CN101417049A - Anti-AIDS traditional Chinese medicine compound composite and preparation method thereof - Google Patents
Anti-AIDS traditional Chinese medicine compound composite and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a compound composition of a traditional Chinese medicine, in particular to an anti-AIDS compound composition and a preparation method thereof. Pilos antler, wolfberry fruits, herba epimedii, rhizoma curculiginis, herba cistanches and other traditional Chinese raw materials are extracted, concentrated, decocted, filtered, concentrated, dried in vacuum, smashed and mixed to prepare the anti-AIDS compound composition. The compound composition is mainly used for treating AIDS patients and HIV-infected patients, and can restrain and kill AIDS virus improve the immunity of human bodies and increase the number of CD4 cells in human body, thereby eliminating all symptoms of patients and restoring the strength and weight of patients so that the patients can work and live healthily. The anti-AIDS compound composition is efficient and safe, causes no drug resistance and has no toxic side effects, no rebound after drug withdraw and wide application range. In addition, the anti-AIDS compound composition can be applied to children and pregnant women as well as all varieties and stages of HIV-infected patients.
Description
Technical field
The present invention relates to a kind of Chinese medicine compound compositions, particularly relate to a kind of Chinese medicine compound composition and method of making the same of anti-AIDS.
Background technology
Acquired immune deficiency syndrome (AIDS) (AIDS) is a kind of infectious disease of serious threat health of people.On June 30th, 2008, World Health Organization (WHO) announced; The whole world has reached 6,800 ten thousand people through the AIDSinfected patient of government registration, in heavenly dies 3,200 ten thousand, and constantly diffusion, estimates 2010 according to the expert and will reach 100,000,000 people, by 2025, will reach 1,000,000,000 people.Acquired immune deficiency syndrome (AIDS) can not be cured after the infection because its infectiousness is strong, popular rapid, and mortality rate is high.Not only cause enormous economic loss, also seriously hinder social development, threaten national living or death, become the serious social concern in the world today, cause so social problem of height ten minutes concern of the national governments and the head of state like this thereby the neither one disease resembles acquired immune deficiency syndrome (AIDS).
The control of AIDS does not at present have specificity vaccine.Efficient antiretroviral therapy is the Western medicine conjoint therapy, is called for short the main method that Hart therapy (HAART) is the AIDS treatment.Reasonably antiviral therapy is to suppressing duplicating of HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) (HIV), and the quality of life and the survival rate that improve the patient have certain effect.But there is following problem in the doctor trained in Western medicine antiviral therapy:
(1) can not fundamentally eliminate HIV (human immunodeficiency virus) (Human Immunodeficiency Virus), though HIV by long term inhibition undetectable level to the blood plasma, HIV is still duplicating low-levelly.
(2) studies show that 67% HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) develops immunity to drugs to the HAART therapy.
(3) because most of chemotherapeutics have bigger toxic and side effects, the patient can't continue to take medicine and withdrawal numerous.
(4) adaptability limitation: to the CD4+T cell〉400/ μ l, HIV the infected of blood plasma HIVRNA＜30000 do not advocate antiviral therapy, and untreated person is developed to the probability of AIDS in 3 years〉30%.
(5) cost an arm and a leg: it is reported, need about 8～100,000 yuan for each person every year,, need 20,000 5 thousand dollars to 50,000 dollars for each person every year the America and Europe the patient of middle national expenditures HAART.The patient that can accept the HAART therapy at present at one's own expense is few.The most poor HIV sufferers in the world are in the available state of no medicine.
(6) the HAART therapy need be taken medicine all the life.Therefore, seeking safely and effectively, natural drug has become the task of top priority that prevents and treats AIDS.
Summary of the invention
Purpose of the present invention is exactly the deficiency that overcomes existing anti-AIDS drug, and a kind of evident in efficacy and safe anti-AIDS Chinese medicine compound compositions is provided, and makes it to be fit to clinical practice.
An object of the present invention is to provide a kind of Chinese medicine compound compositions of anti-AIDS.
Another object of the present invention provides described anti-AIDS Chinese medicine compound preparation of compositions method.
The objective of the invention is to be achieved through the following technical solutions:
A kind of Chinese medicine compound compositions of anti-AIDS is prepared from by the crude drug of following parts by weight;
Cornu Cervi Pantotrichum 100-280 Fructus Lycii 100-140
Herba Cistanches 100-140 Rhizoma Curculiginises 90-120
Herba Epimedii 90-120
Preferably, a kind of Chinese medicine compound compositions of anti-AIDS is prepared from by the crude drug of following parts by weight:
Cornu Cervi Pantotrichum 100-200 Fructus Lycii 100-140
Herba Cistanches 100-140 Rhizoma Curculiginises 90-120
Herba Epimedii 90-120
Cornu Cervi Pantotrichum of the present invention: be meant the still unossified and young horn of band hair on the stag heads such as vertebrates Cervidae Cervus Nippon Temminck or Cervus elaphus linnaeus C.elaphusL..China northeast, northwest, Inner Mongol, Xinjiang and southwestern mountain area, all there are distribution in North America, New Zealand, and the artificial breeding is carried out in existing many areas.Its nature and flavor are sweet, salty, temperature.Return kidney, Liver Channel, its function kidney-replenishing, benefiting essence-blood, bone and muscle strengthening." herbal classic is met the source " said: " Cornu Cervi Pantotrichum is superintended and directed and is the outer wall of kidney, and outer wall was both solid, filled in the kidney qi, and the gate of vitality is mutually big, unlikely rash action, and the QI and blood essence is condensed, invigorating YANG, Gu Yin, non-other vegetations are comparable ".Modern study shows that this product can promote erythrocyte, hemoglobin, reticulocyte regeneration, and makes heart tonifying, the enhancing body ability to work, and allaying tiredness, improving appetite and sleep impel wound, fracture and ulcer healing.
Fructus Lycii: the mature fruit that is meant lycium barbarum Lycium barbarum L. of Solanaceae defoliation bush plant and Fructus Lycii L.Chinese Mill..Originating in the best in quality of Ningxia, Hebei, Xinjiang, Gansu, Qinghai, to pluck during fruit maturation before and after the Summer Solstice, dryness in the sun is given birth to and is used; Its nature and flavor are sweet, flat, return liver, kidney channel.Have foster essence and enrich blood, the effect of replenishing vital essence to improve eyesight; " not Lu " be said: " mending the internal injury Da Lao suction of hissing, hard muscles and bones, reinforcing YIN-essence, sharp intestine and small intestine ", " nourishing the essence and strengthening QI, prosperous and powerful vagina ".Modern study shows that fat deposited and promoted hepatocyte new life in hepatocyte the effect that suppresses is arranged.
Herba Epimedii: the herb that is meant the little Tiller herbaceos perennial Herba Epimedii Epimedium macranthum Morr et Decne. of section and arrow leaf Herba Epimedii E.sagittatum (S.et Z.) Maxim. or lobus cardiacus Herba Epimedii E.brevicornum Maxim.. claim Herba Epimedii again, originate in ground such as Guizhou, Sichuan, Hunan, Hubei, Jiangsu, Zhejiang, Jiangxi, Fujian, Guangdong.Spring and autumn cuts receipts, dries, and shreds, and gives birth to and uses or the crisp usefulness of frying; Nature and flavor suffering, temperature; Return liver, kidney channel; Its function kidney-replenishing, bone and muscle strengthening, expelling wind and removing dampness, relieving cough and asthma.Shennong's Herbal is said: " this product master's impotence is hindered extremely, pains in the penis, diuresis, physical strength profiting, strong will ".Recent studies shows that this product has significant inhibitory effect to poliovirus and enterovirus.Staphylococcus aureus and Diplococcus pneumoniae, hemophilus influenza, tubercule bacillus there is inhibitory action.
Rhizoma Curculiginis: be meant Amaryllidaceae herbaceos perennial Rhizoma Curculiginis Curculigo orchioides Gaertn. rhizome; Originate in southwest and on the south the Changjiang river each province, Sichuan output maximum is plucked before germinateing at the beginning of the spring and when autumn Mo, aerial parts was withered, removes fibrous root, dries, and is mothproof, section give birth to or soak section usefulness through rice-washed water; This product nature and flavor suffering, temperature; Return the kidney,spleen,liver warp; Function: kidney-replenishing, warming the liver sun, bone and muscle strengthening, dispelling cold and dampness." Haiyao Bencao, Oversea Materia Medica " said: " main air is mended warm waist foot, clear settling five organs, and bone and muscle strengthening helps digestion, improve visual and auditory acuity, beneficial biceps is filled out bone marrow, Yiyang is tireless ".
Herba Cistanches: the chylocaulous that is meant the band scale leaf of the annual parasitic herbaceous plant Herba Cistanches Cistanch salsa of Orobanchaceae (C.A.Mey) G.Beck.Ground such as the main product Inner Mongol, Gansu, Xinjiang, Qinghai.Spring and autumn is plucked, and the spring dries after adopting, and is Herba Cistanches; Autumn is salty Herba Cistanches after adopting and flooding in the saline, and section (rip cutting) is used as medicine.Nature and flavor are sweet, salty, warm; Return kidney, large intestine channel; Has the kidney invigorating and essence nourishing, the effect of loosening bowel to relieve constipation; " neural book on Chinese herbal medicine warp " said: " main labor seven kinds of impairments, invigorating middle warmer remove stem invasion by pathogenic cold burning pain, support the five internal organs, reinforcing YIN-essence, beneficial vital essence ".Modern study shows, contains micro-alkaloid, and the crystallization neutral substance.
The traditional Chinese medical science thinks that acquired immune deficiency syndrome (AIDS) belongs to categories such as asthenia, pestilence, YIN YANG toxin syndrome.The kidney being the origin of congenital constitution main store essential substances is the residence of extreme misery, is the root of people's volume elements gas; Kidney yang is prosperous, and then the yang-energy of whole body is all prosperous, and kidney yang declines, and then the yang-energy of whole body all declines, the vital organs of the human body, and the fourteen channels arteries and veins, the physiological function activity of body nine orifices all can weaken, thereby is easy to experience evil poison, simulataneous insufficiency and excessive occurs, based on a series of symptoms of void.
Kidney governing bones, waist is a house of kidney, the then waist knee joint mistake of suffering from a deficiency of the kidney is supported, so owe waist knee joint weakness; Kidney yang is lost empty, warm prosperous dereliction of duty, and skin is supported earlier, coldness of the body with chills then, health is become thin; Kidney governing reproduction, insufficiency of kidney-YANG, the gate of vitality declines greatly, and the reproduction function descends, so hyposexuality; Yang deficiency can not be roused spirit, thus lassitude, fatigue and weakness; Kidney is with two just, insufficiency of kidney-YANG, and YANG failing to warm spleen-YANG, temperatureization is had no right, so answer the frequent micturition number, the loose stool approaches greatly, even has loose bowels; The kidney yang deficiency and coldness, then tongue is former light fat, and tongue is white, deep,thready and forceless pulse." the Huang di's Canon of Medicine element asks negative and positive big opinion " said: " cloudy person, store essential substances and rising urgently also; Yang Zhewei is outward admittedly also ".Kidney yang is lost empty, influences the outer duty of defending of yang-energy, is disease so easily experience exopathogen.
In the Chinese medicine compound compositions of the present invention, be monarch with the Cornu Cervi Pantotrichum, the supporing yang benefiting essence-blood of nourishing kidney; The Herba Cistanches warming and recuperating the kidney-YANG is a minister; Rhizoma Curculiginis, the warm spleen of Herba Epimedii nourishing kidney, strengthening the tendons and bones is assistant; The Fructus Lycii replenishing YIN and blood, replenishing vital essence to improve eyesight makes for assistant, and five medicines are played the merit of nourishing kidney tonifying YANG altogether; " Huang di's Canon of Medicine element ask logical detailed deficiency and excess opinion " said: " healthy energy deposit in, heresy can not be done "; " institute of heresy gathers, and its gas must be empty ".Kidney yang must be mended, and then the yang-energy of whole body rouses oneself, and it is vigorous to protect function, and the poison of getting rid of evils is gone out, so can receive the effect of anti-AIDS.
The Chinese medicine compound preparation of compositions method of a kind of anti-AIDS of the present invention, it may further comprise the steps;
1) take by weighing each raw material by formula ratio, it is standby that Pulveratum Cornu Cervi Pantotrichum is broken to 100-300 orders, add the alcohol reflux secondary after again will Rhizoma Curculiginis pulverizing, and merges the secondary ethanol extract, reclaims ethanol, simmer down to extractum, and extractum separates standby with the Rhizoma Curculiginis medicinal residues;
2) after being mixed, remaining three flavor Chinese medicines add water with till not having a medicine layer, after boiling, decocted again 30-60 minutes, filter, medicinal liquid is standby, add water after the Rhizoma Curculiginis medicinal residues of medicinal residues and step 1 merge with till not having medicinal residues layer 3-6cm, after boiling, decocted again 30-60 minutes, filter, merge twice and decoct medicinal liquid, simmer down to extractum, standby.
3) extractum of step 1 and the extractum of step 2 are merged, vacuum drying is pulverized, and adds the Pulveratum Cornu Cervi Pantotrichum of step 1 again, mix homogeneously.
The Chinese medicine compound compositions of anti-AIDS of the present invention can be made various dosage forms such as tablet, capsule, pill, syrup, oral liquid, electuary, injection again according to conventional method after making powder.
The Chinese medicine compound compositions of a kind of anti-AIDS of the present invention, usage: oral, 20-30 grams of suitable crude drug amount on the one divide and take for 2-3 times, three months courses of treatment.
The Chinese medicine compound compositions of anti-AIDS of the present invention has been finished following research;
Study of pharmacy
1, technology research
1) takes the super extraction that is situated between of facing, to pressure, temperature, time, the flow velocity of extraction and add and carry dosage secretly and carry out preferably.Take orthogonal test, to the amount of water that extracts, soak time and distillation time carry out preferably.
2) research of β-CD enclose volatile oil: take orthogonal test, β during to enclose-CD consumption, enclose temperature and mixing time are carried out preferably.
3) purification research: to ultrafiltration, supercentrifugal process and alcohol deposition method compare, preferred best purifying process.
4) seasoning research: boulton process and nebulization are compared, optimize optimum condition.
5) research of micronizing: the fine degree of Cornu Cervi Pantotrichum is investigated.
6) Study on Forming: to the bonding rate of granule, angle of repose, hydroscopicity is an index, examines or check the influence to granulating process of different auxiliary material and consumption thereof, and packaging material are carried out examine stability.
7) formulate quality standard by country, three batches of pilot products are examined or check.
2, the research of quality standard
Take micro-, thin layer and HPLC method that evolvement method is learned comparative study.
3, examine stability
By national standard, take the reserved sample observing method, determined the storage period of medicine.
Studies show that more than prescription is formed rationally, and has determined advanced technology and reasonability thereof, can adapt to GMP and require into
Row is produced.Steady quality can reach the requirement of international market medicine.
The Chinese medicine compound compositions of anti-AIDS of the present invention can be treated acquired immune deficiency syndrome (AIDS) and HIV patient, can not only suppress and kill HIV (human immunodeficiency virus), and can improve the immunity of human body; Thereby eliminate patient's symptomatology, recover patient's muscle power and body weight, make it live and work healthily.
The specific embodiment
Following examples are in order further to describe the present invention for example, rather than limit the present invention by any way.
Embodiment 1 (g of unit)
Cornu Cervi Pantotrichum 280 Fructus Lycii 140
Herba Cistanches 140 Rhizoma Curculiginises 120
Herba Epimedii 120
Its preparation method is as follows:
1) take by weighing each raw material by formula ratio, it is standby that Pulveratum Cornu Cervi Pantotrichum is broken to 200 orders, add the alcohol reflux secondary after again will Rhizoma Curculiginis pulverizing, and merges the secondary ethanol extract, reclaims ethanol, simmer down to extractum, and extractum separates standby with the Rhizoma Curculiginis medicinal residues;
2) after being mixed, remaining three flavor Chinese medicines add water with till not having a medicine layer, decocted again after boiling 45 minutes, filter, medicinal liquid is standby, adds water after the Rhizoma Curculiginis medicinal residues of medicinal residues and step 1 merge with till not having a medicinal residues layer 5cm, decocts after boiling 45 minutes again, filter, merge twice and decoct medicinal liquid, simmer down to extractum, standby.
3) extractum of step 1 and the extractum of step 2 are merged, vacuum drying is pulverized, and adds the Pulveratum Cornu Cervi Pantotrichum of step 1 again, mix homogeneously.
Embodiment 2 (g of unit)
Cornu Cervi Pantotrichum 200 Fructus Lycii 100
Herba Cistanches 120 Rhizoma Curculiginises 90
Herba Epimedii 90
Its preparation method is as follows:
1) take by weighing each raw material by formula ratio, it is standby that Pulveratum Cornu Cervi Pantotrichum is broken to 200 orders, add the alcohol reflux secondary after again will Rhizoma Curculiginis pulverizing, and merges the secondary ethanol extract, reclaims ethanol, simmer down to extractum, and extractum separates standby with the Rhizoma Curculiginis medicinal residues;
2) after being mixed, remaining three flavor Chinese medicines add water with till not having a medicine layer, decocted again after boiling 55 minutes, filter, medicinal liquid is standby, adds water after the Rhizoma Curculiginis medicinal residues of medicinal residues and step 1 merge with till not having a medicinal residues layer 4cm, decocts after boiling 35 minutes again, filter, merge twice and decoct medicinal liquid, simmer down to extractum, standby.
3) extractum of step 1 and the extractum of step 2 are merged, vacuum drying is pulverized, and adds the Pulveratum Cornu Cervi Pantotrichum of step 1 again, mix homogeneously.
Embodiment 3 (g of unit)
Cornu Cervi Pantotrichum 120 Fructus Lycii 120
Herba Cistanches 100 Rhizoma Curculiginises 100
Herba Epimedii 90
Its preparation method is as follows:
1) take by weighing each raw material by formula ratio, it is standby that Pulveratum Cornu Cervi Pantotrichum is broken to 200 orders, add the alcohol reflux secondary after again will Rhizoma Curculiginis pulverizing, and merges the secondary ethanol extract, reclaims ethanol, simmer down to extractum, and extractum separates standby with the Rhizoma Curculiginis medicinal residues;
2) after being mixed, remaining three flavor Chinese medicines add water with till not having a medicine layer, decocted again after boiling 35 minutes, filter, medicinal liquid is standby, adds water after the Rhizoma Curculiginis medicinal residues of medicinal residues and step 1 merge with till not having a medicinal residues layer 6cm, decocts after boiling 55 minutes again, filter, merge twice and decoct medicinal liquid, simmer down to extractum, standby.
3) extractum of step 1 and the extractum of step 2 are merged, vacuum drying is pulverized, and adds the Pulveratum Cornu Cervi Pantotrichum of step 1 again, mix homogeneously.
Embodiment 4 (g of unit)
Cornu Cervi Pantotrichum 220 Fructus Lycii 100
Herba Cistanches 100 Rhizoma Curculiginises 90
Herba Epimedii 120
Its preparation method is as follows:
1) take by weighing each raw material by formula ratio, it is standby that Pulveratum Cornu Cervi Pantotrichum is broken to 200 orders, add the alcohol reflux secondary after again will Rhizoma Curculiginis pulverizing, and merges the secondary ethanol extract, reclaims ethanol, simmer down to extractum, and extractum separates standby with the Rhizoma Curculiginis medicinal residues;
2) after being mixed, remaining three flavor Chinese medicines add water with till not having a medicine layer, decocted again after boiling 50 minutes, filter, medicinal liquid is standby, adds water after the Rhizoma Curculiginis medicinal residues of medicinal residues and step 1 merge with till not having a medicinal residues layer 3cm, decocts after boiling 30 minutes again, filter, merge twice and decoct medicinal liquid, simmer down to extractum, standby.
3) extractum of step 1 and the extractum of step 2 are merged, vacuum drying is pulverized, and adds the Pulveratum Cornu Cervi Pantotrichum of step 1 again, mix homogeneously.
The experimental data of the Chinese medicine compound compositions of the embodiment of the invention 1 anti-AIDS is as follows;
1, The acute toxicity tests shows, gives mice 2 times/day so that the maximum filling of Cmax body of stomach is long-pending, and this moment, the accumulative total dosage reached 197g/kg, was equivalent to 476 times of clinical adult's consumptions, and animal does not see obvious toxic-side effects.
2, the long term toxicity test result shows, continuous irrigation stomach rat 6 months is compared with the blank group, the every index of rat, main organs coefficient, perusal and the equal no significant difference of mirror undertissue morphological observation or unusual.
3, monkey test: set up simian immunodeficiency virus infected monkey model, infect modeling in back 71 days success with 12 monkey SIV.Treatment group virus load after treating descends obviously, especially after the drug withdrawal during 8 weeks with treatment before the 1.52log that relatively descended, with the relatively lower 1.34log of SIV matched group.And 4 monkey virus loads that should the treatment group change all more regular; therefore can think; experimental result prompting Chinese mugwort volt is brought treatment under control to be had SIV infected monkey model and suppresses virus function preferably, does not occur viral rebound phenomenon after the drug withdrawal, simultaneously immune system is had better protect and restructuration.
4, white mice test: the in vivo test proof has the effect of human body immunity improving power.
Claims (4)
- , a kind of Chinese medicine compound compositions of anti-AIDS, be prepared from by the crude drug of following parts by weight;Cornu Cervi Pantotrichum 100-280 Fructus Lycii 100-140Herba Cistanches 100-140 Rhizoma Curculiginises 90-120Herba Epimedii 90-120.
- 2, the Chinese medicine compound compositions of a kind of anti-AIDS according to claim 1 is prepared from by the crude drug of following parts by weight:Cornu Cervi Pantotrichum 100-200 Fructus Lycii 100-140Herba Cistanches 100-140 Rhizoma Curculiginises 90-120Herba Epimedii 90-120
- 3, the Chinese medicine compound preparation of compositions method of a kind of anti-AIDS according to claim 1, it may further comprise the steps;1) take by weighing each raw material by formula ratio, it is standby that Pulveratum Cornu Cervi Pantotrichum is broken to 100-300 orders, add the alcohol reflux secondary after again will Rhizoma Curculiginis pulverizing, and merges the secondary ethanol extract, reclaims ethanol, simmer down to extractum, and extractum separates standby with the Rhizoma Curculiginis medicinal residues;2) after being mixed, remaining three flavor Chinese medicines add water with till not having a medicine layer, decocted again 30-60 minutes after boiling, filter, medicinal liquid is standby, adds water after the Rhizoma Curculiginis medicinal residues of medicinal residues and step 1 merge with till not having medicinal residues layer 3-6cm, decocts 30-60 minutes after boiling again, filter, merge twice and decoct medicinal liquid, simmer down to extractum, standby.3) extractum of step 1 and the extractum of step 2 are merged, vacuum drying is pulverized, and adds the Pulveratum Cornu Cervi Pantotrichum of step 1 again, mix homogeneously.
- 4, the Chinese medicine compound compositions of a kind of anti-AIDS according to claim 1, it is made into tablet, capsule, pill, syrup, oral liquid, electuary, injection according to a conventional method.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188537A (en) * | 2010-03-17 | 2011-09-21 | 段颖哲 | Chinese medicine composition against AIDS and preparation method thereof |
| CN103735930A (en) * | 2014-01-10 | 2014-04-23 | 张荣印 | Chinese herbal formula for eliminating AIDS (Acquired Immune Deficiency Syndrome) retrovirus |
| CN106975027A (en) * | 2017-04-19 | 2017-07-25 | 贵州黑刺黄生物科技有限公司 | A kind of ancillary drug of AIDS antiretroviral therapy and preparation method thereof |
| CN108635464A (en) * | 2018-07-06 | 2018-10-12 | 大连神植康缘科技有限公司 | A kind of Chinese medicine composition that treating AIDS, preparation method and application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1286103A (en) * | 2000-09-19 | 2001-03-07 | 段荣书 | Medicine for treating AIDS |
| CN1363371A (en) * | 2002-01-11 | 2002-08-14 | 潘文光 | Multifunctional bio-active medicine for preventing and curing AIDS |
| CN1981812B (en) * | 2005-12-12 | 2010-05-05 | 海南亚洲制药有限公司 | Chinese-medicinal preparation for treating AIDS and its production |
-
2008
- 2008-11-28 CN CN2008101804669A patent/CN101417049B/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188537A (en) * | 2010-03-17 | 2011-09-21 | 段颖哲 | Chinese medicine composition against AIDS and preparation method thereof |
| WO2011113190A1 (en) * | 2010-03-17 | 2011-09-22 | 段颖哲 | Pharmaceutical composition for treating aids and preparation method thereof |
| CN102188537B (en) * | 2010-03-17 | 2013-03-13 | 段颖哲 | Chinese medicine composition against AIDS and preparation method thereof |
| CN103735930A (en) * | 2014-01-10 | 2014-04-23 | 张荣印 | Chinese herbal formula for eliminating AIDS (Acquired Immune Deficiency Syndrome) retrovirus |
| CN106975027A (en) * | 2017-04-19 | 2017-07-25 | 贵州黑刺黄生物科技有限公司 | A kind of ancillary drug of AIDS antiretroviral therapy and preparation method thereof |
| CN108635464A (en) * | 2018-07-06 | 2018-10-12 | 大连神植康缘科技有限公司 | A kind of Chinese medicine composition that treating AIDS, preparation method and application |
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| CN101417049B (en) | 2010-12-15 |
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