CN101485823A - Medicament for treating lung cancer and preparation method thereof - Google Patents

Abstract

The invention relates to a medicament for treating lung cancer. Tortoise plastron, turtle shell, ginseng, radix codonopsitis, radix pseudostellariae, pilose antler, root of rehmannia, dioscoreae opposite thumb, angelica, tuckahoe, tokay, cortex moutan, red paeony root, gardenia, rhizoma anemarrhenae, phellodendron amurense, figwort, concocted pangolin, alisma, Chinese eaglewood, radix astragali, cordyceps, pepperweed seed and Szechuan-fritillary bulb are evenly mixed and crushed into fine powder of 100 to 120 meshes; and the fine powder is pressed into tablets. The medicament has the advantages of nourishing kidney-Yin, warming kidney-Yang, benefitting vigor, clearing the lung and moistening dryness, unchoking mechanism of Qi, nourishing the blood and clearing Ying heat, breaking obstruction and relieving tumor, and clearing away heat and toxic material, applies cold and heat, combines tonification and purgation, and can enhance autoimmune function of human body, activate immune cells, promote nutrient recovery of tissues and cells, relieve and alleviate clinical symptoms, improve life quality of patients, and prolong life of the patients.

Description

A kind of lung cancer drugs and preparation method thereof that is used for the treatment of

Technical field

The present invention relates to a kind of treatment lung cancer drugs, particularly relating to a kind of is the treatment lung cancer drugs of feedstock production with Chinese medicine, the invention still further relates to the preparation method of this medicine.

Background technology

Pulmonary carcinoma is a kind of common malignancy, and is very big to human health risk, and its treatment remains a great problem medically.Since nearly half a century, the lung cancer morbidity rate of many countries and regions and mortality rate are all increasing year by year.The cause of disease of primary disease is not clear and definite fully as yet at present, but show according to epidemiologic data, primary disease and smoking, atmospheric pollution and some occupational factor such as asbestos, arsenic, chromium, Colophonium and some radioactive substance have substantial connection, and endocrine regulation may be used in the shaft raising cooperation.

Operation, radiotherapy, chemotherapy can be controlled the pulmonary carcinoma state of an illness rapidly, are 3 large models of current treatment pulmonary carcinoma.Though excision is a kind of of curative effect the best in the various Therapeutic Method, about 80% lung cancer patient does not have surgical condition the sixth of the twelve Earthly Branches when making a definite diagnosis, and in operable 20% case, because later stage relapse rate height, five year survival rate is also very low.The toxicity of radiotherapy, chemotherapy is quite serious, and part patient is forced to therapy discontinued because of tolerating.Especially radiation and chemotherapy can grievous injury immune function, cause body weak depleted and lose the ability of opposing other diseases, finally make the remaining intravital G0 phase " anoxic cell " become the cancerous cell recurrence, shift inevitable root.

The Chinese and western drugs or the cure rate of the treatment pulmonary carcinoma of using are low at present, and perhaps side effect is big, all can't make the people satisfied.Chinese medicine the Chinese patent medicine that much characteristics is arranged respectively, certain curative effect is arranged occurred in characteristic and advantage that oneself is arranged aspect the treatment pulmonary carcinoma.But these Chinese patent medicine ubiquities the shortcoming that curative effect is lower, onset is slower, often need also to use simultaneously with multiple Western medicine.Therefore, the advantage of performance Chinese medicine aspect treatment pulmonary carcinoma, excavation better efficacy, side effect Chinese patent medicine still less are the needs of clinical treatment.

Summary of the invention

The purpose of this invention is to provide a kind of lung cancer drugs that is used for the treatment of, this medicine can play the effect that presses down tumor, raise immunity, the quality of making the life better, prolongs life cycle.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Carapax et Plastrum Testudinis 8～12 Carapax Trionycis 8～12

Radix Ginseng 16～22 Radix Codonopsis 8～12

Radix Pseudostellariae 8～12 Cornu Cervi Pantotrichums 8～12

Huai Radix Rehmanniae 8～12 RHIIZOMA DIOSCOREAE frOm Henan of China 8～12

Radix Angelicae Sinensis 8～12 Poria 8～12

Gecko 8～12 Cortex Moutans 8～12

Radix Paeoniae Rubra 3～6 Fructus Gardeniaes 3～6

The Rhizoma Anemarrhenae 8～12 Cortex Phellodendris 3～6

Radix Scrophulariae 8～12 big gun Squama Manis 8～12

Rhizoma Alismatis 8～12 Lignum Aquilariae Resinatum 8～12

The Radix Astragali 8～12 Cordyceps 16～22

Semen Lepidii (Semen Descurainiae) 8～12 Bulbus Fritillariae Cirrhosaes 8～12.

Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc.The preferred dosage form of the present invention is a tablet, is about to the crude drug mix homogeneously of above-mentioned parts by weight, is ground into 100～120 purpose fine powders, and tabletting is made tablet.

Usually, every heavy 0.5g of the tablet of making is dark brown, and mildly bitter flavor is nontoxic.Oral, every day 3 times, each 10.

The etiology and pathogenesis of pulmonary carcinoma is not illustrated at present as yet fully, relevant record according to the successive dynasties document, in conjunction with patient's onset process and clinical manifestation, primary disease belongs to the category of Chinese medicine " lump in the right hypochondrium ", " painful abdominal mass addiction ", " cough ", " spitting of blood ", " chest pain ", " lump in the right hypochondrium ", " lump at the right hypochondrium " more.The traditional Chinese medical science is emphasized organic conception, thinks that tumor is the topical manifestations of systemic disease, is that whole body belongs to void, local true disease.Lung being a delicate viscus is subject to evil poison invasion and attack, causes lung qi a surname to fall mistake department.Pulmonary carcinoma mostly is the deficiency in origin and excess in superficiality disease, should nourish Kidney-Yin, warming and tonifying primordial YANG, tonification vigour, clearing away lung-heat and moistening for dryness, mediation mechanism of qi, the clearing heat in YING system that nourishes blood, broken abdominal mass dispersing tumor in the treatment.In the prescription of the present invention, Carapax et Plastrum Testudinis nourishing YIN for suppressing the hyperactive YANG, heat extraction Fructus Alpiniae Oxyphyllae; Carapax Trionycis softening the hard mass, removing mass, detumescence tumor; Radix Ginseng strongly invigorating primordial QI, strengthening vital QI to eliminate pathogenic factors strengthen body immunity; Radix Codonopsis QI invigorating, beneficial blood, promote the production of body fluid; The Radix Pseudostellariae tonifying QI to produce body fluid; Three ginseng and usefulness, strongly invigorating primordial QI, lung qi, warm and not dry; Big gun Squama Manis dispel silt eliminating stagnation, the stimulating milk secretion of stimulating the menstrual flow, circulation of qi promoting, to walk scurrying property strong, joins Cortex Moutan, broken all blood stasis of Radix Paeoniae Rubra, joins Lignum Aquilariae Resinatum and open all stagnation of QIs; The kidney-Yang of Cornu Cervi Pantotrichum complement sun, governor vessel improves the immunity to YIN pathogen; Gecko tonifying the lung gas, kidney tonifying sun are joined the big complement sun of Cornu Cervi Pantotrichum, join the big tonifying the lung gas of Radix Ginseng; Carapax et Plastrum Testudinis, Carapax Trionycis complement the moon are joined in Huai Radix Rehmanniae enriching yin and nourishing kidney, clearing away heat and cooling blood, cooling blood for hemostasis, join the purify the blood heat of branch of Cortex Moutan, Radix Scrophulariae, join Carapax et Plastrum Testudinis, the diuresis of Radix Ginseng heart tonifying; RHIIZOMA DIOSCOREAE frOm Henan of China invigorating spleen and reinforcing stomach, lung benefiting reinforce the kidney, tonification vigour, strengthen pulmonary's immunity; Radix Astragali QI invigorating, rise gas, consolidating superficial resistance, poison holding, diuretic; Chinese angelica blood supplementing, invigorate blood circulation, regulating menstruation, intestine moistening; Poria promoting diuresis to eliminate damp pathogen, spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming; Cortex Moutan clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; Radix Paeoniae Rubra clearing away heat and cooling blood, promoting blood circulation and stopping pain; Fructus Gardeniae clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body; Rhizoma Anemarrhenae removing the relative excess fire, clear asthenic fire; Cortex Phellodendri heat clearing away, dampness, pathogenic fire purging, detoxifcation, nourishing YIN to lower pathogenic fire; Radix Scrophulariae clearing away heat and cooling blood, detoxifcation, nourshing Yin and drynsessmoistening prescription; The Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, purge heat and deposit the moon; Lignum Aquilariae Resinatum temperature fortune vigour is joined the Radix Ginseng dispersing obstructed lung-QI, suppresses tumor, and it is swollen to join the Cortex Phellodendri skin ulcer that disappears, and joins the able-bodied Yuanyang of Cornu Cervi Pantotrichum benefit, joins big gun Squama Manis, Carapax Trionycis detumescence tumor, Po Disorder addiction, and it is wet to join Poria, the Rhizoma Dioscoreae lung of dispelling; Bulbus Fritillariae Cirrhosae clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, detoxicating and resolving stagnation of pathogens; Cordyceps tonifying the lung the moon to excite lung qi, complement essence to change living kidney yang, is the panacea of leveling kidney lung yin sun with improving inspiration by invigorating kidney-QI Dingchuan, complement sun with nourishing the lung to arrest cough, tonifying the lung gas; Semen Lepidii (Semen Descurainiae) eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema, lead lung qi off, broken knot row stagnates.All medicines share, nourishing Kidney-Yin, warming and tonifying primordial YANG, tonification vigour, clearing away lung-heat and moistening for dryness, mediation mechanism of qi, the clearing heat in YING system that nourishes blood, broken abdominal mass dispersing tumor, heat-clearing and toxic substances removing, play the effect of pathogenic fire purging, lung moistening, removing heat from blood, benefit essence, QI invigorating and detumescence tumor altogether, play the effect that presses down tumor, raise immunity, the quality of making the life better, prolongs life cycle.

Medicine simultaneously using both cold and hot drugs of the present invention, reinforcement and elimination in combination, be used for the treatment of pulmonary carcinoma, can strengthen and perfect the immunologic function of human body self, immune cell activated, the nutrition rehabilitation of promotion tissue and cell, the enhancing body resistance against diseases, kill the carcinoma cell, the tumor body is dwindled, alleviate and alleviate clinical symptoms, improve patient's life quality, thereby prolong patient's life.

For further investigating the clinical efficacy and the safety of medicine of the present invention, we select 20 routine patients with lung cancer that the curative effect of Drug therapy pulmonary carcinoma of the present invention has been carried out clinical observation.

In the 20 routine patients with lung cancer, 16 examples are not for performing the operation or being reluctant the person of undergoing surgery.According to syndrome-classification, type of deficiency of both QI and YIN 11 examples, insufficiency of primordial QI type 6 examples, Kidney-Yin deficiency 1 example, dryness-heat type 2 examples.Take medicine of the present invention continuously more than 1 year, wherein 14 routine patients accept chemotherapy, radiotherapy in the treatment simultaneously.

Observation of curative effect the results are shown in Table 1.

Table 1 Drug therapy pulmonary carcinoma 20 routine observation of curative effect of the present invention

The case fatality rate of pulmonary carcinoma is very high, and survival rate only was 10% in 5 years, and the year survival rate of Drug therapy of the present invention reaches 30%, surpasses 3 times of present survival rates.Wherein 14 examples are 5 examples with chemotherapy, radiotherapy combined treatment person existence in 5 years number.

The specific embodiment

Embodiment 1

Carapax et Plastrum Testudinis 40g, Carapax Trionycis 40g, Radix Ginseng 80g, Radix Codonopsis 40g, Radix Pseudostellariae 40g, Cornu Cervi Pantotrichum 40g, Huai Radix Rehmanniae 40g, RHIIZOMA DIOSCOREAE frOm Henan of China 40g, Radix Angelicae Sinensis 40g, Poria 40g, Gecko 40g, Cortex Moutan 40g, Radix Paeoniae Rubra 15g, Fructus Gardeniae 15g, Rhizoma Anemarrhenae 40g, Cortex Phellodendri 15g, Radix Scrophulariae 40g, big gun Squama Manis 40g, Rhizoma Alismatis 40g, Lignum Aquilariae Resinatum 40g, Radix Astragali 40g, Cordyceps 80g, Semen Lepidii (Semen Descurainiae) 40g, Bulbus Fritillariae Cirrhosae 40g mix homogeneously with the dry in the sun oven dry, be ground into 120 purpose fine powders, be pressed into the tablet of every heavy 0.5g.

Embodiment 2

Carapax et Plastrum Testudinis 50g, Carapax Trionycis 50g, Radix Ginseng 90g, Radix Codonopsis 50g, Radix Pseudostellariae 50g, Cornu Cervi Pantotrichum 50g, Huai Radix Rehmanniae 50g, RHIIZOMA DIOSCOREAE frOm Henan of China 50g, Radix Angelicae Sinensis 50g, Poria 50g, Gecko 50g, Cortex Moutan 50g, Radix Paeoniae Rubra 25g, Fructus Gardeniae 25g, Rhizoma Anemarrhenae 50g, Cortex Phellodendri 25g, Radix Scrophulariae 50g, big gun Squama Manis 50g, Rhizoma Alismatis 50g, Lignum Aquilariae Resinatum 50g, Radix Astragali 50g, Cordyceps 90g, Semen Lepidii (Semen Descurainiae) 50g, Bulbus Fritillariae Cirrhosae 50g mix homogeneously with the dry in the sun oven dry, be ground into 120 purpose fine powders, be pressed into the tablet of every heavy 0.5g.

Embodiment 3

With Carapax et Plastrum Testudinis 60g, Carapax Trionycis 60g, Radix Ginseng 100g, Radix Codonopsis 60g, Radix Pseudostellariae 60g, Cornu Cervi Pantotrichum 60g, Huai Radix Rehmanniae 60g, RHIIZOMA DIOSCOREAE frOm Henan of China 60g, Radix Angelicae Sinensis 60g, Poria 60g, Gecko 60g, Cortex Moutan 60g, Radix Paeoniae Rubra 30g, Fructus Gardeniae 30g, Rhizoma Anemarrhenae 60g, Cortex Phellodendri 30g, Radix Scrophulariae 60g, big gun Squama Manis 60g, Rhizoma Alismatis 60g, Lignum Aquilariae Resinatum 60g, Radix Astragali 60g, Cordyceps 100g, Semen Lepidii (Semen Descurainiae) 60g, the Bulbus Fritillariae Cirrhosae 60g mix homogeneously after preferred, the dry in the sun oven dry, be ground into 120 purpose fine powders, be pressed into the tablet of every heavy 0.5g.

Claims (4)

1, a kind of lung cancer drugs that is used for the treatment of is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Carapax et Plastrum Testudinis 8～12 Carapax Trionycis 8～12

Radix Ginseng 16～22 Radix Codonopsis 8～12

Radix Pseudostellariae 8～12 Cornu Cervi Pantotrichums 8～12

Huai Radix Rehmanniae 8～12 RHIIZOMA DIOSCOREAE frOm Henan of China 8～12

Radix Angelicae Sinensis 8～12 Poria 8～12

Gecko 8～12 Cortex Moutans 8～12

Radix Paeoniae Rubra 3～6 Fructus Gardeniaes 3～6

The Rhizoma Anemarrhenae 8～12 Cortex Phellodendris 3～6

Radix Scrophulariae 8～12 big gun Squama Manis 8～12

Rhizoma Alismatis 8～12 Lignum Aquilariae Resinatum 8～12

The Radix Astragali 8～12 Cordyceps 16～22

Semen Lepidii (Semen Descurainiae) 8～12 Bulbus Fritillariae Cirrhosaes 8～12.

2, the lung cancer drugs that is used for the treatment of according to claim 1 is characterized in that described medicine is made tablet.

3, the described preparation method that is used for the treatment of lung cancer drugs of claim 2 is the crude drug mix homogeneously with above-mentioned parts by weight, is ground into 100～120 purpose fine powders, and tabletting is made tablet.

4, the preparation method that is used for the treatment of lung cancer drugs according to claim 3 is characterized in that the every heavy 0.5g of tablet that makes.