CN101301501A - 新型药物输送技术 - Google Patents
新型药物输送技术 Download PDFInfo
- Publication number
- CN101301501A CN101301501A CNA2008100832318A CN200810083231A CN101301501A CN 101301501 A CN101301501 A CN 101301501A CN A2008100832318 A CNA2008100832318 A CN A2008100832318A CN 200810083231 A CN200810083231 A CN 200810083231A CN 101301501 A CN101301501 A CN 101301501A
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- Prior art keywords
- chemical compound
- treatment
- pioneer projectile
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F42—AMMUNITION; BLASTING
- F42B—EXPLOSIVE CHARGES, e.g. FOR BLASTING, FIREWORKS, AMMUNITION
- F42B12/00—Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material
- F42B12/02—Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material characterised by the warhead or the intended effect
- F42B12/36—Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material characterised by the warhead or the intended effect for dispensing materials; for producing chemical or physical reaction; for signalling ; for transmitting information
- F42B12/46—Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material characterised by the warhead or the intended effect for dispensing materials; for producing chemical or physical reaction; for signalling ; for transmitting information for dispensing gases, vapours, powders or chemically-reactive substances
- F42B12/54—Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material characterised by the warhead or the intended effect for dispensing materials; for producing chemical or physical reaction; for signalling ; for transmitting information for dispensing gases, vapours, powders or chemically-reactive substances by implantation, e.g. hypodermic projectiles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
- A61M2005/005—Magazines with multiple ampoules directly inserted into an injection or infusion device, e.g. revolver-like magazines containing ampoules with or without needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
- A61M5/3015—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- General Engineering & Computer Science (AREA)
- Combustion & Propulsion (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polarising Elements (AREA)
- Fuel-Injection Apparatus (AREA)
- Threshing Machine Elements (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0121914A GB2379390B (en) | 2001-09-11 | 2001-09-11 | A novel drug delivery technology |
| GB0121914.6 | 2001-09-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028178041A Division CN100425298C (zh) | 2001-09-11 | 2002-09-10 | 新型药物输送技术 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101301501A true CN101301501A (zh) | 2008-11-12 |
Family
ID=9921868
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100832318A Pending CN101301501A (zh) | 2001-09-11 | 2002-09-10 | 新型药物输送技术 |
| CNB028178041A Expired - Lifetime CN100425298C (zh) | 2001-09-11 | 2002-09-10 | 新型药物输送技术 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028178041A Expired - Lifetime CN100425298C (zh) | 2001-09-11 | 2002-09-10 | 新型药物输送技术 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7727223B2 (enExample) |
| EP (2) | EP2065063A1 (enExample) |
| JP (2) | JP4427325B2 (enExample) |
| CN (2) | CN101301501A (enExample) |
| AT (1) | ATE429261T1 (enExample) |
| AU (2) | AU2002350449B2 (enExample) |
| CA (1) | CA2459459C (enExample) |
| DE (1) | DE60232087D1 (enExample) |
| DK (1) | DK1427464T3 (enExample) |
| ES (1) | ES2325488T3 (enExample) |
| GB (2) | GB2404865B (enExample) |
| IL (2) | IL160592A0 (enExample) |
| MX (1) | MXPA04002309A (enExample) |
| NZ (1) | NZ531755A (enExample) |
| PL (1) | PL205096B1 (enExample) |
| PT (1) | PT1427464E (enExample) |
| WO (1) | WO2003023773A1 (enExample) |
| ZA (1) | ZA200401886B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2391480B (en) * | 2002-08-05 | 2007-02-28 | Caretek Medical Ltd | Drug delivery system |
| US7470250B2 (en) | 2002-03-22 | 2008-12-30 | Novo Nordisk A/S | Apparatus for automatic insertion of a solid medicine |
| EP2594259A1 (en) | 2004-08-04 | 2013-05-22 | Brookwood Pharmaceuticals, Inc. | Methods for manufacturing delivery devices and devices thereof |
| BRPI0515759B8 (pt) | 2004-12-01 | 2021-06-22 | Acushot Inc | dispositivo de injeção sem agulha e kit para utilização do mesmo |
| GB2422784A (en) * | 2005-02-07 | 2006-08-09 | Caretek Medical Ltd | Disposable assembly comprising a needle or stylet |
| AU2013200286B2 (en) * | 2005-11-17 | 2014-08-14 | Zogenix, Inc. | Delivery of viscous formulations by needle-free injection |
| WO2007061896A1 (en) | 2005-11-17 | 2007-05-31 | Zogenix, Inc. | Delivery of viscous formulations by needle-free injection |
| ES2329832T3 (es) * | 2005-12-07 | 2009-12-01 | Painless Tech Gmbh | Dispositivo de inyeccion y ampolla. |
| DE202006018609U1 (de) | 2006-08-29 | 2007-05-16 | Euro-Celtique S.A. | Verwendung von Opioidformulierungen in nadellosen Vorrichtungen zur Medikamentenverabreichung |
| GB2446780A (en) * | 2007-02-22 | 2008-08-27 | Glide Pharmaceutical Technolog | An elongate parenteral injection body having an injection point of angle 10 to 40 degrees. |
| DE102007018868A1 (de) | 2007-04-19 | 2008-10-23 | Lts Lohmann Therapie-Systeme Ag | Einweginjektor mit mindestens einem Zughaken und einem Schiebekeilgetriebe zum entsichernden Lösen eines Sperrelements |
| WO2009065835A1 (de) | 2007-11-19 | 2009-05-28 | Painless Tech Gmbh | Injektionsvorrichtung zur nadelfreien injektion eines mediums |
| US8124601B2 (en) * | 2007-11-21 | 2012-02-28 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
| US8728528B2 (en) | 2007-12-20 | 2014-05-20 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
| ES2604968T3 (es) * | 2008-04-28 | 2017-03-10 | Zogenix, Inc. | Nuevas formulaciones para el tratamiento de la migraña |
| AU2013202680C1 (en) * | 2008-04-28 | 2016-06-23 | Zogenix, Inc. | Novel formulations for treatment of migraine |
| RU2545865C2 (ru) * | 2009-09-22 | 2015-04-10 | Евоник Корпорейшн | Имплантируемые устройства с различными вариантами загрузки биологически активного компонента |
| ES2362525B8 (es) | 2009-10-08 | 2013-01-03 | Azurebio, S.L. | Formulación de medicamentos en forma de agujas percutaneas penetrantes. |
| JP2012139407A (ja) * | 2010-12-29 | 2012-07-26 | Terumo Corp | 穿刺体 |
| US8486002B2 (en) | 2011-04-19 | 2013-07-16 | Palo Alto Research Center Incorporated | Drug delivery devices and methods with collimated gas stream and release-activatable tape |
| US8388569B2 (en) * | 2011-04-19 | 2013-03-05 | Xerox Corporation | Delivery devices and methods with collimated gas stream and particle source |
| US8430839B2 (en) * | 2011-04-19 | 2013-04-30 | Palo Alto Research Center Incorporated | Drug delivery devices and methods with collimated gas stream and drug reservoir |
| PL2726091T3 (pl) * | 2011-06-29 | 2020-08-10 | Rani Therapeutics, Llc | Preparaty lecznicze dostarczane do kanału przewodu jelitowego za pomocą połykalnego urządzenia dostarczającego lek |
| CN102914458B (zh) * | 2012-10-16 | 2014-08-13 | 绍兴文理学院 | 一种重塑土直剪试样的制样器及其制样方法 |
| CN102901660B (zh) * | 2012-10-16 | 2014-08-13 | 绍兴文理学院 | 一种旋杆式三轴试样制样器及其制样方法 |
| GB201501697D0 (en) * | 2015-02-02 | 2015-03-18 | Glide Pharmaceutical Technologies Ltd | Injection device |
| US10449297B2 (en) | 2015-02-09 | 2019-10-22 | Palo Alto Research Center Incorporated | Alignment of elongated particles in a particle delivery device |
| US10039885B2 (en) | 2015-02-09 | 2018-08-07 | Palo Alto Research Center Incorporated | System and method for enhancing particle delivery to biological tissue |
| GB2545880A (en) | 2015-10-20 | 2017-07-05 | Glide Pharmaceutical Tech Ltd | Solid formulation |
| US10015274B2 (en) * | 2015-12-31 | 2018-07-03 | International Business Machines Corporation | Enhanced storage clients |
| IL301683B2 (en) | 2017-05-17 | 2025-02-01 | Massachusetts Inst Technology | Self-healing systems and related components and methods |
| US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| EP3960222A1 (en) * | 2017-08-30 | 2022-03-02 | Pirouette Medical Inc. | Compact auto-injector |
| EP3793667A1 (en) | 2018-05-17 | 2021-03-24 | Massachusetts Institute of Technology | Systems for electrical stimulation |
| CN108837238B (zh) * | 2018-07-13 | 2023-09-01 | 江苏省人民医院(南京医科大学第一附属医院) | 一种玻尿酸注射针 |
| GB201819059D0 (en) | 2018-11-22 | 2019-01-09 | Enesi Pharma Ltd | Single-use cassette assembly |
| GB201909280D0 (en) | 2019-06-27 | 2019-08-14 | Enesi Pharma Ltd | Solid dose formulation |
| US11541216B2 (en) * | 2019-11-21 | 2023-01-03 | Massachusetts Institute Of Technology | Methods for manufacturing tissue interfacing components |
| GB2591196B (en) | 2019-12-18 | 2022-03-02 | Enesi Pharma Ltd | Improvements in needle-free delivery |
| US11052196B1 (en) | 2020-11-03 | 2021-07-06 | Sun Pharmaceutical Industries Limited | Method of injecting octreotide acetate into the body |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1819415A (en) * | 1927-09-19 | 1931-08-18 | Channing R Dooley | Hypodermic bullet |
| US2398544A (en) * | 1945-01-06 | 1946-04-16 | Marshall L Lockhart | Hypodermic injector |
| FR1078911A (fr) * | 1949-08-17 | 1954-11-24 | Seringue hypodermique automatique et son ampoule | |
| FR1014881A (fr) | 1950-03-21 | 1952-08-25 | Appareil automatique pour injections parentérales | |
| FR1049564A (fr) | 1951-11-22 | 1953-12-30 | Normeca | Seringue à injection perfectionnée |
| GB993309A (en) | 1961-04-11 | 1965-05-26 | Express Injector Company Ltd | Improved hypodermic injector |
| US3616758A (en) * | 1968-10-24 | 1971-11-02 | Vladil Afanasievich Komarov | Shell for the immobilization of animals |
| US3901158A (en) * | 1969-05-13 | 1975-08-26 | Thomas E Ferb | Hypodermic projectile |
| CA1019638A (en) * | 1973-05-16 | 1977-10-25 | John C. Muirhead | Liquid injection projectile |
| US3948263A (en) * | 1974-08-14 | 1976-04-06 | Minnesota Mining And Manufacturing Company | Ballistic animal implant |
| US3982536A (en) * | 1974-11-15 | 1976-09-28 | Minnesota Mining And Manufacturing Company | Ballistic inoculation of animals and projectile therefor |
| JPS51130094A (en) * | 1975-05-08 | 1976-11-12 | Asahi Chemical Ind | Twoostage pressure injector |
| US4449982A (en) * | 1976-11-10 | 1984-05-22 | Minnesota Mining And Manufacturing Company | Projectile |
| US4664664A (en) * | 1976-11-10 | 1987-05-12 | Minnesota Mining And Manufacturing Company | Ballistic projectile |
| US4116196A (en) * | 1977-03-17 | 1978-09-26 | Survival Technology, Inc. | Additive adapter |
| DE2832252A1 (de) | 1978-07-22 | 1980-01-31 | Hoechst Ag | Impfpistole |
| US4419936A (en) * | 1980-04-11 | 1983-12-13 | The United States Of America As Represented By The Secretary Of The Army | Ballistic projectile |
| US4326524A (en) * | 1980-09-30 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Solid dose ballistic projectile |
| US4518387A (en) * | 1982-12-27 | 1985-05-21 | Frank Murphy | Syringe injection apparatus with adjustable dosage indicator |
| DE3374986D1 (en) | 1983-03-18 | 1988-02-04 | Internationales Forschungsinst | Pressure-powered injection pistol |
| EP0139286B1 (en) | 1983-10-14 | 1991-08-21 | Sumitomo Pharmaceuticals Company, Limited | Prolonged sustained-release preparations |
| EP0229754B1 (en) * | 1985-05-14 | 1990-05-02 | Ao-Forschungsinstitut Davos | Method and apparatus for preparaing a self-curing two component powder/liquid cement |
| DE3644984A1 (de) * | 1986-07-01 | 1988-07-07 | Eberhardt Schlueter | Patrone oder ampulle fuer eine injektionsvorrichtung sowie selbsttaetige injektionsvorrichtung |
| GB2193644A (en) | 1986-08-13 | 1988-02-17 | Sabre Safety Ltd | Device for controlling the release of breathable gas from a storage means |
| US4871094A (en) * | 1986-12-31 | 1989-10-03 | Alcon Laboratories, Inc. | Means and method for dispensing substances |
| US4722728A (en) | 1987-01-23 | 1988-02-02 | Patents Unlimited, Ltd. | Needleless hypodermic injector |
| DE3715258C2 (de) * | 1987-05-08 | 1996-10-31 | Haselmeier Wilhelm Fa | Injektionsgerät |
| US4790824A (en) * | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4863429A (en) * | 1987-06-30 | 1989-09-05 | Baldwin Brian E | Syringe driver/syringe/tube connecting set fluid delivery arrangement, and tube connecting sets therefor |
| FR2627698A1 (fr) | 1988-02-26 | 1989-09-01 | Vci Corp | Cartouche d'injection de medicament a utiliser dans un injecteur a vide-compression |
| DE3839287A1 (de) | 1988-11-21 | 1990-05-23 | Holzer Walter | Verfahren und hilfsmittel zur nadellosen injektion |
| US5206024A (en) * | 1989-04-07 | 1993-04-27 | Alza Corporation | Density element for ruminal delivery device |
| US5085641A (en) | 1989-07-17 | 1992-02-04 | Survival Technology, Inc. | Conveniently carried frequent use auto-injector with improved cap structure |
| CA1325149C (en) | 1989-08-31 | 1993-12-14 | Gavin Mcgregor | Variable intensity remote controlled needleless injector |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| AU6550990A (en) | 1989-11-09 | 1991-05-16 | Bioject, Inc. | Needleless hypodermic injection device |
| GB8926825D0 (en) | 1989-11-28 | 1990-01-17 | Glaxo Group Ltd | Device |
| US5360410A (en) * | 1991-01-16 | 1994-11-01 | Senetek Plc | Safety syringe for mixing two-component medicaments |
| US5354287A (en) * | 1991-01-16 | 1994-10-11 | Senetek Plc | Injector for delivering fluid to internal target tissue |
| NL9200844A (nl) * | 1992-05-13 | 1993-12-01 | De Wijdeven Gijsbertus G P Van | Inrichting en werkwijze voor het injecteren met een vaste stof. |
| IL107038A (en) | 1992-10-05 | 1997-04-15 | Senetek Plc | Medicament injectors and methods for injection using same |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| CZ296649B6 (cs) * | 1993-02-23 | 2006-05-17 | Genentech, Inc. | Zpusob výroby stabilizovaného polypeptidového prostredku zahrnující stabilizování polypeptidu protidenaturaci organickými rozpoustedly, jeho príprava a prostredek pro regulované uvolnování polypeptidu |
| DK42093D0 (da) | 1993-04-07 | 1993-04-07 | Bukh Meditec | Administrationsmetode |
| US5478316A (en) | 1994-02-02 | 1995-12-26 | Becton, Dickinson And Company | Automatic self-injection device |
| US6586006B2 (en) * | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| CN1163578A (zh) * | 1994-09-12 | 1997-10-29 | 科学研究与运用咨询公司 | 无针非胃肠给药装置 |
| US5542920A (en) * | 1994-09-12 | 1996-08-06 | Delab | Needle-less parenteral introduction device |
| NL9401534A (nl) * | 1994-09-21 | 1996-05-01 | Gijsbertus Gerardus Petrus Van | Gebruik van zetmeel voor parenterale toepassingen. |
| US5599302A (en) * | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5747058A (en) * | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| PL323721A1 (en) * | 1995-06-07 | 1998-04-14 | American Cyanamid Co | Needle of lauching home a needle |
| FR2749764B1 (fr) | 1996-06-13 | 1999-12-31 | Moreau Defarges Alain | Dispositif de securite perfectionne pour injection par jet sans aiguille |
| AU739469B2 (en) * | 1996-12-20 | 2001-10-11 | Alza Corporation | Gel composition and methods |
| GB9705588D0 (en) | 1997-03-18 | 1997-05-07 | Anglia Research Foundation | Stable particle in liquid formulations |
| JPH10302310A (ja) * | 1997-04-25 | 1998-11-13 | Sony Corp | 光学記録媒体及び光学ディスク装置 |
| US5911703A (en) | 1997-05-22 | 1999-06-15 | Avant Drug Delivery Systems, Inc. | Two-stage fluid medicament jet injector |
| US6689093B2 (en) * | 1998-11-18 | 2004-02-10 | Bioject, Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
| US6264629B1 (en) * | 1998-11-18 | 2001-07-24 | Bioject, Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
| US6783509B1 (en) * | 1998-11-18 | 2004-08-31 | Bioject Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
| DE19859137C1 (de) * | 1998-12-21 | 2000-05-18 | Ferton Holding Sa | Ejektionsgerät zur Hochdruckejektion einer Flüssigkeit |
| KR100845769B1 (ko) * | 1999-02-03 | 2008-07-11 | 파우더젝트 리서치 리미티드 | 하이드로겔 입자 제제 |
| JP2002541920A (ja) * | 1999-04-16 | 2002-12-10 | ノボ ノルディスク アクティーゼルスカブ | 固形薬剤の保管及び挿入用カセット |
| US6102896A (en) | 1999-09-08 | 2000-08-15 | Cambridge Biostability Limited | Disposable injector device |
| FR2800619B1 (fr) * | 1999-11-05 | 2002-02-08 | Cross Site Technologies | Seringue sans aiguille avec un moyen de poussee temporairement retenu |
| US20020131988A1 (en) * | 1999-12-16 | 2002-09-19 | Foster Todd P. | Pharmaceutical implant containing immediate-release and sustained-release components and method of administration |
| US6375971B1 (en) * | 2000-04-28 | 2002-04-23 | Ballistic Technologies, Inc. | Medicament dosing ballistic implant of improved accuracy |
| CN100374810C (zh) * | 2000-07-28 | 2008-03-12 | 理查德·I·布里奇斯-普赖斯 | 非穿透射弹 |
| GB0030289D0 (en) | 2000-12-12 | 2001-01-24 | Optoplan As | Fibre optic sensor systems |
| DE10110513A1 (de) * | 2001-01-29 | 2002-12-12 | Ulrich Werth | Implantat und Verfahren und Vorrichtung zum Einsetzen des Implantats in lebendes Gewebe |
-
2001
- 2001-09-11 GB GB0424113A patent/GB2404865B/en not_active Expired - Lifetime
- 2001-09-11 GB GB0121914A patent/GB2379390B/en not_active Expired - Fee Related
-
2002
- 2002-09-10 EP EP08022251A patent/EP2065063A1/en not_active Ceased
- 2002-09-10 AT AT02785119T patent/ATE429261T1/de active
- 2002-09-10 JP JP2003527732A patent/JP4427325B2/ja not_active Expired - Fee Related
- 2002-09-10 CN CNA2008100832318A patent/CN101301501A/zh active Pending
- 2002-09-10 WO PCT/EP2002/010394 patent/WO2003023773A1/en not_active Ceased
- 2002-09-10 CA CA2459459A patent/CA2459459C/en not_active Expired - Lifetime
- 2002-09-10 IL IL16059202A patent/IL160592A0/xx unknown
- 2002-09-10 PT PT02785119T patent/PT1427464E/pt unknown
- 2002-09-10 MX MXPA04002309A patent/MXPA04002309A/es active IP Right Grant
- 2002-09-10 AU AU2002350449A patent/AU2002350449B2/en not_active Ceased
- 2002-09-10 NZ NZ531755A patent/NZ531755A/en not_active IP Right Cessation
- 2002-09-10 DE DE60232087T patent/DE60232087D1/de not_active Expired - Lifetime
- 2002-09-10 US US10/489,265 patent/US7727223B2/en not_active Expired - Lifetime
- 2002-09-10 PL PL368750A patent/PL205096B1/pl unknown
- 2002-09-10 EP EP02785119A patent/EP1427464B1/en not_active Expired - Lifetime
- 2002-09-10 CN CNB028178041A patent/CN100425298C/zh not_active Expired - Lifetime
- 2002-09-10 DK DK02785119T patent/DK1427464T3/da active
- 2002-09-10 ES ES02785119T patent/ES2325488T3/es not_active Expired - Lifetime
-
2004
- 2004-02-26 IL IL160592A patent/IL160592A/en active IP Right Grant
- 2004-03-08 ZA ZA200401886A patent/ZA200401886B/xx unknown
-
2009
- 2009-03-09 JP JP2009054371A patent/JP5296577B2/ja not_active Expired - Fee Related
- 2009-07-07 AU AU2009202737A patent/AU2009202737A1/en not_active Abandoned
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Open date: 20081112 |