CN101334405A - Biological chips sample application platform - Google Patents
Biological chips sample application platform Download PDFInfo
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- CN101334405A CN101334405A CNA2007100426625A CN200710042662A CN101334405A CN 101334405 A CN101334405 A CN 101334405A CN A2007100426625 A CNA2007100426625 A CN A2007100426625A CN 200710042662 A CN200710042662 A CN 200710042662A CN 101334405 A CN101334405 A CN 101334405A
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Abstract
The invention discloses a biochip spotting platform which relates to the preparation of a microarray biochip. The biochip spotting platform mainly utilizes a precision linear motor which can carry out the high-speed motion for constituting a three-dimensional distribution mechanical hand, and simultaneously comprises a spotting head with 1 to 48 spotting needles, a chip fixed platform, a sample box platform and a spotting needle cleaning and drying device are arranged on a working platform with the water bath cooling function, an electric control box and the distribution mechanical hand are operated under the control of software of a computer, thereby rapidly completing the spotting and finally forming the complete biochip. The spotting platform is characterized by compact structure, simple and convenient operation, high speed, efficiency and precision, less cross-infection and broad applicability, etc., thereby being very applicable to the scale production of the biochips and also being applicable to scientific research and applications.
Description
Technical field
The present invention relates to the preparation of micro-array biochip, more precisely, relate to the quick sample application platform of a kind of many indexs, many person-portions parallel detection usefulness micro-array biochip.
Background technology
The method of existing several biochip preparations can be divided into two big classes basically: a class is original position synthetic (promptly at a support surface direct in-situ synthetic oligonucleotide probe); One class is a directly point sample of pre-synthetic back, and minim DNA solution is directly put and is solidificated on the chip carrier with the form point of microarray.Because in-situ synthetic method is very complicated, so most dna microarray chip all is to adopt synthetic point sample method.And the preparation of protein chip, because the restriction of method all is the method preparation of adopting synthetic earlier back point sample.Synthetic point sample method is with after, the quantitative test purified by the synthetic good probe of liquid phase chemical in advance, by the microarray sample application platform, accurately and rapidly with the quantitative point sample of different probe sample on relevant positions such as positively charged nylon membrane or silicon chip, promptly obtain dna microarray or protein chip after the curing.The mode of point sample is divided two kinds, and one is the contact point sample, and promptly spotting needle directly contacts with the solid support surface, and sample is stayed on the solid support; It two is contactless point sample, i.e. specking, and it is with piezoelectric principle or micro-solenoid valve break-make principle sample directly to be sprayed onto the solid support surface by kapillary.A lot of company both domestic and external and scientific research institution have successively developed the various biochip point sample instruments of characteristic separately that have.
Prior biological chip point sample instrument, mainly be divided into two kinds: a kind of is small-sized point sample instrument towards individual, laboratory and hospital, its flexible operation, can satisfy the point sample requirement of various personalizations, and it is cheap, but point sample efficient is lower, and precision and job stability are relatively poor, is applicable to scientific research and other simple application.Another kind provides the large-scale workstation to biochip manufacturer or professional research institution, these equipment adopt accurate automatically controlled platform to form mechanical arm more, kinematic accuracy, point sample efficient and job stability all are significantly improved, but its price is high, so this kind equipment is applicable to biochip manufacturer or professional research institution with certain strength and furthers investigate and produce, and this kind equipment mostly is import equipment, because it costs an arm and a leg, the consumables cost height is not suitable for promoting at home.In addition, biochip point sample equipment all is to be designed to probe points on rigid carriers such as slide mostly at present, and is seldom a bit on flexible carriers such as film, more single towards point sample matrix.
But development along with biochip technology, the increase in demand of biochip, requirement to biochip point sample instrument also further improves, the direction higher to precision, that speed is faster, efficient is higher, applicability is wider develops, and prior biological chip point sample instrument can't satisfy the needs that this quick maximization is produced at present.Meanwhile, along with progress of science and technology, developing rapidly of other correlation technique but provides better technical support for the biochip preparation, such as in the movement control technology more at a high speed, the invention of precision linear motor that precision is higher, will inevitably bring the revolution in the biochip point sample technology.
Summary of the invention
The purpose of this invention is to provide a kind of micro-array biochip and prepare platform fast, can overcome the deficiency of above-mentioned technology, provide a kind of high precision, rapidly and efficiently, modularization, multiple functional, compact conformation, can be applied to many indexs, many person-portions detect the production preparation with micro-array biochip.Characteristics such as that the present invention has is easy and simple to handle, speed is fast, efficient is high, precision is high, applicability is wide, be not only applicable to the preparation of laboratory and hospital research with biochip, and be applicable to the biochip large-scale production of biochip manufacturer, can accelerate extensive popularization and the development at home of biochip technology industry.
Technical scheme of the present invention is as follows:
A kind of biological chips sample application platform is made up of workbench, three-dimensional distribution manipulator, sampling head, chip stationary platform, sample box platform, spotting needle clearing and drying device, electric cabinet, computing machine; Wherein three-dimensional distribution manipulator, chip stationary platform, sample box platform, spotting needle ultrasonic cleaning drying device all are fixed on the workbench, and sampling head is fixed or is connected on the three-dimensional distribution manipulator; Connect by data line between three-dimensional distribution manipulator, sampling head, spotting needle clearing and drying device, electric cabinet and the computing machine and be subjected to computer software control.
Described three-dimensional distribution manipulator is combined by X-axis, Y-axis and Z axle, as a kind of improvement of the present invention, wherein X-axis, Y-axis are made up by precision linear motor (or claiming linear motor), and wherein Z axle motion platform can be linear electric machine, also can be common electrical control translation stage.Precision linear motor (or claiming linear motor) has accurate scrambler and feeds back, and forms closed loop control.Described three-dimensional distribution manipulator can be planer type structure---be the X-axis linear electric machine is directly installed on the base, comprise two parallel guide rail and drive motor, the Y-axis linear electric machine is a font and is installed on the X-axis, Z axle motion platform is connected on the Y-axis linear electric machine, and sampling head is installed on the Z axle; The formula of also can hanging down for falling---be the X-axis linear electric machine by strut support in the base sky, the Y-axis linear electric machine is directly installed on the X-axis, Z axle motion platform is connected on the Y-axis linear electric machine then, sampling head is installed on the Z axle.
As another kind of improvement the of the present invention, the chip stationary platform comprises slide stationary platform, standard porous plate stationary platform and three kinds of platforms of film chip stationary platform, the slide stationary platform is made up of microslide supporting plate, the handwheel that is installed, slide making leaf spring etc., slide is installed groove on the microslide supporting plate, cooperate the slide making leaf spring to be used for the slide that is installed, and standard porous plate stationary platform and film chip stationary platform are the parallel-plate with some grooves, the standard that can be installed porous plate, film chip etc.Described slide stationary platform, standard porous plate stationary platform and film chip stationary platform be designed to a plurality of installation dimensions identical can mutual alternative module, can mode for convenience detach be fixed on the workbench by draw-in groove or screw etc., can take off and put from workbench easily, position by the locating piece on the workbench.Can from sample application platform, take out during operation, put into sample application platform again after outside equipment, putting all slides.
As another kind of improvement the of the present invention, described spotting needle clearing and drying device comprises thick washing trough, fine purifiation groove and air-dry groove, thick washing trough and fine purifiation groove are placed with mobile cleaning fluid, thick washing trough and fine purifiation trench bottom are equipped with ultrasonic generator, utilize its " cavitation " effect to strengthen cleaning, spotting needle is put into thick washing trough, the most of residual sample of eccysis earlier, and then put into the fine purifiation groove, further wash obstinate residue, then to the air-dry spotting needle of air-dry groove, dry run is finished through near the keen draft the spotting needle needle point by quick.
Described workbench is highly smooth flat board, and the circuitous airtight pipeline of hollow is arranged in the flat board, is full of mobile liquid coolant in the pipeline, and is connected to cooling tank by 2～8 interfaces and connecting pipe, by cooling tank the liquid coolant in the pipeline is carried out temperature control.
Described computer-controlled program design a model be control XYZ three-dimensional mechanical hand, control point sample pipe system point sample action, control point sample number with can on identical point, repeat.
As one of improvement of the present invention, used the assembly of linear electric machine as three-dimensional distribution manipulator, so also just introduced the advantage of a lot of linear electric machines: miniaturization Design, requisite space is little; High acceleration, high translational speed; Accuracy is high and the location is quick; It is smooth-going to move; The fiduciary level height; No frictional dissipation; Durable use; Do not need to proofread and correct; Safeguard simple.
Compare with present existing products, major advantage of the present invention is:
1) speed is fast.Because the acceleration of linear electric machine can be up to 50m/s
2So, just speed can be risen to setting speed instantaneous, and itself the highest speed can be that the ball screw kind of drive that tradition is used in the existing point sample instrument is beyond one's reach just up to 3m/s.
2) efficient height.Because during move the position that the time of the overwhelming majority is used in distribution manipulator in the process of micro-array biochip point sample, and the high acceleration of linear electric machine and Ke Da high speed performance make the time of its position mobile phase same distance shorten greatly, and point sample efficient improves greatly.The chip stationary platform of being convenient to pick and place can be carried out slide and be put and put into sample application platform again outside point sample equipment, broken existing equipment is put slide successively in workbench operator scheme, put into sample application platform again even when the point sample equipment work, can also outside equipment, put slide, avoided putting the problem that slide takies the point sample equipment task time.
3) precision height.The repetitive positioning accuracy of the ball screw kind of drive that tradition is used in the existing point sample instrument is generally all greater than 10um, and the repetitive positioning accuracy of linear electric machine can cooperate high-precision digital optics chi again up to 2um, can reach higher precision.And do not have frictional dissipation in its operational process, avoided because the error that mechanical wear is brought in the long-play process.
4) compact conformation.Because linear electric machine adopts the mode that directly drives, can reduce the number of parts of positioning system, with three-dimensional distribution manipulator miniaturization, can save more space like this and give workbench, and the modular design of chip stationary platform for changing, not only be suitable for more chip matrix, also make the utilization factor of workbench higher.
5) applicability is wide.Chip stationary platform in this sample application platform comprises the platform that two kinds of film chip stationary platform, standard porous plate stationary platform and slide stationary platforms can mutual alternative, applicable multiple point sample matrix, can be membrane matrixs such as one or more nylon membrane or nitrocellulose membrane, also can be rigid matrixs such as one or more slides, can also be one or more standard porous plate.
6) cross pollution is few.Spotting needle clearing and drying device described in the present invention comprises thick washing trough, fine purifiation groove and air-dry groove, not only overall process employing ultrasonic cleaning, and twice cleaning all is to adopt the cleansing solution that flows to clean, and cooperates air-dry removal raffinate again, improve the efficient of cleaning greatly, reduced cross pollution.
7) cost of instrument itself is low.An external cover instrument price is generally the hundreds of thousands dollar, and the cost instrument hundreds of thousands of this equipment yuan, but its point sample efficient is to be equivalent to many cover overseas equipments, its cost performance is obviously high.
In a word, this sample application platform has compact conformation, easy and simple to handle, characteristics such as speed is fast, efficient is high, precision is high, cross pollution is few, applicability is wide, be not only applicable to the preparation of laboratory and hospital research, and be applicable to the biochip large-scale production of biochip manufacturer with biochip.
Description of drawings
Figure .1 is the schematic three dimensional views of an embodiment of biological chips sample application platform of the present invention;
Figure .2 is the last apparent direction synoptic diagram of an embodiment of biological chips sample application platform described in the present invention;
Figure .3 is a synoptic diagram of going up apparent direction when the slide stationary platform installs slide and compresses slide in the embodiment of the invention;
Figure .4 is that the slide stationary platform installs slide and unclamps schematic three dimensional views in the time of can picking and placeing slide in the embodiment of the invention;
Figure .5 is the schematic three dimensional views when 96 hole on-gauge plate stationary platforms install 96 hole on-gauge plates in the embodiment of the invention;
Figure .6 is the schematic three dimensional views when 48 pore membrane chip stationary platforms install 48 pore membrane chips in the embodiment of the invention;
Figure .7 is the last apparent direction synoptic diagram of spotting needle clearing and drying device in the embodiment of the invention.
Wherein, (1) is X-axis precision linear motor; (2) be cooling tank; (3) be Y-axis precision linear motor; (4) be the accurate automatically controlled mobile platform of Z axle, also can be the precision linear motor; (5) for 1～48 sampling head with spotting needle can be installed; (6) be the slide stationary platform; (7) be a buffering liquid groove; (8) be No. two buffering liquid grooves; (9) be the spotting needle clearing and drying device; (10) be the sample box platform; (11) be sample panel; (12) be workbench; (13) be the evaluation filming apparatus; (14) be the point sample instrument base; (15) be electric cabinet; (16) be adjustable pulley pin group; (17) be the standard slide; (18) be the slide supporting plate; (19) be the slide making leaf spring for the handwheel that is installed, (20); (21) be the standard porous plate; (22) be standard porous plate stationary platform; (23) be 48 pore membrane chips; (24) be 48 pore membrane chip stationary platforms; (25) be the negative pressure outlet of spotting needle clearing and drying device; (26) be an inlet of spotting needle clearing and drying device; (27) be No. two inlets of spotting needle clearing and drying device; (28) be the air-dry dividing plate of spotting needle clearing and drying device; (29) be the fine purifiation groove of spotting needle clearing and drying device, (30) are the thick washing trough of spotting needle clearing and drying device; (31) ultrasonic generator of spotting needle clearing and drying device; (3) 2 is the liquid outlet of spotting needle clearing and drying device.
Embodiment
The present invention is further described below in conjunction with drawings and Examples:
As depicted in figs. 1 and 2, a kind of biological chips sample application platform of the present invention, comprise base (14), be installed in the workbench (12) on the base (14), with the three-dimensional distribution manipulator that precision linear motor (1) and (3) and accurate electronic control translation stage (4) are combined into, has the sampling head (5) of 1～48 spotting needle.Described base (14) can directly be put on the table by adjustable support foot, also can be placed on the ground by support and adjustable pulley pin group (16).Described workbench (12) is provided with chip stationary platform (6), buffering liquid groove (7) and (8), sample box platform (10), spotting needle clearing and drying device (9) and evaluation filming apparatus (13).
Wherein, described three-dimensional distribution manipulator is combined by X-axis (1), Y-axis (3) and Z axle (4), as a kind of improvement of the present invention, wherein X-axis (1), Y-axis (3) are by precision linear motor (or claiming linear motor) combination, and wherein Z axle motion platform (4) can be linear electric machine, also can be accurate electronic control translation stage commonly used.Precision linear motor (or claiming linear motor) (1) (3) have accurate scrambler feeds back, and forms closed loop control.Described three-dimensional distribution manipulator can be planer type structure---be X-axis linear electric machine (1) is directly installed on the base (14), comprise two parallel guide rail and drive part, Y-axis linear electric machine (3) is " door " font by web joint and is installed on the X-axis (1), Z axle motion platform (4) is connected on the Y-axis linear electric machine (3) by web joint, sampling head (5) is installed on the Z axle (4), and spotting needle is installed on the sampling head (5); The formula of also can hanging down for falling---be X-axis linear electric machine (1) by strut support in base (14) sky, Y-axis linear electric machine (3) is directly installed on the X-axis (1), Z axle motion platform (4) is connected on the Y-axis linear electric machine (3) then, and sampling head (5) is installed on the Z axle (4).
As another kind of improvement the of the present invention, described chip stationary platform comprises slide stationary platform (6), standard porous plate stationary platform (22) and (24) three kinds of platforms of film chip stationary platform.Slide stationary platform (6) is made up of microslide supporting plate (18), the handwheel that is installed (19), slide making leaf spring (20) etc., slide is installed groove on microslide supporting plate (18), cooperate slide making leaf spring (20) slide (17) that is used for being installed, the handwheel that is installed (19) then is used for the operation and the location of slide making leaf spring (20); And standard porous plate stationary platform (22) and film chip stationary platform (24) are for having the flat board of some grooves, the standard that can be installed porous plate (21), film chip (24) etc.Described slide stationary platform (6), standard porous plate stationary platform (22) and film chip stationary platform (24) be designed to a plurality of installation dimensions identical can mutual alternative module, can take off and put from workbench (12) easily, position by the locating piece on the workbench (12).Can from sample application platform (12), take out during operation, outside equipment, put and put into sample application platform (12) again behind all slides (17) or standard porous plate (21) or the film chip (24) and carry out point sample.
As another kind of improvement the of the present invention, described spotting needle clearing and drying device (9) comprises thick washing trough (30), fine purifiation groove (29) and air-dry groove (28), thick washing trough (30) and fine purifiation groove (29) all have mobile cleaning fluid, and ultrasonic generator (31) is equipped with in thick washing trough (30) and fine purifiation groove (29) bottom, utilize its " cavitation " effect to strengthen cleaning, spotting needle is put into thick washing trough (30) earlier, the most of residual sample of eccysis, and then put into fine purifiation groove (29), further wash obstinate residue, then to the air-dry spotting needle of air-dry groove (28), dry run is finished through near the keen draft the spotting needle needle point by quick.
Described workbench (12) is highly smooth flat board, the circuitous airtight pipeline that hollow is arranged in the flat board, be full of mobile liquid coolant in the pipeline, and be connected to cooling tank (2), the liquid coolant in the pipeline is carried out temperature control by cooling tank (2) by 2～8 interfaces and connecting pipe.
Described computer-controlled program design a model be control XYZ three-dimensional mechanical hand (1) (3) (4), control point sample pipe system point sample action, control point sample number with can on identical point, repeat.
Below in conjunction with a kind of point sample matrix wherein---the point sample on the slide is further introduced using method of the present invention:
At first open electric cabinet (15) power supply, start computing machine and also open the electric cabinet Control Software, X-axis (1), Y-axis (3) and the Z axle (4) of three-dimensional distribution manipulator made zero respectively to be resetted.Slide stationary platform (6) is placed on the desktop of work, and its slide making leaf spring (20) is opened to the relieving state by the handwheel that is installed (19), the slide (17) that will carry out point sample installs in the groove that is installed corresponding in the microslide supporting plate (18), cross the handwheel that is installed (19) then its slide making leaf spring (20) is put into the state that compresses slide, again slide stationary platform (6) is put into position corresponding in the point sample instrument workbench (12), the sample that needs point sample is added in the sample panel (11), and put into sample stationary platform (10), design spotting template then and carry out the point sample program, before point sample and the point sample of whenever finishing a kind of sample, then carry out 1～10 time spotting needle ultrasonic cleaning program, carry out the point sample of next sample after air-dry again, up to the point sample of finishing all chips, after finishing, point sample carries out 1～10 time spotting needle ultrasonic cleaning program again.
Should be understood that those skilled in the art can do various increases and decreases or modification to the present invention after reading foregoing of the present invention, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Claims (8)
1. a biological chips sample application platform is characterized in that, it is made up of workbench, three-dimensional distribution manipulator, sampling head, chip stationary platform, sample box platform, spotting needle clearing and drying device, electric cabinet, computing machine; Wherein three-dimensional distribution manipulator, chip stationary platform, sample box platform, spotting needle ultrasonic cleaning drying device all are fixed on the workbench, and sampling head is fixed or is connected on the three-dimensional distribution manipulator; Connect by data line between three-dimensional distribution manipulator, sampling head, spotting needle clearing and drying device, electric cabinet and the computing machine and be subjected to computer software control.
2. a kind of biological chips sample application platform according to claim 1 is characterized in that, described three-dimensional distribution manipulator is made up of X-axis linear electric machine, Y-axis linear electric machine and Z axle motion platform; Wherein X-axis linear electric machine, Y-axis linear electric machine are the precision linear motor combination with accurate encoder feedback, and Z axle motion platform is precision linear motor or common electronic control translation stage.
3. according to claim 1 or the described a kind of biological chips sample application platform of claim 2, it is characterized in that, described three-dimensional distribution manipulator structure, can be planer type structure, be that the X-axis linear electric machine is directly installed on the workbench, comprise two parallel guide rail and drive motor, the Y-axis linear electric machine is a font and is installed on the X-axis, Z axle motion platform is connected on the Y-axis linear electric machine, and sampling head is installed on the Z axle motion platform; Also can be for falling to hang down formula, promptly in the base sky, the Y-axis linear electric machine is directly installed on the X-axis X-axis linear electric machine by strut support, and Z axle motion platform is connected on the Y-axis linear electric machine then, and sampling head is installed on the Z axle.
4. according to claim 1 or the described a kind of biological chips sample application platform of claim 3, it is characterized in that described sampling head has 1～48 spotting needle.
5. according to claim 1 or the described a kind of biological chips sample application platform of claim 5, it is characterized in that, described chip stationary platform can be any in slide stationary platform, standard porous plate stationary platform and three kinds of platforms of film chip stationary platform, by draw-in groove or screw can mode for convenience detach being fixed on the workbench; Wherein the slide stationary platform is made up of microslide supporting plate, the handwheel that is installed, slide making leaf spring etc., slide is installed groove on the microslide supporting plate, cooperate the slide making leaf spring to be used for the slide that is installed, and standard porous plate stationary platform and film chip stationary platform are the parallel-plate with some grooves, the standard that can be installed porous plate, film chip etc.
6. according to claim 1 or the described a kind of biological chips sample application platform of claim 5, it is characterized in that, described spotting needle clearing and drying device comprises thick washing trough, fine purifiation groove and air-dry groove, thick washing trough and fine purifiation groove are placed with mobile cleaning fluid, thick washing trough and fine purifiation trench bottom are equipped with ultrasonic generator, utilize its cavitation effect to strengthen cleaning.
7. according to claim 1 or the described a kind of biological chips sample application platform of claim 5, it is characterized in that, described workbench is highly smooth flat board, the circuitous airtight pipeline that hollow is arranged in the flat board, be full of mobile liquid coolant in the pipeline, and be connected to cooling tank by 2～8 interfaces and connecting pipe.
8. a kind of biological chips sample application platform according to claim 1, it is characterized in that, described computer-controlled program design a model be control XYZ three-dimensional mechanical hand, control point sample pipe system point sample action, control point sample number with can on identical point, repeat.
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|---|---|---|---|
| CNA2007100426625A CN101334405A (en) | 2007-06-26 | 2007-06-26 | Biological chips sample application platform |
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| CNA2007100426625A CN101334405A (en) | 2007-06-26 | 2007-06-26 | Biological chips sample application platform |
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| CN102527663A (en) * | 2011-12-29 | 2012-07-04 | 苏州浩欧博生物医药有限公司 | Cleaning method in immunoassay process |
| CN102636378A (en) * | 2012-04-10 | 2012-08-15 | 无锡国盛精密模具有限公司 | Machine vision orientation-based biochip microarrayer and positioning method thereof |
| CN102649931A (en) * | 2012-05-28 | 2012-08-29 | 上海理工大学 | Preparation method for microarray biochip |
| CN102954954A (en) * | 2012-09-19 | 2013-03-06 | 东南大学 | Magnetic separation-based multi-sample multi-site high-flux nucleic acid analysis system |
| CN103212552A (en) * | 2013-04-10 | 2013-07-24 | 上海裕隆生物科技有限公司 | Cleaning dip-drying device for needle head of sample application instrument |
| CN103412135A (en) * | 2013-07-15 | 2013-11-27 | 广东凯普生物科技股份有限公司 | Full-automatic biochip sample applicator |
| CN104593871A (en) * | 2015-02-02 | 2015-05-06 | 上海理工大学 | Method and device for dynamically preparing biochip by virtue of linear-array combined spray head |
| CN104593870A (en) * | 2015-02-02 | 2015-05-06 | 上海理工大学 | Linear-array-sprayer multi-sampling-point method for dynamically preparing biochips |
| CN104950015A (en) * | 2015-06-15 | 2015-09-30 | 苏州慧闻纳米科技有限公司 | Preparation method of multi-channel array gas sensor |
| CN105928766A (en) * | 2016-07-15 | 2016-09-07 | 上海百傲科技股份有限公司 | Biochip spotting machine and spotting bench thereof |
| CN105954532A (en) * | 2016-06-23 | 2016-09-21 | 湖北医药学院 | Bio-cup contact type micro-array biochip sample application system |
| CN108931415A (en) * | 2017-05-23 | 2018-12-04 | 北京诚智光辉科技有限公司 | Sectioning cells with wiper mechanism dye all-in-one machine |
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| CN102527663A (en) * | 2011-12-29 | 2012-07-04 | 苏州浩欧博生物医药有限公司 | Cleaning method in immunoassay process |
| CN102636378A (en) * | 2012-04-10 | 2012-08-15 | 无锡国盛精密模具有限公司 | Machine vision orientation-based biochip microarrayer and positioning method thereof |
| CN102649931A (en) * | 2012-05-28 | 2012-08-29 | 上海理工大学 | Preparation method for microarray biochip |
| CN102954954A (en) * | 2012-09-19 | 2013-03-06 | 东南大学 | Magnetic separation-based multi-sample multi-site high-flux nucleic acid analysis system |
| CN103212552A (en) * | 2013-04-10 | 2013-07-24 | 上海裕隆生物科技有限公司 | Cleaning dip-drying device for needle head of sample application instrument |
| CN103412135A (en) * | 2013-07-15 | 2013-11-27 | 广东凯普生物科技股份有限公司 | Full-automatic biochip sample applicator |
| CN103412135B (en) * | 2013-07-15 | 2014-11-26 | 广东凯普生物科技股份有限公司 | Full-automatic biochip sample applicator |
| CN104593871A (en) * | 2015-02-02 | 2015-05-06 | 上海理工大学 | Method and device for dynamically preparing biochip by virtue of linear-array combined spray head |
| CN104593870A (en) * | 2015-02-02 | 2015-05-06 | 上海理工大学 | Linear-array-sprayer multi-sampling-point method for dynamically preparing biochips |
| CN104950015B (en) * | 2015-06-15 | 2020-03-27 | 江苏智闻智能传感科技有限公司 | Preparation method of multi-channel array gas sensor |
| CN104950015A (en) * | 2015-06-15 | 2015-09-30 | 苏州慧闻纳米科技有限公司 | Preparation method of multi-channel array gas sensor |
| CN105954532A (en) * | 2016-06-23 | 2016-09-21 | 湖北医药学院 | Bio-cup contact type micro-array biochip sample application system |
| CN105928766A (en) * | 2016-07-15 | 2016-09-07 | 上海百傲科技股份有限公司 | Biochip spotting machine and spotting bench thereof |
| CN105928766B (en) * | 2016-07-15 | 2018-10-26 | 上海百傲科技股份有限公司 | Biochip point sample instrument and its print table |
| CN108931415A (en) * | 2017-05-23 | 2018-12-04 | 北京诚智光辉科技有限公司 | Sectioning cells with wiper mechanism dye all-in-one machine |
| CN109406813A (en) * | 2018-12-14 | 2019-03-01 | 贵州大学 | A kind of microfluidic control device for high-throughput droplet array microfluid point sample |
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