CN109260307B - A Chinese medicinal composition with calculus removing effect, and its preparation method - Google Patents
A Chinese medicinal composition with calculus removing effect, and its preparation method Download PDFInfo
- Publication number
- CN109260307B CN109260307B CN201811437227.7A CN201811437227A CN109260307B CN 109260307 B CN109260307 B CN 109260307B CN 201811437227 A CN201811437227 A CN 201811437227A CN 109260307 B CN109260307 B CN 109260307B
- Authority
- CN
- China
- Prior art keywords
- parts
- calculus
- preparation
- traditional chinese
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition with a calculus removing effect, which is prepared from the following raw material medicines in parts by weight: 10.5-19.5 parts of prepared monkshood, 7-13 parts of cinnamon, 14-26 parts of dogwood, 14-26 parts of rehmannia, 21-39 parts of white paeony root, 48.5-51.5 parts of achyranthes root, 21-39 parts of longhairy antenoron herb, 21-39 parts of spora lygodii, 21-39 parts of pyrrosia lingua, 48.5-51.5 parts of endothelium corneum gigeriae galli, 21-39 parts of talcum, 7-13 parts of saltpeter and 10.5-19.5 parts of liquorice. The invention also provides a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention has a precise and appropriate formula, has great advantages in stone discharge promotion, can effectively treat ureteral calculus, and can prevent the broken stone of a urinary tract calculus patient receiving the broken stone of external shock wave from forming a stone street in the ureter.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine composition with a calculus removing effect and a preparation method thereof.
Background
Urinary calculi are common diseases of the urinary system. Calculus can be found in any part of the kidney, bladder, ureter and urethra. But kidney and ureteral stones are common. Renal and ureteral calculi are typically characterized by renal colic and hematuria, before the onset of colic caused by calculi, patients may have no symptoms, and suddenly have severe colic in one side of the waist due to some causes, such as severe exercise, labor, long-distance riding and the like, and radiate to the lower abdomen and perineum with abdominal distension, nausea, vomiting and hematuria of different degrees.
The extracorporeal shock wave lithotripsy which is gradually popularized in recent years is a more effective treatment method for urinary calculus, has unique advantages compared with drug lithotripsy and surgical lithotripsy, and is the first choice treatment method for patients with renal calculus and ureteral calculus at present. However, since the crushed stone is influenced by the gravity of the stone, the driving force generated by the peristalsis of the ureter, the resistance of the ureter wall and other factors in the discharging process, a stone street is easily formed in the ureter, so that the stone is recurrent, and the ureter spasm and even renal colic are complicated, and at the moment, the stone is required to be crushed again to remove obstruction. But repeated morcellation may cause other complications to be exacerbated and may even cause kidney damage to varying degrees.
In order to treat urinary calculus by medicine-assisted external shock wave lithotripsy, CN 102580032 discloses a tablet, powder and oral liquid of a traditional Chinese medicine composition. However, the traditional Chinese medicine composition has complex preparation components and low total effective rate, can not completely and effectively avoid the phenomenon of stone street after extracorporeal calculus breaking, and still has higher probability of recrushing a calculus patient who receives extracorporeal calculus breaking.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition with a high-efficiency calculus-removing effect, which is characterized by comprising the following components in parts by weight: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
10.5-19.5 parts of prepared monkshood, 7-13 parts of cinnamon, 14-26 parts of dogwood, 14-26 parts of rehmannia, 21-39 parts of white paeony root, 48.5-51.5 parts of achyranthes root, 21-39 parts of longhairy antenoron herb, 21-39 parts of spora lygodii, 21-39 parts of pyrrosia lingua, 48.5-51.5 parts of endothelium corneum gigeriae galli, 21-39 parts of talcum, 7-13 parts of saltpeter and 10.5-19.5 parts of liquorice.
The radix Aconiti lateralis Preparata is processed by soaking root of Aconitum carmichaeli Debx of Ranunculaceae in salt, rinsing with water, decocting, and parching; the rehmanniae radix is fresh or dried root tuber of Scrophulariaceae rehmanniae radix Rehm, annia glutinosa Libosch, steaming to black, taking out, sun drying to make it into eight dry pieces, slicing into thick pieces or blocks, and drying. The Achyranthis radix is dried root of Cyathula officinalis of Amaranthaceae Kuan, removed rhizoma Phragmitis, fibrous root and silt, and oven-dried or sun-dried, and has effects of removing blood stasis, dredging channels, promoting articulation, inducing diuresis and treating stranguria.
Further, the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight:
15 parts of prepared aconite, 10 parts of cinnamon, 20 parts of dogwood, 20 parts of rehmannia, 30 parts of white paeony root, 50 parts of twotooth achyranthes root, 30 parts of longhairy antenoron herb, 30 parts of Japanese climbing fern spore, 30 parts of pyrrosia leaf, 50 parts of chicken's gizzard-membrane, 30 parts of talcum, 10 parts of saltpeter and 15 parts of liquorice.
Furthermore, the preparation is prepared by taking crude medicinal powder of prepared aconite, cinnamon, dogwood, rehmannia, white paeony root, twotooth achyranthes root, longhairy antenoron herb, Japanese climbing fern spore, herba pyrrosiae, endothelium corneum gigeriae galli, talcum, saltpeter and liquorice, or water or organic solvent extract as active ingredients and adding pharmaceutically acceptable auxiliary materials or auxiliary ingredients.
Further, the preparation is an oral preparation.
Further, the oral preparation is powder, paste, granules, tablets, capsules, oral liquid or dripping pills.
The invention also provides a method for preparing the traditional Chinese medicine composition, which is characterized by comprising the following steps: it comprises the following steps:
a. weighing raw materials in each weight ratio;
b. pulverizing the raw materials, or decocting the raw materials in water, concentrating decoction, or extracting the raw materials with medicinal organic solvent, concentrating extractive solution, adding pharmaceutically acceptable adjuvants or adjuvant components, and making into common preparation.
The invention finally provides application of the traditional Chinese medicine composition in preparing a medicine for treating ureteral calculus.
Further, the medicament is a stone-expelling promoting medicament.
Further, the medicament is a medicament for promoting the discharge of calculus after extracorporeal lithotripsy.
The traditional Chinese medicine has unique theory and curative effect on preventing and treating the lithangiuria. Ureteral calculus belongs to the scope of 'urolithiasis' in traditional Chinese medicine, and the attack is closely related to emotional, dietary and overstrain. Doctors in different generations have discussed urolithic stranguria (stranguria with urinary stone), which is said by Danxi Xin Fa: "all stranguria occur and the bladder is heat-producing due to kidney deficiency", the records of the theory of origin and symptoms of gonorrhea are: those with stranguria are also marked by kidney deficiency and bladder heat. The inventor considers that the treatment of the ureteral calculus focuses on tonifying the kidney and clearing away damp-heat.
The prepared monkshood, cinnamon, dogwood and rehmannia root in the traditional Chinese medicine composition have the effects of tonifying kidney yang and kidney yin, are monarch drugs, achyranthes root, desmodium, lygodium japonicum, talcum, pyrrosia leaf and endothelium corneum gigeriae galli have the effects of clearing heat, promoting diuresis and treating stranguria, are ministerial drugs, are radix paeoniae alba for relieving spasm and pain, are saltpeter for softening hard masses and eliminating stones, are adjuvant drugs, and are liquorice for relieving pain, and are adjuvant and guiding drugs. Has the effects of tonifying the kidney and the yang, clearing heat and promoting diuresis, treating stranguria and removing urinary calculus.
The traditional Chinese medicine composition provided by the invention has a precise and appropriate formula, has great advantages in stone discharge promotion, can effectively treat ureteral calculus, and can prevent the broken stone of a urinary tract calculus patient receiving the broken stone of external shock wave from forming a stone street in the ureter.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
The raw materials and equipment used in the embodiment of the present invention are known products and obtained by purchasing commercially available products.
EXAMPLE 1 preparation of a pharmaceutical composition of the invention
Weighing 15g of prepared monkshood, 10g of cinnamon, 20g of dogwood, 20g of rehmannia, 30g of white paeony root, 50g of twotooth achyranthes root, 30g of desmodium, 30g of Japanese climbing fern spore, 30g of herba pyrrosiae, 50g of endothelium corneum gigeriae galli, 30g of talcum, 10g of saltpeter and 15g of liquorice.
The preparation method comprises the following steps:
the prepared aconite is put into an earthen pot, 2500ml of water is added, and the mixture is soaked for half an hour. Boiling with strong fire (strong fire) for 1 hr, adding the rest materials, decocting to 250ml, and pouring out the decoction in a clean container. Adding 1500ml water into the above residue, boiling with strong fire for 0.5 hr, decocting with slow fire (slow fire) to obtain 200ml residue, and mixing the two decoctions for administration.
EXAMPLE 2 preparation of pharmaceutical compositions of the invention
Weighing 10.5g of prepared monkshood, 7g of cinnamon, 14g of dogwood, 14g of rehmannia, 21g of white paeony root, 48.5g of achyranthes root, 21g of desmodium, 21g of lygodium japonicum, 21g of pyrrosia lingua, 48.5g of endothelium corneum gigeriae galli, 21g of talcum, 7g of saltpeter and 10.5g of liquorice.
The preparation method comprises the following steps: the preparation method is the same as that of example 1.
EXAMPLE 3 preparation of a pharmaceutical composition of the invention
Weighing 19.5g of prepared monkshood, 13g of cinnamon, 26g of dogwood, 26g of rehmannia, 39g of white paeony root, 51.5g of achyranthes root, 39g of desmodium, 39g of lygodium japonicum, 39g of pyrrosia lingua, 51.5g of endothelium corneum gigeriae galli, 39g of talcum, 13g of saltpeter and 19.5g of liquorice.
The preparation method comprises the following steps: the preparation method is the same as that of example 1.
EXAMPLE 4 preparation of the composition of the invention
Prescription: the same prescription as in example 1.
The preparation process comprises the following steps: weighing the raw materials according to the prescription, pulverizing, sieving, mixing, and packaging.
The following test examples specifically illustrate the advantageous effects of the present invention:
test example 1 verification that the pharmaceutical composition of the present invention treats ureteral calculi
1 data and method
1.1 general data
40 cases of ureteral calculus patients in the hospital of 7 months in 2017 are collected and randomly divided into 2 groups, namely a control group and a test group, wherein 20 cases of patients respectively have no statistical significance (P is more than 0.05) in comparison difference in age, sex, disease course and the like before treatment, and the patients have comparability.
1.2 medicine and preparation
Test drug 1 (prepared as in example 1);
1.3 diagnostic criteria
1.3.1 Western medicine diagnosis standard refers to the guidance principle of clinical research of new Chinese medicines, the 2009 edition of Chinese urinary surgery disease diagnosis and treatment guidelines, the modern urology surgery diagnosis and treatment manual, the diagnosis and treatment of urolithiasis and the like to make ureteral calculus diagnosis.
1.3.2 diagnostic criteria for syndrome of dampness-heat due to kidney deficiency
The diagnosis standard of the kidney deficiency and dampness-heat syndrome in traditional Chinese medicine refers to the syndrome differentiation and classification of the chronic pyelonephritis in traditional Chinese medicine (trial scheme) which is passed through the second national academy of Chinese medicine nephropathy in 1986.
And (3) master certificate: the kidney deficiency syndrome is manifested as soreness of waist, feverish sensation in the palms and soles, or intolerance of cold and weakness in the limbs, and the damp-heat syndrome is manifested as frequent micturition, dribbling pain, yellow and burning urine, thirst and no desire for polydipsia.
Secondary verification: the kidney deficiency syndrome is manifested as night sweat or spontaneous sweating, insomnia, dreaminess, tinnitus and edema, and the damp-heat syndrome is manifested as bitter taste in the mouth, heavy and fatigue, tongue pulse, red tongue with thin, yellow and greasy coating, and soft-superficial and thready pulse.
The combination of 2 items of the principal syndrome and 2 items of the secondary syndrome can be diagnosed.
1.4 criteria for enrolled cases
(1) Those who meet the above diagnostic criteria can be used as test cases.
(2) The diameter of the calculus is not less than 0.6cm and not more than 1.2 cm.
(3) The calculus far end ureter has no deformity, stenosis, obstruction, operation scar adhesion, etc.
(4) The retention time of the calculus at a certain position cannot be too long, and generally cannot exceed 3 months.
(5) No ESWL contraindication.
(6) The general condition of the whole body is good, and the life can be self-managed.
(7) Voluntarily participate in the treatment.
1.5 methods of treatment
Control group: the external shock wave lithotripter is adopted for lithotripsy treatment.
Treatment groups: the test drug 1 (prepared by the method of example 1) was administered on the same treatment basis as the control group, 1 dose per day, 2 times with water, about 450mL of juice each time, and the mixture was divided into 3 divided doses for warm-taking. One treatment course is 4 weeks, and 1 treatment course is observed.
After 2 groups of stones are broken, the patients are treated according to the routine conditions, and order to drink a large amount of water, keep the daily urine volume above 2000mL, and properly do jumping, handstand and other activities to help the stone discharge.
1.6 evaluation of therapeutic Effect
Curing, namely checking that the calculus image disappears through urinary tract ultrasound or a urinary tract flat sheet;
improving symptom, and examining calculus image shrinkage or position downward movement by urinary tract ultrasonic or urinary tract flat sheet;
the symptoms are not relieved, and the calculus image is unchanged through ultrasonic examination or X-ray examination.
1.7 statistical methods
By adopting SPSS17.0 statistical analysis software, the difference is statistically significant when P is less than 0.05.
2 results
The test group comprises 20 cases of treatment, 17 cases of cure (85%), 2 cases of improvement (10%), 1 case of no cure (5%), and 95% of total effective rate.
The control group has 20 cases of treatment, 15 cases of cure (75%), 1 case of improvement (5%), 4 cases of no cure (20%) and 80% of total effective rate.
The comparison difference between the two groups has statistical significance (P is less than 0.05), and the effective rate of the test group is higher than that of the control group.
The application of the traditional Chinese medicine composition can effectively treat ureteral calculus and promote the discharge of calculus after the extracorporeal shock wave lithotripsy.
Clinical trials confirmed that: the traditional Chinese medicine composition has a good effect on promoting the discharge of calculus after the in vitro shock wave lithotripsy, can effectively treat ureteral calculus, and provides a new medicine selection for clinic.
Claims (8)
1. A traditional Chinese medicine composition for treating kidney deficiency and damp heat type ureteral calculus in combination with external shock wave lithotripsy is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
15 parts of prepared aconite, 10 parts of cinnamon, 20 parts of dogwood, 20 parts of rehmannia, 30 parts of white paeony root, 50 parts of twotooth achyranthes root, 30 parts of longhairy antenoron herb, 30 parts of Japanese climbing fern spore, 30 parts of pyrrosia leaf, 50 parts of chicken's gizzard-membrane, 30 parts of talcum, 10 parts of saltpeter and 15 parts of liquorice.
2. The traditional Chinese medicine composition according to claim 1, characterized in that: the preparation is prepared by taking crude medicinal powder or water extract of prepared aconite, cinnamon, dogwood, rehmannia, white paeony root, twotooth achyranthes root, longhairy antenoron herb, Japanese climbing fern spore, herba pyrrosiae, chicken's gizzard-membrane, talc, saltpeter and liquoric root as active ingredients and adding pharmaceutically acceptable auxiliary materials or auxiliary ingredients.
3. The traditional Chinese medicine composition according to claim 2, characterized in that: the preparation is an oral preparation.
4. The traditional Chinese medicine composition according to claim 3, wherein: the oral preparation is powder, paste, granules, tablets, capsules, oral liquid or dripping pills.
5. A method of preparing the Chinese medicinal composition of any one of claims 1-4, wherein: it comprises the following steps:
a. weighing the raw materials in the weight ratio of claim 1;
b. pulverizing the raw materials, or decocting the raw materials in water, concentrating the decoction, adding pharmaceutically acceptable adjuvants or adjuvant ingredients, and making into common preparation.
6. Use of the Chinese medicinal composition of any one of claims 1-4 in the preparation of a medicament for treating kidney deficiency and damp-heat type ureteral calculus in combination with external shock wave lithotripsy.
7. Use according to claim 6, characterized in that: the medicine is a medicine for promoting the removal of urinary calculus.
8. Use according to claim 7, characterized in that: the medicine is a medicine for promoting the discharge of calculus after in vitro calculus breaking.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811437227.7A CN109260307B (en) | 2018-11-28 | 2018-11-28 | A Chinese medicinal composition with calculus removing effect, and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811437227.7A CN109260307B (en) | 2018-11-28 | 2018-11-28 | A Chinese medicinal composition with calculus removing effect, and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109260307A CN109260307A (en) | 2019-01-25 |
| CN109260307B true CN109260307B (en) | 2021-09-03 |
Family
ID=65186365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811437227.7A Active CN109260307B (en) | 2018-11-28 | 2018-11-28 | A Chinese medicinal composition with calculus removing effect, and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109260307B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618068A (en) * | 2008-06-30 | 2010-01-06 | 夏范音 | A kind of medicine for the treatment of cough with asthma |
-
2018
- 2018-11-28 CN CN201811437227.7A patent/CN109260307B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618068A (en) * | 2008-06-30 | 2010-01-06 | 夏范音 | A kind of medicine for the treatment of cough with asthma |
Non-Patent Citations (2)
| Title |
|---|
| 宣肺排石汤治疗泌尿系结石体外碎石后98例;何淑娴等;《新中医》;20061231;第38卷(第12期);第58-59页 * |
| 消石排石汤加减治疗尿路结石47例;刘胜贤;《实用中医药杂志》;20010331;第17卷(第3期);第14-15页，尤其是第14页右栏"2治疗方法" * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109260307A (en) | 2019-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102526616A (en) | Chinese medicinal herb pills for treating cholecystitis and gallstone | |
| CN102106923A (en) | Chinese medicinal preparation for treating osteoporosis | |
| CN102526566B (en) | Chinese medicine preparation for treating hysteromyoma and ovaricyst and preparation method | |
| CN103705797B (en) | A kind of medicine for the treatment of renal calculus | |
| CN105169212A (en) | Traditional Chinese medicine composition for treating chronic gastritis | |
| CN104138460A (en) | Chinese medicinal composition for treatment of pains in necks, waists and legs and preparation method thereof | |
| CN103263601A (en) | Chinese herbal preparation for accelerating fracture post-operation healing and preparation method of Chinese herbal preparation | |
| CN109260307B (en) | A Chinese medicinal composition with calculus removing effect, and its preparation method | |
| CN104645124A (en) | Traditional Chinese medicine preparation for treating lithangiuria and preparation method thereof | |
| CN104225490A (en) | Traditional Chinese medicine for treating cholecystitis | |
| CN101249231B (en) | Medicine composition for treating lithiasis and preparation thereof | |
| CN103142737A (en) | Traditional Chinese medicine capsule for treating fracture Qi-stagnation and blood stasis and preparation method thereof | |
| CN103028087B (en) | Traditional Chinese medicine composition for treating rectal cancer | |
| CN101983666A (en) | Traditional Chinese medicine composition for treating rheumatism and preparation method thereof | |
| CN102743550B (en) | Medicine composition for accelerating healing after fracture surgery, preparation method and application | |
| CN100435840C (en) | Medicament for treating hyperplasia of prostate | |
| CN110478416A (en) | The composition and its preparation method and application for treating rheumatic rheumatoid arthritis | |
| CN102552798B (en) | Medicinal composition for treating cholelithiasis | |
| CN102335304B (en) | Chinese medicine composition for dispelling wind, removing dampness, invigorating blood circulation, and relieving pain and preparation method thereof | |
| CN101658648B (en) | Medicament for treating cervical erosion | |
| CN101637535B (en) | Medicine for treating bone hyperplasia and preparation method thereof | |
| CN101167915B (en) | Traditional Chinese medicine for treating chronic superficial gastritis and its preparation method | |
| CN105796676A (en) | Pills for effectively treating fatty liver | |
| CN105250807A (en) | Traditional Chinese medicine composition for treating gynecologic inflammation | |
| CN104645061A (en) | Medicine for treating blood stasis stationary chronic gastric ulcer and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |