CN101325978A - 用于纤维化的新显像剂 - Google Patents

用于纤维化的新显像剂 Download PDF

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Publication number
CN101325978A
CN101325978A CNA2006800461919A CN200680046191A CN101325978A CN 101325978 A CN101325978 A CN 101325978A CN A2006800461919 A CNA2006800461919 A CN A2006800461919A CN 200680046191 A CN200680046191 A CN 200680046191A CN 101325978 A CN101325978 A CN 101325978A
Authority
CN
China
Prior art keywords
imaging
imaging agent
carrier
group
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800461919A
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English (en)
Chinese (zh)
Inventor
S·切蒂比
B·纽顿
B·吉尔贝
H·托尔斯豪格
M·索尔贝肯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN101325978A publication Critical patent/CN101325978A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CNA2006800461919A 2005-12-08 2006-12-07 用于纤维化的新显像剂 Pending CN101325978A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0524987.5A GB0524987D0 (en) 2005-12-08 2005-12-08 Novel imaging agents for fibrosis
GB0524987.5 2005-12-08

Publications (1)

Publication Number Publication Date
CN101325978A true CN101325978A (zh) 2008-12-17

Family

ID=35735731

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800461919A Pending CN101325978A (zh) 2005-12-08 2006-12-07 用于纤维化的新显像剂

Country Status (6)

Country Link
US (1) US20080279765A1 (enExample)
EP (2) EP2305316A3 (enExample)
JP (1) JP2009518372A (enExample)
CN (1) CN101325978A (enExample)
GB (1) GB0524987D0 (enExample)
WO (1) WO2007066115A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105148291A (zh) * 2015-09-16 2015-12-16 中国海洋大学 多聚糖醛酸为载体的活体染色造影剂及制备方法和应用
CN105343900A (zh) * 2015-09-16 2016-02-24 中国海洋大学 褐藻多糖为载体的淋巴靶向核磁造影剂及制备方法和应用

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US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
JP2009221164A (ja) * 2008-03-17 2009-10-01 Nitto Denko Corp 肺線維症処置剤
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
GB0722650D0 (en) 2007-11-19 2007-12-27 Ge Healthcare Ltd Novel imaging method
WO2009134405A2 (en) * 2008-04-30 2009-11-05 Siemens Medical Solutions Usa, Inc. Novel substrate based pet imaging agents
JP5744723B2 (ja) * 2008-09-12 2015-07-08 日東電工株式会社 線維性疾患のイメージング剤
CN101738468B (zh) * 2008-11-24 2013-03-27 中国医学科学院阜外心血管病医院 胰岛素样生长因子ⅱ受体在检测心力衰竭中的应用及试剂盒
US20100303733A1 (en) * 2009-05-29 2010-12-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, methods, and compositions including ferromagnetic structures
US8106655B2 (en) * 2009-05-29 2012-01-31 The Invention Science Fund I, Llc Multiplex imaging systems, devices, methods, and compositions including ferromagnetic structures
US8063636B2 (en) * 2009-05-29 2011-11-22 The Invention Science Fund I, Llc Systems, devices, methods, and compositions including targeted ferromagnetic structures
US8058872B2 (en) 2009-05-29 2011-11-15 The Invention Science Fund I, Llc Systems, devices, methods, and compositions including functionalized ferromagnetic structures
US8154285B1 (en) 2009-05-29 2012-04-10 The Invention Science Fund I, Llc Non-external static magnetic field imaging systems, devices, methods, and compositions
JP5950428B2 (ja) 2010-08-05 2016-07-13 日東電工株式会社 線維化組織から正常組織を再生するための組成物
JP5517306B2 (ja) * 2011-01-26 2014-06-11 日東電工株式会社 肺線維症処置剤
US8580922B2 (en) 2011-03-04 2013-11-12 Shire Human Genetic Therapies, Inc. Peptide linkers for polypeptide compositions and methods for using same
BR112013022557A2 (pt) * 2011-03-04 2017-08-01 Shire Human Genetic Therapies ligantes de peptídeo composições de polipeptídeo e métodos para uso dos mesmos
EP2866842A1 (en) * 2012-06-29 2015-05-06 GE Healthcare UK Limited Imaging fibrosis
JP6340162B2 (ja) 2012-12-20 2018-06-06 日東電工株式会社 アポトーシス誘導剤
JP6602034B2 (ja) 2014-04-02 2019-11-06 日東電工株式会社 標的化分子およびその使用
CA2943733C (en) 2014-04-07 2022-03-01 Nitto Denko Corporation Polymer-based hydrotropes for hydrophobic drug delivery
CN112546228A (zh) * 2019-09-10 2021-03-26 中国科学院上海营养与健康研究所 非igf1r结合型的物质在预防和/或治疗炎症性疾病中的应用

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US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5217705A (en) * 1987-09-25 1993-06-08 Neorx Corporation Method of diagnosing blood clots using fibrin-binding proteins
ATE120374T1 (de) 1989-07-20 1995-04-15 Sandoz Ag Markierte polypeptidderivate.
DK129293D0 (da) 1993-11-16 1993-11-16 Carlsberg Lab Carbonhydratholdige forbindelser, der kan binde sig til carbonhydratbindende receptorer
US6908903B1 (en) * 1994-12-07 2005-06-21 Aletheon Pharmaceuticals, Inc. Cluster clearing agents
AU770340B2 (en) * 1998-10-08 2004-02-19 Biorion Technologies B.V. Peptide-based carrier devices for stellate cells
EP1436316B1 (en) * 2001-04-30 2008-01-23 ZyStor Therapeutics , Inc. Subcellular targeting of therapeutic proteins
GB0115927D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0115929D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination
GB0206750D0 (en) 2002-03-22 2002-05-01 Amersham Plc Radiofluorination methods
JP4874090B2 (ja) * 2003-01-31 2012-02-08 イミューノメディクス、インコーポレイテッド 治療薬および診断薬を投与するための方法および組成物
ES2302898T3 (es) * 2003-07-11 2008-08-01 Lbr Medbiotech B.V. Transferencia de genes a celulas musculares mediada por el receptor de manosa-6-fosfato.
US7431914B2 (en) * 2003-11-24 2008-10-07 Ge Healthcare As Contrast agent
US20060148740A1 (en) * 2005-01-05 2006-07-06 Prosensa B.V. Mannose-6-phosphate receptor mediated gene transfer into muscle cells

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105148291A (zh) * 2015-09-16 2015-12-16 中国海洋大学 多聚糖醛酸为载体的活体染色造影剂及制备方法和应用
CN105343900A (zh) * 2015-09-16 2016-02-24 中国海洋大学 褐藻多糖为载体的淋巴靶向核磁造影剂及制备方法和应用
WO2017045508A1 (zh) * 2015-09-16 2017-03-23 中国海洋大学 多聚糖醛酸为载体的活体染色造影剂及制备方法和应用
WO2017045509A1 (zh) * 2015-09-16 2017-03-23 中国海洋大学 褐藻多糖为载体的淋巴靶向核磁造影剂及制备方法和应用
CN108837160A (zh) * 2015-09-16 2018-11-20 中国海洋大学 褐藻多糖为载体的淋巴靶向核磁造影剂及制备方法和应用
CN108837160B (zh) * 2015-09-16 2021-04-16 中国海洋大学 褐藻多糖为载体的淋巴靶向核磁造影剂及制备方法和应用
US11103601B2 (en) 2015-09-16 2021-08-31 Ocean University Of China Lymph targeting nuclear magnetic contrast agent using brown algae polysaccharide as carrier and preparation method and use thereof

Also Published As

Publication number Publication date
EP2305316A3 (en) 2011-06-08
GB0524987D0 (en) 2006-01-18
US20080279765A1 (en) 2008-11-13
WO2007066115A2 (en) 2007-06-14
WO2007066115B1 (en) 2008-01-31
EP2305316A2 (en) 2011-04-06
WO2007066115A3 (en) 2007-11-29
EP1957114A2 (en) 2008-08-20
JP2009518372A (ja) 2009-05-07

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AD01 Patent right deemed abandoned

Effective date of abandoning: 20081217

C20 Patent right or utility model deemed to be abandoned or is abandoned