CN101444584A - Muscle-and-tendon nourishing and bone-strengthening pharmaceutical preparation and preparation method thereof - Google Patents
Muscle-and-tendon nourishing and bone-strengthening pharmaceutical preparation and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a muscle-and-tendon-nourishing and bone-strengthening pharmaceutical preparation and a preparation method thereof, mainly comprising one or more ingredients of root of herbaceous peony, angelica, teasel root, gerba pyrolae, yam, achyranthes, costus root, caulis trachelospermi and pawpaw. The preparation method includes: one or more ingredients of the root of herbaceous peony, angelica, teasel root, gerba pyrolae, yam, achyranthes, costus root, caulis trachelospermi and pawpaw are chosen for decoction, the active ingredients are extracted, and the extracted liquid is concentrated to certain concentration, thus obtaining the pharmaceutical preparation. On the basis, the pharmaceutical preparation can be further made into capsule, troche, granule, oral liquid, injection, pill, pulvis, preparation injection and sustained-release preparation. As proven by experiments of toxicology, pharmacology and pharmacodynamics, the pharmaceutical preparation of the invention ensures safe use and can tonify the liver while nourishing the blood, soften the muscle and tendon while strengthening the bone and relax vein while killing pain.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation technology thereof, particularly contain in the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae, Radix Aucklandiae (Radix Vladimiriae), Caulis Trachelospermi, the Fructus Chaenomelis one or more, with its mixing or a kind of nourishing muscle and tendon preparation for strengthening bone that is used for the treatment of osteoarthritis of separately extracting, and preparation technology.
Background technology
Osteoarthritis is a kind of modal arthropathy among the crowd, the title of osteoarthritis is extremely many, as hypertrophiarthritis, degenerative osteoarthritis, osteoarthrisis deformans knee, proliferative arthritis or osteoarthritis, all refer to a kind of disease, arthritis disease is the disease that perplexs human comparison stubbornness for many years, seriously threaten human beings'health, there are confidential relation at the generation and the age of osteoarthritis.Become " human maximum killer of 21 century ".Statistical data shows that the population in the whole world 13.4% suffers from various arthrosiss, and Hesperian sickness rate is higher, according to statistics, has accounted for 2.3% of clinic case at present; Domestic preliminary survey shows that joint disease patient's quantity has reached more than 100,000,000 people, and 40 years old crowd's prevalence is then to reach 50% more than 10%-17%, 60 years old, and in crowd more than 75 years old, 80% suffers from osteoarthritis.The final disability rate of this disease is 53%.The most common with arthralgia, hyperosteogeny and limitation of activity clinically.The morbidity of osteoarthritis does not have region and race difference.Obesity, inflammation, wound and inherited genetic factors may be relevant with the generation of primary disease.
The early stage main clinical manifestation of osteoarthritis is: based on stiff, tired, suffer from cold or microtrauma and increasing the weight of, difficulty when limbs are changed to another position from a position, the stiff very fast alleviation of activity pain slightly: as: get up morning or sitting after rise immediately, occur stiff, pain, symptom is obvious, through movable posterior joint sx or disappearance, because this symptom occurring in early days gets the brush-off, add not treatment in time, this symptom slowly increases the weight of, acute attack in per 1-2 years once, the slight swelling in joint or a small amount of hydrops is arranged during outbreak, sometimes joint motion occur rubbing sassafras sense, function is subjected to certain influence.Osteoarthritis arthralgia in late period increases the weight of, and can ache during night's rest and wake up, and pain is constant, until joint deformity, and enlargement, functional activity is subjected to obstacle and can't take care of oneself.
Arthrocsopic surgery is the major progress of minimally invasive surgery in the orthopaedics field, is the developing direction of joint surgery, is applied to clinically abroad gradually since the seventies in last century, and China has introduced this technology in the eighties.In recent years along with the development of medical knowledge and updating of medical apparatus and instruments, arthrocsopic surgery is accepted by increasing doctor and patient with its significant advantage, there has been special arthroscope doctor in some hospital, the hospital that also has has set up special Arthroscopic Treatment center, build prestige as middle ferrum and join German international arthroscope diagnosis and treatment center, therapeutic effect is near international standard, for vast joint disease patient has brought Gospel.
Summary of the invention
The objective of the invention is to provide a kind of Chinese medicine preparation of treatment of arthritis disease: nourishing muscle and tendon preparation for strengthening bone and preparation technology thereof.
This nourishing muscle and tendon preparation for strengthening bone proposed by the invention mainly contains in the Radix Paeoniae Alba and Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae, Radix Aucklandiae (Radix Vladimiriae), Caulis Trachelospermi, the Fructus Chaenomelis one or more.
Below be to be introduced to inventing selected Chinese medicine and extract thereof:
The Radix Paeoniae Alba, particularly Radix Paeoniae Alba total glucosides have pharmacological actions such as antiinflammatory and immunomodulating.Radix Paeoniae Alba total glucosides is by extracting in the Chinese medicine Radix Paeoniae Alba, recently studies show that white peony root's total glycoside is used for the treatment of arthritis and senile disease clinically.Former of rats with arthritis and secondary inflammation all there is inhibitory action.At present clinically be used for the treatment of osteoarthritis (OA), but pathogenesis (OA) is not clear, numerous research concentrates on the mechanism of explaining synovial cell proliferation.In recent years, because the deep understanding of pair cell apoptosis, the existing paraplasm of OA synovial tissue of joint and the apoptosis discovered is closely related unusually, and synovial cell's hyperplasia comes from the relative deficiency of synovial cell's apoptosis.And Bc1-2, Bax are a pair of apoptosis-related genes, play an important role in apoptotic control.
Radix Angelicae Sinensis is the water soluble ingredient that Chinese medicine angelica extracts, and modern pharmacological research proves: Radix Angelicae Sinensis can be removed oxygen-derived free radicals, antioxidation, can promote the macrophage ability, improves immunologic function.Suppress platelet aggregation, anticoagulation, improve effects such as hemorheology feature, antiinflammatory, spasmolysis and analgesia.
Radix Dipsaci has another name called Radix Dipsaci, Radix Dipsaci, and the beginning is stated from Shennong's Herbal.Its source is the root of Dipsacaceae herbaceos perennial Radix Dipsaci (Dipsacus aspercides CY.Cheng et TMAI).Because of making muscles and bones the continuing of fracture, it gains the name.As " medicine justice " cloud: " Radix Dipsaci ... kind treating blood disorders arteries and veins trauma, muscles and bones the wrecking of continuing is so a Radix Dipsaci." another name among the people is Rhizoma seu Herba Elatostematis stewardii (" health easily letter side ").This product nature and flavor hardship, sweet, hot, tepor is returned the Liver and kidney warp.Has invigorating the liver and kidney, bone and muscle strengthening, promoting the circulation of blood arteries and veins, the continuous folding effect of curing the wound.Be that invigorating the liver and kidney treats the key medicine of bone injury, the clinical soreness of waist and knee joint due to the deficiency of the liver and kindey that are used for the treatment of, cards such as the soft unable and traumatic injury of foot, fracture more.
Herba Pyrolae is the herb of Pyrolaceae plant Herba pyrolae japonicae or Pylora rotundolia etc.Have the kidney invigorating, kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation is controlled weak cough, over-strained hemoptysis, rheumatic arthritis, metrorrhagia, leucorrhea, the effect of traumatic hemorrhage.Its concrete effect mainly shows the following aspects: disease such as the muscles and bones joint numbness pain of 1, be used to suffer from a deficiency of the kidney weak bone or Liver and kidney asthenia of essence and blood, soreness of waist and knee joint.The effect of reinforcing the kidney to strengthen the bone is arranged.2, be used for Fengshi Guanjie and ache, the waist foot is unable etc.Wind-damp dispelling is arranged, the dual function of bone and muscle strengthening.3, be used for chronic cough due to asthenia of viscera, spitting of blood, haematemesis, or menorrhagia etc.Nourishing lung and kidney is arranged, admittedly hold back the hemostatic effect again.
Rhizoma Dioscoreae Nipponicae can suppress the mice auricular concha inflammation that dimethylbenzene brings out, suppress arthroncus of mice ankle and mouse peritoneal capillary permeability that carrageenin brings out, and it is swollen to suppress rat granuloma, show that Rhizoma Dioscoreae Nipponicae not only has significant preventive effect in early days to inflammation, and the inflammation later stage also there is remarkable result, Rhizoma Dioscoreae Nipponicae can prolong the pain time of mice that the burn method causes pain, and that reduces that acetic acid causes the pain mice turns round the body number of times, and Rhizoma Dioscoreae Nipponicae has significant analgesia role.
Radix Achyranthis Bidentatae is to look for following of section's Radix Achyranthis Bidentatae, and main product is in Henan Province.Effect with invigorating the liver and kidney, QI and blood regulating, bone and muscle strengthening, the meridian dredging, tranquilizing the mind, promotion bone tissue growth.Pharmacological research shows that Radix Achyranthis Bidentatae has analgesia, antiinflammatory, raise immunity, anti-aging effects.The back callus that is usually used in clinically fracturing is difficult for forming and giving up and take off with property, have significant curative effect, and various toxicity test is not seen toxicity.
Radix Aucklandiae (Radix Vladimiriae) is the root of the feverfew Radix Aucklandiae.Warm in nature, acrid in the mouth, hardship.Have promoting the circulation of QI to relieve pain, the effect of strengthening the spleen to promote digestion.Be used for breast gastral cavity distending pain, let out heavy after the dysentery, food stagnation does not disappear, anorexia.
Caulis Trachelospermi is a conventional Chinese medicine, beginning is stated from Shennong's Herbal, classify as top grade, " Chinese pharmacopoeia version in 2000 stipulates that its source is the dry zone leaf rattan of apocynaceae plant Caulis Trachelospermi, effect with dispelling wind and removing obstruction in the collateral, promoting blood circulation and detumescence is used for rheumatic arthralgia, soreness of waist and knee joint, the contracture of muscle arteries and veins, sore throat, carbuncle, injury from falling down.
Extract the Fructus Chaenomelis total glycosides in the Fructus Chaenomelis, the glucosides of Fructus Chaenomelis of turning round the rough estimates amount of hand lamp reflection by acetic acid can suppress the acetic acid of mice and turn round body reflection and formaldehyde second-phase reaction: PEG2 and TNF-a level that glucosides of Fructus Chaenomelis can make adjuvant arthritis rats cause scorching the 28th synovium of joint cell rising significantly reduce.Glucosides of Fructus Chaenomelis analgesic activity mechanism may be relevant with its inhibition periphery inflammatory mediator, it is also to collagen induced arthritis simultaneously, foot swelling all has the obvious suppression effect due to carrageenin, the albumen, can obviously resist acetic acid stimulates caused mouse peritoneal capillary permeability to increase, and suppresses the bullate formation of rat granuloma
The present invention can play the effect of treatment osteoarthritis by comprehensive approach.
Technical scheme of the present invention is as follows:
" part " that relates among the present invention all is meant " part by weight ratio ".
The nourishing muscle and tendon preparation for strengthening bone is the medicament of being made by following Chinese medicine raw materials by weight proportion:
Radix Paeoniae Alba 1-50 part, Radix Angelicae Sinensis 1-25 part, Radix Dipsaci 1-25 part,
Herba Pyrolae 1-25 part, Rhizoma Dioscoreae Nipponicae 1-25 part, Radix Achyranthis Bidentatae 1-25 part,
Radix Aucklandiae (Radix Vladimiriae) 0-25 part, Caulis Trachelospermi 0-25 part Fructus Chaenomelis 0-25 part.
The nourishing muscle and tendon preparation for strengthening bone is the medicament of being made by following Chinese medicine raw materials by weight proportion:
Radix Paeoniae Alba 10-50 part, Radix Angelicae Sinensis 5-25 part, Radix Dipsaci 5-25 part,
Herba Pyrolae 5-25 part, Rhizoma Dioscoreae Nipponicae 5-25 part, Radix Achyranthis Bidentatae 5-25 part,
The preparation technology of nourishing muscle and tendon preparation for strengthening bone, wherein:
1) chooses various raw material of Chinese medicine extracting in water effective ingredient respectively;
2) choose various raw material of Chinese medicine respectively and add the alcohol extraction effective ingredient;
3) effective ingredient that extracts separately or after mixing, is added adjuvant, make preparation.
The nourishing muscle and tendon preparation for strengthening bone nourishes blood in tonifying liver, the application on the gentle muscle bone strengthening, removing obstruction in the collateral to relieve pain.
The nourishing muscle and tendon preparation for strengthening bone at antiinflammatory, ease pain, enrich blood, improve because of deficiency of the liver and kindey, the muscle arteries and veins stasis of blood let out due to the effect of inflammatory symptom such as pain, swelling, stiff and dysfunction of knee joint osseous arthritis.
The preparation technology of nourishing muscle and tendon preparation for strengthening bone: choose respectively in the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae, Radix Aucklandiae (Radix Vladimiriae), Caulis Trachelospermi, the Fructus Chaenomelis one or more or all, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, dry, be ground into fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
The preparation technology of nourishing muscle and tendon preparation for strengthening bone: choose respectively in the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Rhizoma Dioscoreae Nipponicae, the Fructus Chaenomelis one or more or all, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, drying is ground into fine powder, and is standby; Choose in Herba Pyrolae, Radix Achyranthis Bidentatae, Radix Aucklandiae (Radix Vladimiriae), the Caulis Trachelospermi one or more, add 6-10 and doubly measure 60% ethanol extraction secondary, each 1-2 hour, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and drying is ground into fine powder; Merge with above-mentioned fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Above-mentioned technology can in nine kinds of the Radix Paeoniae Albas, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae, Radix Aucklandiae (Radix Vladimiriae), Caulis Trachelospermi, Fructus Chaenomelis, reduce one or several operate.
Multiformity in view of pharmaceutical dosage form and production technology, and consider acceptance and the using method of patient to medicine, composite reagent of the present invention can be made capsule, tablet, granule, oral liquid, injection, pill, powder, injection, sustained-release preparation by above-mentioned prescription and Technology thereof.In view of pharmaceutical dosage form and the needs that produce to use, can be on the basis of above-mentioned prescription reasonable pharmaceutic adjuvants such as absorb fillers, excipient, pH value regulator, correctives, cosolvent, antioxidant, to satisfy drug manufacture and use.
Advantage of the present invention: cost is low, drug effect is high, have no side effect.This pharmaceutical preparation is used for laboratory animal, finds to have antiinflammatory, analgesia, subside a swelling, enrich blood.This drug regimen can also be regulated by hormone in vivo, obviously improves the articular chondrocytes metabolism, helps to treat the degeneration and the related inflammation symptom of osteoarthritis.Through experimentation, truly have that tonifying liver nourishes blood, the effect of gentle muscle bone strengthening, removing obstruction in the collateral to relieve pain.To swelling, pain, the stiff and joint function disturbance of treatment due to the knee joint osseous arthritis, not only rapid-action, and also curative effect is obvious.
The specific embodiment:
Prescription one:
30 parts of the Radix Paeoniae Albas, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Dipsacis,
15 parts of Herba Pyrolaes, 15 parts of Rhizoma Dioscoreae Nipponicae, 15 parts of Radix Achyranthis Bidentataes,
15 parts of Radix Aucklandiae (Radix Vladimiriae), 15 parts of Caulis Trachelospermis, 15 parts of Fructus Chaenomeliss.
Prescription two:
30 parts of the Radix Paeoniae Albas, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Dipsacis,
15 parts of Herba Pyrolaes, 15 parts of Rhizoma Dioscoreae Nipponicae, 15 parts of Radix Achyranthis Bidentataes,
15 parts of Radix Aucklandiae (Radix Vladimiriae), 15 parts of Caulis Trachelospermis.
Prescription three:
30 parts of the Radix Paeoniae Albas, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Dipsacis,
15 parts of Herba Pyrolaes, 15 parts of Rhizoma Dioscoreae Nipponicae, 15 parts of Radix Achyranthis Bidentataes.
15 parts of Radix Aucklandiae (Radix Vladimiriae).
Prescription four:
30 parts of the Radix Paeoniae Albas, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Dipsacis,
15 parts of Herba Pyrolaes, 15 parts of Rhizoma Dioscoreae Nipponicae, 15 parts of Radix Achyranthis Bidentataes.
Prescription five:
30 parts of the Radix Paeoniae Albas, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Dipsacis,
15 parts of Herba Pyrolaes, 15 parts of Rhizoma Dioscoreae Nipponicae, 15 parts of Radix Achyranthis Bidentataes,
15 parts of Radix Aucklandiae (Radix Vladimiriae), 15 parts of Fructus Chaenomeliss.
Prescription six:
30 parts of the Radix Paeoniae Albas, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Dipsacis,
15 parts of Herba Pyrolaes, 15 parts of Rhizoma Dioscoreae Nipponicae, 15 parts of Radix Achyranthis Bidentataes,
15 parts of Caulis Trachelospermis, 15 parts of Fructus Chaenomeliss.
Prescription seven:
30 parts of the Radix Paeoniae Albas, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Dipsacis,
15 parts of Herba Pyrolaes, 15 parts of Rhizoma Dioscoreae Nipponicae, 15 parts of Radix Achyranthis Bidentataes,
15 parts of Caulis Trachelospermis.
Prescription eight:
30 parts of the Radix Paeoniae Albas, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Dipsacis,
15 parts of Herba Pyrolaes, 15 parts of Rhizoma Dioscoreae Nipponicae, 15 parts of Radix Achyranthis Bidentataes,
15 parts of Fructus Chaenomeliss.
Prescription nine:
10 parts of the Radix Paeoniae Albas, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Dipsacis,
25 parts of Herba Pyrolaes, 30 parts of Rhizoma Dioscoreae Nipponicae, 25 parts of Radix Achyranthis Bidentataes.
Prescription ten:
50 parts of the Radix Paeoniae Albas, 25 parts of Radix Angelicae Sinensis, 30 parts of Radix Dipsacis,
5 parts of Herba Pyrolaes, 5 parts of Rhizoma Dioscoreae Nipponicae, 5 parts of Radix Achyranthis Bidentataes.
Nourishing muscle and tendon bone-strengthening grain of the present invention agent through pharmacodynamic experiment research, is studied its treatment osteoarthritis effect, the results are shown in hereinafter experimental example.
Experiment 1: nourishing muscle and tendon bone-strengthening grain preparation on Carrageenan causes the research that toes swelling has the inflammation-inhibiting effect.
Process recipes:
Prescription one
Prescription one the 1st kind of technology, choose the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae, Radix Aucklandiae (Radix Vladimiriae), Caulis Trachelospermi, Fructus Chaenomelis respectively, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, dry, be ground into fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Prescription one the 2nd kind of technology, choose the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Rhizoma Dioscoreae Nipponicae, Fructus Chaenomelis respectively, decoct with water secondary, each 1-2 hour, collecting decoction filtered, and filtrate decompression is condensed into thick paste, and drying is ground into fine powder, and is standby; Choose Herba Pyrolae, Radix Achyranthis Bidentatae, Radix Aucklandiae (Radix Vladimiriae), Caulis Trachelospermi, add 6-10 and doubly measure 60% ethanol extraction secondary, each 1-2 hour, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and drying is ground into fine powder; Merge with above-mentioned fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Prescription two, choose the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae, Radix Aucklandiae (Radix Vladimiriae), Caulis Trachelospermi respectively, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, dry, be ground into fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Prescription three, choose the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae, Radix Aucklandiae (Radix Vladimiriae) respectively, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, dry, be ground into fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Prescription four: choose the red Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae respectively, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, dry, be ground into fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Prescription five: choose the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae, Radix Aucklandiae (Radix Vladimiriae), Fructus Chaenomelis respectively, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, dry, be ground into fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Prescription six: choose the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae, Caulis Trachelospermi, Fructus Chaenomelis respectively, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, dry, be ground into fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Prescription seven: choose the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae, Caulis Trachelospermi respectively, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, dry, be ground into fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Prescription eight: choose the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae, Fructus Chaenomelis respectively, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, dry, be ground into fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Prescription nine: choose the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae respectively, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, dry, be ground into fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Prescription ten: choose the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Dipsaci, Herba Pyrolae, Rhizoma Dioscoreae Nipponicae, Radix Achyranthis Bidentatae respectively, decoct with water secondary, each 1-2 hour, collecting decoction filters, and filtrate decompression is condensed into thick paste, dry, be ground into fine powder, add conventional adjuvant and make clinical acceptable forms, as dosage forms such as tablet, capsule, granules.
Experiment is divided into groups and the dosage design, gets 210 of SD rats, male and female half and half, and body weight 180～220g is divided into 35 groups at random by sex, body weight, 6 every group: prescription 1 compares with indomethacin enteric coatel tablets group, model control group to three groups of prescription 10 high, medium and low dosage.
1. animal pattern is organized: 210 of laboratory animals are divided into 35 groups every group 6 at random.Each is organized rat and does a labelling with marking pen around the rat right hind leg ankle joint, adopts the glass container method to measure every rat right hind leg normal foot sole of the foot volume.After measuring normal foot sole of the foot volume, I group rat is irritated and gives normal saline, and II group, III group, IV group, V group rat oral gavage give corresponding medicine, 1 time/d, continuous 3d, 30min after the 3d administration only causes inflammation at rat right hind leg foot plantar subcutaneous injection 1% carrageenin suspension 0.1mL/ respectively.
2. indomethacin enteric coatel tablets group: 6 of laboratory animals, carry out modeling according to the model preparation method, and with modeling before gavage indomethacin enteric coatel tablets (10mg/kg is equivalent to 6 times of clinical consumption).For three days on end.
3. the 1 whole water of filling a prescription improve the dosage groups: 6 of laboratory animals, and carry out modeling according to the model preparation method, and before modeling, gavage prescription 1 whole water and carry medicinal liquid (15g raw medicinal herbs/kg is equivalent to 18 times of clinical consumption).For three days on end.
4. the 1 whole water of filling a prescription are put forward middle dosage group: 6 of laboratory animals, and carry out modeling according to the model preparation method, and before modeling, gavage prescription 1 whole water and carry medicinal liquid (7.5g raw medicinal herbs/kg is equivalent to 9 times of clinical consumption).For three days on end.
5. the 1 whole water of filling a prescription are put forward low dose group: 6 of laboratory animals, and carry out modeling according to the model preparation method, and before modeling, gavage prescription 1 medicinal liquid (3.75g raw medicinal herbs/kg is quite with 4.5 times of clinical consumption).For three days on end.
6. the 1 part water of filling a prescription is carried+the part alcohol extraction, and prescription 2 is to filling a prescription 10 as prescription 1 administration.
Observation index: after the above-mentioned modeling, all by last method, each surveys once sufficient sole of the foot volume every 1h, and continuous 4 times, the record result, and be calculated as follows swelling rate (%) and suppression ratio (%) respectively.
Experimental result sees Table 1:
Table 1: nourishing muscle and tendon bone-strengthening grain (A) on Carrageenan cause rat paw edema influence (x ± s, n=6)
Annotate: compare * P＜0.05, * * P＜0.01 with the normal saline group
Experimental result shows: high, medium and low group of each dosage of nourishing muscle and tendon bone-strengthening grain causes the effect that the swelling of rat toes has inflammation-inhibiting in the equal on Carrageenan of 4h.
Experiment 2: nourishing muscle and tendon bone-strengthening grain preparation Dichlorodiphenyl Acetate lumbar injection causes the research of writhing response experiment effect
Experiment grouping and dosage design, 350 of laboratory animals, male and female half and half, body weight 18～22g is divided into 35 groups at random by sex, body weight, 10 every group.Prescription 1 to prescription 10 whole water improve, in, three groups of low dosages, with the ibuprofen group, the model control group comparison.
1. animal pattern is organized: get 350 of mices, mice is divided into 35 groups every group 10 at random.Each is organized mice and all gives corresponding medicine by 0.2ml/10g filling stomach, and 1 time/d, continuous 3d, 30min after the 3d administration, the equal lumbar injection 0.6% freshly prepared acetic acid 0.2ml/ of each Mus are only.
2. ibuprofen group: 10 of laboratory animals according to the modeling of model preparation method, and gavage ibuprofen solution before modeling.Successive administration 3 days.
3. the 1 whole water of filling a prescription improve the dosage groups: 10 of laboratory animals according to the modeling of model preparation method, and gavage prescription 1 whole water extracts (15g raw medicinal herbs/kg is equivalent to 18 times of clinical consumption) before modeling.Give 3 days continuously.
4. the 1 whole water of filling a prescription are put forward middle dosage group: 10 of laboratory animals according to the modeling of model preparation method, and gavage prescription 1 whole water extracts (7.5g raw medicinal herbs/kg is equivalent to 9 times of clinical consumption) before modeling.Successive administration 3 days.
5. the 1 whole water of filling a prescription are put forward low dose group: 10 of laboratory animals according to the modeling of model preparation method, and gavage prescription 1 whole water extracts (3.75g raw medicinal herbs/kg, quite and 4.5 times of clinical consumption) before modeling.Successive administration 3 days.
6. the 1 part water of filling a prescription is carried+the part alcohol extraction, and prescription 2 to prescription 10 carries out administration as prescription 1.
Detect index: the influence of writhing response: after the modelling, observe the number of times that writhing response (the abdominal part indent stretches hind leg, and buttocks is raised) appears in interior each Mus of 15min, and calculate the analgesia percentage rate.
Table 2 nourishing muscle and tendon bone-strengthening grain Dichlorodiphenyl Acetate lumbar injection causes the influence of mouse writhing reaction
Annotate: compare with model group: * P＜0.05, * * P＜0.01
Experimental result shows: in the 15min, the body number of times of turning round of model group mice is 29.4 behind the lumbar injection acetic acid, and the ibuprofen group is 5.1, and as can be seen from the above table, each nourishing muscle and tendon bone-strengthening grain of organizing dosage all has analgesic activity to mice.
Claims (5)
1, nourishing muscle and tendon preparation for strengthening bone is characterized in that: be the medicament of being made by following Chinese medicine raw materials by weight proportion:
Radix Paeoniae Alba 1-50 part, Radix Angelicae Sinensis 1-25 part, Radix Dipsaci 1-25 part,
Herba Pyrolae 1-25 part, Rhizoma Dioscoreae Nipponicae 1-25 part, Radix Achyranthis Bidentatae 1-25 part,
Radix Aucklandiae (Radix Vladimiriae) 0-25 part, Caulis Trachelospermi 0-25 part Fructus Chaenomelis 0-25 part.
2, nourishing muscle and tendon preparation for strengthening bone according to claim 1 is characterized in that: be the medicament of being made by following Chinese medicine raw materials by weight proportion:
Radix Paeoniae Alba 10-50 part, Radix Angelicae Sinensis 5-25 part, Radix Dipsaci 5-25 part,
Herba Pyrolae 5-25 part, Rhizoma Dioscoreae Nipponicae 5-25 part, Radix Achyranthis Bidentatae 5-25 part.
3, the preparation technology of claim 1 or 2 described nourishing muscle and tendon preparation for strengthening bone is characterized in that:
1) chooses various raw material of Chinese medicine extracting in water effective ingredient respectively;
2) choose various raw material of Chinese medicine respectively and add the alcohol extraction effective ingredient;
3) effective ingredient that extracts separately or after mixing, is added adjuvant, make preparation.
4, claim 1 or 2 described nourishing muscle and tendon preparation for strengthening bone nourish blood in tonifying liver, the application on the gentle muscle bone strengthening, removing obstruction in the collateral to relieve pain.
5, claim 1 or 2 described nourishing muscle and tendon preparation for strengthening bone at antiinflammatory, ease pain, enrich blood, improve because of deficiency of the liver and kindey, the muscle arteries and veins stasis of blood let out due to the effect of inflammatory symptom such as pain, swelling, stiff and dysfunction of knee joint osseous arthritis.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127358A (en) * | 2013-03-01 | 2013-06-05 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method |
| CN107080796A (en) * | 2017-04-26 | 2017-08-22 | 辽宁中医药大学附属医院 | A kind of Chinese medicine preparation for being used to treat Osteoarthritis |
| CN110393775A (en) * | 2018-04-23 | 2019-11-01 | 胡世杰 | A kind of Tai Ji oil and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1200724C (en) * | 2003-01-03 | 2005-05-11 | 黄远清 | Pill for activating collateral flow and removing spur |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127358A (en) * | 2013-03-01 | 2013-06-05 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method |
| CN103127358B (en) * | 2013-03-01 | 2015-03-25 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method |
| CN107080796A (en) * | 2017-04-26 | 2017-08-22 | 辽宁中医药大学附属医院 | A kind of Chinese medicine preparation for being used to treat Osteoarthritis |
| CN107080796B (en) * | 2017-04-26 | 2020-05-12 | 辽宁中医药大学附属医院 | Traditional Chinese medicine preparation for treating osteoarthritis |
| CN110393775A (en) * | 2018-04-23 | 2019-11-01 | 胡世杰 | A kind of Tai Ji oil and preparation method thereof |
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