CN101296731A - 作为钾通道开启剂的苯并吡喃和吡喃并吡啶衍生物 - Google Patents

作为钾通道开启剂的苯并吡喃和吡喃并吡啶衍生物 Download PDF

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Publication number
CN101296731A
CN101296731A CNA2006800401602A CN200680040160A CN101296731A CN 101296731 A CN101296731 A CN 101296731A CN A2006800401602 A CNA2006800401602 A CN A2006800401602A CN 200680040160 A CN200680040160 A CN 200680040160A CN 101296731 A CN101296731 A CN 101296731A
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alkyl
amino
halogen
alkoxy
phenyl
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Chinese (zh)
Inventor
X·张
X·李
Z·隋
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
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    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
CNA2006800401602A 2005-09-01 2006-08-30 作为钾通道开启剂的苯并吡喃和吡喃并吡啶衍生物 Pending CN101296731A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71355005P 2005-09-01 2005-09-01
US60/713,550 2005-09-01

Publications (1)

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CN101296731A true CN101296731A (zh) 2008-10-29

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CNA2006800401602A Pending CN101296731A (zh) 2005-09-01 2006-08-30 作为钾通道开启剂的苯并吡喃和吡喃并吡啶衍生物

Country Status (7)

Country Link
US (1) US7812183B2 (https=)
EP (1) EP1940516A2 (https=)
JP (1) JP2009509927A (https=)
CN (1) CN101296731A (https=)
AU (1) AU2006284860A1 (https=)
CA (1) CA2620846A1 (https=)
WO (1) WO2007027780A2 (https=)

Families Citing this family (7)

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WO2007027780A2 (en) * 2005-09-01 2007-03-08 Janssen Pharmaceutica N.V. Benzopyran and pyranopyridine derivatives as potassium channel openers
AU2006284675A1 (en) * 2005-09-01 2007-03-08 Janssen Pharmaceutica N.V. Novel benzopyran derivatives as potassium channel openers
JP5569857B2 (ja) * 2007-08-10 2014-08-13 アステラス製薬株式会社 二環式アシルグアニジン誘導体
US9059628B2 (en) 2012-02-22 2015-06-16 International Electronic Machines Corp. Energy harvesting
EP2948147B1 (en) * 2013-01-28 2019-03-13 H. Lundbeck A/S N-substituted-5-substituted phthalamic acids as sortilin inhibitors
US9573921B2 (en) * 2013-09-30 2017-02-21 Polfarmex S.A. Substituted N, N-dimethylaminoalkyl ethers of isoflavanone oximes as H1-receptor antagonists
CA3176531A1 (en) * 2020-04-24 2021-10-28 Sumitomo Pharma Co., Ltd. 2-heteroarylaminoquinazolinone derivative

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AU2006284860A1 (en) 2007-03-08
CA2620846A1 (en) 2007-03-08
WO2007027780A3 (en) 2007-07-12
EP1940516A2 (en) 2008-07-09
US7812183B2 (en) 2010-10-12
US20070072832A1 (en) 2007-03-29
JP2009509927A (ja) 2009-03-12

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