CN101296937B - 肽的不对称合成 - Google Patents

肽的不对称合成 Download PDF

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Publication number
CN101296937B
CN101296937B CN2005800519703A CN200580051970A CN101296937B CN 101296937 B CN101296937 B CN 101296937B CN 2005800519703 A CN2005800519703 A CN 2005800519703A CN 200580051970 A CN200580051970 A CN 200580051970A CN 101296937 B CN101296937 B CN 101296937B
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CN
China
Prior art keywords
alkyl
phenyl
aryl
hydrogen
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2005800519703A
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English (en)
Chinese (zh)
Other versions
CN101296937A (zh
Inventor
劳伦斯·M·哈伍德
严苒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Reading
Original Assignee
University of Reading
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Reading filed Critical University of Reading
Publication of CN101296937A publication Critical patent/CN101296937A/zh
Application granted granted Critical
Publication of CN101296937B publication Critical patent/CN101296937B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2005800519703A 2005-09-13 2005-09-30 肽的不对称合成 Expired - Fee Related CN101296937B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0518667.1A GB0518667D0 (en) 2005-09-13 2005-09-13 Method
GB0518667.1 2005-09-13
PCT/GB2005/003797 WO2007031698A1 (en) 2005-09-13 2005-09-30 Asymmetric synthesis of peptides

Publications (2)

Publication Number Publication Date
CN101296937A CN101296937A (zh) 2008-10-29
CN101296937B true CN101296937B (zh) 2012-05-09

Family

ID=35221406

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800519703A Expired - Fee Related CN101296937B (zh) 2005-09-13 2005-09-30 肽的不对称合成

Country Status (7)

Country Link
US (1) US8399612B2 (cg-RX-API-DMAC7.html)
EP (2) EP2161277B1 (cg-RX-API-DMAC7.html)
JP (1) JP4930951B2 (cg-RX-API-DMAC7.html)
CN (1) CN101296937B (cg-RX-API-DMAC7.html)
CA (1) CA2622173A1 (cg-RX-API-DMAC7.html)
GB (1) GB0518667D0 (cg-RX-API-DMAC7.html)
WO (1) WO2007031698A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2482739A (en) 2010-08-13 2012-02-15 Univ Reading Processes and compounds useful in peptide synthesis
CN102260224B (zh) * 2011-06-14 2013-04-17 南京信息工程大学 一种合成2-吗啉酮衍生物的方法
CN107629111B (zh) * 2017-10-26 2021-06-04 陕西慧康生物科技有限责任公司 一种乙酰基四肽-2的液相合成方法
US20240368217A1 (en) * 2021-05-31 2024-11-07 Chubu University Educational Foundation Peptide compound production method and amidation agent

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017418A2 (en) * 1993-12-22 1995-06-29 The Coca-Cola Company NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPARTYL-D-α-AMINOALKANOYL-(S)-N-α-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS
US6294539B1 (en) * 1999-01-19 2001-09-25 Advanced Syntech, Llc Heterocyclic hydroxamic acid derivatives as MMP inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251438A (en) * 1979-06-14 1981-02-17 The Upjohn Company Piperazinone and piperazine polypeptides
US5939451A (en) 1996-06-28 1999-08-17 Hoffmann-La Roche Inc. Use of sulfonamides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017418A2 (en) * 1993-12-22 1995-06-29 The Coca-Cola Company NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPARTYL-D-α-AMINOALKANOYL-(S)-N-α-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS
US6294539B1 (en) * 1999-01-19 2001-09-25 Advanced Syntech, Llc Heterocyclic hydroxamic acid derivatives as MMP inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Timothy P.Kogan et al.The synthesis of chiral 3-oxo-6-[(phenylmethoxy)-carbonyl]-2-piperazineacetic acid esters designed for the presentation of an Aspartic acid side chain.A subsequent novel fridedl crafts reaction.《Tetrahedron Letters》.1992,第33卷(第47期),7089-7092. *

Also Published As

Publication number Publication date
JP2009507906A (ja) 2009-02-26
GB0518667D0 (en) 2005-10-19
EP2161277A3 (en) 2010-10-27
CA2622173A1 (en) 2007-03-22
US8399612B2 (en) 2013-03-19
EP1937708A1 (en) 2008-07-02
JP4930951B2 (ja) 2012-05-16
US20120190816A9 (en) 2012-07-26
EP2161277B1 (en) 2013-04-10
CN101296937A (zh) 2008-10-29
US20110275784A1 (en) 2011-11-10
EP2161277A2 (en) 2010-03-10
WO2007031698A1 (en) 2007-03-22

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Granted publication date: 20120509

Termination date: 20140930

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