CN101288749B - Medicine for treating renal calculus and its preparing process - Google Patents
Medicine for treating renal calculus and its preparing process Download PDFInfo
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- CN101288749B CN101288749B CN2008100550858A CN200810055085A CN101288749B CN 101288749 B CN101288749 B CN 101288749B CN 2008100550858 A CN2008100550858 A CN 2008100550858A CN 200810055085 A CN200810055085 A CN 200810055085A CN 101288749 B CN101288749 B CN 101288749B
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Abstract
The invention relates to a medicine for treating kidney calculi, which takes herba lysimachiae, corn beard, lygodium japonicum, raw oysters, malva verticillata L, etc. as raw materials which are boiled out with water. And the decoction solution is concentrated and dried to be made into capsules. The medicine of the invention can eliminate and reinforce simultaneously and activate blood circulation to dissipate blood stasis and is applied to the treatment of kidney calculi and calculus in urinary system. The medicine can also prevent calculi infection, can relieve the pains of patients, protect renal function, try to remove calculi and prevent the recurrence. Clinical 586 cases of the patients with kidney calculi validates that the total effective rate of the medicine of the invention reaches to 95.9 percent and the drug of the invention has the advantages of good taste, fast efficacy and less side effects.
Description
Technical field
The present invention relates to a kind of medicine, be specifically related to a kind of Chinese medicine preparation for the treatment of renal calculus, the invention still further relates to the preparation method of this medicine.
Background technology
Renal calculus is worldwide common frdquently encountered disease, also is a kind of serious disease that influences human health.In recent years, because living standards of the people improve, its sickness rate also obviously improves.The clinical manifestation of renal calculus is mainly renal colic, hematuria, can cause urinary tract obstruction or urinary tract infection.Renal calculus is a kind of disease that influenced by multiple extraneous factor, and is relevant with geographical environments such as regional water quality, temperature, height above sea level; Relevant with patient's sex, inherited genetic factors; And diet structure, living habit also are considered to possible key factor.
Calcium oxalate is one of main component of lithangiuria.In China, with the calcium oxalate be relapse rate after the calculus of main component is cured up to 60~80%, and quite a few patient's cause of disease is unclear, its formation mechanism is not illustrated as yet fully.
The Western medicine medicine that is used for the treatment of renal calculus is less, often based on symptomatic treatment.Though being arranged in recent years, extracorporeal shock-wave lithotomy and some non-open operations got minimally-invasive treatment application such as stone, make a lot of former patients with surgical that need reduce wound, it is painful to have exempted operation, the cooperation of medicine but calculus behind its rubble and prevention recurrence of hepatolithiasis are still needed, its treatment can only take stopgap measures, and is difficult to reach the purpose of effecting a permanent cure.And the extracorporeal shock-wave lithotomy therapy has certain indication, and kidney is also had certain damage.
Motherland's traditional medical theory thinks, lithangiuria belongs to the traditional Chinese medical science " stranguria dne to urolithiasis ", " hematuria ", " lumbago ", " deficient " and reaches sick categories such as " obstruction and rejection ".The etiology and pathogenesis of relevant stranguria caused by urinary stone, before the Tang Dynasty, motherland's medical science just has more complete understanding under " interior warp " guide of theory.Especially should be noted that Chinese Huatuo " Huatuo's Zhongzang classic " record: " the sand Stranguria person, this is by deficiency of kidney-QI ... void is hindered vital qi, the pathogenic heat crescendo; knot is poly-to form sand, and and for example with decocting in water salt, fiery big flood is few; salt is Cheng Shi and so on gradually, lid kidney person, water is also; become to belong to kidney; salty amassing in kidney, water are stayed in down, and deficiency-heat day is very; fry in shallow oil knot and give birth to, the work in non-again a period of time is also ".Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases " carries: " kidney master water, the water knot then turns to stone, so kidney visitor sandstone, skin is empty to be taken advantage of by heat, heat then becomes to drench ".Think that sand Stranguria is to fry in shallow oil water by the pathogenic heat of suffering from a deficiency of the kidney to form the work in non-a period of time.And " alkali amasss in kidney ", " kidney visitor sandstone " have pointed out that stone location is at kidney.Unit's Zhu Zhenheng " danxi's experiential therapy " is thought " all pouring are sent out, and the bladder of all suffering from a deficiency of the kidney life heat also ".Clear Li Zhongzi's " Required Readings for Medical Professionals " thinks that " the stranguria caused by urinary stone person, just like sandstone, the bladder accumulation of heat forms.For a long time in water, the white alkali of bear building-up also as the soup bottle ".Ancient Chinese medicine doctor thinks it mainly is that sick position is at kidney or at bladder or at excessive key owing to suffer from a deficiency of the kidney and part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat causes to the morbidity of " sand Stranguria ", " stranguria caused by urinary stone " in a word, and void is intrinsic factor.Exterior and interior relation between kidney and bladder, the power of functioning of bladder are from kidney, and suffering from a deficiency of the kidney then causes functioning of bladder unfavorable, and urinary function is not normal, helps the formation of calculus.Multiple because of the damp and hot part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels of accumulating, damp and hot can also can causing by being invaded by exogenous pathogen by the polyphagia delicious food, make urine decocted by it, impurity is then formed sandstone in the urine.It is " sand Stranguria " that little person becomes sand, big person Cheng Shiwei " stranguria caused by urinary stone ", and injury of blood collaterals by heat, the absurd row of forcing blood is the blood underflow then, hematuria occurs and is " stranguria with blood ".
The traditional Chinese medical science mainly is to carry out determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs according to clinical syndrome for the treatment of last lithangiuria, and its rule of treatment is based on Tonglin Paishi, in conjunction with tongue arteries and veins, symptom assistant with heat clearing away, regulate the flow of vital energy, invigorate blood circulation, methods such as YIN nourishing, QI invigorating and the kidney warming, thereby urinary calculus is carried out treating both the principal and secondary aspects of a disease.Therefore, the Chinese medicine calculus is with its special advantages, and lithangiuria can improve the nature lithagogue rate in the treatment, reduces operability, improves hydronephrosis, renal function, and part Chinese medicine solubilized oxalate calculus also can be prevented the recurrence of oxalate calculus.
Summary of the invention
The purpose of this invention is to provide the Chinese medicine of a kind of prevention and treatment renal calculus, this medicine mouthfeel is good, and clinical efficacy is good, and does not have obvious toxic and side effects.
Medicine of the present invention is to be the preparation that crude drug prepares with following parts by weight of traditional Chinese medicines:
10~20 meters palpuses 15~25 of Herba Lysimachiae
Spora Lygodii 10~20 Concha Ostreae 20~40
Semen Abutili 5~15 Rhizoma Imperataes 10~20
Folium Pyrrosiae 5~15 Radix Glycyrrhizae uralensiss 3~9
Semen Plantaginis 10~20.
Further, the preferred parts by weight of each crude drug are in the medicine of the present invention:
Herba Lysimachiae 15 Stigma Maydis 20
Spora Lygodii 15 Concha Ostreae 30
Semen Abutili 10 Rhizoma Imperataes 15
Folium Pyrrosiae 10 Radix Glycyrrhizae uralensiss 6
Semen Plantaginis 15.
Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.
The concrete preparation method of medicine of the present invention being made capsule is:
The crude drug of above-mentioned parts by weight is added decocting endure 3 times, each 2h merges 3 times decocting liquid, is condensed into the thick paste of relative density 1.20~1.24 after the filtration, after the drying and crushing, makes capsule in incapsulating.
In the prescription of the present invention, Herba Lysimachiae has diuresis, cholagogic and lithagogue, remuval of damp and hot, and the merit of jaundice eliminating subcutaneous ulcer and heat-clearing and toxic substances removing is applicable to sand Stranguria, stranguria caused by urinary stone, urine is puckery has a pain and all diseases of jaundice; The sweet light diuresis of Spora Lygodii, but cold heat clearing away, its property decline, kind property decline is kindly rushed down small intestinal, the bladder blood system is damp and hot, the special tonneau water channel of merit, and for controlling the key medicine that the gonorrhea urethra is had a pain; More than two medicines be monarch drug altogether.Semen Abutili inducing diuresis for treating stranguria syndrome, lactogenesis have the laxation effect, can be used in the dry secret disease of stool; Folium Pyrrosiae inducing diuresis for treating stranguria syndrome, clearing away heat to stop bleeding are applicable to uroschesis and pyretic stranguria, stranguria with blood, stranguria caused by urinary stone and hematuria person are arranged, and control metrorrhagia due to blood-heat, spit blood, and the merit of clearing away heat to stop bleeding is arranged; More than two medicines be ministerial drug altogether.The Semen Plantaginis clearing away heat and promoting diuresis, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, preventing phlegm from forming and stopping coughing; The Stigma Maydis inducing diuresis to remove edema, blood pressure lowering, blood sugar lowering; The Concha Ostreae tranquillizing and allaying excitement, restrain astringent or styptic treatment for spontaneous sweating, hard masses softening and resolving; The Rhizoma Imperatae clearing away heat and promoting production of body fluid, clearing away heat and cooling blood, inducing diuresis to remove edema; The Radix Glycyrrhizae uralensis invigorating vital QI, relieving spasm to stop pain, heat-clearing and toxic substances removing, and the mediation property of medicine have diuresis concurrently; Below be adjuvant altogether.All medicines cooperates, can reinforcement and elimination in combination, again can blood circulation promoting and blood stasis dispelling, and it is then logical that the stasis of blood is dispelled, and the gas foot pushes away stone, and the water foot is towards stone, the performance synergism.
Medicine of the present invention is applicable to that (<0.6cm) treatment can prevent calculus to infect, and removes the patient suffering, and the protection renal function is removed calculus as much as possible, and prevents recurrence for renal calculus and urinary system calculus.
The present invention has collected 586 routine renal calculus patients altogether and has carried out the clinical verification of described medicine.The all main lumbago of stating in various degree of above-mentioned case, or typical renal colic and hematuria are all made a definite diagnosis through ultrasound diagnosis.
Therapeutic Method:
1, increase amount of drinking water, every day, the urine amount kept discharging in order to microlith about 2000mL;
2, according to calculus character decision diet, the phosphatic calculus patient meat food of taking food, uric acid, cystine stone patient take food fruit, vegetable more more;
3, companion the infected gives antibiotic therapy, as ampicillin or norfloxacin; The hydronephrosis person gives hydrochlorothiazide;
4, renal colic, abdominal distention, feel sick, vomiting etc. all gives symptomatic treatment, infused local hot compress, processing such as injecting atropine, rotundine as emergency case;
5, take Drug therapy of the present invention, 3 times on the one, each 4.3 months is a course of treatment, and observing 3 years is late result.
Criterion of therapeutical effect:
Produce effects: subjective symptoms disappears in 1 course of treatment, and routine urinalysis is normal, and B ultrasonic or X line are taken the photograph sheet and confirmed the calculus discharge.
Effectively: subjective symptoms disappears or alleviates in 1 course of treatment, and routine urinalysis RBC (0~+), WBC (0~+), B ultrasonic or X line take the photograph sheet and confirm that calculus partly discharges or move down.
Invalid: through the treatment of 1 course of treatment, pain alleviates to some extent, routine urinalysis RBC (±~+++), WBC (0~+), B ultrasonic or X line are taken the photograph sheet and are confirmed that the preceding contrast nothing of calculus position, quantity and treatment obviously changes.
Therapeutic outcome:
Through the therapy of combining Chinese and Western medicine of 1 course of treatment, among the 586 routine renal calculus patients, produce effects 175 examples, obvious effective rate 29.9%; Effective 387 examples, effective percentage 66%; Invalid 24 examples, inefficiency 4%.Its total effective rate reaches 95.9%, proves that medicine mouthfeel of the present invention is good, and curative effect is fast, few side effects.
The specific embodiment
Embodiment 1
Getting Herba Lysimachiae 100Kg, Spora Lygodii 60Kg, Semen Abutili 30Kg, Folium Pyrrosiae 60Kg, Semen Plantaginis 100Kg, Stigma Maydis 120Kg, Concha Ostreae 100Kg, Rhizoma Imperatae 50Kg, Radix Glycyrrhizae uralensis 40Kg packs in the extraction pot, add 700Kg water, decoct 2h, leach decocting liquid, the water that adds same amount again, decoct each 2h 2 times.Merge 3 times decocting liquid, filter, be condensed into the thick paste of relative density 1.20~1.24, drying is ground into 80 purpose fine powders, and in incapsulating, sterilization is made the capsule product.
Embodiment 2
Getting Herba Lysimachiae 75Kg, Spora Lygodii 75Kg, Semen Abutili 50Kg, Folium Pyrrosiae 50Kg, Semen Plantaginis 75Kg, Stigma Maydis 100Kg, Concha Ostreae 150Kg, Rhizoma Imperatae 75Kg, Radix Glycyrrhizae uralensis 30Kg packs in the extraction pot, add 700Kg water, decoct 2h, leach decocting liquid, the water that adds same amount again, decoct each 2h 2 times.Merge 3 times decocting liquid, filter, be condensed into the thick paste of relative density 1.20~1.24, be dried and crushed into 80 purpose fine powders, in incapsulating, sterilization is made the capsule product.
Embodiment 3
Getting Herba Lysimachiae 50Kg, Spora Lygodii 100Kg, Semen Abutili 70Kg, Folium Pyrrosiae 30Kg, Semen Plantaginis 50Kg, Stigma Maydis 80Kg, Concha Ostreae 200Kg, Rhizoma Imperatae 100Kg, Radix Glycyrrhizae uralensis 20Kg packs in the extraction pot, add 700Kg water, decoct 2h, leach decocting liquid, the water that adds same amount again, decoct each 2h 2 times.Merge 3 times decocting liquid, filter, be condensed into the thick paste of relative density 1.20~1.24, be dried and crushed into 80 purpose fine powders, in incapsulating, sterilization is made the capsule product.
Claims (4)
1. medicine for the treatment of renal calculus is to be the medicament that crude drug prepares with following parts by weight of traditional Chinese medicines:
Herba Lysimachiae 10~20 Stigma Maydis 15~25
Spora Lygodii 10~20 Concha Ostreae 20~40
Semen Abutili 5~15 Rhizoma Imperataes 10~20
Folium Pyrrosiae 5~15 Radix Glycyrrhizae uralensiss 3~9
Semen Plantaginis 10~20.
2. the medicine of treatment renal calculus according to claim 1 is characterized in that wherein the parts by weight of each crude drug are:
Herba Lysimachiae 15 Stigma Maydis 20
Spora Lygodii 15 Concha Ostreae 30
Semen Abutili 10 Rhizoma Imperataes 15
Folium Pyrrosiae 10 Radix Glycyrrhizae uralensiss 6
Semen Plantaginis 15.
3. the medicine of treatment renal calculus according to claim 1 and 2 is characterized in that described medicine is made capsule.
4. the preparation method of the medicine of the described treatment renal calculus of claim 3 is that crude drug with above-mentioned parts by weight adds decocting and endures each 2h 3 times, merge 3 times decocting liquid, be condensed into the thick paste of relative density 1.20~1.24 after the filtration, after the drying and crushing, make capsule in incapsulating.
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CN102579706B (en) * | 2012-02-21 | 2013-05-15 | 简福川 | Traditional Chinese medicine for treating urinary stone |
CN103110770A (en) * | 2012-12-22 | 2013-05-22 | 潘海燕 | Medicinal liquor for treating calculus |
CN105687375A (en) * | 2016-03-21 | 2016-06-22 | 刘琴兰 | Medicine for treating lithiasis in urinary system |
CN114306523B (en) * | 2021-12-20 | 2023-07-11 | 安徽九洲方圆制药有限公司 | Traditional Chinese medicine composition for treating gout and nephropathy |
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孙莉姬.中医药治疗泌尿系结石临床研究近况.河北中医.2006,28(12), * |
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