CN101327175A - Zedoary turmeric oil dental health article - Google Patents

Abstract

The invention relates to a zedoary turmeric oil application to the preparation of toothpastes, rinse solution, oral inhalants and the like. The oral sanitary product containing the zedoary turmeric oil has the function of inhibiting various pathogenic bacteria and virus growth while guaranteeing the tooth sanitation. Thus, the oral sanitary products containing the zedoary turmeric oil are the most convenient daily necessaries which can effectively prevent the bacteria and virus infection and diminish the inflammation.

Description

Zedoary turmeric oil dental health article

Technical field:

The present invention relates to a kind of a series of dental health articles that contain Oleum Curcumae, be particularly related to Oleum Curcumae and make multifunctional oral cavity health product such as antibiotic, antiviral, antiinflammatory, as antibiotic, antiviral, antiphlogistic toothpaste and antibiotic, antiviral, antiphlogistic collutory or the like.

Background technology:

Antibiotic, the antiinflammatory of selling on the market at present,, anti-periodontal disease or eliminate in the toothpaste of halitosis and have some problems.At first, contain the phosphoramidite chemical antibacterial mostly in some antiseptic toothpastes, this antibacterial has also been killed profitable strain in the oral cavity together, has destroyed the ecological balance of flora in the oral cavity, and the oral cavity often uses and can produce drug resistance, aggravates disease on the contrary; Simultaneously, there are some researches show that the adult brushes teeth and will have the 15%-20% of each consumption to be swallowed by mistake, the child brushes teeth about 40% being swallowed that consumption is arranged by mistake, and life-time service certainly will work the mischief to health.Secondly, on the market more than the Chinese medicinal toothpaste of Xiao Shouing based on antibiotic, the not only antibiotic but also antiviral of a kind of Chinese medicine, antiphlogistic multipurpose tooth paste are seldom arranged.

The invention reside in when addressing the above problem, relate generally to antibiotic, the antiviral of giving full play to the Chinese medicine Rhizoma Curcumae, antioxidation, microcirculation improvement, antiinflammatory etc. and act on application in the oral health care product, the value of Rhizoma Curcumae can better be embodied.

Specify:

Oleum Curcumae is the volatile oil that extracts from the Chinese medicine Rhizoma Curcumae, and its effective ingredient is curcumenol, curzerenone, can suppress staphylococcus aureus, β ₂The growth of Hemolytic streptococcus, escherichia coli, Bacillus typhi etc. has direct repression to respiratory syncytial virus (RSV), and influenza virus A1, A3 type are had direct deactivation.In addition, other virus there is direct repression as rubella, chickenpox virus, may inhibitory action be also arranged to parainfluenza virus, paramyxovirus, Coxsackie virus etc. simultaneously ^[1]It is with virion dissolution mechanism antiviral, and prolonged application does not have harm to main organs, is low toxicity, safe drugs.Therefore, Oleum Curcumae has caused extensive attention as a kind of new potential anti-virus formulation.1,985 one ones of Chinese medicine Rhizoma Curcumae income Pharmacopoeias of People's Republic of China, Oleum Curcumae glucose sugar injection is two antiviral agents that newly record of Chinese Pharmacopoeia nineteen ninety-five version, normal clinically and antimicrobial drug share.Be applicable to flu that virus causes, upper respiratory tract infection etc., infantile viral pneumonia, mumps, digestive tract ulcer, hepatitis A, infantile viral enteritis and viral myocarditis, encephalitis, viral keratitis etc.In addition, Oleum Curcumae also has multiple pharmacological effect such as antioxidation.

Because viral infection at first enters the oral mucosa and the upper respiratory tract epithelial cell of human body, the blood circulation that just enters the people through 1-7 days incubation periods after the breeding is bred again, just is positioned some organ-tissue of human body then.Virus is eliminated incubation period in the oral cavity, the Chinese medicinal toothpaste that is used in external quick inhibition and kill bacteria and virus composition is brushed teeth, is gargled, to can directly suppress fast or kill slipping into intraoral antibacterial and virus, reduce it and enter intravital chance, reach the morbidity chance that reduces malignant bacteria and virus, hold " illness finds its way in by the mouth " this pass effectively, this is the not only science but also a kind of easily way that reduces morbidity.In addition, the present invention has also added antibiotic, the antiinflammation that Borneolum Syntheticum strengthens this dental health article.Traditional medicine thinks, but Borneolum Syntheticum removing the necrotic tissue and promoting granulation, reducing swelling and alleviating pain, thus be used for aphtha, carbuncle more, the modern medicine and pharmacology evidence, that Borneolum Syntheticum has is antibiotic, antiinflammatory, analgesic effect.

The product that is used for oral hygiene of the present invention can adopt any type of preparation, for example toothpaste, collutory or inhalant etc., the appropriate carrier that will comprise Oleum Curcumae, additive and be used for this dosage form in these prescriptions.

Different product provided by the invention, for example toothpaste, collutory or inhalant or the like can obtain by using routine techniques as known in the art.

The following example is used for illustrating the present invention, and should not be considered to limitation of the scope of the invention.

In order to illustrate, when the product that is used for oral hygiene of the present invention provides with the form of toothpaste, this product is except Oleum Curcumae, can contain promising product provides other chemical compounds of some properties, suitable carrier and additive, for example abrasive, wetting agent, surfactant, thickening agent, flavoring agent, antiseptic, spice, coloring agent or the like.

(1) its function of abrasive is the friction that increases toothbrush and tooth surface, removes dirt and coloring matter attached to dental surface.Abrasive should have suitable hardness, granularity and clean effect preferably, damage tooth tissue not, chemically stable, nontoxic free from extraneous odour etc.Abrasive commonly used has calcium carbonate, calcium hydrogen phosphate, water-insoluble Polymeric sodium metaphosphate., calcium pyrophosphate, hydrated alumina, silicon dioxide, sodium aluminosilicate etc.

(2) its effect of thickening agent is to become paste after each component of toothpaste is mixed, and makes mastic exquisiteness, stable.Thickening agent commonly used has CMC, HEC, PVA, polyacrylamide, carrageenin, tragacanth, Sodium Alginate, bentonite, silicon dioxide, PVP synthetic earth etc.

(3) wetting agent can make toothpaste moisture be not easy to lose, be easy to extrude, and makes mastic keep gloss.The ordinary toothpaste consumption is 20%～30%, and transparent toothpaste can reach 75%.Wetting agent commonly used has glycerol, sorbitol, propylene glycol, Polyethylene Glycol and xylitol etc.

(4) surfactant has effects such as washing, foaming, emulsifying, dispersion, moistening.It can make a large amount of foam of generation when brushing teeth, and diffusion rapidly makes fragrance be easy to bring out in the oral cavity, promotes dirt to break away from dental surface.Consumption is generally 2%～3%.Foaming agent commonly used has sodium laurylsulfate, N-sodium N-lauroyl sarcosinate, N-lauroyl L-Tyrosine, sodium salt, lauroyl sulfoacetic acid sodium, dioctyl sodium sulphosuccinate etc.

(5) its effect of antiseptic is to prevent the toothpaste moldy metamorphism, and commonly used have sodium benzoate, methyl hydroxybenzoate and a propyl ester etc.

(6) corrosion inhibiter is used for the anticorrosive of toothpaste aluminum skin, and commonly used have sodium silicate, Chile saltpeter and a phosphate etc.

(7) spice of sweeting agent toothpaste mostly is bitterness, and abrasive has the dust flavor again, needs to add sweeting agent and is corrected, and use saccharin sodium, consumption at present is 0.05%～0.25% more.

(8) spice can improve the taste of toothpaste, and consumption is 1%～2%.The spice that toothpaste is used requires to adapt to the taste and the fragrance of raw materials such as foaming agent, gives toothpaste body with characteristic pure and fresh, tasty and refreshing sensation.Have Oleum Menthae Rotundifoliae, Oleum menthae, wintergreen oil, Oleum Caryophylli, orange oil, Cladrastis kentukea Rudd oil, Oleum Anisi Stellati and the Cortex Cinnamomi wet goods generally selected for use also have fruit flavouring.

(9) coloring agent is commonly used aluminium oxide, hydrated alumina, zirconium oxide or titanium dioxide.Be used to illustrate the toothpaste of toothpaste provided by the present invention, have following composition:

The percent of ingredients constitute gross weight (%)

Abrasive 20-50

Thickening agent 0.5-3

Wetting agent 15-50

Surfactant 0.5-3

Oleum Curcumae 0.01-0.1

Borneolum Syntheticum 0.05-0.1

Essence 0.5-2.5

Coloring agent 0.5-2.5

Sweeting agent is an amount of

Antiseptic is an amount of

Water an amount of 100

Embodiment 1

Toothpaste with Oleum Curcumae

By conventional method, by the different component of abundant mixing Sq, the toothpaste of prescription shown in the preparation tool table 1.

Toothpaste with Oleum Curcumae

Weight percentages of components (%)

Glycerol 32.000

Sodium carboxymethyl cellulose 1.200

Calcium carbonate 45.000

Sodium laurylsulfate 1.500

Oleum Curcumae 0.01-0.1

Borneolum Syntheticum 0.080

Saccharin sodium 0.300

Essence 1.000

Water 18.870

Preparation method:

Adopt the kneading method, the technology difference can be divided into two kinds of methods, a kind of with the moistening of thickening agent elder generation in wetting agent in the glycerol, and then be scattered in the liquid part that contains glucide and antibiotic antiseptic etc., it is expanded form even gel, even gel is squeezed in the stirring kneader that suits with pump, slowly adds the opaque abrasivus in stirring, until whole mix homogeneously; Also can earlier the abrasivus of opaque be put into the cream machine of mixing, under agitation slowly add liquid gel, until forming uniform mastic.Add essence and surfactant mix homogeneously at last, will avoid squeezing into too much bubble when adding surfactant.

Another kind method is that thickening agent is pre-mixed in the opaque abrasivus, admixes the liquid part that contains wetting agent antibiotic antiseptic and glucide etc. in the cream machine in suitable mixing then, and the back that stirs adds essence and surfactant.Also can there be some uneven grains in the mastic that said method is made, also sneaks into air in certain amount in the mastic simultaneously, must be through grinding and the degassing.Grind and use colloid mill, the degassing can be adopted the vacuum degasser of mastic.Present embodiment adopts first method that the present invention is described.

Processing technology:

1, the same sodium carboxymethyl cellulose of glycerol, saccharin sodium and suitable quantity of water are made colloid by stirring, store standby more than 12 hours.

2, in the colloid of stocking, add calcium carbonate, Oleum Curcumae, Borneolum Syntheticum etc. and stir into uniform paste.

3, add essence and sodium laurylsulfate mix homogeneously.

4, lotion of toothpaste grinds by colloid mill, makes the lotion of toothpaste of fine and smooth light again through vacuum outgas.

5, by the canned finished product of can packing machine.

In order to illustrate, when the product that is used for oral hygiene of the present invention provided with the form of collutory, this product can contain other chemical compounds that promising product provides some properties, suitable carrier and additive except Oleum Curcumae.Common collutory main component is made up of alcohol, wetting agent, surfactant and essence.

(1) alcohol mainly is ethanol, and with 10%～20%, its effect is to increase the essence effect, covers the sense of taste of some " activity " component, and ethanol still is good solubilizing agent.

(2) the wetting agent consumption is 5%～20% in the wetting agent collutory, and common humectants has glycerol and Sorbitol, xylitol etc.The effect of wetting agent is to increase the product viscosity, controls the activity of water, also can increase the sweet taste of collutory.

(3) non-ionic surface active agent that surfactant is commonly used has polyoxyethylene or polyoxypropylene copolymer to use with tween, and consumption is 0.1%～0.5%, and anion surfactant is only used sodium lauryl sulphate; Cationic surfactant is the cetylpyridinium chloride father-in-law.Their effect is solubilising, foaming, sterilization.

(4) effect of essence essence is to make people's mind frankness, covers the offending abnormal smells from the patient of component.The essence that gargarism uses has Oleum menthae, Oleum Menthae Rotundifoliae, Oleum Cinnamomi, wintergreen oil, menthol, methyl salicylate/menthol mixture.

(5) other antiseptic, pigment and deionized water etc.

Collutory is a kind of dental care product that uses when gargling, and that its advantage is to use is easy, save time, and does not need special apparatus, is a kind of very effective dental care products.

Be used to illustrate the collutory of collutory provided by the present invention, have following composition:

Weight percentages of components (%)

Ethanol 10-20

Wetting agent 5-20

Surfactant 0.1-0.5

Oleum Curcumae 0.01-0.1

Essence is an amount of

Antiseptic is an amount of

Water is in right amount to 100

Embodiment 2

By routine techniques, by the different component of abundant mixing Sq, the preparation collutory, their prescription is as follows.

Weight percentages of components (%)

Ethanol 10.000

Glycerol 15.000

Sodium lauryl sulphate 0.300

Oleum Curcumae 0.01-0.1

Xylitol 10.000

Essence 0.050

Water 64.600

Processing technology: each component in the above-mentioned prescription is fully mixed, stir promptly in the distilled water of falling people then.

Claims (6)

1. Oleum Curcumae is used for the application of antibiotic, antiviral, antiphlogistic dental health article in preparation.

2. according to claim 1, the wherein said product that is used for oral hygiene is selected from toothpaste, collutory or oral cavity inhalant.

3. according to claim 2, the wherein said dental health product that is used for is a toothpaste.

4. according to claim 2, the wherein said dental health product that is used for is a collutory.

5. according to claim 3, the wherein said dental health product that is used for adds Borneolum Syntheticum.

6. according to claim 3～5, the content of Oleum Curcumae is 0.01-1% in toothpaste, collutory and the oral cavity inhalant.