CN101370492B - 环状硝基化合物及其药物组合物和用途 - Google Patents
环状硝基化合物及其药物组合物和用途 Download PDFInfo
- Publication number
- CN101370492B CN101370492B CN2006800382847A CN200680038284A CN101370492B CN 101370492 B CN101370492 B CN 101370492B CN 2006800382847 A CN2006800382847 A CN 2006800382847A CN 200680038284 A CN200680038284 A CN 200680038284A CN 101370492 B CN101370492 B CN 101370492B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- acid
- chemical compound
- nitro compound
- cyclic nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (19)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70785105P | 2005-08-12 | 2005-08-12 | |
US60/707,851 | 2005-08-12 | ||
US11/502,810 US7507842B2 (en) | 2005-08-12 | 2006-08-11 | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
US11/502,810 | 2006-08-11 | ||
PCT/US2006/031917 WO2007022225A2 (en) | 2005-08-12 | 2006-08-14 | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101370492A CN101370492A (zh) | 2009-02-18 |
CN101370492B true CN101370492B (zh) | 2011-04-20 |
Family
ID=37758325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800382847A Active CN101370492B (zh) | 2005-08-12 | 2006-08-14 | 环状硝基化合物及其药物组合物和用途 |
Country Status (13)
Country | Link |
---|---|
US (10) | US7507842B2 (zh) |
EP (1) | EP1924253B1 (zh) |
JP (1) | JP5176063B2 (zh) |
KR (2) | KR101226168B1 (zh) |
CN (1) | CN101370492B (zh) |
AU (1) | AU2006279589B8 (zh) |
CA (1) | CA2620612C (zh) |
DK (1) | DK1924253T3 (zh) |
ES (1) | ES2532457T3 (zh) |
IL (3) | IL189439A (zh) |
MX (1) | MX2008001983A (zh) |
PT (1) | PT1924253E (zh) |
WO (1) | WO2007022225A2 (zh) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
US20070135380A1 (en) | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
US8278289B2 (en) * | 2006-03-21 | 2012-10-02 | Borivoj Galic | Boroxine composition for removal of skin changes |
KR100967848B1 (ko) * | 2008-05-28 | 2010-07-05 | 국방과학연구소 | 분자화약이 도입된, 고에너지 결합제용1-글리시딜-3,3-디니트로아제티딘 및 그의 제조방법 |
US8471041B2 (en) * | 2010-02-09 | 2013-06-25 | Alliant Techsystems Inc. | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
WO2012078992A1 (en) * | 2010-12-09 | 2012-06-14 | Radiorx, Inc. | Organonitro compounds for use in treating non-hodgkin's lymphoma and leukemia, and methods relating thereto |
US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
AU2012319071B2 (en) * | 2011-10-07 | 2017-08-03 | Epicentrx, Inc. | Organonitro thioether compounds and medical uses thereof |
WO2013052803A2 (en) * | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
KR101496681B1 (ko) * | 2014-05-19 | 2015-03-04 | 국방과학연구소 | N-치환된 3,3-디니트로아제티딘 고에너지 가소제 및 그의 제조방법 |
JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
UA122423C2 (uk) | 2015-11-02 | 2020-11-10 | Янссен Фармацевтика Нв | [1,2,4]ТРИАЗОЛО[1,5-a]ПІРИМІДИН-7-ІЛЬНА СПОЛУКА |
ES2880482T3 (es) * | 2016-01-11 | 2021-11-24 | Epicentrx Inc | Composiciones y métodos para la administración intravenosa de 2-bromo-1-(3,3-dinitroazetidin-1-il)etanona |
US11008287B2 (en) * | 2016-10-14 | 2021-05-18 | Epicentrx, Inc. | Sulfoxyalkyl organonitro and related compounds and pharmaceutical compounds for use in medicine |
MX2019005123A (es) | 2016-11-02 | 2019-06-20 | Janssen Pharmaceutica Nv | Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de pde2. |
JP7076441B2 (ja) | 2016-11-02 | 2022-05-27 | ヤンセン ファーマシューティカ エヌ.ベー. | PDE2阻害剤としての[1,2,4]トリアゾロ[1,5-a]ピリミジン誘導体 |
KR20190071721A (ko) | 2016-11-02 | 2019-06-24 | 얀센 파마슈티카 엔.브이. | Pde2 억제제로서의 [1,2,4]트리아졸로[1,5-a]피리미딘 화합물 |
US11744859B2 (en) | 2017-07-07 | 2023-09-05 | Epicentrx, Inc. | Compositions and methods for parenteral administration of therapeutic agents |
TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗rsv活性之吡唑并嘧啶 |
CN112165937A (zh) * | 2018-01-08 | 2021-01-01 | 埃皮辛特瑞柯斯公司 | 利用RRx-001进行辐射防护的方法和组合物 |
US11510901B2 (en) | 2018-01-08 | 2022-11-29 | Epicentrx, Inc. | Methods and compositions utilizing RRx-001 combination therapy for radioprotection |
EP3746444B1 (en) | 2018-01-31 | 2023-09-27 | Janssen Sciences Ireland Unlimited Company | Cycloalkyl substituted pyrazolopyrimidines having activity against rsv |
EA202092439A1 (ru) | 2018-04-23 | 2021-03-05 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Гетероароматические соединения, обладающие активностью против rsv |
WO2021119433A1 (en) | 2019-12-11 | 2021-06-17 | Epicentrx, Inc. | Medication infusion devices, systems, and methods |
CN114621125A (zh) * | 2020-12-14 | 2022-06-14 | 中国科学技术大学 | Nlrp3炎症小体抑制剂及其应用 |
EP4351567A1 (en) * | 2021-06-09 | 2024-04-17 | EpicentRx, Inc. | Crystalline abdnaz compositions and methods of making and using the same |
EP4355320A1 (en) * | 2021-06-16 | 2024-04-24 | EpicentRx, Inc. | Organonitro and sulfoxyalkyl organonitro compounds for use in treating medical disorders |
WO2023154480A1 (en) * | 2022-02-10 | 2023-08-17 | Epicentrx, Inc. | Compositions and methods for treatment of nafld and nash and related dyslipidemias |
WO2023178283A1 (en) | 2022-03-18 | 2023-09-21 | Epicentrx, Inc. | Co-crystals of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone and methods |
WO2023244973A1 (en) | 2022-06-13 | 2023-12-21 | Epicentrx, Inc. | Compositions and methods for reducing adverse side effects in cancer treatment |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5580988A (en) * | 1995-05-15 | 1996-12-03 | The United States Of America As Represented By The Secretary Of The Army | Substituted azetidines and processes of using them |
US6245799B1 (en) * | 1999-11-08 | 2001-06-12 | American Home Products Corp | [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders |
US6407236B1 (en) * | 1998-09-16 | 2002-06-18 | Medco Research, Inc. | Adenosine A3 receptor modulators |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2978453A (en) * | 1956-12-12 | 1961-04-04 | Aerojet General Co | 3, 3, 5, 5-tetranitropiperidine |
JPS4830376B1 (zh) | 1970-12-29 | 1973-09-19 | ||
US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
JPS5511509A (en) | 1978-07-07 | 1980-01-26 | Toomasu Gorudon Robaato | Cancer therapy |
US4935450A (en) | 1982-09-17 | 1990-06-19 | Therapeutical Systems Corporation | Cancer therapy system for effecting oncolysis of malignant neoplasms |
GB8504253D0 (en) * | 1985-02-19 | 1985-03-20 | Ici Plc | Electrostatic spraying apparatus |
US4584130A (en) | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
GB8728418D0 (en) | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
DE3815221C2 (de) * | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
US5693794A (en) | 1988-09-30 | 1997-12-02 | The United States Of America As Represented By The Secretary Of The Navy | Caged polynitramine compound |
JP2659614B2 (ja) | 1990-11-13 | 1997-09-30 | 株式会社日立製作所 | 表示制御装置 |
TW198712B (zh) | 1991-04-17 | 1993-01-21 | Hoffmann La Roche | |
US5698155A (en) * | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
EP0611306B1 (en) | 1991-11-08 | 1998-07-08 | Somatogen, Inc. | Hemoglobins as drug delivery agents |
DE4226974C2 (de) | 1992-08-14 | 1994-08-11 | Fresenius Ag | Verfahren und Vorrichtung zur kontinuierlichen Aufbereitung einer Zellsuspension |
US5336784A (en) * | 1993-06-07 | 1994-08-09 | The Regents Of The University Of California | Synthesis of 1,3,3-trinitroazetidine |
DK1051972T3 (da) | 1994-05-27 | 2008-01-28 | Strakan Int Ltd | Nitrogenoxiddonorsammensætning og fremgangsmåde til behandling af anale lidelser |
ZA962077B (en) * | 1995-03-14 | 1997-03-26 | Siemens Ag | Ultrasonic atomizer device with removable precision dosating unit |
WO1996028205A1 (en) * | 1995-03-14 | 1996-09-19 | Siemens Aktiengesellschaft | Ultrasonic atomizer device with removable precision dosing unit |
WO1996036602A1 (en) * | 1995-05-15 | 1996-11-21 | The United States Of America | Adnaz, compositions and processes |
US5898038A (en) | 1996-03-19 | 1999-04-27 | Board Of Regents, The University Of Texas System | Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors |
EP0932598A1 (en) | 1996-10-11 | 1999-08-04 | Warner-Lambert Company | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME |
AU3129097A (en) | 1996-10-15 | 1998-05-11 | Eastman Chemical Company | Explosive formulations |
HUP9701554D0 (en) | 1997-09-18 | 1997-11-28 | Human Oltoanyagtermeloe Gyogys | Pharmaceutical composition containing plazma proteins |
GB9720797D0 (en) | 1997-09-30 | 1997-12-03 | Rhodes John | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
NZ504021A (en) * | 1997-10-17 | 2003-04-29 | Systemic Pulmonary Delivery Lt | Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication |
US6056966A (en) | 1998-05-18 | 2000-05-02 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for treating impotence |
EP1098641B1 (en) | 1998-07-27 | 2016-04-27 | St. Jude Pharmaceuticals, Inc. | Chemically induced intracellular hyperthermia |
US20020077276A1 (en) | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
US20020156033A1 (en) | 2000-03-03 | 2002-10-24 | Bratzler Robert L. | Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer |
KR20020087134A (ko) | 2000-04-10 | 2002-11-21 | 화이자 프로덕츠 인크. | 벤조아미드 피페리딘 함유 화합물 및 관련 화합물 |
US6861530B2 (en) | 2000-07-07 | 2005-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Piperidine derivatives |
DE10111049A1 (de) | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen, zur Prophylaxe und Behandlung von entzündlichen Hautzuständen und/oder zum Hautschutz bei empfindlich determinierter trockener Haut |
AU2002359918A1 (en) | 2001-12-28 | 2003-07-24 | Terumo Kabushiki Kaisha | Blood bag system and method of inactivating pathogenic microorganisms |
US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
AU2003247792B2 (en) * | 2002-07-03 | 2009-09-24 | Nicox S.A. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
AU2003282534A1 (en) | 2002-10-07 | 2004-05-04 | Radiorx, Inc. | X-nitro compounds, pharmaceutical compositions thereof and uses therof |
EP1603933A2 (en) | 2003-03-13 | 2005-12-14 | Nitromed, Inc. | Nitrosated and nitrosylated compounds, compositions and methods of use |
WO2004113281A1 (en) | 2003-06-25 | 2004-12-29 | Je Il Pharmaceutical Co., Ltd. | Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them |
AU2004255268B2 (en) | 2003-07-09 | 2010-04-01 | Loma Linda University | Use of nitrite salts for the treatment of cardiovascular conditions |
GB0326047D0 (en) | 2003-11-07 | 2003-12-10 | Univ Sheffield | Substance |
RU2265440C2 (ru) | 2004-01-13 | 2005-12-10 | Ростовский научно-исследовательский онкологический институт МЗ РФ | Способ предоперационного лечения рака молочной железы |
JP2008512490A (ja) | 2004-09-08 | 2008-04-24 | チェルシー・セラピューティクス,インコーポレイテッド | 異常細胞増殖および炎症の障害を治療するための代謝的に不活性な葉酸拮抗剤 |
EP1863804A1 (en) | 2005-04-01 | 2007-12-12 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US20070135380A1 (en) | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
WO2007038459A2 (en) | 2005-09-27 | 2007-04-05 | Novartis Ag | Carboxyamine compounds and their use in the treatment of hdac dependent diseases |
FR2891843A1 (fr) | 2005-10-06 | 2007-04-13 | Erytech Pharma Soc Par Actions | Erythrocytes contenant du 5-fluorouracile |
GB0611405D0 (en) | 2006-06-09 | 2006-07-19 | Univ Belfast | FKBP-L: A novel inhibitor of angiogenesis |
CN200946766Y (zh) | 2006-06-09 | 2007-09-12 | 刘余厚 | 一种套管式紫外灯 |
US8122281B2 (en) | 2007-04-13 | 2012-02-21 | International Business Machines Corporation | System and method for dependent failure-aware allocation of distributed data-processing systems |
CN101708337B (zh) | 2009-08-18 | 2011-08-10 | 上海交通大学医学院附属新华医院 | 一种包载奥沙利铂的人血白蛋白纳米粒的制备方法 |
RU2411953C1 (ru) | 2009-09-02 | 2011-02-20 | Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт" Федерального агентства по высокотехнологичной мед. помощи | Способ лечения рака молочной железы |
US8471041B2 (en) | 2010-02-09 | 2013-06-25 | Alliant Techsystems Inc. | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
WO2012078992A1 (en) | 2010-12-09 | 2012-06-14 | Radiorx, Inc. | Organonitro compounds for use in treating non-hodgkin's lymphoma and leukemia, and methods relating thereto |
US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
WO2013052803A2 (en) | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
AU2012319071B2 (en) * | 2011-10-07 | 2017-08-03 | Epicentrx, Inc. | Organonitro thioether compounds and medical uses thereof |
EP2687225A1 (en) | 2012-07-19 | 2014-01-22 | Alfact Innovation | HIP/PAP protein and derivatives thereof for use in treating cancer |
US20140220163A1 (en) | 2014-02-04 | 2014-08-07 | Hamzeh Soleimani Babadi | Powder mixture composition of natural materials for controlling deficiencies in polypeptide alpha and beta hemoglobin chains |
US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
ES2880482T3 (es) | 2016-01-11 | 2021-11-24 | Epicentrx Inc | Composiciones y métodos para la administración intravenosa de 2-bromo-1-(3,3-dinitroazetidin-1-il)etanona |
US11008287B2 (en) | 2016-10-14 | 2021-05-18 | Epicentrx, Inc. | Sulfoxyalkyl organonitro and related compounds and pharmaceutical compounds for use in medicine |
US11744859B2 (en) | 2017-07-07 | 2023-09-05 | Epicentrx, Inc. | Compositions and methods for parenteral administration of therapeutic agents |
CN112165937A (zh) | 2018-01-08 | 2021-01-01 | 埃皮辛特瑞柯斯公司 | 利用RRx-001进行辐射防护的方法和组合物 |
US11510901B2 (en) | 2018-01-08 | 2022-11-29 | Epicentrx, Inc. | Methods and compositions utilizing RRx-001 combination therapy for radioprotection |
US20210244870A1 (en) | 2018-06-11 | 2021-08-12 | Epicentrx, Inc. | Medication infusion devices, systems, and methods |
WO2021119433A1 (en) | 2019-12-11 | 2021-06-17 | Epicentrx, Inc. | Medication infusion devices, systems, and methods |
-
2006
- 2006-08-11 US US11/502,810 patent/US7507842B2/en active Active
- 2006-08-14 AU AU2006279589A patent/AU2006279589B8/en active Active
- 2006-08-14 KR KR1020117019133A patent/KR101226168B1/ko active IP Right Grant
- 2006-08-14 MX MX2008001983A patent/MX2008001983A/es active IP Right Grant
- 2006-08-14 CA CA2620612A patent/CA2620612C/en active Active
- 2006-08-14 EP EP06801575.9A patent/EP1924253B1/en active Active
- 2006-08-14 PT PT68015759T patent/PT1924253E/pt unknown
- 2006-08-14 JP JP2008526299A patent/JP5176063B2/ja active Active
- 2006-08-14 ES ES06801575.9T patent/ES2532457T3/es active Active
- 2006-08-14 WO PCT/US2006/031917 patent/WO2007022225A2/en active Application Filing
- 2006-08-14 KR KR1020087006018A patent/KR101220942B1/ko active IP Right Grant
- 2006-08-14 CN CN2006800382847A patent/CN101370492B/zh active Active
- 2006-08-14 DK DK06801575.9T patent/DK1924253T3/en active
-
2008
- 2008-02-11 IL IL189439A patent/IL189439A/en active IP Right Grant
- 2008-10-15 US US12/252,278 patent/US7745643B2/en active Active
-
2009
- 2009-03-04 US US12/397,651 patent/US8299053B2/en active Active
-
2010
- 2010-05-26 US US12/788,014 patent/US8178698B2/en active Active
-
2012
- 2012-03-26 IL IL218840A patent/IL218840A/en active IP Right Grant
- 2012-10-19 US US13/655,618 patent/US8927527B2/en active Active
-
2013
- 2013-09-12 IL IL228402A patent/IL228402A0/en active IP Right Grant
-
2014
- 2014-12-29 US US14/584,177 patent/US9226915B2/en active Active
-
2015
- 2015-12-10 US US14/965,062 patent/US10149832B2/en active Active
-
2017
- 2017-08-04 US US15/669,403 patent/US20180085346A1/en not_active Abandoned
-
2019
- 2019-03-14 US US16/353,047 patent/US20200046682A1/en not_active Abandoned
-
2021
- 2021-02-26 US US17/186,724 patent/US11925617B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5580988A (en) * | 1995-05-15 | 1996-12-03 | The United States Of America As Represented By The Secretary Of The Army | Substituted azetidines and processes of using them |
US6407236B1 (en) * | 1998-09-16 | 2002-06-18 | Medco Research, Inc. | Adenosine A3 receptor modulators |
US6245799B1 (en) * | 1999-11-08 | 2001-06-12 | American Home Products Corp | [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101370492B (zh) | 环状硝基化合物及其药物组合物和用途 | |
CN101687788A (zh) | 取代的吲哚 | |
KR20090023327A (ko) | O-니트로 화합물, 그의 약학적 조성물 및 그의 용도 | |
JP2010523694A (ja) | 高血圧治療のための置換重水素濃縮チオフェン | |
CN106565763B (zh) | pH敏感的轴向取代硅酞菁配合物及其制备方法和在医药上的应用 | |
CN101389219A (zh) | O-硝基化合物及其药物组合物和用途 | |
CN1791398B (zh) | 用gaba类似物的前药治疗或预防潮热 | |
AU2012203557B2 (en) | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof | |
CN116444447A (zh) | 一种sos1和hdac双靶点喹唑啉羟肟酸化合物及其制法和应用 | |
CN101528264A (zh) | 酚类阿片的受控释放 | |
JP2012520314A (ja) | 癌治療のためのインダゾリルアミノピロロトリアジンとタキサンの併用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: WESTWARD VENTURE CAPITAL INVESTMENT ORGANIZATION ( |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20110321 Address after: American Minnesota Applicant after: Atk Thiokol Propulsion Inc. Co-applicant after: Radi, AUX, Limited by Share Ltd turned west venture capital institutions Address before: American Minnesota Applicant before: Atk Thiokol Propulsion Inc. |
|
C56 | Change in the name or address of the patentee | ||
CP03 | Change of name, title or address |
Address after: Virginia Patentee after: ALLIANT TECHSYSTEMS INC Patentee after: Simpson Rx Limited by Share Ltd. Address before: American Minnesota Patentee before: Atk Thiokol Propulsion Inc. Patentee before: Radi, AUX, Limited by Share Ltd turned west venture capital institutions |