CN101291926A - 可用作Tec家族非受体酪氨酸激酶抑制剂的3,5-二取代的吡啶-2-酮 - Google Patents

可用作Tec家族非受体酪氨酸激酶抑制剂的3,5-二取代的吡啶-2-酮 Download PDF

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Publication number
CN101291926A
CN101291926A CNA2006800393748A CN200680039374A CN101291926A CN 101291926 A CN101291926 A CN 101291926A CN A2006800393748 A CNA2006800393748 A CN A2006800393748A CN 200680039374 A CN200680039374 A CN 200680039374A CN 101291926 A CN101291926 A CN 101291926A
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alkyl
aliphatic
compound
group
compound according
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CNA2006800393748A
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Chinese (zh)
Inventor
J-D·沙里耶
S·拉玛雅
S·杜兰特
J-M·吉米内斯
J·M·C·戈利克
M·莫蒂默尔
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of CN101291926A publication Critical patent/CN101291926A/zh
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
CNA2006800393748A 2005-08-29 2006-08-25 可用作Tec家族非受体酪氨酸激酶抑制剂的3,5-二取代的吡啶-2-酮 Pending CN101291926A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71245705P 2005-08-29 2005-08-29
US60/712,457 2005-08-29

Publications (1)

Publication Number Publication Date
CN101291926A true CN101291926A (zh) 2008-10-22

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ID=37565557

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Application Number Title Priority Date Filing Date
CNA2006800393748A Pending CN101291926A (zh) 2005-08-29 2006-08-25 可用作Tec家族非受体酪氨酸激酶抑制剂的3,5-二取代的吡啶-2-酮

Country Status (10)

Country Link
US (1) US7786120B2 (https=)
EP (1) EP1919905B1 (https=)
JP (2) JP5112317B2 (https=)
CN (1) CN101291926A (https=)
AT (1) ATE499362T1 (https=)
AU (1) AU2006285145A1 (https=)
CA (1) CA2620631A1 (https=)
DE (1) DE602006020293D1 (https=)
ES (1) ES2361338T3 (https=)
WO (1) WO2007027528A2 (https=)

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WO2007027594A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
WO2009053269A1 (en) 2007-10-23 2009-04-30 F. Hoffmann-La Roche Ag Novel kinase inhibitors
US7683064B2 (en) 2008-02-05 2010-03-23 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
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WO2013153539A1 (en) 2012-04-13 2013-10-17 Glenmark Pharmaceuticals S.A. Tricyclic compounds as tec kinase inhibitors

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CA2620631A1 (en) 2007-03-08
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DE602006020293D1 (de) 2011-04-07
US7786120B2 (en) 2010-08-31
AU2006285145A1 (en) 2007-03-08
WO2007027528A3 (en) 2007-05-03
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EP1919905B1 (en) 2011-02-23

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