CN101491601A - External transdermal administrated combination preparation of superfine traditional Chinese medicine capable of increasing human disease resistance - Google Patents
External transdermal administrated combination preparation of superfine traditional Chinese medicine capable of increasing human disease resistance Download PDFInfo
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Abstract
The invention relates to an ultrafine powder Chinese medicine external transdermal composition preparation for strengthening human disease resisting capability. A main drug is prepared from the following traditional Chinese medicines in portion by weight: 16 to 25 portions of astragalus root, 16 to 25 portions of rhizoma atractylodis alba, 6 to 15 portions of parsnip, 6 to 12 portions of frankincense, 6 to 12 portions of myrrh, 6 to 12 portions of cinnamon, 6 to 12 portions of radix aconiti carmichaeli, 5 to 10 portions of fennel seed and 5 to 10 portions of clove. The main drug is pulverized into ultrafine powders with the particle diameter of less than 200 to 500 meshes; the ultrafine powders are evenly mixed and moisturized by 75 percent ethanol; the ultrafine powders and gel liquid A, B and c are evenly stirred and coated on a mounting material with a medical pressure-sensitive adhesive; the mounting material is cut into drug films with specification needed for treatment; and the drug film is applied on a selected acupuncture point according to requirement. The invention is a drug preparation formulation which has a reasonable formula, small dosage, remarkable treatment effect and convenient use, is suitable for the youth and the old and has no toxicity, no side effect and no environmental pollution.
Description
Technical field
The present invention relates to utilize the superfine powder traditional Chinese medicine technology in the tcm field, relate in particular to the composite preparation that a kind of superfine powder Chinese medicine external transdermal administration strengthens the human body resistance against diseases.Can effectively improve the resistance against diseases of Susceptible population, reach anti-and be better than the purpose of controlling, play the effect of preventive treatment of disease.
Background technology
Improving the immunity of human body, strengthen the resistance against diseases of human body, is the most effectual way of maintaining health, belongs to the category of the traditional Chinese medical science " preventive treatment of disease "." preventive treatment of disease " actual to be that oneself health status is managed, this management is to pass through health assessment, formulate according to different health problems and risk factor and to improve target, select intervening measure for use, finally reach the purpose of effective reduction risk factor at target.Various body constitution are biased to be the inherence foundation that imbalance takes place disease.Simultaneously, just because of the difference of body constitution, cause the generation of organism disease and lapse to also being not quite similar.Therefore, by the body constitution identification, can realize personalized, health control targetedly.
Body constitution be meant human body because the natural endowment factor and the day after tomorrow all multifactor impacts, the individuality of formation is metastable particularity on form and function.Tcm constitution is meant human body based on natural endowment, the individual particularity in posteriori growth promoter and aging course in formed structure, function and the metabolism.Physical factors has two-layer meaning aspect morbidity: the one, and the specificity of body constitution is determining the susceptibility to paathogenic factor or some disease; The 2nd, physical factors is determining the advancing of disease process.
To regular flu patient, send out Allergic Rhinitis and seasonal chronic bronchitis patient's treatment aspect well, the Chinese medicine of prior art lays particular emphasis on oral drugs basically, and oral medicine have inevitably in digestive system destroyed and the degraded drawback.
Summary of the invention
The objective of the invention is to, a kind of Susceptible population that is suitable for the various clinical commonly encountered diseases is provided, reach the resistance against diseases that strengthens human body, improve the new medicine formulation products of quality of life.
The application's goal of the invention is achieved in that
Develop the composite preparation that a kind of superfine powder Chinese medicine external transdermal administration strengthens the human body resistance against diseases, it is characterized in that principal agent made by the Chinese medicine of following weight proportion:
5～10 parts of 16～25 parts of the Radixs Astragali, 16～25 parts of the Rhizoma Atractylodis Macrocephalaes, 6～15 parts of Radix Saposhnikoviaes, 6～12 parts of Olibanums, 6～12 parts of Myrrhas, 6～12 parts of Cortex Cinnamomis, 6～12 parts of Radix Aconiti Lateralis Preparatas, 5～10 parts of Fructus Foeniculi and Flos Caryophyllis.
Above-mentioned superfine powder Chinese medicine external transdermal administration strengthens the composite preparation of human body resistance against diseases, it is characterized in that principal agent made by the Chinese medicine of following weight proportion:
8～10 parts of 18～22 parts of the Radixs Astragali, 18～22 parts of the Rhizoma Atractylodis Macrocephalaes, 7～12 parts of Radix Saposhnikoviaes, 8～11 parts of Olibanums, 8～11 parts of Myrrhas, 8～11 parts of Cortex Cinnamomis, 8～11 parts of Radix Aconiti Lateralis Preparatas, 8～10 parts of Fructus Foeniculi and Flos Caryophyllis.
Above-mentioned superfine powder Chinese medicine external transdermal administration strengthens the composite preparation of human body resistance against diseases, it is characterized in that principal agent made by the Chinese medicine of following weight proportion:
7～9 parts of 18～20 parts of the Radixs Astragali, 18～20 parts of the Rhizoma Atractylodis Macrocephalaes, 9～11 parts of Radix Saposhnikoviaes, 7～10 parts of Olibanums, 7～10 parts of Myrrhas, 7～10 parts of Cortex Cinnamomis, 7～10 parts of Radix Aconiti Lateralis Preparatas, 7～9 parts of Fructus Foeniculi and Flos Caryophyllis.
Above-mentioned superfine powder Chinese medicine external transdermal administration strengthens the composite preparation method for making of human body resistance against diseases, it is characterized in that said preparation is the external use plaster of percutaneous dosing point-application, and its preparation mainly comprises the steps:
(1) preparation Chinese medicine ultra-fine powder ethanol wetting agent
Be ground into particle diameter≤200～500 purpose micropowders after above-mentioned Chinese medicine cleaned, mixing, moistening with 75% ethanol, consumption is a Chinese medicine micropowders total amount: 75% ethanol=1: 0.5; It is standby to mix the airtight placement 〉=12h in back thoroughly:
(2) preparation coagulant liquid
1. coagulant liquid A
Part by weight: cellulose ethers: pure water=1: 8～10,
Cellulose ethers is soluble in water, and 12h is placed in the back that stirs, and makes transparent viscous gel liquid A; Low temperature is placed standby; Cellulose ethers uses carboxymethyl cellulose (claiming Sodium Tvlose again), hydroxyethyl-cellulose, hydroxypropyl cellulose and hydroxypropyl emthylcellulose etc.; Pure water can be with the pure water of distilled water or other modes (for example reverse osmosis technology) preparation (down with).
By pharmacopeia regulation low temperature means≤60 ℃.
2. coagulant liquid B
Part by weight: nipagin A: nipasol: polyvinylpyrrolidone: pure water=1: 1: 12～14: 50～60,
Nipagin A and nipasol are dissolved in the hot water, put and be chilled to room temperature; Add polyvinylpyrrolidone, stir evenly post-heating and make its swelling, make clear gel liquid B; Low temperature is placed standby;
3. coagulant liquid C
Part by weight: polyvinyl alcohol: glycerol: Tween-80: pure water=1: 1: 0.5: 8～10,
With polyvinyl alcohol, after glycerol and Tween-80 mixing stir evenly, add pure water again and stir evenly, leave standstill 10～16h post-heating and make the polyvinyl alcohol swelling, make coagulant liquid C, low temperature is placed standby;
(3) preparation medicine film
1. with above-mentioned Chinese medicine ultra-fine powder ethanol wetting agent, coagulant liquid A, B and C in the same container of impouring, are coated with into the uniform thin layer of thickness, oven drying at low temperature after stirring;
2. with the above-mentioned medicine diaphragm for preparing; place and evenly scribble the mounting on the backing material of medical pressure-sensitive adhesive, medicine film surface coverage composite plastic protecting film, plastic protective film for plastics with mount backing compress cement after; be cut into and treat the medicine diaphragm that needs specification, be packaged in and promptly get the patch finished product in the plastic bag.
The present invention's alleged " patch " is similar to " cataplasma (cataplasmata) " that the pharmacopeia appendix is put down in writing, have equally with cataplasma " with the skin good biocompatibility, ventilative, sweat proof, no sensitization, non-stimulated; Medicine-releasing performance is good; " etc. advantage, and don't be same as cataplasma, the principal agent of cataplasma is a Chinese medical concrete; And the principal agent of this patch is a Chinese medicine ultra-fine powder.
Above-mentioned superfine powder Chinese medicine external transdermal administration strengthens the application of the composite preparation of human body resistance against diseases, it is characterized in that the regular easy catching a cold patient of treatment, sends out the application in Allergic Rhinitis and seasonal chronic bronchitis patient's the pharmaceutical preparation well.
Improving the immunity of human body, strengthen the resistance against diseases of human body, is the most effectual way of maintaining health, belongs to the category of the traditional Chinese medical science " preventive treatment of disease ".
The Chinese medicine meridian theory thinks that meridians are important component parts of human tissue structure, is human qi and blood running's path, is the conducting system of the uniqueness that human body is linked up about the exterior and the interior, the contact whole body is inside and outside.Chinese medicine is sticked on the acupuncture points on the human body by stimulation and the conduction of medicine to acupuncture points on the human body, make the effect of the relevant zang-fu diseases of Chinese medicine performance treatment.And drug effect is amplified by the strong reaction that the group effect that absorption process produced and the meridional point of meridional point are made medicine irritation.
The applicant has used for reference the preparation and the medicine-feeding technology of modern Chinese medicine, integrated the approach of technology path and treatment, a kind of externally used ultramicro powder form of Chinese drug is provided, it has the percutaneous dosing diseased region that can go directly, no oral medicine in digestive system destroyed and the degraded drawback, non-stimulated and the toxic and side effects to human body, dosage is little, and is evident in efficacy, convenient to use, user does not have any misery, can treat and stop treatment at any time, non-environmental-pollution.The deficiencies in the prior art have been solved.
The present invention at disease, its morbidity is many because of innate deficiency, has a delicate constitution or desires institute because of prolonged illness, diet, labor and hinders, causes lung, spleen, kidney three deficiency of five ZANG-organs damage, when the heresy of wind and cold is attacked, inspires disease.Therefore, improving the function of the internal organs that easily cause a disease, is exactly the best morbific approach of diseases prevention.
Except the adjusting and enhancing of immunity, Chinese medicine also can help to build up one's resistance to disease.This group disease traditional Chinese medical science thinks it mainly is the positive QI-insufficiency of susceptible colony, due in the easy intrusive body of exopathogen, and the insufficient reason of healthy energy is insufficiency of lung-QI, insufficiency of the spleen, deficiency of kidney-QI and insufficiency of vital energy and blood, strengthen the defence capability of health, except that the exercise of strengthening physical ability, increase outdoor activities, also want tonify deficiency.
In the superfine powder Chinese prescription that uses, the Radix Astragali has invigorating the spleen and replenishing QI, and benefit is defended the effect of consolidating superficial resistance, and modern pharmacological research shows: the Radix Astragali has enhancing human body immunity function and antibiosis and antiviral functions; Then can strengthen the phagocytic activity of macrophage with compatibilities such as the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviaes, improve immunity; Radix Aconiti Lateralis Preparata, Cortex Cinnamomi etc. have the effect that suppresses complement activity, the antianaphylaxis that tool is stronger on immunologic function.
Selecting the Radix Astragali for use is the QI invigorating key medicine, qi as the commander of blood, and blood being the mother of qi, and the handsome blood of gas is capable, and the nutrition foot is contained, and promotes the human righteousness, and the enhance immunity function improves immunity, and Fructus Foeniculi is dispeled cold-damp, and removing summer-heat is damp and hot; Flos Caryophylli, Cortex Cinnamomi causing resuscitation with aromatic drugs are kept away affection of exogenous wind-cold, the strong gas of defending; The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae compatibility can strengthen the human righteousness, inspire vigour, and the kidney invigorating vital essence strengthens brain development, improves memory.Olibanum, Myrrha can ventilation meridians, tonneau QI and blood, blood circulation promoting and blood stasis dispelling.
Therapeutic modality
The patient gets comfortable posture, above-mentioned superfine powder Chinese medicine patch is spread on selected place, acupuncture point, again (for example with the TDP lamp, Chongqing Medical Apparatus and Instruments Industry Co. produces " TDP ZH-41 type ", be called for short " TDP lamp ") irradiation 15～30min, take off plaster and clean, stick medicine 3～12h in SHENQUE acupoint again.Once, treat five times next day of general, again every three days once, treat three times, again every five days once, treat three times, whole this process is a course of treatment.
The acupuncture point is selected
Select the cave: fei shu, Pishu, shen shu, region below the heart, big vertebra, air door, the gate of vitality, Shenque, Zhongfu etc.Wherein, regular easy catching a cold patient: select the cave fei shu, big vertebra, air door, Shenque, Zhongfu; Send out Allergic Rhinitis well: select the cave fei shu, Pishu, big vertebra, air door, the gate of vitality, Shenque, Zhongfu; Seasonal chronic bronchitis patient: select the cave fei shu, Pishu, shen shu, region below the heart, big vertebra, air door, the gate of vitality, Shenque, Zhongfu.
The applicant is in conjunction with the common feature of common clinical Susceptible population, be primarily aimed at regular easy catching a cold patient, send out Allergic Rhinitis well, the seasonal chronic bronchitis patient uses superfine powder Chinese medicine percutaneous dosing, point application therapy has been obtained good effect.
The clinic trial curative effect:
The patient of Susceptible population 102 examples, regular easy catching a cold patient 49 examples are observed in outpatient service; Send out Allergic Rhinitis 31 examples well; Seasonal chronic bronchitis patient 22 examples.Wherein,
1. regular easy catching a cold person: total effective rate 100%.2. send out Allergic Rhinitis well: total effective rate 100%.3. chronic bronchitis is not sent out well the person: total effective rate 95.45%.
Model case.
Example one:
The king *, man, 9 years old.From 2006, repeated cold showed as repeated cold, 8～15 days left side flu once, flu one outbreak, pharyngalgia, cough, expectoration, occur together when serious heat, tonsillitis, cough increases the weight of.Inappetence, listless.For improving patient's body constitution, use our Therapeutic Method, give the patient and treat two courses of treatment continuously, follow up a case by regular visits to half a year, body constitution is obviously improved, and flu occurs.
Example two:
Lee * *, woman, 15 years old.Suffered from allergic rhinitis in 2004 2 years, clinical manifestation is rhinocnesmus, nasal obstruction, sneeze, stream clear water sample nasal mucus with itching throat, eye symptom such as itch.Check: the pale swelling of two nasal mucosas, pharyngeal diffusivity hyperemia, lateral pharyngeal band hyperemia, uvula hyperemia.Use our course of treatment of Therapeutic Method treatment, patient's symptom is obviously improved, and answers patient's requirement, adds to control a course of treatment again, and patient's body constitution is good, and allergic rhinitis is not recurrence so far.
Example three:
Slowly * *, man, 53 years old.Suffered from chronic bronchitis 5 years, and all can fall ill in the winter time, the course of disease is longer, and outbreak increases the weight of year by year repeatedly.Cardinal symptom be repeatedly cough, expectoration, pant or breathe hard, expectoration in early morning amount is many.The patient often uses the medicine of antibiotic and relieving cough and resolving phlegm, and physical condition is relatively poor.The patient, follows up a case by regular visits to through a year and a half by our two courses of treatment of Therapeutic Method treatment for improving physical condition, and the patient does not see the chronic bronchitis recurrence winter, and health body constitution is strengthened, the medicines such as antibiotic and relieving cough and resolving phlegm of having stopped using.The patient is very satisfied to therapeutic effect.
Advantage of the present invention is:
1. opened up a kind of reasonable recipe, dosage is little, and is evident in efficacy, easy to use, and old children is all suitable, has no side effect the medicament form of pharmaceutical preparation of non-environmental-pollution;
2. the present invention's preparation, easy to use, quick, user does not have any misery, can treat and stop treatment at any time;
3. superfine powder Chinese medicine external transdermal administration of the present invention strengthens the composite preparation of human body resistance against diseases, is similar to the cataplasma of pharmacopeia appendix record, have equally " with the skin good biocompatibility, ventilative, sweat proof, no sensitization, non-stimulated; Medicine-releasing performance is good " etc. advantage, and don't be same as cataplasma; The principal agent of cataplasma is a Chinese medical concrete; And the principal agent of this preparation is " genuineness " Chinese crude drug superfine powder, the possible active component of all existence in the medical material, not loss.
4. medical material is processed into≤during 200～500 order superfine powder, particle diameter reaches≤25 μ m～74 μ m, and drug effect improves significantly.
The specific embodiment
Embodiment 1
Proportioning:
Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 25g, Radix Saposhnikoviae 15g, Olibanum 12g, Myrrha 12g, Cortex Cinnamomi 12g, Radix Aconiti Lateralis Preparata 12g, Fructus Foeniculi 10g and Flos Caryophylli 10g.
Medical material all adopts 2005 editions Chinese crude drugs that record of Chinese Pharmacopoeia.Use times power super micron mill (cell wall breaking) the BFM-6 series vibromill pulverizing mill of Jinan times power crushing technology Engineering Co., Ltd development, the sporoderm-broken rate height, Chinese crude drug processing back micropowder can reach≤200～500 orders.Each medical material cleans back processing separately.
Preparation process:
(1) preparation Chinese medicine ultra-fine powder ethanol wetting agent
Be ground into particle diameter≤200～500 purpose micropowders after above-mentioned Chinese medicine cleaned, each medical material micropowder mixing of distinguishing the flavor of, moistening with 75% ethanol, consumption is a Chinese medicine micropowders total amount: 75% ethanol=1: 0.5; It is standby to mix the airtight placement 12h in back thoroughly:
(2) preparation coagulant liquid
1. coagulant liquid A
Proportioning: cellulose ethers: pure water=1: 8; This example is used commercial goods Sodium Tvlose (CMC-Na) 50g, distilled water 400ml.
CMC-Na is soluble in water, and 12h is placed in the back that stirs, and makes transparent viscous gel liquid A; Low temperature is placed standby;
2. coagulant liquid B
Proportioning: nipagin A: nipasol: polyvinylpyrrolidone: pure water=1: 1: 12～14: 50～60,
This example is used commercial goods ethyl hydroxybenzoate 4g, propylparaben 4g, polyvinylpyrrolidone (model PVPK 30, pharmaceutical grade) 48g; Distilled water 200ml.
Dosage nipagin A and nipasol are dissolved in the hot water, put and be chilled to room temperature; Add polyvinylpyrrolidone, stir evenly post-heating and make its swelling, make clear gel liquid B; Low temperature is placed standby;
3. coagulant liquid C
Part by weight: polyvinyl alcohol: glycerol: Tween-80: pure water
＝1∶1∶0.5∶8～10，
This example is used commercial goods pva powder (PVA, product type 17-88) 40g, glycerol (trade name glycerol) 40g, Tween-80 (trade name tween 80) 20g and distillation 320ml.
With polyvinyl alcohol, after glycerol and Tween-80 mixing stir evenly, add pure water again and stir evenly, place the 16h post-heating and make the polyvinyl alcohol swelling, make coagulant liquid C, low temperature is placed standby;
(3) preparation medicine film
1. with above-mentioned Chinese medicine ultra-fine powder ethanol wetting agent, coagulant liquid A, B and C, in the same container of impouring,
Be coated with into the uniform thin layer of thickness (being advisable) after stirring with 0.2～0.5mm; place and evenly scribble the mounting on the backing material (for example medical adhesive-bonded fabric) of medical pressure-sensitive adhesive; medicine film surface coverage composite plastic protecting film; plastic protective film for plastics with mount backing compress cement after; (for example be cut into medicine diaphragm that treatment needs specification; 50mm * 50mm), be packaged in and promptly get the patch finished product in the plastic bag.
The superfine powder Chinese medicine external transdermal administration that makes strengthens the application of the composite preparation (patch) of human body resistance against diseases, the regular easy catching a cold patient of treatment, send out on probation in Allergic Rhinitis and seasonal chronic bronchitis patient's the pharmaceutical preparation through the applicant well; The patient of Susceptible population 102 examples, regular easy catching a cold patient 49 examples are observed in outpatient service; Send out Allergic Rhinitis 31 examples well; Seasonal chronic bronchitis patient 22 examples.Wherein,
1. regular easy catching a cold person: total effective rate 100%.
2. send out Allergic Rhinitis well: total effective rate 100%.
3. chronic bronchitis is not sent out well the person: total effective rate 95.45%.
Reached the goal of the invention of expection satisfactorily.
Embodiment 2
Proportioning:
Radix Astragali 16g, Rhizoma Atractylodis Macrocephalae 16g, Radix Saposhnikoviae 6g, Olibanum 6g, Myrrha 6g, Cortex Cinnamomi 6g, Radix Aconiti Lateralis Preparata 6g, Fructus Foeniculi 5g and Flos Caryophylli 5g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 16h in back thoroughly: preparation coagulant liquid A uses hydroxyethyl-cellulose 50g, deionized water 500ml; Use polyvinylpyrrolidone 56g, distilled water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 16h; All the other are with embodiment 1.
Embodiment 3
Proportioning:
Radix Astragali 18g, Rhizoma Atractylodis Macrocephalae 18g, Radix Saposhnikoviae 7g, Olibanum 8g, Myrrha 8g, Cortex Cinnamomi 8g, Radix Aconiti Lateralis Preparata 8g, Fructus Foeniculi 7g and Flos Caryophylli 7g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 14h in back thoroughly: preparation coagulant liquid A uses hydroxypropyl cellulose 50g, pure water 400ml; Use polyvinylpyrrolidone 52g, pure water 200ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 12h; All the other are with embodiment 1.
Embodiment 4
Proportioning:
Radix Astragali 22g, Rhizoma Atractylodis Macrocephalae 22g, Radix Saposhnikoviae 12g, Olibanum 11g, Myrrha 11g, Cortex Cinnamomi 11g, Radix Aconiti Lateralis Preparata 11g, Fructus Foeniculi 9g and Flos Caryophylli 9g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 18h in back thoroughly: preparation coagulant liquid A uses carboxymethyl cellulose 50g, distilled water 500ml; Use polyvinylpyrrolidone 50g, distilled water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 10h; All the other are with embodiment 1.
Embodiment 5
Proportioning:
Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 20g, Radix Saposhnikoviae 11g, Olibanum 10g, Myrrha 10g, Cortex Cinnamomi 10g, Radix Aconiti Lateralis Preparata 10g, Fructus Foeniculi 8g and Flos Caryophylli 8g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 24h in back thoroughly: preparation coagulant liquid A uses hydroxypropyl emthylcellulose 50g, pure water 400ml; Use polyvinylpyrrolidone 56g, pure water 200ml during preparation coagulant liquid B; During preparation coagulant liquid C, use distilled water 400ml, place 16h; All the other are with embodiment 1.
Embodiment 6
Proportioning:
Radix Astragali 16g, Rhizoma Atractylodis Macrocephalae 16g, Radix Saposhnikoviae 6g, Olibanum 6g, Myrrha 6g, Cortex Cinnamomi 6g, Radix Aconiti Lateralis Preparata 6g, Fructus Foeniculi 5g and Flos Caryophylli 5g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 16h in back thoroughly: preparation coagulant liquid A uses hydroxyethyl-cellulose 50g, distilled water 500ml; Use polyvinylpyrrolidone 56g, distilled water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 11h; All the other are with embodiment 1.
Embodiment 7
Proportioning:
Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 18g, Radix Saposhnikoviae 15g, Olibanum 11g, Myrrha 8g, Cortex Cinnamomi 11g, Radix Aconiti Lateralis Preparata 8g, Fructus Foeniculi 7g and Flos Caryophylli 8g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 14h in back thoroughly: preparation coagulant liquid A uses hydroxypropyl cellulose 50g, pure water 400ml; Use polyvinylpyrrolidone 52g, pure water 200ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400m, place 10h; All the other are with embodiment 1.
Embodiment 8
Proportioning:
Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 22g, Radix Saposhnikoviae 15g, Olibanum 12g, Myrrha 11g, Cortex Cinnamomi 12g, Radix Aconiti Lateralis Preparata 11g, Fructus Foeniculi 10g and Flos Caryophylli 9g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 18h in back thoroughly: preparation coagulant liquid A uses carboxymethyl cellulose 50g, distilled water 500ml; Use polyvinylpyrrolidone 50g, distilled water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 15h; All the other are with embodiment 1.
Embodiment 9
Proportioning:
Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 22g, Radix Saposhnikoviae 15g, Olibanum 10g, Myrrha 10g, Cortex Cinnamomi 8g, Radix Aconiti Lateralis Preparata 8g, Fructus Foeniculi 8g and Flos Caryophylli 9g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 24h in back thoroughly: preparation coagulant liquid A uses hydroxypropyl emthylcellulose 50g, distilled water 400ml; Use polyvinylpyrrolidone 56g, distilled water 200ml during preparation coagulant liquid B; During preparation coagulant liquid C, use distilled water 400ml, place 13h; All the other are with embodiment 1.
Embodiment 10
Proportioning:
Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 16g, Radix Saposhnikoviae 15g, Olibanum 8g, Myrrha 8g, Cortex Cinnamomi 6g, Radix Aconiti Lateralis Preparata 6g, Fructus Foeniculi 10g and Flos Caryophylli 5g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 12h in back thoroughly: preparation coagulant liquid A uses hydroxyethyl-cellulose 50g, pure water 500ml; Use polyvinylpyrrolidone 56g, pure water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400m, place 14h; All the other are with embodiment 1.
Embodiment 11
Proportioning:
Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 18g, Radix Saposhnikoviae 15g, Olibanum 8g, Myrrha 9g, Cortex Cinnamomi 8g, Radix Aconiti Lateralis Preparata 9g, Fructus Foeniculi 7g and Flos Caryophylli 7g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 16h in back thoroughly: preparation coagulant liquid A uses carboxymethyl cellulose 50g, distilled water 400ml; Use polyvinylpyrrolidone 52g, distilled water 200ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 12h; All the other are with embodiment 1.
Embodiment 12
Proportioning:
Radix Astragali 22g, Rhizoma Atractylodis Macrocephalae 20g, Radix Saposhnikoviae 15g, Olibanum 10g, Myrrha 11g, Cortex Cinnamomi 10g, Radix Aconiti Lateralis Preparata 11g, Fructus Foeniculi 9g and Flos Caryophylli 8g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 18h in back thoroughly: preparation coagulant liquid A uses hydroxyethyl-cellulose 50g, distilled water 500ml; Use polyvinylpyrrolidone 50g, distilled water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 10h; All the other are with embodiment 1.
Embodiment 13
Proportioning:
Radix Astragali 18g, Rhizoma Atractylodis Macrocephalae 20g, Radix Saposhnikoviae 12g, Olibanum 10g, Myrrha 12g, Cortex Cinnamomi 10g, Radix Aconiti Lateralis Preparata 12g, Fructus Foeniculi 9g and Flos Caryophylli 8g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol soaked into, it was standby to mix the airtight placement 24h in back thoroughly: preparation coagulant liquid A uses carboxymethyl cellulose 50g, pure water 400ml; Use polyvinylpyrrolidone 56g, pure water 200ml during preparation coagulant liquid B; During preparation coagulant liquid C, use distilled water 400ml, place 16h; All the other are with embodiment 1.
Claims (5)
1. a superfine powder Chinese medicine external transdermal administration strengthens the composite preparation of human body resistance against diseases, it is characterized in that principal agent made by the Chinese medicine of following weight proportion:
5～10 parts of 16～25 parts of the Radixs Astragali, 16～25 parts of the Rhizoma Atractylodis Macrocephalaes, 6～15 parts of Radix Saposhnikoviaes, 6～12 parts of Olibanums, 6～12 parts of Myrrhas, 6～12 parts of Cortex Cinnamomis, 6～12 parts of Radix Aconiti Lateralis Preparatas, 5～10 parts of Fructus Foeniculi and Flos Caryophyllis.
2. strengthen the composite preparation of human body resistance against diseases according to the administration of the described superfine powder Chinese medicine of claim 1 external transdermal, it is characterized in that principal agent made by the Chinese medicine of following weight proportion:
8～10 parts of 18～22 parts of the Radixs Astragali, 18～22 parts of the Rhizoma Atractylodis Macrocephalaes, 7～12 parts of Radix Saposhnikoviaes, 8～11 parts of Olibanums, 8～11 parts of Myrrhas, 8～11 parts of Cortex Cinnamomis, 8～11 parts of Radix Aconiti Lateralis Preparatas, 8～10 parts of Fructus Foeniculi and Flos Caryophyllis.
3. strengthen the composite preparation of human body resistance against diseases according to the administration of the described superfine powder Chinese medicine of claim 1 external transdermal, it is characterized in that principal agent made by the Chinese medicine of following weight proportion:
7～9 parts of 18～20 parts of the Radixs Astragali, 18～20 parts of the Rhizoma Atractylodis Macrocephalaes, 9～11 parts of Radix Saposhnikoviaes, 7～10 parts of Olibanums, 7～10 parts of Myrrhas, 7～10 parts of Cortex Cinnamomis, 7～10 parts of Radix Aconiti Lateralis Preparatas, 7～9 parts of Fructus Foeniculi and Flos Caryophyllis.
4. strengthen the composite preparation method for making of human body resistance against diseases according to claim 1,2 or 3 described superfine powder Chinese medicine external transdermal administrations, it is characterized in that said preparation is the external use plaster of percutaneous dosing point-application, its preparation mainly comprises the steps:
(1) preparation Chinese medicine ultra-fine powder ethanol wetting agent
Be ground into particle diameter≤200～500 purpose micropowders after above-mentioned Chinese medicine cleaned, mixing, moistening with 75% ethanol, consumption is a Chinese medicine micropowders total amount: 75% ethanol=1: 0.5; It is standby to mix the airtight placement 〉=12h in back thoroughly:
(2) preparation coagulant liquid
1. coagulant liquid A
Part by weight: cellulose ethers: pure water=1: 8～10,
Cellulose ethers is soluble in water, and 12h is placed in the back that stirs, and makes transparent viscous gel liquid A; Low temperature is placed standby;
2. coagulant liquid B
Part by weight: nipagin A: nipasol: polyvinylpyrrolidone: pure water=1: 1: 12～14: 50～60,
Nipagin A and nipasol are dissolved in the hot water, put and be chilled to room temperature; Add polyvinylpyrrolidone, stir evenly post-heating and make its swelling, make clear gel liquid B; Low temperature is placed standby;
3. coagulant liquid C
Part by weight: polyvinyl alcohol: glycerol: Tween-80: pure water=1: 1: 0.5: 8～10,
With polyvinyl alcohol, after glycerol and Tween-80 mixing stir evenly, add pure water again and stir evenly, leave standstill 10～16h post-heating and make the polyvinyl alcohol swelling, make coagulant liquid C, low temperature is placed standby;
(3) preparation medicine film
1. with above-mentioned Chinese medicine ultra-fine powder ethanol wetting agent, coagulant liquid A, B and C in the same container of impouring, are coated with into the uniform thin layer of thickness, oven drying at low temperature after stirring;
2. with the above-mentioned medicine diaphragm for preparing; place and evenly scribble the mounting on the backing material of medical pressure-sensitive adhesive, medicine film surface coverage composite plastic protecting film, plastic protective film for plastics with mount backing compress cement after; be cut into and treat the medicine diaphragm that needs specification, be packaged in and promptly get the patch finished product in the plastic bag.
5. strengthen the application of the composite preparation of human body resistance against diseases according to the administration of the described superfine powder Chinese medicine of claim 4 external transdermal, it is characterized in that sending out the application in Allergic Rhinitis and seasonal chronic bronchitis patient's the pharmaceutical preparation well the regular easy catching a cold patient of treatment.
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