CN101491601B - Externally administrated preparation of superfine traditional Chinese medicine capable of increasing human disease resistance - Google Patents
Externally administrated preparation of superfine traditional Chinese medicine capable of increasing human disease resistance Download PDFInfo
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- CN101491601B CN101491601B CN 200910014449 CN200910014449A CN101491601B CN 101491601 B CN101491601 B CN 101491601B CN 200910014449 CN200910014449 CN 200910014449 CN 200910014449 A CN200910014449 A CN 200910014449A CN 101491601 B CN101491601 B CN 101491601B
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Abstract
The invention relates to an ultrafine powder Chinese medicine external composition preparation for strengthening human disease resisting capability. A main drug is prepared from the following traditional Chinese medicines in portion by weight: 16 to 25 portions of astragalus root, 16 to 25 portions of rhizoma atractylodis alba, 6 to 15 portions of parsnip, 6 to 12 portions of frankincense, 6 to 12 portions of myrrh, 6 to 12 portions of cinnamon, 6 to 12 portions of radix aconiti carmichaeli, 5 to 10 portions of fennel seed and 5 to 10 portions of clove. The main drug is pulverized into ultrafine powders with the particle diameter of less than 200 to 500 meshes; the ultrafine powders are evenly mixed and moisturized by 75 percent ethanol; the ultrafine powders and gel liquid A, B and C are evenly stirred and coated on a mounting material with a medical pressure-sensitive adhesive; the mounting material is cut into drug films with specification needed for treatment; and the drug film is applied on a selected acupuncture point according to requirement. The invention is applied in the drugs for treating the usualness cold, anaphylactic rhinitis and seasonal chronic bronchitis.
Description
Technical field
The present invention relates to utilize the ultrafine powder traditional Chinese medicine technology in the tcm field, relate in particular to a kind of ultrafine powder traditional Chinese medicine external preparation that strengthens the human body resistance against diseases.The resistance against diseases of energy Effective Raise Susceptible population reaches anti-and is better than the purpose of controlling, and plays the effect of preventive treatment of disease.
Background technology
Improving the immunity of human body, strengthen the resistance against diseases of human body, is the most effectual way of maintaining health, belongs to the category of the traditional Chinese medical science " preventive treatment of disease "." preventive treatment of disease " actual to be that oneself health status is managed, this management is to pass through health assessment, formulate according to different health problems and risk factor and to improve target, select the intervening measure for target, finally reach the purpose of effective reduction risk factor.Various body constitution are biased to be the inherence foundation that imbalance occurs disease.Simultaneously, just because of the difference of body constitution, cause the generation of organism disease and lapse to also being not quite similar.Therefore, by Constitution Identification, can realize Extraordinary, targetedly health control.
Body constitution refer to human body because the natural endowment factor and the day after tomorrow many factors, the individuality of formation is metastable particularity on morphology and function.Tcm constitution refers to that human body is take natural endowment as basis, the individual particularity in posteriori growth promoter and aging course in formed structure, function and the metabolism.Physical factors has two-layer meaning aspect morbidity: the one, and the specificity of body constitution is determining the susceptibility to paathogenic factor or some disease; The 2nd, physical factors is determining the advancing of disease process.
To regular flu patient, send out well Allergic Rhinitis and seasonal chronic bronchitis patient's treatment aspect, the Chinese medicine of prior art lays particular emphasis on oral drugs basically, and oral medicine has drawback destroyed in digestive system and degraded inevitably.
Summary of the invention
The object of the invention is to, a kind of Susceptible population that is suitable for the various clinical commonly encountered diseases is provided, reach the resistance against diseases that strengthens human body, improve the new medicine formulation products of quality of life.
The application's goal of the invention is achieved in that
Develop a kind of ultrafine powder traditional Chinese medicine external preparation that strengthens the human body resistance against diseases, it is characterized in that principal agent made by the Chinese medicine of following weight proportion:
5～10 parts of 16～25 parts of the Radixs Astragali, 16～25 parts of the Rhizoma Atractylodis Macrocephalaes, 6～15 parts of Radix Saposhnikoviaes, 6～12 parts of Olibanums, 6～12 parts of Myrrhas, 6～12 parts of Cortex Cinnamomis, 6～12 parts of Radix Aconiti Lateralis Preparatas, 5～10 parts of Fructus Foeniculi and Flos Caryophyllis.
The ultrafine powder traditional Chinese medicine external preparation of above-mentioned enhancing human body resistance against diseases is characterized in that principal agent made by the Chinese medicine of following weight proportion:
8～10 parts of 18～22 parts of the Radixs Astragali, 18～22 parts of the Rhizoma Atractylodis Macrocephalaes, 7～12 parts of Radix Saposhnikoviaes, 8～11 parts of Olibanums, 8～11 parts of Myrrhas, 8～11 parts of Cortex Cinnamomis, 8～11 parts of Radix Aconiti Lateralis Preparatas, 8～10 parts of Fructus Foeniculi and Flos Caryophyllis.
The ultrafine powder traditional Chinese medicine external preparation of above-mentioned enhancing human body resistance against diseases is characterized in that principal agent made by the Chinese medicine of following weight proportion:
7～9 parts of 18～20 parts of the Radixs Astragali, 18～20 parts of the Rhizoma Atractylodis Macrocephalaes, 9～11 parts of Radix Saposhnikoviaes, 7～10 parts of Olibanums, 7～10 parts of Myrrhas, 7～10 parts of Cortex Cinnamomis, 7～10 parts of Radix Aconiti Lateralis Preparatas, 7～9 parts of Fructus Foeniculi and Flos Caryophyllis.
Above-mentioned preparation is the external use plaster of percutaneous dosing point-application, and its preparation mainly comprises the steps:
(1) preparation Chinese medicine ultra-fine powder ethanol wetting agent
Be ground into particle diameter≤200～500 purpose micropowders after above-mentioned Chinese medicine cleaned, mixing, moistening with 75% ethanol, consumption is Chinese medicine micropowders total amount: 75% ethanol=1: 0.5; Mix rear airtight placement 〉=12h thoroughly for subsequent use;
(2) preparation coagulant liquid
1. coagulant liquid A
Part by weight:
Cellulose ethers: pure water=1: 8～10,
Cellulose ethers is soluble in water, and the rear placement 12h that stirs makes transparent viscous gel liquid A; Low temperature is placed for subsequent use;
Described cellulose ethers is carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose or hydroxypropyl emthylcellulose; Pure water can be with the pure water of distilled water or other modes (for example reverse osmosis technology) preparation (lower with).
By pharmacopeia regulation low temperature means≤60 ℃.
2. coagulant liquid B
Part by weight:
Nipagin A: nipasol: polyvinylpyrrolidone: pure water=l: l: 12～14: 50～60;
Nipagin A and nipasol are dissolved in the hot water, let cool to room temperature; Add polyvinylpyrrolidone, stir evenly post-heating and make its swelling, make clear gel liquid B; Low temperature is placed for subsequent use;
3. coagulant liquid C
Part by weight:
Polyvinyl alcohol: glycerol: Polysorbate-80: pure water=1:1:0.5:8～10;
With polyvinyl alcohol, after-80 mixing of glycerol and Polysorbate stir evenly, add again pure water and stir evenly, leave standstill 10～16h post-heating and make the polyvinyl alcohol swelling, make coagulant liquid C, low temperature is placed for subsequent use;
(3) preparation medicine film
1. with above-mentioned Chinese medicine ultra-fine powder ethanol wetting agent, coagulant liquid A, B and C in the same container of impouring, are coated with into the uniform thin layer of thickness, oven drying at low temperature after stirring;
2. with the above-mentioned medicine diaphragm for preparing; place on the framed back material that evenly scribbles medical pressure-sensitive adhesive, medicine film surface coverage composite plastic protecting film, plastic protective film for plastics with mount backing compress cement after; being cut into treatment needs the medicine diaphragm of specification, is packaged in and namely gets the patch finished product in the plastic bag.
The present invention's alleged " patch " is similar to " cataplasma (cataplasmata) " of pharmacopeia appendix record, has equally with cataplasma that " with the skin good biocompatibility, ventilative, sweat proof are without sensitization, non-stimulated; Medicine-releasing performance is good; " etc. advantage, and don't be same as cataplasma, the principal agent of cataplasma is Chinese medical concrete; And the principal agent of this patch is Chinese medicine ultra-fine powder.
The application of the ultrafine powder traditional Chinese medicine external preparation of above-mentioned enhancing human body resistance against diseases is characterized in that sending out well the application in Allergic Rhinitis and seasonal chronic bronchitis patient's the pharmaceutical preparation the regular easy catching a cold patient for the treatment of.
Improving the immunity of human body, strengthen the resistance against diseases of human body, is the most effectual way of maintaining health, belongs to the category of the traditional Chinese medical science " preventive treatment of disease ".
The Chinese medicine meridian theory thinks, meridians are important component parts of human tissue structure, are human qi and blood running's paths, is the conducting system of the uniqueness that human body is linked up about the exterior and the interior, the contact whole body is inside and outside.With Chinese medicine application on acupuncture points on the human body by stimulation and the conduction of medicine to acupuncture points on the human body, make the effect of the relevant zang-fu diseases of Chinese medicine performance treatment.And the group effect that the absorption process by meridional point produces and meridional point amplify drug effect to the strong reaction that medicine irritation is made.
The applicant has used for reference preparation and the medicine-feeding technology of modern Chinese medicine, integrated the approach of technology path and treatment, a kind of externally used ultramicro powder form of Chinese drug is provided, it has the percutaneous dosing diseased region that can go directly, without oral medicine destroyed drawback with degrading in digestive system, non-stimulated and the toxic and side effects to human body, dosage is little, and is evident in efficacy, convenient to use, user can treat and stop treatment, non-environmental-pollution at any time without any misery.The deficiencies in the prior art have been solved.
The present invention for disease, its morbidity is many because of innate deficiency, has a delicate constitution or wants institute because of prolonged illness, diet, labor and hinders, causes lung, spleen, kidney three deficiency of five ZANG-organs damage, when the heresy of wind and cold is attacked, inspires disease.Therefore, improving the function of the internal organs that easily cause a disease, is exactly the approach that best diseases prevention is caused a disease.
Except the adjusting and enhancing of immunity, Chinese medicine also can help to build up one's resistance to disease.This group disease traditional Chinese medical science thinks it mainly is the positive QI-insufficiency of susceptible colony, due in the easy intrusive body of exopathogen, and the reason of positive QI-insufficiency is insufficiency of lung-QI, insufficiency of the spleen, deficiency of kidney-QI and insufficiency of vital energy and blood, strengthen the defence capability of health, except the exercise of strengthening physical ability, increase outdoor activities, also want tonify deficiency.
In the ultrafine powder traditional Chinese medicine prescription that uses, the Radix Astragali has invigorating the spleen and replenishing QI, and benefit is defended the effect of consolidating superficial resistance, and modern pharmacological research shows: the Radix Astragali has enhancing human body immunity function and antibiosis and antiviral functions; Then can strengthen the phagocytic activity of macrophage with compatibilities such as the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviaes, improve immunity; Radix Aconiti Lateralis Preparata, Cortex Cinnamomi etc. have the effect that suppresses complement activity, the antianaphylaxis that tool is stronger in immunologic function.
Selecting the Radix Astragali is the QI invigorating key medicine, qi as the commander of blood, and blood being the mother of qi, the handsome blood of gas, the nutrition foot is contained, and promotes the human righteousness, strengthens immune function, improves immunity, and Fructus Foeniculi is dispelled cold-damp, and removing summer-heat is damp and hot; Flos Caryophylli, Cortex Cinnamomi causing resuscitation with aromatic drugs are kept away affection of exogenous wind-cold, the strong gas of defending; The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae compatibility can strengthen the human righteousness, inspire vigour, and the kidney invigorating vital essence strengthens brain development, improves memory.Olibanum, Myrrha can ventilation meridians, tonneau QI and blood, blood circulation promoting and blood stasis dispelling.
Therapeutic modality
The patient gets comfortable posture, above-mentioned ultrafine powder traditional Chinese medicine is sticked in selected place, acupuncture point, again with the TDP lamp (for example, Chongqing Medical Apparatus and Instruments Industry Co. produces " TDP ZH-41 type ", be called for short " TDP lamp ") irradiation 15～30min, take off plaster and clean, stick medicine 3～12h in SHENQUE acupoint again.Once, treat five times next day of general, again every three days once, treat three times, again every five days once, treat three times, whole this process is a course for the treatment of.
The acupuncture point is selected
Select the cave: fei shu, Pishu, shen shu, region below the heart, big vertebra, air door, the gate of vitality, Shenque, Zhongfu etc.Wherein, regular easy catching a cold patient: select the cave fei shu, big vertebra, air door, Shenque, Zhongfu; Send out well Allergic Rhinitis: select the cave fei shu, Pishu, big vertebra, air door, the gate of vitality, Shenque, Zhongfu; Seasonal chronic bronchitis patient: select the cave fei shu, Pishu, shen shu, region below the heart, big vertebra, air door, the gate of vitality, Shenque, Zhongfu.
The applicant is in conjunction with the common feature of common clinical Susceptible population, mainly for regular easy catching a cold patient, send out Allergic Rhinitis well, the seasonal chronic bronchitis patient uses the ultrafine powder traditional Chinese medicine percutaneous dosing, point application therapy has been obtained good effect.
The clinic trial curative effect:
The patient of Susceptible population 102 examples, regular easy catching a cold patient 49 examples are observed in outpatient service; Send out well Allergic Rhinitis 31 examples; Seasonal chronic bronchitis patient 22 examples.Wherein,
1. regular easy catching a cold person: total effective rate 100%.2. send out well Allergic Rhinitis: total effective rate 100%.3. chronic bronchitis is not sent out well the person: total effective rate 95.45%.
Model case.
Example one:
The king *, man, 9 years old.From 2006, repeated cold showed as repeated cold, 8～15 days left flu once, flu one outbreak, pharyngalgia, cough, expectoration, occur together when serious heat, tonsillitis, cough increases the weight of.Inappetence, listless.For improving patient's body constitution, use our Therapeutic Method, give the patient and treat two courses for the treatment of continuously, follow up a case by regular visits to half a year, body constitution is obviously improved, and flu occurs.
Example two:
Lee * *, woman, 15 years old.Suffered from allergic rhinitis in 2004 2 years, clinical manifestation is rhinocnesmus, nasal obstruction, sneeze, stream clear water sample nasal mucus with itching throat, the eye symptom such as itch.Check: the pale swelling of two nasal mucosas, pharyngeal diffusivity is congested, and lateral pharyngeal band is congested, and uvula is congested.Use our course for the treatment of of Therapeutic Method treatment, patient's symptom is obviously improved, and answers patient's requirement, adds to control a course for the treatment of again, and patient's body constitution is good, and allergic rhinitis is not recurrence so far.
Example three:
Slowly * *, man, 53 years old.Suffered from chronic bronchitis 5 years, and all can fall ill in the winter time, the course of disease is longer, and outbreak increases the weight of year by year repeatedly.Cardinal symptom be repeatedly cough, expectoration, pant or breathe hard, expectoration in early morning amount is many.The patient often uses the medicine of antibiotic and relieving cough and resolving phlegm, and physical condition is relatively poor.The patient, follows up a case by regular visits to through a year and a half by our two courses for the treatment of of Therapeutic Method treatment for improving physical condition, and the patient has no the chronic bronchitis recurrence winter, and health body constitution is strengthened, the medicines such as antibiotic and relieving cough and resolving phlegm of having stopped using.The patient is very satisfied to therapeutic effect.
Advantage of the present invention is:
1. opened up a kind of reasonable recipe, dosage is little, and is evident in efficacy, easy to use, and old children is all suitable, has no side effect the medicament form of pharmaceutical preparation of non-environmental-pollution;
2. the present invention's preparation, easy to use, quick, user can treat and stop treatment at any time without any misery;
3. the present invention strengthens the ultrafine powder traditional Chinese medicine external preparation of human body resistance against diseases, is similar to the cataplasma of pharmacopeia appendix record, has equally that " with the skin good biocompatibility, ventilative, sweat proof are without sensitization, non-stimulated; Medicine-releasing performance is good " etc. advantage, and don't be same as cataplasma; The principal agent of cataplasma is Chinese medical concrete; And the principal agent of this preparation is " genuineness " Chinese crude drug superfine powder, the possible active component of all existence in the medical material, not loss.
4. medical material is processed into≤during 200～500 order superfine powder, particle diameter reaches≤25 μ m～74 μ m, and drug effect improves significantly.
The specific embodiment
Embodiment 1
Proportioning:
Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 25g, Radix Saposhnikoviae 15g, Olibanum 12g, Myrrha 12g, Cortex Cinnamomi 12g, Radix Aconiti Lateralis Preparata 12g, Fructus Foeniculi 10g and Flos Caryophylli 10g.
Medical material all adopts 2005 editions Chinese crude drugs that record of Chinese Pharmacopoeia.Use times power super micron mill (cell wall breaking) the BFM-6 series vibromill pulverizing mill of Jinan times power crushing technology Engineering Co., Ltd development, sporoderm-broken rate is high, and micropowder can reach≤200～500 orders after the Chinese crude drug processing.Each medical material cleans rear independent processing.
Preparation process:
⑴ prepare Chinese medicine ultra-fine powder ethanol wetting agent
Be ground into particle diameter≤200～500 purpose micropowders after above-mentioned Chinese medicine cleaned, ingredients micropowder mixing, moistening with 75% ethanol, consumption is Chinese medicine micropowders total amount: 75% ethanol=1: 0.5; Mix rear airtight placement 12h thoroughly for subsequent use:
⑵ prepare coagulant liquid
1. coagulant liquid A
Proportioning: cellulose ethers: pure water=1: 8; This example is used commercial goods sodium carboxymethyl cellulose (CMC-Na) 50g, distilled water 400ml.
CMC-Na is soluble in water, and the rear placement 12h that stirs makes transparent viscous gel liquid A; Low temperature is placed for subsequent use;
2. coagulant liquid B
Proportioning: nipagin A: nipasol: polyvinylpyrrolidone: pure water
=1∶1∶12～14∶50～60，
This example is used commercial goods ethyl hydroxybenzoate 4g, propylparaben 4g, polyvinylpyrrolidone (model PVPK30, pharmaceutical grade) 48g; Distilled water 200ml.
Dosage nipagin A and nipasol are dissolved in the hot water, let cool to room temperature; Add polyvinylpyrrolidone, stir evenly post-heating and make its swelling, make clear gel liquid B; Low temperature is placed for subsequent use;
3. coagulant liquid C
Part by weight: polyvinyl alcohol: glycerol: Tween-80: pure water
=1∶1∶0.5∶8～10，
This example is used commercial goods pva powder (PVA, product type 17-88) 40g, glycerol (trade name glycerol) 40g, Tween-80 (trade name tween 80) 20g, and distillation 320ml.
With polyvinyl alcohol, after glycerol and Tween-80 mixing stir evenly, add again pure water and stir evenly, place the 16h post-heating and make the polyvinyl alcohol swelling, make coagulant liquid C, low temperature is placed for subsequent use;
⑶ prepare the medicine film
1. with above-mentioned Chinese medicine ultra-fine powder ethanol wetting agent; coagulant liquid A, B and C; in the same container of impouring; be coated with into the uniform thin layer of thickness (being advisable with 0.2～0.5mm) after stirring, place on the framed back material (for example medical adhesive-bonded fabric) that evenly scribbles medical pressure-sensitive adhesive medicine film surface coverage composite plastic protecting film; plastic protective film for plastics with mount backing compress cement after; being cut into treatment needs the medicine diaphragm of specification (for example, 50mm * 50mm), be packaged in and namely get the patch finished product in the plastic bag.
The application of the ultrafine powder traditional Chinese medicine external preparation (patch) of the enhancing human body resistance against diseases that makes the regular easy catching a cold patient for the treatment of, is sent out well on probation in Allergic Rhinitis and seasonal chronic bronchitis patient's the pharmaceutical preparation through the applicant; The patient of Susceptible population 102 examples, regular easy catching a cold patient 49 examples are observed in outpatient service; Send out well Allergic Rhinitis 31 examples; Seasonal chronic bronchitis patient 22 examples.Wherein,
1. regular easy catching a cold person: total effective rate 100%.
2. send out well Allergic Rhinitis: total effective rate 100%.
3. chronic bronchitis is not sent out well the person: total effective rate 95.45%.
Reached satisfactorily the goal of the invention of expection.
Embodiment 2
Proportioning:
Radix Astragali 16g, Rhizoma Atractylodis Macrocephalae 16g, Radix Saposhnikoviae 6g, Olibanum 6g, Myrrha 6g, Cortex Cinnamomi 6g, Radix Aconiti Lateralis Preparata 6g, Fructus Foeniculi 5g and Flos Caryophylli 5g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 16h thoroughly for subsequent use: preparation coagulant liquid A uses hydroxyethyl-cellulose 50g, deionized water 500ml; Use polyvinylpyrrolidone 56g, distilled water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 16h; All the other are with embodiment 1.
Embodiment 3
Proportioning:
Radix Astragali 18g, Rhizoma Atractylodis Macrocephalae 18g, Radix Saposhnikoviae 7g, Olibanum 8g, Myrrha 8g, Cortex Cinnamomi 8g, Radix Aconiti Lateralis Preparata 8g, Fructus Foeniculi 7g and Flos Caryophylli 7g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 14h thoroughly for subsequent use: preparation coagulant liquid A uses hydroxypropyl cellulose 50g, pure water 400ml; Use polyvinylpyrrolidone 52g, pure water 200ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 12h; All the other are with embodiment 1.
Embodiment 4
Proportioning:
Radix Astragali 22g, Rhizoma Atractylodis Macrocephalae 22g, Radix Saposhnikoviae 12g, Olibanum 11g, Myrrha 11g, Cortex Cinnamomi 11g, Radix Aconiti Lateralis Preparata 11g, Fructus Foeniculi 9g and Flos Caryophylli 9g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 18h thoroughly for subsequent use: preparation coagulant liquid A uses carboxymethyl cellulose 50g, distilled water 500ml; Use polyvinylpyrrolidone 50g, distilled water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 10h; All the other are with embodiment 1.
Embodiment 5
Proportioning:
Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 20g, Radix Saposhnikoviae 11g, Olibanum 10g, Myrrha 10g, Cortex Cinnamomi 10g, Radix Aconiti Lateralis Preparata 10g, Fructus Foeniculi 8g and Flos Caryophylli 8g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 24h thoroughly for subsequent use: preparation coagulant liquid A uses hydroxypropyl emthylcellulose 50g, pure water 400ml; Use polyvinylpyrrolidone 56g, pure water 200ml during preparation coagulant liquid B; During preparation coagulant liquid C, use distilled water 400ml, place 16h; All the other are with embodiment 1.
Embodiment 6
Proportioning:
Radix Astragali 16g, Rhizoma Atractylodis Macrocephalae 16g, Radix Saposhnikoviae 6g, Olibanum 6g, Myrrha 6g, Cortex Cinnamomi 6g, Radix Aconiti Lateralis Preparata 6g, Fructus Foeniculi 5g and Flos Caryophylli 5g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 16h thoroughly for subsequent use: preparation coagulant liquid A uses hydroxyethyl-cellulose 50g, distilled water 500ml; Use polyvinylpyrrolidone 56g, distilled water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 11h; All the other are with embodiment 1.
Embodiment 7
Proportioning:
Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 18g, Radix Saposhnikoviae 15g, Olibanum 11g, Myrrha 8g, Cortex Cinnamomi 11g, Radix Aconiti Lateralis Preparata 8g, Fructus Foeniculi 7g and Flos Caryophylli 8g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 14h thoroughly for subsequent use: preparation coagulant liquid A uses hydroxypropyl cellulose 50g, pure water 400ml; Use polyvinylpyrrolidone 52g, pure water 200ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400m, place 10h; All the other are with embodiment 1.
Embodiment 8
Proportioning:
Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 22g, Radix Saposhnikoviae 15g, Olibanum 12g, Myrrha 11g, Cortex Cinnamomi 12g, Radix Aconiti Lateralis Preparata 11g, Fructus Foeniculi 10g and Flos Caryophylli 9g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 18h thoroughly for subsequent use: preparation coagulant liquid A uses carboxymethyl cellulose 50g, distilled water 500ml; Use polyvinylpyrrolidone 50g, distilled water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 15h; All the other are with embodiment 1.
Embodiment 9
Proportioning:
Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 22g, Radix Saposhnikoviae 15g, Olibanum 10g, Myrrha 10g, Cortex Cinnamomi 8g, Radix Aconiti Lateralis Preparata 8g, Fructus Foeniculi 8g and Flos Caryophylli 9g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 24h thoroughly for subsequent use: preparation coagulant liquid A uses hydroxypropyl emthylcellulose 50g, distilled water 400ml; Use polyvinylpyrrolidone 56g, distilled water 200ml during preparation coagulant liquid B; During preparation coagulant liquid C, use distilled water 400ml, place 13h; All the other are with embodiment 1.
Embodiment 10
Proportioning:
Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 16g, Radix Saposhnikoviae 15g, Olibanum 8g, Myrrha 8g, Cortex Cinnamomi 6g, Radix Aconiti Lateralis Preparata 6g, Fructus Foeniculi 10g and Flos Caryophylli 5g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 12h thoroughly for subsequent use: preparation coagulant liquid A uses hydroxyethyl-cellulose 50g, pure water 500ml; Use polyvinylpyrrolidone 56g, pure water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400m, place 14h; All the other are with embodiment 1.
Embodiment 11
Proportioning:
Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 18g, Radix Saposhnikoviae 15g, Olibanum 8g, Myrrha 9g, Cortex Cinnamomi 8g, Radix Aconiti Lateralis Preparata 9g, Fructus Foeniculi 7g and Flos Caryophylli 7g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 16h thoroughly for subsequent use: preparation coagulant liquid A uses carboxymethyl cellulose 50g, distilled water 400ml; Use polyvinylpyrrolidone 52g, distilled water 200ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 12h; All the other are with embodiment 1.
Embodiment 12
Proportioning:
Radix Astragali 22g, Rhizoma Atractylodis Macrocephalae 20g, Radix Saposhnikoviae 15g, Olibanum 10g, Myrrha 11g, Cortex Cinnamomi 10g, Radix Aconiti Lateralis Preparata 11g, Fructus Foeniculi 9g and Flos Caryophylli 8g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 18h thoroughly for subsequent use: preparation coagulant liquid A uses hydroxyethyl-cellulose 50g, distilled water 500ml; Use polyvinylpyrrolidone 50g, distilled water 240ml during preparation coagulant liquid B;
During preparation coagulant liquid C, use distilled water 400ml, place 10h; All the other are with embodiment 1.
Embodiment 13
Proportioning:
Radix Astragali 18g, Rhizoma Atractylodis Macrocephalae 20g, Radix Saposhnikoviae 12g, Olibanum 10g, Myrrha 12g, Cortex Cinnamomi 10g, Radix Aconiti Lateralis Preparata 12g, Fructus Foeniculi 9g and Flos Caryophylli 8g.
In the preparation process, when Chinese medicine ultra-fine powder ethanol infiltrates, mix rear airtight placement 24h thoroughly for subsequent use: preparation coagulant liquid A uses carboxymethyl cellulose 50g, pure water 400ml; Use polyvinylpyrrolidone 56g, pure water 200ml during preparation coagulant liquid B; During preparation coagulant liquid C, use distilled water 400ml, place 16h; All the other are with embodiment 1.
Claims (4)
1. ultrafine powder traditional Chinese medicine external preparation that strengthens the human body resistance against diseases is characterized in that being made by the Chinese medicine of following weight proportion:
5～10 parts of 16～25 parts of the Radixs Astragali, 16～25 parts of the Rhizoma Atractylodis Macrocephalaes, 6～15 parts of Radix Saposhnikoviaes, 6～12 parts of Olibanums, 6～12 parts of Myrrhas, 6～12 parts of Cortex Cinnamomis, 6～12 parts of Radix Aconiti Lateralis Preparatas, 5～10 parts of Fructus Foeniculi and Flos Caryophyllis;
Described preparation is the external use plaster of percutaneous dosing point-application, and its preparation mainly comprises the steps:
(1) preparation Chinese medicine ultra-fine powder ethanol wetting agent
Be ground into particle diameter≤200～500 purpose micropowders after above-mentioned Chinese medicine cleaned, mixing, moistening with 75% ethanol, consumption is Chinese medicine micropowders total amount: 75% ethanol=1: 0.5; Mix rear airtight placement 〉=12h thoroughly for subsequent use;
(2) preparation coagulant liquid
1. coagulant liquid A
Part by weight:
Cellulose ethers: pure water=1: 8～10,
Cellulose ethers is soluble in water, and the rear placement 12h that stirs makes transparent viscous gel liquid A; Low temperature is placed for subsequent use;
Described cellulose ethers is carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose or hydroxypropyl emthylcellulose;
2. coagulant liquid B
Part by weight:
Nipagin A: nipasol: polyvinylpyrrolidone: pure water=l: l: 12～14: 50～60;
Nipagin A and nipasol are dissolved in the hot water, let cool to room temperature; Add polyvinylpyrrolidone, stir evenly post-heating and make its swelling, make clear gel liquid B; Low temperature is placed for subsequent use;
3. coagulant liquid C
Part by weight:
Polyvinyl alcohol: glycerol: Polysorbate-80: pure water=1:1:0.5:8～10;
With polyvinyl alcohol, after-80 mixing of glycerol and Polysorbate stir evenly, add again pure water and stir evenly, leave standstill 10～16h post-heating and make the polyvinyl alcohol swelling, make coagulant liquid C, low temperature is placed for subsequent use;
(3) preparation medicine film
1. with above-mentioned Chinese medicine ultra-fine powder ethanol wetting agent, coagulant liquid A, B and C in the same container of impouring, are coated with into the uniform thin layer of thickness, oven drying at low temperature after stirring;
2. with the above-mentioned medicine diaphragm for preparing; place on the framed back material that evenly scribbles medical pressure-sensitive adhesive, medicine film surface coverage composite plastic protecting film, plastic protective film for plastics with mount backing compress cement after; being cut into treatment needs the medicine diaphragm of specification, is packaged in and namely gets the patch finished product in the plastic bag.
2. according to the ultrafine powder traditional Chinese medicine external preparation of enhancing human body resistance against diseases claimed in claim 1, it is characterized in that being made by the Chinese medicine of following weight proportion:
8～10 parts of 18～22 parts of the Radixs Astragali, 18～22 parts of the Rhizoma Atractylodis Macrocephalaes, 7～12 parts of Radix Saposhnikoviaes, 8～11 parts of Olibanums, 8～11 parts of Myrrhas, 8～11 parts of Cortex Cinnamomis, 8～11 parts of Radix Aconiti Lateralis Preparatas, 8～10 parts of Fructus Foeniculi and Flos Caryophyllis.
3. according to the ultrafine powder traditional Chinese medicine external preparation of enhancing human body resistance against diseases claimed in claim 1, it is characterized in that being made by the Chinese medicine of following weight proportion:
7～9 parts of 18～20 parts of the Radixs Astragali, 18～20 parts of the Rhizoma Atractylodis Macrocephalaes, 9～11 parts of Radix Saposhnikoviaes, 7～10 parts of Olibanums, 7～10 parts of Myrrhas, 7～10 parts of Cortex Cinnamomis, 7～10 parts of Radix Aconiti Lateralis Preparatas, 7～9 parts of Fructus Foeniculi and Flos Caryophyllis.
4. catch a cold the application in the pharmaceutical preparation of allergic rhinitis and chronic bronchitis according to the ultrafine powder traditional Chinese medicine external preparation of claim 1,2 or 3 described enhancing human body resistances against diseases in the preparation treatment.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1475229A (en) * | 2002-08-14 | 2004-02-18 | 卫永生 | Antifatigue compound Chinese medicine prescription and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1475229A (en) * | 2002-08-14 | 2004-02-18 | 卫永生 | Antifatigue compound Chinese medicine prescription and its preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 宋诚等.体虚感冒合剂防治虚证感冒294例.《陕西中医》.2003,第24卷(第6期),505-507. * |
| 李颖等.体虚感冒合剂治疗慢性单纯性鼻炎60例疗效观察.《中国中医药信息杂志》.2008,第15卷(第1期),73. * |
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