CN101437491B - 用于免疫疗法的纳米颗粒 - Google Patents

用于免疫疗法的纳米颗粒 Download PDF

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Publication number
CN101437491B
CN101437491B CN2007800143677A CN200780014367A CN101437491B CN 101437491 B CN101437491 B CN 101437491B CN 2007800143677 A CN2007800143677 A CN 2007800143677A CN 200780014367 A CN200780014367 A CN 200780014367A CN 101437491 B CN101437491 B CN 101437491B
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nano
particle
granule
antigen
polymer
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Chinese (zh)
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CN101437491A (zh
Inventor
赛·T·雷迪
杰弗里·A·哈贝尔
梅洛迪·A·斯沃茨
安德烈·范德弗利斯
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Ecole Polytechnique Federale de Lausanne EPFL
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Ecole Polytechnique Federale de Lausanne EPFL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2007800143677A 2006-02-21 2007-02-21 用于免疫疗法的纳米颗粒 Active CN101437491B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77513206P 2006-02-21 2006-02-21
US60/775,132 2006-02-21
US11/707,627 US8021689B2 (en) 2006-02-21 2007-02-19 Nanoparticles for immunotherapy
US11/707,627 2007-02-19
PCT/US2007/004671 WO2007098254A2 (fr) 2006-02-21 2007-02-21 Nanoparticules pour immunothérapie

Publications (2)

Publication Number Publication Date
CN101437491A CN101437491A (zh) 2009-05-20
CN101437491B true CN101437491B (zh) 2013-01-02

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CN2007800143677A Active CN101437491B (zh) 2006-02-21 2007-02-21 用于免疫疗法的纳米颗粒

Country Status (8)

Country Link
US (1) US8021689B2 (fr)
EP (1) EP1993511B1 (fr)
JP (1) JP5506196B2 (fr)
CN (1) CN101437491B (fr)
AU (1) AU2007217514B2 (fr)
CA (1) CA2661700C (fr)
ES (1) ES2709391T3 (fr)
WO (1) WO2007098254A2 (fr)

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US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
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AU2008314647B2 (en) * 2007-10-12 2013-03-21 Massachusetts Institute Of Technology Vaccine nanotechnology
US8323696B2 (en) * 2008-08-29 2012-12-04 Ecole Polytechnique Federale De Lausanne Nanoparticles for immunotherapy
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
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US8343498B2 (en) * 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
WO2010068432A1 (fr) * 2008-11-25 2010-06-17 Ecole Polytechnique Federale De Lausanne (Epfl) Copolymères en bloc et leurs utilisations
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EP2575876B1 (fr) 2010-05-26 2017-12-06 Selecta Biosciences, Inc. Vaccins polyvalents à nanovéhicules synthétiques
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
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DE102010040565A1 (de) 2010-09-10 2012-03-15 Robert Bosch Gmbh Verfahren zum Einstellen der von einer Feststellbremse ausgeübten Klemmkraft
WO2012061717A1 (fr) 2010-11-05 2012-05-10 Selecta Biosciences, Inc. Composés nicotiniques modifiés et procédés associés
KR102112002B1 (ko) * 2011-04-29 2020-05-18 셀렉타 바이오사이언시즈, 인크. 치료적 단백질에 대해 면역 반응을 감소시키는 관용원성 합성 나노운반체
MX2014001142A (es) * 2011-07-29 2014-02-27 Selecta Biosciences Inc Nanoportadores sinteticos que generan respuestas inmunitarias humorales y de linfocitos t citotoxicos (ctl).
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WO2015013510A1 (fr) 2013-07-25 2015-01-29 Ecole Polytechnique Federale De Lausanne Epfl Matériaux en nanofibrilles à rapport d'aspect élevé
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US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
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CN114053433A (zh) * 2021-10-20 2022-02-18 北京中医药大学东方医院 刺激响应型纳米材料及其在制备原位肿瘤疫苗中的用途
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Also Published As

Publication number Publication date
CN101437491A (zh) 2009-05-20
AU2007217514B2 (en) 2013-02-21
WO2007098254A2 (fr) 2007-08-30
EP1993511B1 (fr) 2018-10-31
JP5506196B2 (ja) 2014-05-28
EP1993511A4 (fr) 2014-11-05
WO2007098254A3 (fr) 2008-09-25
JP2009527566A (ja) 2009-07-30
US20080031899A1 (en) 2008-02-07
AU2007217514A1 (en) 2007-08-30
EP1993511A2 (fr) 2008-11-26
US8021689B2 (en) 2011-09-20
CA2661700C (fr) 2020-07-07
CA2661700A1 (fr) 2007-08-30
ES2709391T3 (es) 2019-04-16

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