CN101491668A - Composite with blood-sugar reducing function and preparation method thereof - Google Patents
Composite with blood-sugar reducing function and preparation method thereof Download PDFInfo
- Publication number
- CN101491668A CN101491668A CNA2008100566979A CN200810056697A CN101491668A CN 101491668 A CN101491668 A CN 101491668A CN A2008100566979 A CNA2008100566979 A CN A2008100566979A CN 200810056697 A CN200810056697 A CN 200810056697A CN 101491668 A CN101491668 A CN 101491668A
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- Prior art keywords
- radix
- caulis opuntiae
- opuntiae dillenii
- centrifugal
- extract
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a composition with the function of lowering blood glucose, and a preparation method thereof. The composition is prepared from rice-bran crude polysaccharide, cactus extract and beer yeast albumen powder according to certain weight mixture ratio. The composition can be prepared into any common formulation. The composition has the efficacy in lowering blood glucose and can be used for treating diabetes.
Description
Technical field
The present invention relates to a kind of composition and method of making the same, belong to medicine and field of health care food with function of blood sugar reduction.
Background technology
Diabetes are the one group of Developmental and Metabolic Disorder syndromes that is caused by the h and E factor interaction.Long-term diabetes can cause the chronic complicating diseases of a plurality of systems organ, cause dysfunction and depletion, become disable, lethal main cause.At present, the nearly youngster of the prevalence of diabetes has the trend of remarkable rising year in the population of China.Because the cause of disease and the pathogenesis of diabetes are not clear fully as yet, therefore also lack effective etiological treatment method at present.Clinically treatment of diabetes is adopted insulinize and oral hypoglycemic drug therapy more now, yet diabetes spp is in kind of a lifelong participation disease, need long-term prescription, the drug administration by injection method of insulin tends to bring many inconvenience to the patient, and clinical orally-taken blood sugar reducing medicine commonly used belongs to chemical drugs more, takes for a long time also and can cause a series of untoward reaction.In view of there being above problem, so exploitation a kind of blood sugar lowering medicine and health food safe, effective, that be suitable for taking for a long time are badly in need of on present market very much.
Summary of the invention
The object of the invention just provides a kind of compositions with function of blood sugar reduction.
Another object of the present invention has provided the preparation method of said composition.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Rice-bran crude polysaccharide 0.5-5 part, Radix et Caulis Opuntiae Dillenii extract 0.1-10 part, beer yeast albumen powder 10-30 part.
Be preferably:
2 parts of rice-bran crude polysaccharide, 2 parts of Radix et Caulis Opuntiae Dillenii extracts, 15 parts of beer yeast albumen powder.
The preparation method of the present composition is as follows:
Testa oryzae is pushed in defat, the hot water lixiviate, centrifugal, get supernatant, enzymolysis, centrifugal, get supernatant, adjust pH, centrifugal, get supernatant, add the ethanol standing over night, centrifugal, get precipitation, will precipitate lyophilization or spray drying, pulverize, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process, filter, get filtrate, use ethanol precipitation, centrifugal, taking precipitate, washing with alcohol, lyophilization is pulverized, and gets Radix et Caulis Opuntiae Dillenii crude polysaccharides extract; With rice-bran crude polysaccharide, Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the beer yeast albumen powder mix homogeneously, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, teabag, oral liquid etc.
The preferred for preparation method of the present composition is as follows:
Testa oryzae (crossing 120 mesh sieves) is pushed in defat, the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With rice-bran crude polysaccharide, Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the beer yeast albumen powder mix homogeneously, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, teabag, oral liquid etc.
Wherein, described rice-bran crude polysaccharide, Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract can also outsourcings.
Drug mechanism of the present invention is as follows:
Rice-bran crude polysaccharide: rice bran polysaccharide (RBP) (Rice Bran Polysacchride, RBP) be present in the caryopsis cortex of Oryza glutinosa, mainly be meant the class non-starch polysaccharides(nsp) that molecular weight does not wait, its chemical constitution is with all polysaccharide is different, be baroque heteroglycan, mainly contain lipopolysaccharide, araboxylan and glucosan etc.The Testa oryzae active polysaccharide not only has the physiological function of general active polysaccharide, but also has the function of control old cardiovascular diseases such as stronger raising blood serum tumor necrosin level, enhancing human body immunity function and blood sugar lowering, blood pressure lowering, cholesterol reducing.Adopt streptozotocin (STZ) to bring out experimental diabetic animal scale-model investigation rice bran polysaccharide (RBP) to the hypoglycemic effect of diabetic mice and to the influence of its hepatic antioxidative function, result of the test shows: compare with diabetic model group, the rice bran polysaccharide (RBP) of middle and high dosage can significantly reduce the blood sugar level (P＜0.05) of diabetic mice, obviously improve its glucose tolerance (P＜0.05), significantly improve liver SOD, GSH-Px activity (P＜0.05), and can obviously reduce MDA content in the liver (P＜0.05).
The Radix et Caulis Opuntiae Dillenii extract: Radix et Caulis Opuntiae Dillenii bitter in the mouth cold in nature has the effect of detoxifcation analgesia, detumescence and apocenosis, promoting flow of QI and blood.Pharmacological research shows that Radix et Caulis Opuntiae Dillenii has the obvious functions of blood sugar effect, can improve type ii diabetes patient's carbohydrate metabolism effectively.On Mexico, the U.S. and other places, Radix et Caulis Opuntiae Dillenii is used to treat diseases such as diabetes, ulcer, has been made into various tablets and soft gelatin capsule.In China, the Radix et Caulis Opuntiae Dillenii compound preparation also is used for treating diabetes.In the test that the alloxan diabetes model that with Wistar is animal pattern foundation carries out, find; The extract of Radix et Caulis Opuntiae Dillenii does not have obvious influence to normal rat blood sugar, but can significantly reduce the blood glucose of model induced by alloxan diabetes rat, and its blood sugar reducing function is relevant with dosage.Its high dose can also significantly reduce diabetes rat 24h urine amount.Simultaneously, induce at streptozotocin (STZ) on the rat diabetes model basis of foundation, Radix et Caulis Opuntiae Dillenii juice is used for the treatment of the disease Mus.The result shows that it is normal that its glucose amount of the diabetic mice of administration group and serum insulin levels are recovered, and matched group is still unusual, shows that the Radix et Caulis Opuntiae Dillenii extract has the effect for the treatment of diabetes, improving insulin resistant.
Beer yeast albumen powder: beer yeast albumen powder is that to select the beer yeast of post-directed training for use be raw material, the pure natural microprotein that adopts modern crafts and wall breaking technology to process.It contain albumen that 50% human body of having an appointment is easy to absorb and human body can't be synthetic voluntarily must aminoacid, be rich in vitamin B group, natural dietary fiber, zymosan and nicotinic acid, folic acid, pantothenic acid, nucleic acid, magnesium, zinc, chromium, zinc, selenium etc.Be described as the most attractive nutritious health product of 21 century by nutrition educational circles.Beer yeast albumen powder itself also is an organism, its grow required trophic structure and human body are closely similar, and the content ratio of each nutritional labeling meets the requirement of human body best nutritional proportioning, and fat is relative less with the content of monosaccharide, to obese people, old people and diabetics, the ideal especially supplementary of beer yeast albumen powder.Natural dietary fiber in the beer yeast can increase the viscosity of food, delays the absorption of glucose in the food; Increase satiety, the absorption of sugar is reduced, prevented that post-prandial glycemia from sharply rising; Form one deck " sealing coat " on the mucous membrane of small intestine surface, hinder the absorption of intestinal, excrete glucose; Increase the sensitivity of insulin, the hypoglycemic effect by insulin is helped each other reduces the demand to insulin.Therefore dietary fiber has the double effects of blood sugar regulation and blood fat, is considered to prevent the effective ingredient with adjuvant therapy of diabetes and cardiovascular and cerebrovascular complication.Contain trivalent chromium in the beer yeast, find that through scientific research beer yeast chromium has nicotinic acid-chromium-nicotinic acid biological activity axle, has great safety.In addition, scientist also finds, has glutathion around the chromium of this biological activity axle, can make the GTF chromium absorptivity height that derives from beer yeast, and biological activity is good, and performance is more stable.GTF chromium in the beer yeast (glucose tolerance factor chromium): be the important composition composition of glucose tolerance factor, have the effect of regulating lipid metabolism, improving carbohydrate tolerance; Transphosphorylase in the effect glucose metabolism; Promoting that body is lipometabolic normally carries out; The activation insulin helps the conversion of glucose, reduces the demand to exogenous insulin.
In the present composition, rice-bran crude polysaccharide contains the beneficial element of the usual fewer contact of diabetes patient as the material that extracts from coarse grain; Radix et Caulis Opuntiae Dillenii has the effect of detoxifcation analgesia, detumescence and apocenosis, can effectively discharge the intravital toxin of diabetes patient; Beer yeast albumen powder is ideal diabetes patient's a supplementary; Three medicines are harmonious and fundamentally regulate diabetes patient's body comprehensively, improve diabetes patient's physical condition, and three flavor medicines all have very clear and definite blood sugar lowering pharmacology effect, can be with diabetes patient's blood glucose regulation to normal level.
In sum, the present composition has the effect of detoxifcation analgesia, detumescence and apocenosis, additional multiple beneficial element.Can be used for prevention and treatment diabetes.
The present invention with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage.
Come further lock to state the beneficial effect of compositions of the present invention by following experiment.
1 materials and methods
1.1 experiment material:
Experimental subject: 40 of Wistar rats, male and female half and half, body weight 160 ± 20g.
Experimental drug: present composition extract, alloxan, glucose oxidase enzyme reagent kit.
Experiment equipment: 4 of spectrophotometer standard cuvettes, one on rat oral gavage pin, corresponding No. 4, No. 5 syringe needles of 5ml syringe, test tube, dropper, pipet, scalpel.
1.2 experimental technique:
Modelling: with getting 30 rats (male and female half and half), by 250mg/kg lumbar injection alloxan (being dissolved in aseptic injection water).2 survey blood glucose before and after modeling are defined as whole modelings successes.
The experiment grouping: modeling success rat is divided into three groups (male and female half and half) at random, and remaining rat is one group:
First group: normal blank group; Every day normal diet.
Second group: not administration of Cheng Mo group; Every day, normal saline was irritated stomach, ended normal diet.
The 3rd group: become mould low dosage administration group; Press the 100mg/kg body weight every day and irritate stomach, normal diet with present composition extract.
The 4th group: become mould high dose administration group; Press the 200mg/kg body weight every day and irritate stomach, normal diet with present composition extract.
1.3 experimental index: laboratory animal tail point is got blood, surveys concentration of glucose in the blood.
1.4 date processing: (x ± s) expression, relatively check with t in the group by data with means standard deviation for each index.
2 results: see Table 1
The statistical value of each experimental group of table 1
Compare * P＜0.05 with matched group, * * P＜0.01
The result shows, low dose therapy group of the present invention compares with matched group that there were significant differences (* P＜0.05), high-dose therapy group of the present invention is compared the difference (* * P＜0.01) that highly significant is arranged with matched group, illustrate that the present composition has clear and definite hypoglycemic effect.
The specific embodiment
Embodiment 1:
The preparation of the capsule of the present composition
A) take by weighing commercially available rice-bran crude polysaccharide 2kg, commercially available Radix et Caulis Opuntiae Dillenii extract 2kg, beer yeast albumen powder 15kg;
B) mix homogeneously, drying, the snap fit capsule of packing into.
Embodiment 2:
The preparation of the granule of the present composition
A) take by weighing commercially available rice-bran crude polysaccharide 0.5kg, commercially available Radix et Caulis Opuntiae Dillenii extract 0.1kg, beer yeast albumen powder 10kg;
B) be ground into powder, mix homogeneously adds ethanol and makes adhesive, adds appropriate amount of starch and makes filler, makes granule.
Embodiment 3:
The preparation of the granule of the present composition
A) defat is pushed Testa oryzae (crossing 120 mesh sieves), the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract;
B) take by weighing rice-bran crude polysaccharide 5kg, Radix et Caulis Opuntiae Dillenii extract 10kg, beer yeast albumen powder 30kg, be ground into powder, mix homogeneously adds ethanol and makes adhesive, adds appropriate amount of starch and makes filler, makes granule.
Embodiment 4:
The preparation of the tablet of the present composition
A) defat is pushed Testa oryzae (crossing 120 mesh sieves), the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii, to clean, cutting is dried, and pulverizes, soak, pretreatment, supersound process is filtered, and gets filtrate, uses ethanol precipitation, centrifugal (4500r/min), and taking precipitate, washing with alcohol, lyophilization is pulverized, and gets Radix et Caulis Opuntiae Dillenii crude polysaccharides extract;
B) take by weighing rice-bran crude polysaccharide 2kg, Radix et Caulis Opuntiae Dillenii crude polysaccharides extract 5kg, beer yeast albumen powder 15kg, be ground into powder, mix homogeneously adds adjuvant and makes granule, and dry, and compacting in flakes.
Embodiment 5:
The preparation of the tablet of the present composition
A) defat is pushed Testa oryzae (crossing 120 mesh sieves), the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii, to clean, cutting is dried, and pulverizes, soak, pretreatment, supersound process is filtered, and gets filtrate, uses ethanol precipitation, centrifugal (4500r/min), and taking precipitate, washing with alcohol, lyophilization is pulverized, and gets Radix et Caulis Opuntiae Dillenii crude polysaccharides extract;
B) take by weighing rice-bran crude polysaccharide 5kg, Radix et Caulis Opuntiae Dillenii crude polysaccharides extract 5kg, beer yeast albumen powder 15kg, be ground into powder, mix homogeneously adds adjuvant and makes granule, and dry, and compacting in flakes.
Embodiment 6:
The preparation of the effervescent tablet of the present composition
A) defat is pushed Testa oryzae (crossing 120 mesh sieves), the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii, to clean, cutting is dried, and pulverizes, soak, pretreatment, supersound process is filtered, and gets filtrate, uses ethanol precipitation, centrifugal (4500r/min), and taking precipitate, washing with alcohol, lyophilization is pulverized, and gets Radix et Caulis Opuntiae Dillenii crude polysaccharides extract;
B) take by weighing rice-bran crude polysaccharide 5kg, Radix et Caulis Opuntiae Dillenii crude polysaccharides extract 5kg, beer yeast albumen powder 20kg, be ground into powder, mix homogeneously, add tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, granulate drying with dehydrated alcohol, add the lubricant mixing, tabletting, promptly.
Embodiment 7:
The preparation of the dispersible tablet of the present composition
A) defat is pushed Testa oryzae (crossing 120 mesh sieves), the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add ALPHA amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii, to clean, cutting is dried, and pulverizes, soak, pretreatment, supersound process is filtered, and gets filtrate, uses ethanol precipitation, centrifugal (4500r/min), and taking precipitate, washing with alcohol, lyophilization is pulverized, and gets Radix et Caulis Opuntiae Dillenii crude polysaccharides extract;
B) take by weighing rice-bran crude polysaccharide 1kg, Radix et Caulis Opuntiae Dillenii crude polysaccharides extract 1kg, beer yeast albumen powder 15kg, be ground into powder, mix homogeneously adds disintegrating agent, filler or diluent, mix homogeneously, add binding agent and make soft material, the system granule, drying adds part disintegrating agent, fluidizer or lubricant mixing, tabletting, promptly.
Claims (5)
1, a kind of compositions with hypoglycemic activity is characterized in that, it is to be made by following bulk drugs: rice-bran crude polysaccharide 0.5-5 part, Radix et Caulis Opuntiae Dillenii extract 0.1-10 part, beer yeast albumen powder 10-30 part.
According to the compositions of claim 1, it is characterized in that 2, it is to be made by following bulk drugs: 2 parts of rice-bran crude polysaccharide, 2 parts of Radix et Caulis Opuntiae Dillenii extracts, 15 parts of beer yeast albumen powder.
3, claim 1 or 2 described preparation of compositions methods is characterized in that this method is: Testa oryzae is pushed in defat, the hot water lixiviate, centrifugal, get supernatant, enzymolysis, centrifugal, get supernatant, adjust pH, centrifugal, get supernatant, add the ethanol standing over night, centrifugal, get precipitation, to precipitate lyophilization or spray drying, pulverize, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process, filter, get filtrate, use ethanol precipitation, centrifugal, taking precipitate, washing with alcohol, lyophilization is pulverized, and gets Radix et Caulis Opuntiae Dillenii crude polysaccharides extract; With rice-bran crude polysaccharide, Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the beer yeast albumen powder mix homogeneously is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
4, preparation of compositions method according to claim 3 is characterized in that, it comprises the following steps: Testa oryzae (crossing 120 mesh sieves) is pushed in defat, the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, add alpha amylase (pH6.0,1h), add saccharifying enzyme (pH4.0,1h), centrifugal (3000r/min, 20min), get supernatant, add TCA (pH4.5), centrifugal (1200r/min, 10min), get supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With rice-bran crude polysaccharide, Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the beer yeast albumen powder mix homogeneously is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
5, claim 1 or 2 described compositionss are used to prepare prevention and the medicine of treatment diabetes disease or the application of health food.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105106961A (en) * | 2015-09-24 | 2015-12-02 | 程君 | Compound with beer yeast extracts, method for producing compound and application thereof |
| CN111011576A (en) * | 2019-12-30 | 2020-04-17 | 杭州衡美食品科技有限公司 | Preparation method and application of high-dispersion soybean protein |
| CN116326642A (en) * | 2023-01-18 | 2023-06-27 | 岭南师范学院 | Cactus polysaccharide chewable tablet and preparation method thereof |
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| CN1435131A (en) * | 2002-12-23 | 2003-08-13 | 刘作明 | cactus Milpa Alta beverage and producing process thereof |
| HUP0500582A1 (en) * | 2005-06-13 | 2007-08-28 | Csaba Jozsef Dr Jaszberenyi | Foods food-additives and nutriment supplements or feed-additives with synergetic physiological effect |
| CN1965799A (en) * | 2006-11-07 | 2007-05-23 | 刘家宝 | Daily used cosmetics using pearl as main ingredient and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105106961A (en) * | 2015-09-24 | 2015-12-02 | 程君 | Compound with beer yeast extracts, method for producing compound and application thereof |
| CN105106961B (en) * | 2015-09-24 | 2018-06-19 | 程君 | Composition, production method and application containing beer yeast extract |
| CN111011576A (en) * | 2019-12-30 | 2020-04-17 | 杭州衡美食品科技有限公司 | Preparation method and application of high-dispersion soybean protein |
| CN116326642A (en) * | 2023-01-18 | 2023-06-27 | 岭南师范学院 | Cactus polysaccharide chewable tablet and preparation method thereof |
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