CN101415692B - 用于蛋白质纯化的吸附剂 - Google Patents
用于蛋白质纯化的吸附剂 Download PDFInfo
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- CN101415692B CN101415692B CN2007800118656A CN200780011865A CN101415692B CN 101415692 B CN101415692 B CN 101415692B CN 2007800118656 A CN2007800118656 A CN 2007800118656A CN 200780011865 A CN200780011865 A CN 200780011865A CN 101415692 B CN101415692 B CN 101415692B
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- -1 cyciohexyl Chemical group 0.000 claims abstract description 16
- 125000003118 aryl group Chemical group 0.000 claims abstract description 11
- 125000006850 spacer group Chemical group 0.000 claims abstract description 9
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical group C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims abstract description 8
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 5
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- 125000000217 alkyl group Chemical group 0.000 abstract description 15
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical group C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 abstract description 10
- 229910052736 halogen Inorganic materials 0.000 abstract description 8
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract description 8
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- 125000004423 acyloxy group Chemical group 0.000 abstract description 6
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- 229910052757 nitrogen Inorganic materials 0.000 abstract description 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
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- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
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- 238000011002 quantification Methods 0.000 abstract 1
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 16
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- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
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- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 2
- 229940038773 trisodium citrate Drugs 0.000 description 2
- NHJVRSWLHSJWIN-UHFFFAOYSA-N 2,4,6-trinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O NHJVRSWLHSJWIN-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
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- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
- B01J20/3251—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
- B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Abstract
Description
Claims (18)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0604236.0 | 2006-03-02 | ||
GBGB0604236.0A GB0604236D0 (en) | 2006-03-02 | 2006-03-02 | Adsorbents for protein purification |
PCT/GB2007/050095 WO2007099374A1 (en) | 2006-03-02 | 2007-03-02 | Adsorbents for protein purification |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101415692A CN101415692A (zh) | 2009-04-22 |
CN101415692B true CN101415692B (zh) | 2013-10-02 |
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US (1) | US8076477B2 (zh) |
EP (1) | EP1989189B1 (zh) |
JP (1) | JP5192398B2 (zh) |
CN (1) | CN101415692B (zh) |
AU (1) | AU2007220260B2 (zh) |
BR (1) | BRPI0708451A2 (zh) |
CA (1) | CA2645675C (zh) |
DK (1) | DK1989189T3 (zh) |
ES (1) | ES2430556T3 (zh) |
GB (1) | GB0604236D0 (zh) |
PT (1) | PT1989189E (zh) |
WO (1) | WO2007099374A1 (zh) |
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GB0808908D0 (en) * | 2008-05-16 | 2008-06-25 | Avecia Biolog Ltd | Purification process |
CN102549012B (zh) * | 2009-05-07 | 2015-07-01 | 诺维信生物制药丹麦公司 | 纯化白蛋白的方法 |
JP2013526542A (ja) | 2010-05-12 | 2013-06-24 | アッヴィ・インコーポレイテッド | キナーゼのインダゾール阻害薬 |
JP2012018135A (ja) * | 2010-07-09 | 2012-01-26 | Mitsubishi Chemicals Corp | 分離剤 |
JP6038774B2 (ja) * | 2011-03-24 | 2016-12-07 | 株式会社カネカ | タンパク性物質結合性低分子化合物 |
EP2918641A1 (en) | 2014-03-13 | 2015-09-16 | Basf Se | Method for purification of antibodies, antibody fragments or engineered variants thereof using specific anthraquinone dye-ligand structures |
CN106925212A (zh) * | 2015-12-31 | 2017-07-07 | 中国石油天然气股份有限公司 | 一种脱除丙烯腈中噁唑的吸附剂及方法 |
CN108246273B (zh) * | 2018-02-08 | 2021-01-22 | 天津大学 | 磺酸化海藻酸钠接枝琼脂糖凝胶色谱介质及制备方法和应用 |
Citations (3)
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US5674688A (en) * | 1991-04-02 | 1997-10-07 | Terrapin Technologies, Inc. | Method for analyte classification by SC profiles |
CN1200680A (zh) * | 1995-09-20 | 1998-12-02 | 诺沃挪第克公司 | 新亲合配位体及其应用 |
CN1350476A (zh) * | 1999-05-10 | 2002-05-22 | 普罗米蒂克生物科学有限公司 | 新的以三唑为基础的解毒剂和它们的应用 |
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US6117996A (en) * | 1995-09-20 | 2000-09-12 | Novo Nordisk A/S | Triazine based ligands and use thereof |
WO2003050237A2 (en) * | 2001-12-12 | 2003-06-19 | New York University | Triazine library with linkers |
GB0224446D0 (en) * | 2002-10-21 | 2002-11-27 | Univ Cambridge Tech | Affinity adsorbents for immunoglobulins |
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2006
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2007
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- 2007-03-02 US US12/281,346 patent/US8076477B2/en not_active Expired - Fee Related
- 2007-03-02 DK DK07712978.1T patent/DK1989189T3/da active
- 2007-03-02 CA CA2645675A patent/CA2645675C/en active Active
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- 2007-03-02 AU AU2007220260A patent/AU2007220260B2/en active Active
- 2007-03-02 ES ES07712978T patent/ES2430556T3/es active Active
- 2007-03-02 CN CN2007800118656A patent/CN101415692B/zh active Active
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US5674688A (en) * | 1991-04-02 | 1997-10-07 | Terrapin Technologies, Inc. | Method for analyte classification by SC profiles |
CN1200680A (zh) * | 1995-09-20 | 1998-12-02 | 诺沃挪第克公司 | 新亲合配位体及其应用 |
CN1350476A (zh) * | 1999-05-10 | 2002-05-22 | 普罗米蒂克生物科学有限公司 | 新的以三唑为基础的解毒剂和它们的应用 |
Also Published As
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DK1989189T3 (da) | 2013-10-21 |
ES2430556T3 (es) | 2013-11-21 |
CA2645675C (en) | 2015-11-03 |
PT1989189E (pt) | 2013-10-14 |
CN101415692A (zh) | 2009-04-22 |
BRPI0708451A2 (pt) | 2011-06-07 |
JP2009531653A (ja) | 2009-09-03 |
JP5192398B2 (ja) | 2013-05-08 |
US20090221801A1 (en) | 2009-09-03 |
US8076477B2 (en) | 2011-12-13 |
AU2007220260B2 (en) | 2011-06-09 |
WO2007099374A1 (en) | 2007-09-07 |
CA2645675A1 (en) | 2007-09-07 |
EP1989189B1 (en) | 2013-07-10 |
EP1989189A1 (en) | 2008-11-12 |
AU2007220260A1 (en) | 2007-09-07 |
GB0604236D0 (en) | 2006-04-12 |
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