CN101347569B

CN101347569B - Chinese medicine preparation for treating bronchial asthma

Info

Publication number: CN101347569B
Application number: CN2008101507605A
Authority: CN
Inventors: 杨军岭; 吕玉东
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-08-22
Filing date: 2008-08-22
Publication date: 2011-06-08
Anticipated expiration: 2028-08-22
Also published as: CN101347569A

Abstract

The invention relates to a traditional Chinese medicine preparation for treating bronchial asthma, which is prepared by raw materials of traditional Chinese medicine according to the following parts by weight: 10-15 parts of marsdenia tenacissima, 10-15 parts of airpotato yam, 8-12 parts of toad, 4-8 parts of white pepper, 4-8 parts of tuber pinellia, 4-6 parts of dried orange peel, 13-18 parts of adenophora elata, 7-11 parts of almond, 7-11 parts of Chinese ephedra, 10-15 parts of mulberry leaf, 10-14 parts of glossy ganoderma, and 13-18 parts of epimedium herb. The invention can be used for inhibiting the inflammation of air passages so as to reduce high reactivity of air passages, increasing the nonspecific immunity of an organism, gradually improving pulmonary function, and improving microcirculation. Therefore, the goals of long-term remission and symptom removal are achieved.

Description

The Chinese medicine preparation of treatment bronchial asthma

Technical field

The invention belongs to the pharmaceutical product technical field, particularly is the Chinese medicine preparation of raw material with the natural Chinese medicinal herb.

Background technology

Bronchial asthma (bronchial asthma) is the air flue chronic inflammation disease that is participated in by various kinds of cell (as eosinophilic granulocyte, mastocyte, T lymphocyte, neutrophil cell, airway epithelia cell) and cell blood system, cause airway hyperreactivity to increase, cause repeatedly symptoms such as the panting of outbreak, out of breath, uncomfortable in chest or cough, night or the early morning outbreak of being everlasting aggravates, and occurs extensively changeable reversibility flow limitation usually.This disease has the course of disease and grows, shows effect repeatedly, delays the difficult characteristics that heal.But most of patients spontaneous remission or alleviate through treatment.Primary disease developed country is with fastest developing speed, and American-European countries accounts for 10%, and the Asia accounts for 5%, and China's number of patients 2～3,000 ten thousand people is one of maximum medical care problems of the crowd of getting involved.Prevalence and mortality rate rise always, and child's sickness rate is higher than the adult, and after being ill the adult delay work, student's mistake class, now become world's problem, common problem.Though controlling symptoms is not so difficult for the moment in the treatment, does not still have specific Therapeutic Method at present, key is to prevent recurrence.

Summary of the invention

The object of the invention provides a kind of Chinese medicine preparation for the treatment of bronchial asthma.

Bronchial asthma is clinical common type i allergic reaction (allergy) sexually transmitted disease (STD) card, in the visible multiple acute and chronic diseases." bronchial wheezing ", " breathing heavily disease " of being equivalent to Chinese medicine.Primary disease is a retained phlegm volt lung, and because of exopathogen, diet, feelings will, overstrain factor cause stagnation of QI causing phlegm retention, the air flue contraction is anxious narrow and fall ill.Pathological factor is based on expectorant.Red small stream cloud: " bronchial wheezing is specially main in expectorant ".Asthma one card, Chang Yinfu feels exopathogen and outbreak repeatedly, and through multiple Chinese and western drugs treatment, disease feelings complexity.But in the whole course of disease, exopathogen, phlegm retention, deficiency of both the lung and kidney are the three elements of its pathological change, and deficiency in origin and excess in superficiality is a principal contradiction, so must differential diagnosis of diseases combine with dialectical in treatment, negative and positive are taken into account, and the kidney warming is not forgotten tonifying the lung, consolidates to take into account to take stopgap measures.

Based on these understanding, the present invention has mainly chosen the Rhizoma Pinelliae, Pericarpium Citri Reticulatae eliminates the phlegm and reduces phlegm; Caulis Marsdeniae Tenacissimae, Semen Armeniacae Amarum, Ganoderma come relieving cough and asthma; Adopt Radix Adenophorae (Radix Glehniae), Radix orixae japonicae nourishing the lung to arrest cough, the promoting the circulation of QI to relieve pain of main lung.Therefore, a kind of Chinese medicine preparation for the treatment of bronchial asthma, it is to make with the raw material of Chinese medicine of following weight parts:

Caulis Marsdeniae Tenacissimae 10-15, Rhizoma Dioscoreae Bulbiferae 10-15, Radix orixae japonicae 4-8, Bufo siccus 8-12, Rhizoma Pinelliae 4-8, Pericarpium Citri Reticulatae 4-6, Radix Adenophorae (Radix Glehniae) 13-18, Semen Armeniacae Amarum 7-11, Herba Ephedrae 7-11, Folium Mori 10-15, Ganoderma 10-14, Herba Epimedii 13-18.

The preferential prescription of recommending of the present invention is: Caulis Marsdeniae Tenacissimae 13, Rhizoma Dioscoreae Bulbiferae 13, Bufo siccus 8, Radix orixae japonicae 6, the Rhizoma Pinelliae 6, Pericarpium Citri Reticulatae 5, Radix Adenophorae (Radix Glehniae) 15, Semen Armeniacae Amarum 9, Herba Ephedrae 9, Folium Mori 13, Ganoderma 12, Herba Epimedii 15.

Bufo siccus is only used its kindred powder among the present invention, and concrete concocting method is after Bufo siccus removes internal organs and crust, with the calcining of yellow mud sealing people fire, dry back porphyrize powder.

The present invention treats Analysis on Mechanism:

Caulis Marsdeniae Tenacissimae-anticancer dispersing, relieving cough and asthma

Rhizoma Dioscoreae Bulbiferae-toxin expelling softening the hard mass, cooling blood for hemostasis, relieving cough and asthma

Bufo siccus-1 (removing internal organs and crust) is used the yellow mud sealing, goes into after fire forges, and grinds each 3 grams into powder.

Radix orixae japonicae-warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain

The Rhizoma Pinelliae-removing dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI

Pericarpium Citri Reticulatae-drying dampness to eliminate phlegm, regulating qi-flowing for strengthening spleen

Radix Adenophorae (Radix Glehniae)-nourishing the lung to arrest cough, nourishing the stomach to promote the production of body fluid

Semen Armeniacae Amarum-relieving cough and asthma, loosening bowel to relieve constipation

Herba Ephedrae-diaphoresis row table, depressed lung-energy dispersing, diuretic detumescent

Folium Mori-dispelling wind and heat pathogens, clearing away lung-heat to relieve cough, suppressing the hyperactive liver makes eye bright

Ganoderma-invigorating QI and tranquilization, relieving cough and asthma

Herba Epimedii-kidney invigorating and YANG supporting, expelling wind and removing dampness, blood pressure lowering, eliminates the phlegm, relievings asthma at antitussive

The present invention can suppress airway inflammation and reduce airway hyperreactivity, improves the body non-specific immunity, improves pulmonary function gradually, microcirculation improvement and reach long-term remission and even symptomatolytic purpose.

The specific embodiment

Prescription 1: Caulis Marsdeniae Tenacissimae 15, Rhizoma Dioscoreae Bulbiferae 10, Bufo siccus 8, Radix orixae japonicae 8, the Rhizoma Pinelliae 4, Pericarpium Citri Reticulatae 6, Radix Adenophorae (Radix Glehniae) 13, Semen Armeniacae Amarum 11, Herba Ephedrae 7, Folium Mori 15, Ganoderma 10, Herba Epimedii 18.

Prescription 2: Caulis Marsdeniae Tenacissimae 13, Rhizoma Dioscoreae Bulbiferae 13, Bufo siccus 10, Radix orixae japonicae 6, the Rhizoma Pinelliae 6, Pericarpium Citri Reticulatae 5, Radix Adenophorae (Radix Glehniae) 15, Semen Armeniacae Amarum 9, Herba Ephedrae 9, Folium Mori 13, Ganoderma 12, Herba Epimedii 15.

Prescription 3: Caulis Marsdeniae Tenacissimae 10, Rhizoma Dioscoreae Bulbiferae 15, Bufo siccus 12, Radix orixae japonicae 4, the Rhizoma Pinelliae 8, Pericarpium Citri Reticulatae 4, Radix Adenophorae (Radix Glehniae) 18, Semen Armeniacae Amarum 7, Herba Ephedrae 11, Folium Mori 10, Ganoderma 14, Herba Epimedii 13.

Preparation method: Bufo siccus is only used its kindred powder, and concrete concocting method is after Bufo siccus removes internal organs and crust, goes into the fire calcining with the yellow mud sealing, makes the encapsulated back of the above fine powder of 100 orders irradiation sterilization after dry back porphyrize powder and all the other medicament mixed of above-mentioned prescription and gets final product.

Take 20-30 gram every day, divide three to take inferior to early, middle and late warm water.

Drug therapy bronchial asthma 132 routine data of the present invention are as follows

1 clinical data

1.1 physical data

This is organized 132 routine patients and all comes the self-gate people that diagnoses a disease, wherein male 78 examples, women 54 examples; Minimum 12 years old of age, maximum 68 years old; The course of disease is the shortest 1 year, and is the longest 5 years.The patient all is X and checks other pathological changes of eliminating before treatment.

1.2 diagnostic criteria

" prevention and control of bronchial asthma guide " with reference to pneumatology branch of Chinese Medical Association whole nation asthma meeting (Qingdao) proposition for the second time in 1997.

1.3 analytical standard

1. acute attack stage: tachypnea, cough, symptom such as uncomfortable in chest take place suddenly, and dyspnea is often arranged.2. catabasis: disappear through treatment or untreated symptom, sign, pulmonary function returns to level before the acute attack, and keeps more than 4 weeks.

1.4 the standard of including in

1. meet genus " asthma of cold-type disease " diagnostic criteria of " bronchial asthma " Western medicine diagnose and the traditional Chinese medical science " heavy breathing disease " catabasis and stage of attack; 2. acute attack stage belongs to light, moderate person, and non-acute attack stage belongs to intermittent and light, moderate person; 3. the person that do not use the adrenocortical hormone in 4 weeks; 4. age more than 10 years old, person below 70 years old.

1.5 exclusion standard

1. the age is less than 10 years old, greater than 70 years old; 2. use the adrenocortical hormone person in 4 weeks; 3. merge disease patients such as severe cardiac, cerebrovascular, liver, kidney, hemopoietic system; 4. the status asthmaticus or the state of an illness are divided into severe, critical person; 5. anemia of pregnant woman, mass formed by blood stasis, heating, skin are to the responsive especially person of medicine.

2 Therapeutic Method

Obey 30 grams every day asthma attack phase, divide three respectively to obey 1 time inferior to early, middle and late, serveing on 7 days is 1 course of treatment; Asthma is alleviated the back and is done to consolidate curative effect or send out well and make prevention usefulness season, the next day clothes 1 day, serve on 7 days and be 1 and consolidate the course of treatment.

3 therapeutic outcomes

3.1 criterion of therapeutical effect is formulated according to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " asthma efficacy assessment standard.Asthma control, wheezing sound disappears, and observes and does not see that recurrence was for curing in 1 year; Asthma is alleviated, or attack times is reduced to improvement; The symptom no change is not for healing.

3.2 therapeutic outcome: after this was organized 132 routine patients and takes we, curative effect was good: clinical cure 86 examples, and 41 examples that take a turn for the better, 11 examples more, total effective rate is 91.7%.

3.3 the model case woman 51 years old, is engaged in agriculture.Have surplus the asthma medical history 10 year, through not good with multiple Chinese and western drugs therapeutic effect, and attack times increases year by year.Recently bring out first visit because of suffering from cold after the fatigue again: rapid breathing, wheezing sound is arranged in the larynx, moving then pant more even opening mouth and lifting shoulder due to dyspnea, abundant expectoration color white matter is rare, and xerostomia is the desire drink not, and is uncomfortable in chest, is hard and dry the aversion to wind fear of cold.Check: emaciated physique, pale complexion, lip cyanosis, barrel chest, two lung wheezing sounds, T36.5 ℃, HR90 time/min, rule is neat, and body of the tongue is fat slightly, and there is indentation on the limit, white and thin fur, deep,thready and rapid pulse, the X-ray Chest X-rays prompts for " chronic bronchitis ", " emphysema ".Determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs: in patient's year seventy-seven, menses gradually exhausts, and kidney qi declines, prolonged illness in addition, and kidney is taken the photograph to receive and is had no right, and the gasification dereliction of duty wetly gathers into expectorant, sends out with abnormal rising of lung-QI be asthma, and controlling should the kidney warming lung benefiting, resolving phlegm and relieving asthma, controls it above throwing then.Through obeying three days, breathe heavily gesture decrescence, stool is logical, and two lung wheezing sounds also reduce.Serve on 1 course of treatment, asthma must be put down, and surplus disease is also removed, and it is normal that spirit, diet and two just all recover.

Claims

1. Chinese medicine preparation for the treatment of bronchial asthma is characterized in that forming with the raw material of Chinese medicine of following weight parts:

Caulis Marsdeniae Tenacissimae 10-15, Rhizoma Dioscoreae Bulbiferae 10-15, Bufo siccus 8-12, Radix orixae japonicae 4-8, Rhizoma Pinelliae 4-8, Pericarpium Citri Reticulatae 4-6, Radix Adenophorae (Radix Glehniae) 13-18, Semen Armeniacae Amarum 7-11, Herba Ephedrae 7-11, Folium Mori 10-15, Ganoderma 10-14, Herba Epimedii 13-18.

2. a kind of Chinese medicine preparation for the treatment of bronchial asthma according to claim 1 is characterized in that forming with the raw material of Chinese medicine of following weight parts:

Caulis Marsdeniae Tenacissimae 13, Rhizoma Dioscoreae Bulbiferae 13, Bufo siccus 8, Radix orixae japonicae 6, the Rhizoma Pinelliae 6, Pericarpium Citri Reticulatae 5, Radix Adenophorae (Radix Glehniae) 15, Semen Armeniacae Amarum 9, Herba Ephedrae 9, Folium Mori 13, Ganoderma 12, Herba Epimedii 15.

3. a kind of Chinese medicine preparation for the treatment of bronchial asthma according to claim 1 and 2 is characterized in that Bufo siccus only uses its kindred powder, and concrete concocting method is after Bufo siccus removes internal organs and crust, use the yellow mud sealing, puts the fire calcining into, dry after the porphyrize powder.