CN101327294B - Chinese medicinal composition for treating common cold, acute and chronic tracheitis and preparation method thereof - Google Patents
Chinese medicinal composition for treating common cold, acute and chronic tracheitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicine combination for remedying cold, acute and chronic tracheitis and a preparation method thereof. The medicine combination is made from the raw materials with the following weight portions of 8-12 portions of antelope horn, 30-60 portions of bulbus fritillariae ussuriensis, 20-40 portions of rhubarb, 10-20 portions of scutellaria, 10-20 portions of lapis chloriti, 15-30 portions of plaster stone, 5-15 portions of artificial calculus bovis and 20-40 portions of licorice.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly a kind of pharmaceutical composition for the treatment of flu and acute, chronic bronchitis and preparation method thereof.
Background technology
Infantile bronchitis, bronchopneumonia belong to lung pattern disease category in motherland's medical science, and phlegm-heat cough is one of main pattern of syndrome in the lung pattern disease.How because of wind and cold or wind-heat invading the lung, give birth in expectorant is turbid, strongly fragrant and heat-transformation is due to the impairment of dispersing and descending function of the lung.Lung-heat excess syndromes such as clinical manifestation is cough, thick, thirsty, the pharyngalgia of expectorant, and very then out of breath, flaring of nares, yellow fur are thick.
Infantile bronchitis, bronchopneumonia are one of usual diseases of childhood, frequently-occurring disease.Its pathogen mostly is viral infection, because antibiotic medicine treatment viral infection is invalid, and toxic and side effects is in various degree arranged, and therefore chases a kind of safe, effective, medicine of having no side effect, is the urgent problem that the department of pediatrics medical worker will solve.
Applicant of the present invention has applied for that on August 20th, 2002 name is called the patent of " treatment flu and anxious; Chinese medicine composition of chronic tracheitis and preparation method thereof ", application number: 02129192.6, this patent disclosure a kind of treatment flu and anxious, Chinese medicine composition of chronic tracheitis and preparation method thereof, in these years, applicant of the present invention is furtheing investigate this invention always, along with deepening continuously of research, we are surprised to find that under the constant situation of original invention crude drug flavour of a drug, change the dose ratio between each crude drug, its curative effect of medication can be better than original invention.
Summary of the invention
One object of the present invention is to disclose a kind of flu and pharmaceutical composition acute, chronic bronchitis for the treatment of; Another object of the present invention is to disclose this preparation of drug combination method.
The present invention seeks to be achieved through the following technical solutions:
This Chinese medicine composition is to be made by following crude drug:
Cornu Saigae Tataricae 8～12 weight portion Bulbus Fritillariae Ussuriensiss 30～60 weight portions
Radix Et Rhizoma Rhei 20～40 weight portion Radix Scutellariaes 10～20 weight portions
Lapis Chloriti 10～20 weight portion Gypsum Fibrosum 15～30 weight portions
Artificial Calculus Bovis 5～15 weight portion Radix Glycyrrhizaes 20～40 weight portions.
The crude drug composition and the proportion optimization of Chinese medicine composition of the present invention are as follows:
Cornu Saigae Tataricae 9.45 weight portion Bulbus Fritillariae Ussuriensiss 47.25 weight portions
Radix Et Rhizoma Rhei 31.50 weight portion Radix Scutellariaes 15.75 weight portions
Lapis Chloriti 15.75 weight portion Gypsum Fibrosum 23.62 weight portions
Artificial Calculus Bovis 9.45 weight portion Radix Glycyrrhizaes 31.50 weight portions.
Chinese medicine composition of the present invention is prepared from by the following method:
Cornu Saigae Tataricae powder is broken into fine powder, adds 8～12 times of water gagings and sodium hydroxide 2～6 weight portions, back hydrolysis filters, medicinal residues add 3～6 times of water gagings and sodium hydroxide 1～2 weight portion, and back hydrolysis to almost molten entirely, filters, merging filtrate, being concentrated into relative density is 1.020～1.030, obtains extractum I; Lapis Chloriti, gypsum powder are broken into coarse powder, decoct 1～3 hour with 8～12 times of water gaging heating, filter, and medicinal residues add 6～10 times of water gagings and decocted 1～2 hour, filter, and merge filtrate twice, and being concentrated into relative density is 1.015～1.019, obtains extractum II; 3～6 times of amounts of artificial Calculus Bovis, 50%～90% ethanol extraction 2～4 hours, medicinal residues were measured 50%～90% alcohol reflux 1～2 hour with 3～6 times, filter, merging filtrate, decompression recycling ethanol, being concentrated into relative density is 1.020～1.030, obtains extractum III; Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae four Chinese medicine add 8～12 times of water gagings and decocted 1～3 hour, filter, medicinal residues add 3～6 times of water gaging heating and decocted 1～2 hour, filter merging filtrate, be concentrated into the extractum of relative density 1.10～1.20, centrifugal, get supernatant and add 2～5 times of amount 50%～90 % ethanol, stir evenly, leave standstill, get supernatant, filter, reclaim ethanol, be concentrated into relative density and be about 1.08, obtain extractum IV; Get above-mentioned extractum I, extractum II, extractum III, extractum IV mixing, add conventional adjuvant and make clinical acceptable forms.
The preferred version of above-mentioned preparation method is as follows:
Cornu Saigae Tataricae powder is broken into fine powder, add 10 times of water gagings and sodium hydroxide 4 weight portions, back hydrolysis 24 hours filters, and medicinal residues add 5 times of water gagings and sodium hydroxide 1.5 weight portions, back hydrolysis, to almost molten entirely, filter, merge filtrate twice, being concentrated into 20 ℃ of relative densities is 1.020～1.030, obtains extractum I; Lapis Chloriti, gypsum powder are broken into coarse powder, decoct 2 hours with 10 times of water gaging heating, filter, and medicinal residues add 8 times of water gagings and decocted 1.5 hours, filter, and merge filtrate twice, and being concentrated into 85 ℃ of relative densities is 1.015～1.019, obtains extractum II; 5 times of amounts of artificial Calculus Bovis, 70% ethanol extraction 3 hours, medicinal residues were measured 70% alcohol reflux 1.5 hours with 5 times, filtered, and merged filtrate twice, decompression recycling ethanol, being concentrated into 85 ℃ of relative densities is 1.020～1.030, obtains extractum III; Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae four Chinese medicine add 10 times of water gagings and decocted 2 hours, filter, medicinal residues add 5 times of water gaging heating and decocted 1.5 hours, filter, and merge filtrate twice, be concentrated into the extractum of 85 ℃ of relative densities 1.10～1.20, centrifugal, get supernatant and add 4 times of amount 70% ethanol, stir evenly, left standstill 48 hours, get supernatant, filter, decompression recycling ethanol is concentrated into 85 ℃ of relative densities and is about 1.08, obtains extractum IV; Get above-mentioned extractum I, extractum II, extractum III, extractum IV and 0.2% stevioside, stir, mixing, heated and boiled 20 minutes, cold preservation 48 hours filters, filtrate adds the water adjustment, makes oral liquid.
Figure of description
Accompanying drawing 1: Chinese medicine pharmaceutical composition of the present invention influences variation diagram to heating rat temperature due to the dry yeast
The specific embodiment
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
Pharmacology and effect experiment research:
The experiment purpose of following experimental example 1-6 is by, analgesia analgesic to compositions A and compositions B, antiinflammatory, antitussive, expectoration, to the observation that influences several respects test of specific immune function, estimates compositions A and compositions B and catches a cold and the effect of aspect such as acute, chronic bronchitis in treatment;
The reagent thing that is subjected to of following experimental example 1-6 is compositions A and compositions B, and its preparation method is as follows:
Compositions A:
Cornu Saigae Tataricae 9.45, Bulbus Fritillariae Ussuriensis 17.25, Radix Et Rhizoma Rhei 31.50, Radix Scutellariae 15.75, Lapis Chloriti 15.75, Gypsum Fibrosum 23.62, the artificial Calculus Bovis 9.45, Radix Glycyrrhizae 31.50;
Compositions B:
Cornu Saigae Tataricae 9.45, Bulbus Fritillariae Ussuriensis 47.25, Radix Et Rhizoma Rhei 31.50, Radix Scutellariae 15.75, Lapis Chloriti 15.75, Gypsum Fibrosum 23.62, the artificial Calculus Bovis 9.45, Radix Glycyrrhizae 31.50.
The following method that all adopts of above-mentioned composition A and compositions B is prepared:
Cornu Saigae Tataricae powder is broken into fine powder, add 10 times of water gagings and sodium hydroxide 4 weight portions, back hydrolysis 24 hours filters, and medicinal residues add 5 times of water gagings and sodium hydroxide 1.5 weight portions, back hydrolysis, to almost molten entirely, filter, merge filtrate twice, being concentrated into 20 ℃ of relative densities is 1.020～1.030, obtains extractum I; Lapis Chloriti, gypsum powder are broken into coarse powder, decoct 2 hours with 10 times of water gaging heating, filter, and medicinal residues add 8 times of water gagings and decocted 1.5 hours, filter, and merge filtrate twice, and being concentrated into 85 ℃ of relative densities is 1.015～1.019, obtains extractum II; 5 times of amounts of artificial Calculus Bovis, 70% ethanol extraction 3 hours, medicinal residues were measured 70% alcohol reflux 1.5 hours with 5 times, filtered, and merged filtrate twice, decompression recycling ethanol, being concentrated into 85 ℃ of relative densities is 1.020～1.030, obtains extractum III; Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae four Chinese medicine add 10 times of water gagings and decocted 2 hours, filter, medicinal residues add 5 times of water gaging heating and decocted 1.5 hours, filter, and merge filtrate twice, be concentrated into the extractum of 85 ℃ of relative densities 1.10～1.20, centrifugal, get supernatant and add 4 times of amount 70% ethanol, stir evenly, left standstill 48 hours, get supernatant, filter, decompression recycling ethanol is concentrated into 85 ℃ of relative densities and is about 1.08, obtains extractum IV; Get above-mentioned extractum I, extractum II, extractum III, extractum IV mixing, promptly get compositions.
Be subjected to reagent agent amount to be the crude drug amount among the following experimental example 1-6.
Experimental example 1: pharmaceutical composition of the present invention is to the influence of heating rat temperature due to the dry yeast
Get male SD rat adaptability every day and survey the anus temperature 1 time, continuous 3d, water 12h is can't help in fasting before the formal experiment, survey the anus temperature inferior morning 2 times, interval 1h, average and be normal body temperature, choose twice temperature difference and be qualified rat less than 0.3 ℃ of person, every Mus back subcutaneous injection 20% sterilised yeast suspension 10ml/kg, select heating to reach more than 1 ℃ 60 of persons behind the 6h, be divided into 6 groups at random, i.e. blank group (isometric(al) distilled water), compositions A low dose group (14g/kg), compositions A high dose group (28g/kg), compositions B low dose group (17g/kg), compositions B high dose group (34g/kg), aspirin group (0.2g/kg), each organizes rat with the 10mL/kg gastric infusion, 1h after the administration, 2h, 3h, 4h respectively surveys the anus temperature once, with the normal body temperature is radix, calculates each time point body temperature changing value after the administration, the results are shown in Table 1 and accompanying drawing 1:
Table 1: pharmaceutical composition to the influence of heating rat temperature due to the dry yeast (x ± s, n=10)
Annotate: compare * P＜0.05 with the blank group; * P＜0.01.
The result shows that the rat fever that compositions A and compositions B cause dry yeast has tangible refrigeration function, and compositions B is particularly evident, shows that compositions A and compositions B all have the better antipyretic effect.
Experimental example 2: pharmaceutical composition Dichlorodiphenyl Acetate of the present invention causes the influence of mouse writhing reaction
Get 60 of 18～22 Kunming mouses, male and female half and half, it is divided into 6 groups at random, every group 10, be blank group (isometric(al) distilled water), compositions A low dose group (20g/kg), compositions A high dose group (40g/kg), compositions B low dose group (24g/kg), compositions B high dose group (48g/kg), aspirin group (0.2g/kg), each organizes mice with the 20mL/kg gastric infusion, behind the administration 1h, the acetic acid of mouse peritoneal injection 0.7%, 0.2ml/ only, begin to observe and write down the number of times of mouse writhing in the 20min immediately, writhing response is with the abdominal part indent, stretch hind leg, buttocks is raised and is the standard counting, the results are shown in Table 2:
Table 2: the pharmaceutical composition Dichlorodiphenyl Acetate cause mouse writhing reaction influence (x ± SD, n=10)
Annotate: compare * P＜0.05 with the blank group; * P＜0.01.
The result shows that compositions A and compositions B Dichlorodiphenyl Acetate cause the mouse writhing reaction the obvious suppression effect, and compositions B is particularly evident; Show that compositions A and compositions B all have certain analgesic activity.
Experimental example 3: pharmaceutical composition of the present invention is to the influence of mouse peritoneal capillary permeability
Get 60 of 18～22 Kunming mouses, male and female half and half, grouping and administration are with experimental example 2, the 1h vein injects 0.5% azovan blue normal saline solution 0.1ml/10g body weight (the mice of the disposable injection azovan blue of pin normal saline solution is not given it up) after administration, the acetic acid of lumbar injection 0.7% immediately, 0.2ml/ only, behind the 20min mice being taken off cervical vertebra puts to death, cut off skin of abdomen muscle, divide several to wash the abdominal cavity with the 10ml normal saline, draw cleaning mixture and be incorporated into 10ml, 3000 rev/mins of centrifugal 15min; Get supernatant with 752 type spectrophotometers in its absorbance of 590nm place colorimetric determination, the results are shown in Table 3:
Table 3: Chinese medicine composition to the influence of mouse peritoneal capillary permeability (x ± SD, n=10)
Annotate: compare * P＜0.05, * * P＜0.01 with the blank group.
The result shows that compositions A and compositions B all can extremely significantly reduce the mouse peritoneal capillary permeability, show that compositions A and compositions B all have certain antiinflammatory action.
Experimental example 4: pharmaceutical composition of the present invention to mice because of the cough caused influence of ammonia
Get 18～22 Kunming mouse and screened in preceding 24 hours in the administration first time, grouping again after the screening, the cough standard is: abdominal muscle shrinks, and magnifies mouth simultaneously, can cough sound sometimes; If incubation period is less than 1min, and occur in 1min that typical cough person be " cough is arranged " responsive animal more than 3 times, cough and eliminate otherwise do not have; Get 60 of the qualified mices of screening, male and female half and half, it is divided into 6 groups at random, every group 10, be blank group (isometric(al) distilled water), compositions A low dose group (20g/kg), compositions A high dose group (40g/kg), compositions B low dose group (24g/kg), compositions B high dose group (48g/kg), codeine phosphate group (0.06g/kg), each organizes mice with the 20mL/kg gastric infusion, mice placed in the 5L glass bell jar in 1 hour after the administration, with 400～500mmHg constant voltage 28% ammonia is sprayed into bell jar, sprayed 5 seconds, cough number of times in cough latent period of observed and recorded mice and the 3min the results are shown in Table 4:
Table 4: pharmaceutical composition to because of the cough caused influence of ammonia (x ± SD, n=10)
Annotate: compare * P＜0.05, * * P＜0.01 with the blank group.
The result shows, compositions A and compositions B all can obviously prolong mice because of ammonia causes incubation period of cough, reduce the number of times of coughing, and compositions B is particularly evident, shows that compositions A and compositions B all have antitussive effect preferably.
Experimental example 5: pharmaceutical composition of the present invention is to the influence of rat capillary tube expectoration amount
Get 60 of SD rats, be divided into 6 groups at random, every group 10, be blank group (isometric(al) distilled water), compositions A low dose group (14g/kg), compositions A high dose group (28gkg), compositions B low dose group (17g/kg), compositions B high dose group (34g/kg), ammonium chloride group (1g/kg), each organizes rat with the 10mL/kg gastric infusion; Each treated animal 30min after administration with 1g/kg urethane intraperitoneal injection of anesthesia, faces upward the position and fixes; Cut off neck middle part skin, isolate trachea, hit exactly between two cartilaginous rings at thyroid cartilage lower edge and prick an aperture, insert one of capillary glass tube, make capillary tube just contact the organ lower surface, so as to drawing the sputum at trachea rear portion with sharp-pointed injection needle; When being full of by blanket liquid in the capillary tube, change one immediately in addition; Draw sputum length as the effect of reducing phlegm of estimating medicine with capillary tube; After writing down the preceding 2 hours normal secretory volume of administration, gastric infusion continues to observe the 2h secretory volume again; Average secretory volume per hour before and after the administration relatively the results are shown in Table 5:
Table 5: pharmaceutical composition to the influence of rat capillary tube expectoration amount (x ± SD, n=10)
Annotate: compare * P＜0.05, * * P＜0.01 with the blank group.
The result shows that compositions A and compositions B all can obviously increase rat capillary tube expectoration amount, and compositions B is particularly evident; Show that compositions A and compositions B have phlegm-dispelling functions preferably.
Experimental example 6: pharmaceutical composition of the present invention is to the influence of mice non-specific immunity
Get 60 of body weight 18～22 Kunming mouses, be divided into 6 groups at random, every group 10, be blank group (isometric(al) distilled water), compositions A low dose group (20g/kg), compositions A high dose group (40g/kg), compositions B low dose group (24g/kg), compositions B high dose group (48g/kg), levamisole hydrochloride group (0.02g/kg), each organizes mice with the 20mL/kg gastric infusion; 1h is by the india ink 0.1ml/10g of tail vein injection 1:10 dilution after the administration, and 2min and 10min add the 0.1%NaCO that fills 4ml from the ophthalmic corner of the eyes venous plexus 50 μ L that take a blood sample after injection respectively
3In the solution test tube, shake all after, measure trap with 752 type spectrophotometers at 680nm, take by weighing each Mus body weight and liver, spleen weight simultaneously, calculate and to clean up index K value and phagocytic index α value:
K＝(1gOD
1—1gOD
2)/(T
2—T
1)?
OD is a carbon granule absorbance in the blood in the formula, and T is the time, and W is a body weight, and WLS closes heavily for the liver spleen; The results are shown in Table 6:
Table 6: pharmaceutical composition to carbon clean up ability influence (x ± SD, n=10)
Annotate: compare * P＜0.05, * * P＜0.01 with the normal saline group.
The result shows that compositions A and compositions B all can obviously increase cytophagous index K value and the phagocytic index α value cleaned up of mice, and compositions B is particularly evident; Show that compositions A and compositions B all can improve the mouse macrophage function.
Experiment conclusion:
The experimental result of above-mentioned experimental example 1-6 shows, compositions A and compositions B are in analgesic, analgesia, antiinflammatory, antitussive, expectoration, all have better action to the influence of specific immune function several respects, point out its compositions A and compositions B curative effect preferably all to be arranged, and compositions B effect is particularly remarkable at aspects such as treatment flu and acute, chronic bronchitiss.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1: the oral liquid of compositions
Cornu Saigae Tataricae 9.45 weight portion Bulbus Fritillariae Ussuriensiss 47.25 weight portions
Radix Et Rhizoma Rhei 31.50 weight portion Radix Scutellariaes 15.75 weight portions
Lapis Chloriti 15.75 weight portion Gypsum Fibrosum 23.62 weight portions
Artificial Calculus Bovis 9.45 weight portion Radix Glycyrrhizaes 31.50 weight portions.
Cornu Saigae Tataricae powder is broken into fine powder, add 10 times of water gagings and sodium hydroxide 4 weight portions, back hydrolysis 24 hours filters, and medicinal residues add 5 times of water gagings and sodium hydroxide 1.5 weight portions, back hydrolysis, to almost molten entirely, filter, merge filtrate twice, being concentrated into 20 ℃ of relative densities is 1.020～1.030, obtains extractum I; Lapis Chloriti, gypsum powder are broken into coarse powder, decoct 2 hours with 8.5 times of water gaging heating, filter, and medicinal residues add 8 times of water gagings and decocted 1.5 hours, filter, and merge filtrate twice, and being concentrated into 85 ℃ of relative densities is 1.015～1.019, obtains extractum II; 5 times of amounts of artificial Calculus Bovis, 70% ethanol extraction 3 hours, medicinal residues were measured 70% alcohol reflux 1.5 hours with 5 times, filtered, and merged filtrate twice, decompression recycling ethanol, being concentrated into 85 ℃ of relative densities is 1.020～1.030, obtains extractum III; Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae four Chinese medicine add 10 times of water gagings and decocted 2 hours, filter, medicinal residues add 5 times of water gaging heating and decocted 1.5 hours, filter, and merge filtrate twice, be concentrated into the extractum of 85 ℃ of relative densities 1.10～1.20, centrifugal, get supernatant and add 4 times of amount 70% ethanol, stir evenly, left standstill 48 hours, get supernatant, filter, decompression recycling ethanol is concentrated into 85 ℃ of relative densities and is about 1.08, obtains extractum IV; Get the stevioside of above-mentioned extractum I, extractum II, extractum III, extractum IV and 0.2%, stir, mixing, heated and boiled 20 minutes, cold preservation 48 hours filters, and filtrate adds the water adjustment, makes oral liquid.
Embodiment 2: the tablet of compositions
Cornu Saigae Tataricae 11.5 weight portion Bulbus Fritillariae Ussuriensiss 32.25 weight portions
Radix Et Rhizoma Rhei 38.50 weight portion Radix Scutellariaes 12.75 weight portions
Lapis Chloriti 11.85 weight portion Gypsum Fibrosum 16.55 weight portions
Artificial Calculus Bovis 14.45 weight portion Radix Glycyrrhizaes 21.50 weight portions.
Cornu Saigae Tataricae powder is broken into fine powder, add 8 times of water gagings and sodium hydroxide 3 weight portions, back hydrolysis 18 hours filters, and medicinal residues add 4 times of water gagings and sodium hydroxide 1.5 weight portions, back hydrolysis, to almost molten entirely, filter, merge filtrate twice, being concentrated into 20 ℃ of relative densities is 1.020～1.030, obtains extractum I; Lapis Chloriti, gypsum powder are broken into coarse powder, decoct 2 hours with 10 times of water gaging heating, filter, and medicinal residues add 8 times of water gagings and decocted 1.5 hours, filter, and merge filtrate twice, and being concentrated into 85 ℃ of relative densities is 1.015～1.019, obtains extractum II; 3 times of amounts of artificial Calculus Bovis, 80% ethanol extraction 3 hours, medicinal residues were measured 80% alcohol reflux 1.5 hours with 3 times, filtered, and merged filtrate twice, decompression recycling ethanol, being concentrated into 85 ℃ of relative densities is 1.020～1.030, obtains extractum III; Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae four Chinese medicine add 8 times of water gagings and decocted 2 hours, filter, medicinal residues add 3 times of water gaging heating and decocted 1 hour, filter, and merge filtrate twice, be concentrated into the extractum of 85 ℃ of relative densities 1.10～1.20, centrifugal, get supernatant and add 3 times of amount 80% ethanol, stir evenly, left standstill 48 hours, get supernatant, filter, decompression recycling ethanol is concentrated into 85 ℃ of relative densities and is about 1.08, obtains extractum IV; Get above-mentioned extractum I, extractum II, extractum III, extractum IV mixing, granulate, add appropriate amount of starch and magnesium stearate, granulate, tabletting, promptly.
Embodiment 3: the hard capsule of compositions
Cornu Saigae Tataricae 8.5 weight portion Bulbus Fritillariae Ussuriensiss 58.15 weight portions
Radix Et Rhizoma Rhei 22.65 weight portion Radix Scutellariaes 18.85 weight portions
Lapis Chloriti 11.85 weight portion Gypsum Fibrosum 27.55 weight portions
Artificial Calculus Bovis 6.45 weight portion Radix Glycyrrhizaes 36.50 weight portions.
Cornu Saigae Tataricae powder is broken into fine powder, adds 9 times of water gagings and sodium hydroxide 2 weight portions, back hydrolysis 30 hours filters, medicinal residues add 5 times of water gagings and sodium hydroxide 2 weight portions, and back hydrolysis to almost molten entirely, filters, merge filtrate twice, being concentrated into 20 ℃ of relative densities is 1.020～1.030, obtains extractum I; Lapis Chloriti, gypsum powder are broken into coarse powder, decoct 1.5 hours with 9 times of water gaging heating, filter, and medicinal residues add 7 times of water gagings and decocted 2 hours, filter, and merge filtrate twice, and being concentrated into 85 ℃ of relative densities is 1.015～1.019, obtains extractum II; 4 times of amounts of artificial Calculus Bovis, 85% ethanol extraction 3 hours, medicinal residues were measured 85% alcohol reflux 2 hours with 4 times, filtered, and merged filtrate twice, decompression recycling ethanol, being concentrated into 85 ℃ of relative densities is 1.020～1.030, obtains extractum III; Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae four Chinese medicine add 9 times of water gagings and decocted 1.5 hours, filter, medicinal residues add 4 times of water gaging heating and decocted 2 hours, filter, and merge filtrate twice, be concentrated into the extractum of 85 ℃ of relative densities 1.10～1.20, centrifugal, get supernatant and add 3 times of amount 85% ethanol, stir evenly, left standstill 48 hours, get supernatant, filter, decompression recycling ethanol is concentrated into 85 ℃ of relative densities and is about 1.08, obtains extractum IV; Get above-mentioned extractum I, extractum II, extractum III, extractum IV mixing, add an amount of calcium carbonate and starch, mixing sieves, and oven dry is encapsulated, promptly.
Embodiment 4: the soft capsule of compositions
Cornu Saigae Tataricae 11.5 weight portion Bulbus Fritillariae Ussuriensiss 32.25 weight portions
Radix Et Rhizoma Rhei 38.50 weight portion Radix Scutellariaes 12.75 weight portions
Lapis Chloriti 18.65 weight portion Gypsum Fibrosum 16.55 weight portions
Artificial Calculus Bovis 14.45 weight portion Radix Glycyrrhizaes 38.50 weight portions.
Cornu Saigae Tataricae powder is broken into fine powder, add 12 times of water gagings and sodium hydroxide 6 weight portions, back hydrolysis 30 hours filters, and medicinal residues add 6 times of water gagings and sodium hydroxide 2 weight portions, back hydrolysis, to almost molten entirely, filter, merge filtrate twice, being concentrated into 20 ℃ of relative densities is 1.020～1.030, obtains extractum I; Lapis Chloriti, gypsum powder are broken into coarse powder, decoct 3 hours with 12 times of water gaging heating, filter, and medicinal residues add 10 times of water gagings and decocted 2 hours, filter, and merge filtrate twice, and being concentrated into 85 ℃ of relative densities is 1.015～1.019, obtains extractum II; 6 times of amounts of artificial Calculus Bovis, 65% ethanol extraction 4 hours, medicinal residues were measured 65% alcohol reflux 1.5 hours with 6 times, filtered, and merged filtrate twice, decompression recycling ethanol, being concentrated into 85 ℃ of relative densities is 1.020～1.030, obtains extractum III; Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae four Chinese medicine add 12 times of water gagings and decocted 3 hours, filter, medicinal residues add 6 times of water gaging heating and decocted 2 hours, filter, and merge filtrate twice, be concentrated into the extractum of 85 ℃ of relative densities 1.10～1.20, centrifugal, get supernatant and add 5 times of amount 65% ethanol, stir evenly, left standstill 48 hours, get supernatant, filter, decompression recycling ethanol is concentrated into 85 ℃ of relative densities and is about 1.08, obtains extractum IV; Get above-mentioned extractum I, extractum II, extractum III, extractum IV mixing, be concentrated into thick paste, drying is pulverized, and crosses sieve No. five, and powder gets dry extract; Add PEG-400, make suspension, adopt pressing, make soft capsule, promptly.
Embodiment 5: the drop pill of compositions
Cornu Saigae Tataricae 11.5 weight portion Bulbus Fritillariae Ussuriensiss 58.15 weight portions
Radix Et Rhizoma Rhei 35.55 weight portion Radix Scutellariaes 18.85 weight portions
Lapis Chloriti 11.85 weight portion Gypsum Fibrosum 27.55 weight portions
Artificial Calculus Bovis 12.65 weight portion Radix Glycyrrhizaes 26.50 weight portions.
Cornu Saigae Tataricae powder is broken into fine powder, add 11 times of water gagings and sodium hydroxide 5 weight portions, back hydrolysis 28 hours filters, and medicinal residues add 5 times of water gagings and sodium hydroxide 1.5 weight portions, back hydrolysis, to almost molten entirely, filter, merge filtrate twice, being concentrated into 20 ℃ of relative densities is 1.020～1.030, obtains extractum I; Lapis Chloriti, gypsum powder are broken into coarse powder, decoct 2.5 hours with 11 times of water gaging heating, filter, and medicinal residues add 9 times of water gagings and decocted 1.5 hours, filter, and merge filtrate twice, and being concentrated into 85 ℃ of relative densities is 1.015～1.019, obtains extractum II; 5 times of amounts of artificial Calculus Bovis, 60% ethanol extraction 2.5 hours, medicinal residues were measured 60% alcohol reflux 1.5 hours with 5 times, filtered, and merged filtrate twice, decompression recycling ethanol, being concentrated into 85 ℃ of relative densities is 1.020～1.030, obtains extractum III; Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae four Chinese medicine add 11 times of water gagings and decocted 2.5 hours, filter, medicinal residues add 5 times of water gaging heating and decocted 1.5 hours, filter, and merge filtrate twice, be concentrated into the extractum of 85 ℃ of relative densities 1.10～1.20, centrifugal, get supernatant and add 4 times of amount 60% ethanol, stir evenly, left standstill 52 hours, get supernatant, filter, decompression recycling ethanol is concentrated into 85 ℃ of relative densities and is about 1.08, obtains extractum IV; Get above-mentioned extractum I, extractum II, extractum III, extractum IV mixing, concentrate, be heated to 80 ℃, splash in the cold vegetable oil, make drop pill, promptly.
Embodiment 6: the suppository of compositions
Cornu Saigae Tataricae 8.5 weight portion Bulbus Fritillariae Ussuriensiss 38.25 weight portions
Radix Et Rhizoma Rhei 22.65 weight portion Radix Scutellariaes 12.25 weight portions
Lapis Chloriti 11.85 weight portion Gypsum Fibrosum 17.50 weight portions
Artificial Calculus Bovis 6.45 weight portion Radix Glycyrrhizaes 36.50 weight portions.
Cornu Saigae Tataricae powder is broken into fine powder, add 9 times of water gagings and sodium hydroxide 3 weight portions, back hydrolysis 20 hours filters, and medicinal residues add 4 times of water gagings and sodium hydroxide 1 weight portion, back hydrolysis, to almost molten entirely, filter, merge filtrate twice, being concentrated into 20 ℃ of relative densities is 1.020～1.030, obtains extractum I; Lapis Chloriti, gypsum powder are broken into coarse powder, decoct 1.5 hours with 9 times of water gaging heating, filter, and medicinal residues add 7 times of water gagings and decocted 1 hour, filter, and merge filtrate twice, and being concentrated into 85 ℃ of relative densities is 1.015～1.019, obtains extractum II; 4 times of amounts of artificial Calculus Bovis, 75% ethanol extraction 3 hours, medicinal residues were measured 75% alcohol reflux 1 hour with 4 times, filtered, and merged filtrate twice, decompression recycling ethanol, being concentrated into 85 ℃ of relative densities is 1.020～1.030, obtains extractum III; Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae four Chinese medicine add 9 times of water gagings and decocted 1.5 hours, filter, medicinal residues add 4 times of water gaging heating and decocted 1 hour, filter, and merge filtrate twice, be concentrated into the extractum of 85 ℃ of relative densities 1.10～1.20, centrifugal, get supernatant and add 3 times of amount 75% ethanol, stir evenly, left standstill 48 hours, get supernatant, filter, decompression recycling ethanol is concentrated into 85 ℃ of relative densities and is about 1.08, obtains extractum IV; Get above-mentioned extractum I, extractum II, extractum III, extractum IV mixing, be concentrated into thick paste, drying is pulverized, and powder gets dry extract; Other gets semi-synthetic fatty acid ester heating and dissolves, and is incubated about 40 ℃, adds above-mentioned dried cream powder, mixing, and injection molding, take out the cooling back, promptly.
Claims (4)
1. Chinese medicine composition with analgesic, analgesia, antiinflammatory, antitussive, expectoration, adjusting immunization is characterized in that this Chinese medicine composition is to be made by following crude drug:
Cornu Saigae Tataricae 8～12 weight portion Bulbus Fritillariae Ussuriensiss 30～60 weight portions
Radix Et Rhizoma Rhei 20～40 weight portion Radix Scutellariaes 10～20 weight portions
Lapis Chloriti 10～20 weight portion Gypsum Fibrosum 15～30 weight portions
Artificial Calculus Bovis 5～15 weight portion Radix Glycyrrhizaes 20～40 weight portions.
2. the Chinese medicine composition with analgesic, analgesia, antiinflammatory, antitussive, expectoration, adjusting immunization as claimed in claim 1 is characterized in that this Chinese medicine composition made by following crude drug:
Cornu Saigae Tataricae 9.45 weight portion Bulbus Fritillariae Ussuriensiss 47.25 weight portions
Radix Et Rhizoma Rhei 31.50 weight portion Radix Scutellariaes 15.75 weight portions
Lapis Chloriti 15.75 weight portion Gypsum Fibrosum 23.62 weight portions
Artificial Calculus Bovis 9.45 weight portion Radix Glycyrrhizaes 31.50 weight portions.
3. preparation method with Chinese medicine composition of analgesic, analgesia, antiinflammatory, antitussive, expectoration, adjusting immunization is characterized in that this method is:
Cornu Saigae Tataricae 8～12 weight portion Bulbus Fritillariae Ussuriensiss 30～60 weight portions
Radix Et Rhizoma Rhei 20～40 weight portion Radix Scutellariaes 10～20 weight portions
Lapis Chloriti 10～20 weight portion Gypsum Fibrosum 15～30 weight portions
Artificial Calculus Bovis 5～15 weight portion Radix Glycyrrhizaes 20～40 weight portions.
Cornu Saigae Tataricae powder is broken into fine powder, adds 8～12 times of water gagings and sodium hydroxide 2～6 weight portions, back hydrolysis filters, medicinal residues add 3～6 times of water gagings and sodium hydroxide 1～2 weight portion, and back hydrolysis to almost molten entirely, filters, merging filtrate, being concentrated into relative density is 1.020～1.030, obtains extractum I; Lapis Chloriti, gypsum powder are broken into coarse powder, decoct 1～3 hour with 8～12 times of water gaging heating, filter, and medicinal residues add 6～10 times of water gagings and decocted 1～2 hour, filter, and merge filtrate twice, and being concentrated into relative density is 1.015～1.019, obtains extractum II; 3～6 times of amounts of artificial Calculus Bovis, 50%～90% ethanol extraction 2～4 hours, medicinal residues were measured 50%～90% alcohol reflux 1～2 hour with 3～6 times, filter, merging filtrate, decompression recycling ethanol, being concentrated into relative density is 1.020～1.030, obtains extractum III; Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae four Chinese medicine add 8～12 times of water gagings and decocted 1～3 hour, filter, medicinal residues add 3～6 times of water gaging heating and decocted 1～2 hour, filter merging filtrate, be concentrated into the extractum of relative density 1.10～1.20, centrifugal, get supernatant and add 2～5 times of amount 50%～90% ethanol, stir evenly, leave standstill, get supernatant, filter, reclaim ethanol, be concentrated into relative density and be about 1.08, obtain extractum IV; Get above-mentioned extractum I, extractum II, extractum III, extractum IV mixing, add conventional adjuvant and make clinical acceptable forms.
4. the preparation method with Chinese medicine composition of analgesic, analgesia, antiinflammatory, antitussive, expectoration, adjusting immunization as claimed in claim 3 is characterized in that this method is:
Cornu Saigae Tataricae 9.45 weight portion Bulbus Fritillariae Ussuriensiss 47.25 weight portions
Radix Et Rhizoma Rhei 31.50 weight portion Radix Scutellariaes 15.75 weight portions
Lapis Chloriti 15.75 weight portion Gypsum Fibrosum 23.62 weight portions
Artificial Calculus Bovis 9.45 weight portion Radix Glycyrrhizaes 31.50 weight portions.
Cornu Saigae Tataricae powder is broken into fine powder, add 10 times of water gagings and sodium hydroxide 4 weight portions, back hydrolysis 24 hours filters, and medicinal residues add 5 times of water gagings and sodium hydroxide 1.5 weight portions, back hydrolysis, to almost molten entirely, filter, merge filtrate twice, being concentrated into 20 ℃ of relative densities is 1.020～1.030, obtains extractum I; Lapis Chloriti, gypsum powder are broken into coarse powder, decoct 2 hours with 10 times of water gaging heating, filter, and medicinal residues add 8 times of water gagings and decocted 1.5 hours, filter, and merge filtrate twice, and being concentrated into 85 ℃ of relative densities is 1.015～1.019, obtains extractum II; 5 times of amounts of artificial Calculus Bovis, 70% ethanol extraction 3 hours, medicinal residues were measured 70% alcohol reflux 1.5 hours with 5 times, filtered, and merged filtrate twice, decompression recycling ethanol, being concentrated into 85 ℃ of relative densities is 1.020～1.030, obtains extractum III; Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae four Chinese medicine add 10 times of water gagings and decocted 2 hours, filter, medicinal residues add 5 times of water gaging heating and decocted 1.5 hours, filter, and merge filtrate twice, be concentrated into the extractum of 85 ℃ of relative densities 1.10, centrifugal, get supernatant and add 4 times of amount 70% ethanol, stir evenly, left standstill 48 hours, get supernatant, filter, decompression recycling ethanol is concentrated into 85 ℃ of relative densities and is about 1.08, obtains extractum IV; Get the stevioside of above-mentioned extractum I, extractum II, extractum III, extractum IV and 0.2%, stir, mixing, heated and boiled 20 minutes, cold preservation 48 hours filters, and filtrate adds the water adjustment, makes oral liquid.
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| CN2007100238486A CN101327294B (en) | 2007-06-22 | 2007-06-22 | Chinese medicinal composition for treating common cold, acute and chronic tracheitis and preparation method thereof |
| HK09102625.0A HK1121967A1 (en) | 2007-06-22 | 2009-03-19 | A chinese medicine composition having effects of antipyretics, analgesics, anti-inflammatory, antitussive, expectorant and immunoregulation and a preparation method thereof |
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| CN101991763B (en) * | 2009-08-20 | 2012-05-23 | 江苏康缘药业股份有限公司 | Application of traditional Chinese medicinal composition to preparing medicaments for resisting influenza virus |
| CN105548375A (en) * | 2014-10-29 | 2016-05-04 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition and fingerprint detection method of raw material herb of traditional Chinese medicine composition |
| CN104826076A (en) * | 2015-05-27 | 2015-08-12 | 苗怡文 | Traditional Chinese medicine preparation for treating cough during pregnancy and preparation method thereof |
| CN108704058B (en) * | 2018-08-21 | 2021-05-04 | 江苏康缘药业股份有限公司 | Composition for treating pharyngitis and preparation method and application thereof |
| CN109820947B (en) * | 2019-02-26 | 2021-07-13 | 江苏康缘药业股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating upper airway cough syndrome |
| CN116251150A (en) * | 2021-12-02 | 2023-06-13 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition and application thereof |
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| CN1239188C (en) * | 2003-08-16 | 2006-02-01 | 江苏康缘药业股份有限公司 | Use of Chinese medicine composition in preparing medicine for anti SARS virus |
| CN1251740C (en) * | 2002-08-20 | 2006-04-19 | 江苏康缘药业股份有限公司 | Chinese medicine composition and its preparation method |
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| CN1251740C (en) * | 2002-08-20 | 2006-04-19 | 江苏康缘药业股份有限公司 | Chinese medicine composition and its preparation method |
| CN1239188C (en) * | 2003-08-16 | 2006-02-01 | 江苏康缘药业股份有限公司 | Use of Chinese medicine composition in preparing medicine for anti SARS virus |
Non-Patent Citations (1)
| Title |
|---|
| 杨玉静.高效液相色谱法测定青羚散中甘草酸的含量.《中医药学报》.2006,第34卷(第3期),33. * |
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