CN101310733B - 一种治疗心血管疾病的药物组合物及其制备方法 - Google Patents
一种治疗心血管疾病的药物组合物及其制备方法 Download PDFInfo
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- CN101310733B CN101310733B CN2007101075522A CN200710107552A CN101310733B CN 101310733 B CN101310733 B CN 101310733B CN 2007101075522 A CN2007101075522 A CN 2007101075522A CN 200710107552 A CN200710107552 A CN 200710107552A CN 101310733 B CN101310733 B CN 101310733B
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- Prior art keywords
- ginsenoside
- pharmaceutical composition
- herba epimedii
- radix ginseng
- cardiovascular disease
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- 238000007796 conventional method Methods 0.000 claims abstract description 19
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- GZYPWOGIYAIIPV-JBDTYSNRSA-N ginsenoside Rb1 Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)O[C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(CC[C@H]4C(C)(C)[C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)CC[C@]4(C)[C@H]3C[C@H]2O)C)(C)CC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GZYPWOGIYAIIPV-JBDTYSNRSA-N 0.000 claims description 25
- TXEWRVNOAJOINC-UHFFFAOYSA-N ginsenoside Rb2 Natural products CC(=CCCC(OC1OC(COC2OCC(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C)C TXEWRVNOAJOINC-UHFFFAOYSA-N 0.000 claims description 25
- PWAOOJDMFUQOKB-WCZZMFLVSA-N ginsenoside Re Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]3C(C)(C)[C@@H](O)CC[C@]3(C)[C@@H]3[C@@]([C@@]4(CC[C@@H]([C@H]4[C@H](O)C3)[C@](C)(CCC=C(C)C)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C)(C)C2)O[C@H](CO)[C@@H](O)[C@@H]1O PWAOOJDMFUQOKB-WCZZMFLVSA-N 0.000 claims description 25
- YURJSTAIMNSZAE-HHNZYBFYSA-N ginsenoside Rg1 Chemical compound O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YURJSTAIMNSZAE-HHNZYBFYSA-N 0.000 claims description 25
- CBEHEBUBNAGGKC-UHFFFAOYSA-N ginsenoside Rg1 Natural products CC(=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5CC(OC6OC(CO)C(O)C(O)C6O)C34C)C CBEHEBUBNAGGKC-UHFFFAOYSA-N 0.000 claims description 25
- AOGZLQUEBLOQCI-UHFFFAOYSA-N ginsenoside-Re Natural products CC1OC(OCC2OC(OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(CCC=C(C)C)OC6OC(CO)C(O)C(O)C6O)C7(C)CCC(O)C(C)(C)C37)C(O)C(O)C2O)C(O)C(O)C1O AOGZLQUEBLOQCI-UHFFFAOYSA-N 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 22
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- 239000002671 adjuvant Substances 0.000 claims description 20
- TZJALUIVHRYQQB-XLRXWWTNSA-N icariin Chemical compound C1=CC(OC)=CC=C1C1=C(O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)C(=O)C2=C(O)C=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-XLRXWWTNSA-N 0.000 claims description 20
- TZJALUIVHRYQQB-UHFFFAOYSA-N icariine Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(C)O2)O)C(=O)C2=C(O)C=C(OC3C(C(O)C(O)C(CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-UHFFFAOYSA-N 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 17
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- 229930003935 flavonoid Natural products 0.000 abstract 2
- 150000002215 flavonoids Chemical class 0.000 abstract 2
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- 230000008485 antagonism Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (12)
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CN2007101075522A CN101310733B (zh) | 2007-05-21 | 2007-05-21 | 一种治疗心血管疾病的药物组合物及其制备方法 |
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CN2007101075522A CN101310733B (zh) | 2007-05-21 | 2007-05-21 | 一种治疗心血管疾病的药物组合物及其制备方法 |
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CN101310733A CN101310733A (zh) | 2008-11-26 |
CN101310733B true CN101310733B (zh) | 2010-11-17 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102091114B (zh) * | 2009-12-15 | 2014-11-26 | 河北以岭医药研究院有限公司 | 一种中药冻干注射剂及其制备方法 |
CN102125594B (zh) * | 2010-01-12 | 2012-09-05 | 河北以岭医药研究院有限公司 | 一种中药冻干注射剂中活性化合物含量的测定方法 |
WO2012100408A1 (zh) * | 2011-01-25 | 2012-08-02 | 河北以岭医药研究院有限公司 | 一种环糊精包合物、其制备方法以及包含所述包合物的药物制剂 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1124141C (zh) * | 2000-04-12 | 2003-10-15 | 辛耀禄 | 治疗心脑血管病的胶囊及其制备工艺 |
CN1626103A (zh) * | 2004-08-10 | 2005-06-15 | 浙江大学 | 一种含三七总皂苷和淫羊藿苷的药物组合物及其用途 |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1124141C (zh) * | 2000-04-12 | 2003-10-15 | 辛耀禄 | 治疗心脑血管病的胶囊及其制备工艺 |
CN1626103A (zh) * | 2004-08-10 | 2005-06-15 | 浙江大学 | 一种含三七总皂苷和淫羊藿苷的药物组合物及其用途 |
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C06 | Publication | ||
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SICHUAN KELUN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SICHUAN PEARL PHARMACEUTICAL CO., LTD. Effective date: 20120417 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20120417 Address after: 610500, No. 520, industrial road, Xindu District, Xindu, Sichuan, Chengdu Patentee after: Sichuan Kelun Pharmaceutical Co., Ltd. Address before: 610500 Sichuan province Chengdu City satellite city industrial development zone two South Road Patentee before: Sichuan Pearl Pharmaceutical Co., Ltd. |