CN101363042B - 酶法检测糖化血红蛋白的试剂盒 - Google Patents
酶法检测糖化血红蛋白的试剂盒 Download PDFInfo
- Publication number
- CN101363042B CN101363042B CN2008101663266A CN200810166326A CN101363042B CN 101363042 B CN101363042 B CN 101363042B CN 2008101663266 A CN2008101663266 A CN 2008101663266A CN 200810166326 A CN200810166326 A CN 200810166326A CN 101363042 B CN101363042 B CN 101363042B
- Authority
- CN
- China
- Prior art keywords
- reagent
- hcl
- sodium salt
- test kit
- morpholino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 102000004190 Enzymes Human genes 0.000 title claims description 38
- 108090000790 Enzymes Proteins 0.000 title claims description 38
- 238000000034 method Methods 0.000 title claims description 28
- 102000017011 Glycated Hemoglobin A Human genes 0.000 title claims description 12
- 108010014663 Glycated Hemoglobin A Proteins 0.000 title claims description 12
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 35
- 238000012360 testing method Methods 0.000 claims abstract description 28
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 21
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract description 16
- 239000000872 buffer Substances 0.000 claims abstract description 14
- 238000006386 neutralization reaction Methods 0.000 claims abstract description 14
- -1 tetrazole sodium salt Chemical class 0.000 claims abstract description 14
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000004474 valine Substances 0.000 claims abstract description 13
- 206010018910 Haemolysis Diseases 0.000 claims abstract description 11
- 102000057297 Pepsin A Human genes 0.000 claims abstract description 11
- 108090000284 Pepsin A Proteins 0.000 claims abstract description 11
- 230000008588 hemolysis Effects 0.000 claims abstract description 11
- 229940111202 pepsin Drugs 0.000 claims abstract description 11
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims abstract description 10
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims abstract description 8
- SXGZJKUKBWWHRA-UHFFFAOYSA-N 2-(N-morpholiniumyl)ethanesulfonate Chemical compound [O-]S(=O)(=O)CC[NH+]1CCOCC1 SXGZJKUKBWWHRA-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229940088598 enzyme Drugs 0.000 claims description 37
- 229960002737 fructose Drugs 0.000 claims description 15
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 12
- 238000013016 damping Methods 0.000 claims description 12
- 239000012530 fluid Substances 0.000 claims description 12
- 230000001590 oxidative effect Effects 0.000 claims description 12
- 150000001413 amino acids Chemical group 0.000 claims description 10
- 102000003992 Peroxidases Human genes 0.000 claims description 9
- 108040007629 peroxidase activity proteins Proteins 0.000 claims description 9
- FSEBHBXGQQSYMW-UHFFFAOYSA-N 1-aminobutane-2-sulfonic acid Chemical compound CCC(CN)S(O)(=O)=O FSEBHBXGQQSYMW-UHFFFAOYSA-N 0.000 claims description 6
- DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 claims description 6
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 claims description 6
- GMINAVQFPSYEOF-UHFFFAOYSA-N [Na].C1(=CC=CC=C1)NC1=CC=CC=C1.CNC Chemical compound [Na].C1(=CC=CC=C1)NC1=CC=CC=C1.CNC GMINAVQFPSYEOF-UHFFFAOYSA-N 0.000 claims description 2
- AHIBWURJLGCHAY-UHFFFAOYSA-N [S].C1=CC=CC=C1 Chemical compound [S].C1=CC=CC=C1 AHIBWURJLGCHAY-UHFFFAOYSA-N 0.000 claims 2
- 159000000000 sodium salts Chemical class 0.000 claims 2
- 102000001554 Hemoglobins Human genes 0.000 abstract description 17
- 108010054147 Hemoglobins Proteins 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 10
- 229930091371 Fructose Natural products 0.000 abstract description 4
- 239000005715 Fructose Substances 0.000 abstract description 4
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 abstract 1
- NMILGIZTAZXMTM-UHFFFAOYSA-N 4-propylmorpholine Chemical compound CCCN1CCOCC1 NMILGIZTAZXMTM-UHFFFAOYSA-N 0.000 abstract 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- 102000004316 Oxidoreductases Human genes 0.000 abstract 1
- 108090000854 Oxidoreductases Proteins 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 235000011148 calcium chloride Nutrition 0.000 abstract 1
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 description 14
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 12
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- 102000005741 Metalloproteases Human genes 0.000 description 7
- 108010006035 Metalloproteases Proteins 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
- 108091005996 glycated proteins Proteins 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 230000035772 mutation Effects 0.000 description 6
- 235000001014 amino acid Nutrition 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 5
- 241000745841 Arthrobacter sp. 2-4-1 Species 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 4
- 238000006460 hydrolysis reaction Methods 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 241000186216 Corynebacterium Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000012408 PCR amplification Methods 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 238000006479 redox reaction Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 108010033276 Peptide Fragments Proteins 0.000 description 2
- 102000007079 Peptide Fragments Human genes 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000002797 proteolythic effect Effects 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- ZTQGWROHRVYSPW-UHFFFAOYSA-N 3-(n-ethyl-3-methylanilino)-2-hydroxypropane-1-sulfonic acid Chemical compound OS(=O)(=O)CC(O)CN(CC)C1=CC=CC(C)=C1 ZTQGWROHRVYSPW-UHFFFAOYSA-N 0.000 description 1
- 102000004400 Aminopeptidases Human genes 0.000 description 1
- 108090000915 Aminopeptidases Proteins 0.000 description 1
- 102000035101 Aspartic proteases Human genes 0.000 description 1
- 108091005502 Aspartic proteases Proteins 0.000 description 1
- 238000009010 Bradford assay Methods 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 108010067770 Endopeptidase K Proteins 0.000 description 1
- 102000010750 Metalloproteins Human genes 0.000 description 1
- 108010063312 Metalloproteins Proteins 0.000 description 1
- 108090000787 Subtilisin Proteins 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 description 1
- SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 description 1
- RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 1
- HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 description 1
- NHVNXKFIZYSCEB-XLPZGREQSA-N dTTP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C1 NHVNXKFIZYSCEB-XLPZGREQSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000007824 enzymatic assay Methods 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229940049547 paraxin Drugs 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 230000009465 prokaryotic expression Effects 0.000 description 1
- 238000002331 protein detection Methods 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
HPLC法(%) | 2.9 | 4.0 | 5.2 | 6.0 | 6.9 | 7.9 | 9.1 | 10.1 | 10.9 | 12.1 | 13.2 |
本发明试剂盒(%) | 3.1 | 4.1 | 5.1 | 5.9 | 7.0 | 8.2 | 9.1 | 10.0 | 10.8 | 12.0 | 13.2 |
金属蛋白酶试剂盒(%) | 2.8 | 3.8 | 4.9 | 6.1 | 7.3 | 7.9 | 8.9 | 9.8 | 11.2 | 11.7 | 13.4 |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008101663266A CN101363042B (zh) | 2008-09-23 | 2008-09-23 | 酶法检测糖化血红蛋白的试剂盒 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008101663266A CN101363042B (zh) | 2008-09-23 | 2008-09-23 | 酶法检测糖化血红蛋白的试剂盒 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101363042A CN101363042A (zh) | 2009-02-11 |
CN101363042B true CN101363042B (zh) | 2011-03-23 |
Family
ID=40389645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008101663266A Active CN101363042B (zh) | 2008-09-23 | 2008-09-23 | 酶法检测糖化血红蛋白的试剂盒 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101363042B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102043043A (zh) * | 2010-12-10 | 2011-05-04 | 张会生 | 一种多项目生化检验分析集成试剂盒及其方法 |
CN102692411B (zh) * | 2012-06-08 | 2016-12-14 | 上海蓝怡科技股份有限公司 | 一种测定糖化血红蛋白百分比的试剂 |
CN110023503A (zh) * | 2016-11-30 | 2019-07-16 | 东洋纺株式会社 | 血红蛋白的糖化率测定方法 |
CN107164456A (zh) * | 2017-06-22 | 2017-09-15 | 美康生物科技股份有限公司 | 糖化血红蛋白在线溶血酶法检测试剂盒 |
CN113075143B (zh) * | 2021-03-31 | 2023-01-03 | 奥研生物科技(南京)有限公司 | 一种糖化血红蛋白检测试剂及其检测方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1161374A (zh) * | 1996-04-03 | 1997-10-08 | 株式会社京都第一科学 | 果糖氨基酸氧化酶及其生产方法 |
-
2008
- 2008-09-23 CN CN2008101663266A patent/CN101363042B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1161374A (zh) * | 1996-04-03 | 1997-10-08 | 株式会社京都第一科学 | 果糖氨基酸氧化酶及其生产方法 |
Non-Patent Citations (2)
Title |
---|
GenBank.BAB91123.1,AB073548.1.《GenBank》.2003, * |
Sakurabayashi I, et al..New Enzymatic Assay for Glycohemoglobin.《Clinical Chemistry》.2003,第49卷(第2期),269-274. * |
Also Published As
Publication number | Publication date |
---|---|
CN101363042A (zh) | 2009-02-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7588910B2 (en) | Hemoglobin A1c determination method, enzyme to be used therefor, and production method thereof | |
CN101363042B (zh) | 酶法检测糖化血红蛋白的试剂盒 | |
CN101426911B (zh) | 具有对底物提高的亲和性的修饰的肌酸酐酰胺水解酶,和用于测定肌酸酐的试剂组合物 | |
CN101358229B (zh) | 糖化血红蛋白酶法检测试剂盒 | |
JPH08154672A (ja) | フルクトシルアミノ酸オキシダーゼ及びその製造方法 | |
AU710652B2 (en) | Materials and methods for detection of oxalate | |
CN110044881B (zh) | 一种酶法测定肌酐的检测试剂盒及其使用方法 | |
CN103091498A (zh) | 植物体外泛素蛋白降解系统及其应用 | |
CN109082419A (zh) | 一种3α-羟基类固醇脱氢酶突变体、编码核苷酸序列及试剂盒 | |
CN108949729B (zh) | 一种经热稳定性改造的角蛋白酶突变体 | |
CN101698834A (zh) | 3α-羟基类固醇脱氢酶及其核苷酸序列、重组载体、重组宿主细胞和试剂盒 | |
CN109706130A (zh) | 果糖基氨基酸氧化酶突变体、检测试剂盒及检测方法 | |
CN102559624B (zh) | 一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法 | |
CN109554376B (zh) | 一种碱性尿酸氧化酶及其在检测试剂盒和降低食品中尿酸的应用 | |
CN101368174B (zh) | 高活性果糖缬氨酸氧化酶 | |
EP0201333B1 (en) | Reagent for measuring amylase activity and measuring method thereof | |
JPWO2018052005A1 (ja) | 改変型ザルコシンオキシダーゼ並びにその遺伝子及び製造法 | |
CN105734027B (zh) | 一种黄嘌呤脱氢酶及其编码基因与应用 | |
CN108517348B (zh) | 一种基于dna的可视化检测碱性磷酸酶的试剂盒 | |
CN105331590A (zh) | 葡萄糖特异性改善的可溶性吡咯喹啉醌依赖性葡萄糖脱氢酶突变体、聚核苷酸及其应用 | |
JP4890133B2 (ja) | 安定な尿酸測定試薬 | |
CA2516029A1 (en) | Method of measuring homocysteine | |
CN108982885B (zh) | 一种测定血清中α-淀粉酶的试剂盒 | |
CN111455018B (zh) | 含有枯草芽孢杆菌漆酶的直接胆红素检测试剂盒 | |
WO2007038568A1 (en) | Methods for detection of fungal disease |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Zou Bingde Inventor before: Zou Bingde Inventor before: Jiang Yunfei |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZOU BINGDE JIANG YUNFEI TO: ZOU BINGDE |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: NINGBO MEDICAL SYSTEM BIOTECHNOLOGY CO., LTD. Free format text: FORMER NAME: MEIKANG BIOTECH CO., LTD., NINGBO |
|
CP01 | Change in the name or title of a patent holder |
Address after: 315100 Ningbo science and technology zone, Yinzhou City, Zhejiang, Ma Ma Industrial Park Road, No. 358 Patentee after: NINGBO MEDICAL SYSTEM BIOTECHNOLOGY Co.,Ltd. Address before: 315100 Ningbo science and technology zone, Yinzhou City, Zhejiang, Ma Ma Industrial Park Road, No. 358 Patentee before: Ningbo Medical System Biotechnology Co.,Ltd. |
|
CP03 | Change of name, title or address |
Address after: 315104 Zhejiang city of Ningbo province Yinzhou District Qiming Road No. 299 Patentee after: MEDICAL SYSTEM BIOTECHNOLOGY Co.,Ltd. Address before: 315100 Ningbo science and technology zone, Yinzhou City, Zhejiang, Ma Ma Industrial Park Road, No. 358 Patentee before: NINGBO MEDICAL SYSTEM BIOTECHNOLOGY Co.,Ltd. |
|
CP03 | Change of name, title or address | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20090211 Assignee: Ningbo Shengyuan Biotechnology Co., Ltd. Assignor: MEDICAL SYSTEM BIOTECHNOLOGY Co.,Ltd. Contract record no.: X2022330000361 Denomination of invention: Kit for Enzymatic Detection of Glycated Hemoglobin Granted publication date: 20110323 License type: Common License Record date: 20220809 |
|
EE01 | Entry into force of recordation of patent licensing contract |