomination of invention: An antibacterial lotion containing antibacterial peptide of Rana chensinensis and its preparation method Effective date of registration: 20201119 Granted publication date: 20110209 Pledgee: Tonghua Branch of China Everbright Bank Co.,Ltd. Pledgor: TONGHUA KANG YUAN BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: Y2020220000085 |
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Denomination of invention: An antibacterial lotion containing forest frog antibacterial peptide and its preparation method Effective date of registration: 20220620 Granted publication date: 20110209 Pledgee: Tonghua Branch of China Everbright Bank Co.,Ltd. Pledgor: TONGHUA KANG YUAN BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: Y2022220000018 |
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Denomination of invention: An Antibacterial Lotion Containing Forest Frog Antibacterial Peptide and Its Preparation Method Effective date of registration: 20230324 Granted publication date: 20110209 Pledgee: Tonghua Branch of China Everbright Bank Co.,Ltd. Pledgor: TONGHUA KANG YUAN BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: Y2023220000019 |
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