CN101460570B - 多层丝蛋白薄膜 - Google Patents

多层丝蛋白薄膜 Download PDF

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Publication number
CN101460570B
CN101460570B CN2007800204740A CN200780020474A CN101460570B CN 101460570 B CN101460570 B CN 101460570B CN 2007800204740 A CN2007800204740 A CN 2007800204740A CN 200780020474 A CN200780020474 A CN 200780020474A CN 101460570 B CN101460570 B CN 101460570B
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China
Prior art keywords
film
multilayer
spider silk
gly
multilayer film
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CN2007800204740A
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English (en)
Chinese (zh)
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CN101460570A (zh
Inventor
托马斯·沙伊贝尔
乌特·斯洛塔
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AMSilk GmbH
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Technical University of Munich
AMSilk GmbH
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D189/00—Coating compositions based on proteins; Coating compositions based on derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2389/00—Characterised by the use of proteins; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31725—Of polyamide
    • Y10T428/3175—Next to addition polymer from unsaturated monomer[s]
    • Y10T428/31754—Natural source-type polyamide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31725—Of polyamide
    • Y10T428/31768—Natural source-type polyamide [e.g., casein, gelatin, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Insects & Arthropods (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Laminated Bodies (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN2007800204740A 2006-05-03 2007-04-13 多层丝蛋白薄膜 Active CN101460570B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06113438.3 2006-05-03
EP20060113438 EP1852470A1 (en) 2006-05-03 2006-05-03 Multilayer Silk Protein Films
PCT/EP2007/003304 WO2007128378A1 (en) 2006-05-03 2007-04-13 Multilayer silk protein films

Publications (2)

Publication Number Publication Date
CN101460570A CN101460570A (zh) 2009-06-17
CN101460570B true CN101460570B (zh) 2012-09-05

Family

ID=37025251

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800204740A Active CN101460570B (zh) 2006-05-03 2007-04-13 多层丝蛋白薄膜

Country Status (9)

Country Link
US (1) US20090263430A1 (enExample)
EP (2) EP1852470A1 (enExample)
JP (1) JP2009535242A (enExample)
KR (1) KR20090023365A (enExample)
CN (1) CN101460570B (enExample)
AU (1) AU2007247539C1 (enExample)
CA (1) CA2650836C (enExample)
RU (1) RU2008146255A (enExample)
WO (1) WO2007128378A1 (enExample)

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RU2444527C2 (ru) 2005-12-30 2012-03-10 Спибер Текнолоджиз Аб Рекомбинантный спидроиновый белок главной ампулярной железы, способный к полимеризации, рекомбинантный слитый белок, способный к управляемой полимеризации, полимер спидроинового белка главной ампулярной железы, композиция для управляемой полимеризации, рекомбинантная молекула нуклеиновой кислоты (варианты), способ получения растворимого слитого белка, способ получения полимера спидроинового белка главной ампулярной железы и способ культивирования эукариотических клеток
EP2650112B1 (en) 2006-11-03 2016-08-24 Trustees Of Tufts College Nanopatterned biopolymer optical device and method of manufacturing the same
US20100096763A1 (en) 2006-11-03 2010-04-22 Trustees Of Tufts College Biopolymer optofluidic device and method of manufacturing the same
CA2704768A1 (en) * 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer sensor and method of manufacturing the same
AU2008265231B2 (en) * 2007-06-20 2014-05-01 Basf Se Synthetic repetitive proteins, the production and use thereof
GB2461125A (en) * 2008-06-25 2009-12-30 Spintec Engineering Gmbh A silk membrane for bone graft material
JP2011530491A (ja) 2008-08-08 2011-12-22 ビーエーエスエフ ソシエタス・ヨーロピア バイオポリマーに基づいた活性物質含有連続繊維層、その使用、およびその生産のための方法
GB2464348A (en) * 2008-10-17 2010-04-21 Spintec Engineering Gmbh Applying a liquid protein onto a permeable surface, and silk mono-filament having specific properties
DK2435102T3 (da) * 2009-05-28 2020-10-19 Addbio Ab Flerlagsproteinfilm, fremstillingsfremgangsmåder og lægemiddelafgivelsesindretninger samt biomedicinske implantater med anvendelse af filmene
WO2011069643A2 (en) * 2009-12-08 2011-06-16 Amsilk Gmbh Silk protein coatings
RU2443805C1 (ru) * 2010-08-20 2012-02-27 Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет технологии и дизайна" (СПГУТД) Способ получения пленки на основе фиброина шелка для изготовления контактных линз
CN103270049B (zh) 2010-10-27 2017-10-13 思百博技术股份公司 用于结合有机靶的蜘蛛丝融合蛋白结构
US20120236298A1 (en) * 2011-03-15 2012-09-20 Michael Josef Stuke Tunable apparatus for performing sers
CA2833144C (en) * 2011-04-14 2020-09-29 The Regents Of The University Of California Multilayer thin film drug delivery device and methods of making and using the same
WO2012145594A2 (en) * 2011-04-20 2012-10-26 Trustees Of Tufts College Molded regenerated silk geometries using temperature control and mechanical processing
US9956387B2 (en) * 2011-07-08 2018-05-01 Timothy Brown Article of clothing for applying a pharmaceutical, a pharmaceutical delivery kit and method
US9377409B2 (en) 2011-07-29 2016-06-28 Hewlett-Packard Development Company, L.P. Fabricating an apparatus for use in a sensing application
WO2013142119A1 (en) * 2012-03-20 2013-09-26 Trustees Of Tufts College Silk reservoirs for drug delivery
US9856308B2 (en) 2012-05-02 2018-01-02 Spiber Technologies Ab Spider silk fusion protein structures incorporating immunoglobulin fragments as affinity ligands
CN104394953B (zh) 2012-05-02 2018-01-23 思百博技术股份公司 用于结合有机靶的没有重复片段的蜘蛛丝融合蛋白结构
JP5678283B2 (ja) 2012-12-26 2015-02-25 スパイバー株式会社 クモ糸タンパク質フィルム及びその製造方法
CN103341214B (zh) * 2013-07-08 2014-12-31 苏州大学 一种丝素蛋白膜及其制备方法
US11324852B2 (en) * 2014-02-04 2022-05-10 Amsilk Gmbh Coated silk films, methods for the production thereof and uses thereof
CN104323927A (zh) * 2014-11-06 2015-02-04 济南星河康泰贸易有限公司 贻贝粘蛋白在制备皮肤美容化妆品上的应用
JP6544040B2 (ja) * 2015-05-21 2019-07-17 日立化成株式会社 フィブロインナノ薄膜、ナノ薄膜シート及び転写方法
JP6693049B2 (ja) * 2015-05-21 2020-05-13 日立化成株式会社 ナノ薄膜転写シート及び転写方法
CN105297440B (zh) * 2015-11-11 2018-01-12 浙江理工大学 一种对蚕丝接枝改性的方法
EP3207947A1 (en) * 2016-02-17 2017-08-23 Ruprecht-Karls-Universität Heidelberg Bioactive compound delivery assembly
WO2018006037A1 (en) * 2016-07-01 2018-01-04 Trustees Of Tufts College Innervated artificial skin
CN106188923A (zh) * 2016-08-04 2016-12-07 叶剑 一种聚苯乙烯基复合装饰板及其制造方法
EP3688017A1 (en) * 2017-09-26 2020-08-05 Spiber Technologies AB Structuring of surface-active macromolecules
JP2021080304A (ja) * 2018-01-26 2021-05-27 Ｓｐｉｂｅｒ株式会社 タンパク質成形体用素材、タンパク質成形体、及びタンパク質成形体の製造方法
JP6743939B2 (ja) * 2019-05-09 2020-08-19 日立化成株式会社 ナノ薄膜転写シート及び転写方法
WO2021113054A2 (en) * 2019-11-13 2021-06-10 Rapp Robert James Spider silk proteins - small particle process and products
CN113652033B (zh) * 2021-08-22 2022-12-06 茂泰(福建)鞋材有限公司 一种贻贝足丝防滑橡胶鞋底的制备方法
US20240002682A1 (en) * 2022-07-01 2024-01-04 Ayro, Inc. Coating gradient property management for sustainable vehicles, systems, methods, and apparatus
CN116285719B (zh) * 2022-09-09 2026-03-24 之江实验室 一种丝素蛋白塑封膜及其制备方法和应用
AU2023355666A1 (en) 2022-10-03 2025-04-03 Xampla Limited Alginate-starch films
CN116103933B (zh) * 2023-02-21 2024-08-13 现代纺织技术创新中心(鉴湖实验室) 一种高牢度双层组合丝素蛋白涂层织物的制备方法
CN117445491B (zh) * 2023-12-06 2026-05-12 江西丝科生物科技有限公司 一种蛋白膜的复合方法及复合蛋白膜
CN117771440A (zh) * 2023-12-26 2024-03-29 上海交通大学医学院附属第九人民医院 一种负载SDF-1α的双层蚕丝蛋白生物膜及其制备方法
CN117771441A (zh) * 2023-12-26 2024-03-29 上海交通大学医学院附属第九人民医院 一种负载egcg的双层蚕丝蛋白生物膜的制备方法
WO2025202391A1 (en) 2024-03-29 2025-10-02 XAMPLA Ltd. Triple layer film
WO2025202394A1 (en) 2024-03-29 2025-10-02 XAMPLA Ltd. Bilayer film

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Also Published As

Publication number Publication date
CA2650836C (en) 2014-05-27
EP2013290A1 (en) 2009-01-14
RU2008146255A (ru) 2010-06-20
CA2650836A1 (en) 2007-11-15
AU2007247539A1 (en) 2007-11-15
WO2007128378A1 (en) 2007-11-15
EP1852470A1 (en) 2007-11-07
CN101460570A (zh) 2009-06-17
KR20090023365A (ko) 2009-03-04
JP2009535242A (ja) 2009-10-01
AU2007247539B2 (en) 2013-03-28
AU2007247539C1 (en) 2013-08-15
EP2013290B1 (en) 2013-06-12
US20090263430A1 (en) 2009-10-22

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