CN101375948B - External-use formulation for impotence and preparation method thereof - Google Patents
External-use formulation for impotence and preparation method thereof Download PDFInfo
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- CN101375948B CN101375948B CN200810151934XA CN200810151934A CN101375948B CN 101375948 B CN101375948 B CN 101375948B CN 200810151934X A CN200810151934X A CN 200810151934XA CN 200810151934 A CN200810151934 A CN 200810151934A CN 101375948 B CN101375948 B CN 101375948B
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Abstract
The invention relates to an external preparation for impotence and the preparation method thereof. The external preparation for the impotence is prepared by the following medicament raw materials according to the weight ratio: 90-210 parts of epimedium, 25-70 parts of cassia, 100-200 parts of cnidium fruit, 20-65 parts of pepper stem and 12-32 parts of camphor. The external preparation for the impotence extracts the effective constituents in the medicament raw materials by using a water cooking and extraction method and keeps the activity thereof. Therefore, not only the dissolution rate of the effective constituents in the medicament is improved greatly, but also the medicament can be absorbed effectively, thereby improving the bioavailability. In addition, the medicament of the invention is a pure traditional Chinese medicine preparation, so that no toxic and side effects are existent after a patient uses for a long time, and the preparation has good safety. Moreover, the preparation method of the invention has the advantages of simple process and convenient operation.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly relating to a kind of is external-use formulation for impotence of making of raw material and preparation method thereof with Chinese medicine.
Background technology
Sexual impotence is a kind of because man's erectile disfunction, faces room penis anorthosis, and it is not hard perhaps to erect, and is perhaps hard and soon, so that can not finish the disease of normal sexual intercourse, is one of modal disease of male sexual disorder.Though it is many to be used for the treatment of the types of drugs of sexual impotence at present clinically, specific aim is not strong, and the toxic and side effects of some medicine is big, so use back DeGrain for this disease of treatment sexual impotence.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide a kind of treatment blood stasis blocking type sexual impotence effect obvious, thereby with strong points, and the external-use formulation for impotence that has no side effect.
Another object of the present invention is to provide a kind of method that is used to prepare above-mentioned external-use formulation for impotence.
In order to achieve the above object, external-use formulation for impotence provided by the invention is that the following medicine material of weight ratio is made by consumption mainly:
Herba Epimedii 90-210 Cortex Cinnamomis 25-70 Fructus Cnidiis 100-200
Caulis Piperis Kadsurae 20-65 Camphoras 12-32
The preparation method of described external-use formulation for impotence is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, will decoct with water 2 times after other the 4 kinds of medicine materials mixing except that Camphora then, each 2 hours, merging filtrate filtered, and is concentrated into the clear paste that relative density is 1.05-1.18 (60 ℃);
(b) in above-mentioned clear paste, add ethanol, and make and contain alcohol amount and reach 70%, left standstill 48 hours, get supernatant, reclaim ethanol, in clear paste, add an amount of water and Camphora then and make medicinal liquid, stir, filter, at last filtrate is added water to desired concn, detect and promptly make spray after qualified; Or in above-mentioned medicinal liquid, add pharmaceutic adjuvant commonly used and make ointment or gel.
External-use formulation for impotence provided by the invention is that the method for employing decocting in water extraction is extracted the effective ingredient in the material medicine, and keep its activity, can make so not only that the dissolution of effective ingredient improves greatly in the medicine, and help the absorption of medicine, thereby can improve its bioavailability.In addition, medicine of the present invention is a pure Chinese medicinal preparation, thus patient's life-time service with after can not produce toxic and side effects, so safety is good.In addition, preparation method technology of the present invention is simple, easy to operate.
The specific embodiment
External-use formulation for impotence provided by the invention is that the theory according to the traditional Chinese medical science " inner disease outer treat " develops.The one of the main reasons that sexual impotence forms is because the penis passages through which vital energy circulates is obstructed, blood flow is not enough, cause erection not hard, soon, not hard, thereby the intact activity that does not become normal sexual intercourse.With the traditional Chinese medical science " internal treatment's " theory, dialectical opinion is controlled, and suits the remedy to the case treating both the principal and secondary aspects of a disease.Chinese medicine for oral administration, though effect certainly, effective in cure, the time is longer relatively, can not play the effect of getting instant result.In order to reach the effect of getting instant result, external-use formulation for impotence provided by the invention can directly spray or spread upon on the penis, transdermal, and local absorption makes penis reach congested effect in a few minutes.This therapy was both convenient and safe, had no side effect again, and was through clinical practice, effective.
The Herba Epimedii acrid-sweet flavor is warm in nature in the side, goes into Liver and kidney two warps, and the effect of kidney invigorating and YANG supporting is arranged.Pharmacological testing proves that extract has the effect of androgen sample.The effect that the irritability function is arranged, raises libido is monarch drug.Fructus Cnidii acrid in the mouth hardship, warm in nature, go into kidney channel, the effect of warming the kidney to activate YANG is arranged.Pharmacological testing proves that extract also has the similarity functions of hormones, is ministerial drug.The Cortex Cinnamomi acrid-sweet flavor, hot in nature, return the Liver and kidney warp, the effect of existing reinforcing the kidney and supporting YANG has the promote blood circulation effect of network, blood circulation promoting competent silt of temperature again.The pharmacological action of Oleum Cinnamomi reduces vascular resistance in addition, promotes the effect of mucosal blood flow, is adjuvant drug.Caulis Piperis Kadsurae, acrid in the mouth, slightly warm in nature, gas delicate fragrance, the GUIXIN kidney channel, the power that existing temperature is logical, but the meridian dredging have the effect of the arteries and veins of invigorating blood circulation again, scurry because of being apt to away again, and Gu can make the efficacy of a drug sick institute that goes directly, and is messenger drug.Add Camphora, existing innervation has transdermal again, directly expands the effect of penis blood vessel.Share with medicine-feeding, directly spray or spread upon on the penis, play kidney invigorating and YANG supporting, promoting the flow of QI in the collateral by warming the meridian altogether, erection gets instant result, hard, of a specified duration, hard effect.
Below in conjunction with embodiment external-use formulation for impotence provided by the invention and preparation method thereof is elaborated.
Embodiment 1:
External-use formulation for impotence in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Herba Epimedii 160 Cortex Cinnamomis 50 Fructus Cnidiis 160
Caulis Piperis Kadsurae 48 Camphoras 20
Preparation method:
(a) the said medicine raw material is carried out weighing according to proportioning, will decoct with water 2 times after other the 4 kinds of medicine materials mixing except that Camphora then, each 2 hours, merging filtrate filtered, and is concentrated into the clear paste that relative density is 1.05-1.18 (60 ℃);
(b) in above-mentioned clear paste, add ethanol, and make and contain alcohol amount and reach 70%, left standstill 48 hours, get supernatant, reclaim ethanol, in clear paste, add an amount of water and Camphora then and make medicinal liquid, stir, filter, at last filtrate is added water to desired concn, detect and promptly make spray after qualified; Or in above-mentioned medicinal liquid, add pharmaceutic adjuvant commonly used and make ointment or gel.
Embodiment 2:
External-use formulation for impotence in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Herba Epimedii 90 Cortex Cinnamomis 25 Fructus Cnidiis 100
Caulis Piperis Kadsurae 20 Camphoras 12
Preparation method is with embodiment 1.
Embodiment 3:
External-use formulation for impotence in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Herba Epimedii 210 Cortex Cinnamomis 70 Fructus Cnidiis 200
Caulis Piperis Kadsurae 65 Camphoras 32
Preparation method is with embodiment 1.
External-use formulation for impotence provided by the invention is brown or brownish red; The special fragrance of tool.In order to verify the therapeutic effect of this external-use formulation for impotence, the inventor utilizes the spray in the above-mentioned external-use formulation for impotence 126 routine impotence patients to be carried out system's clinical observation, wherein 25 years old of the age minimum, the maximum 45 years old, 32 years old mean age, each 2-3 press, and 10 times is a course of treatment.After 1 course of therapy, cure (sexual intercourse is erected normally, and the sexual satisfaction sense is good, and each the same branch of a family all can be successful) 36 examples altogether, account for 28.6%, produce effects (sexual intercourse erect still can, sexual gratification, the same branch of a family success rate about 70%) 35 examples account for 27.8%, effectively (can have sexual intercourse, sometimes lift and not hard the same branch of a family success rate about 30%) 42 examples, account for 33.3%, invalid (normally sexual intercourse, the penis anorthosis) 13 examples account for 10.3%, and total effective rate is 89.7%.
Simultaneously, the inventor cures using behind the external-use formulation for impotence provided by the invention, produce effects and effectively totally 113 routine patients' responding time add up, the results are shown in Table 1:
Table 1: the responding time table that uses patient behind the external-use formulation for impotence provided by the invention
| Responding time | The example number | With total routine number than (%) |
| In 1 week | 12 | 10.6％ |
| In 1-2 weeks | 32 | 28.3％ |
| In 2-3 weeks | 69 | 61.1％ |
| Add up to | 113 | 100％ |
Claims (2)
1. an external-use formulation for impotence is characterized in that; Described external-use formulation for impotence is that the following medicine material of weight ratio is made by consumption:
Herba Epimedii 90-210 Cortex Cinnamomi 25-70 Fructus Cnidii 100-200
Caulis Piperis Kadsurae 20-65 Camphora 12-32.
2. the preparation method of an external-use formulation for impotence as claimed in claim 1, it is characterized in that: the preparation method of described external-use formulation for impotence is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, decoct with water 2 times after 4 kinds of medicine materials of other that then will be except that Camphora mix, each 2 hours, merging filtrate filtered, and was concentrated into 60 ℃ and surveys the clear paste that relative density is 1.05-1.18 constantly;
(b) in above-mentioned clear paste, add ethanol, and make and contain alcohol amount and reach 70%, left standstill 48 hours, get supernatant, reclaim ethanol, in clear paste, add an amount of water and Camphora then and make medicinal liquid, stir, filter, at last filtrate is added water to desired concn, detect and promptly make spray after qualified; Or in above-mentioned medicinal liquid, add pharmaceutic adjuvant commonly used and make ointment or gel.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810151934XA CN101375948B (en) | 2008-09-27 | 2008-09-27 | External-use formulation for impotence and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810151934XA CN101375948B (en) | 2008-09-27 | 2008-09-27 | External-use formulation for impotence and preparation method thereof |
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| CN101375948B true CN101375948B (en) | 2011-03-30 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772075A (en) * | 2004-11-13 | 2006-05-17 | 刘汉光 | Health-care product (or medicine) for improving and curing impotence and prospermia by external application on penis |
| CN1872244A (en) * | 2006-04-28 | 2006-12-06 | 涂冲林 | Composition of Chinese traditional medicine for treating disorder of erection function |
| CN101164586A (en) * | 2006-10-18 | 2008-04-23 | 山西太行药业股份有限公司 | Medicinal composition for treating sexual impotence and preparation process thereof |
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2008
- 2008-09-27 CN CN200810151934XA patent/CN101375948B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772075A (en) * | 2004-11-13 | 2006-05-17 | 刘汉光 | Health-care product (or medicine) for improving and curing impotence and prospermia by external application on penis |
| CN1872244A (en) * | 2006-04-28 | 2006-12-06 | 涂冲林 | Composition of Chinese traditional medicine for treating disorder of erection function |
| CN101164586A (en) * | 2006-10-18 | 2008-04-23 | 山西太行药业股份有限公司 | Medicinal composition for treating sexual impotence and preparation process thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李水银.药浴治阳痿.《开卷有益.求医问药 》.2003,(第1期), * |
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