CN101277696B8 - 作为抗菌药物的喹啉衍生物 - Google Patents

作为抗菌药物的喹啉衍生物 Download PDF

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Publication number
CN101277696B8
CN101277696B8 CN200680036751.2D CN200680036751D CN101277696B8 CN 101277696 B8 CN101277696 B8 CN 101277696B8 CN 200680036751 D CN200680036751 D CN 200680036751D CN 101277696 B8 CN101277696 B8 CN 101277696B8
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CN
China
Prior art keywords
alkyl
group
het
hydrogen
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200680036751.2D
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English (en)
Chinese (zh)
Other versions
CN101277696A (zh
CN101277696B (zh
Inventor
J·E·G·吉尔蒙特
E·T·J·帕斯奎尔
D·F·A·兰科伊斯
K·J·L·M·安德里斯
A·考尔
L·J·J·巴克克斯
L·米尔波尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35744723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101277696(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of CN101277696B publication Critical patent/CN101277696B/zh
Publication of CN101277696B8 publication Critical patent/CN101277696B8/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
CN200680036751.2D 2005-08-03 2006-07-31 作为抗菌药物的喹啉衍生物 Expired - Fee Related CN101277696B8 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05107164 2005-08-03
EP05107164.5 2005-08-03
PCT/EP2006/064858 WO2007014941A2 (en) 2005-08-03 2006-07-31 Quinoline derivatives as antibacterial agents

Publications (2)

Publication Number Publication Date
CN101277696B CN101277696B (zh) 2015-09-02
CN101277696B8 true CN101277696B8 (zh) 2016-07-06

Family

ID=35744723

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200680036751.2D Expired - Fee Related CN101277696B8 (zh) 2005-08-03 2006-07-31 作为抗菌药物的喹啉衍生物
CNA2006800367512A Granted CN101277696A (zh) 2005-08-03 2006-07-31 作为抗菌药物的喹啉衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2006800367512A Granted CN101277696A (zh) 2005-08-03 2006-07-31 作为抗菌药物的喹啉衍生物

Country Status (30)

Country Link
US (1) US8802671B2 (enExample)
EP (1) EP1912648B1 (enExample)
JP (1) JP5302680B2 (enExample)
KR (1) KR101413997B1 (enExample)
CN (2) CN101277696B8 (enExample)
AP (1) AP2654A (enExample)
AR (1) AR054890A1 (enExample)
AU (1) AU2006274880B2 (enExample)
BR (1) BRPI0614493B8 (enExample)
CA (1) CA2615903C (enExample)
CY (1) CY1114318T1 (enExample)
DK (1) DK1912648T3 (enExample)
EA (1) EA014833B1 (enExample)
ES (1) ES2414956T3 (enExample)
HR (1) HRP20130540T1 (enExample)
IL (1) IL189142A0 (enExample)
JO (1) JO2855B1 (enExample)
ME (1) ME01616B (enExample)
MX (1) MX2008001603A (enExample)
MY (1) MY159560A (enExample)
NO (1) NO341242B1 (enExample)
NZ (1) NZ565947A (enExample)
PL (1) PL1912648T3 (enExample)
PT (1) PT1912648E (enExample)
RS (1) RS52808B (enExample)
SI (1) SI1912648T1 (enExample)
TW (1) TWI422374B (enExample)
UA (1) UA95915C2 (enExample)
WO (1) WO2007014941A2 (enExample)
ZA (1) ZA200801110B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004186452A (ja) 2002-12-04 2004-07-02 Renesas Technology Corp 不揮発性半導体記憶装置およびその製造方法
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO3271B1 (ar) * 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
ES2576491T3 (es) 2012-04-27 2016-07-07 Janssen Pharmaceutica, N.V. Derivados de quinolina antibacterianos
AU2013254670B2 (en) 2012-04-27 2017-03-30 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
HK1213887A1 (zh) 2012-10-16 2016-07-15 Janssen Pharmaceutica N.V. RORγt的苯基连接的喹啉基调节剂
MY189505A (en) 2012-10-16 2022-02-16 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of roryt
WO2014062655A1 (en) 2012-10-16 2014-04-24 Janssen Pharmaceutica Nv HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
CA2927182A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Quinolinyl modulators of ror.gamma.t
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
CA2926339A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of roryt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
CN109111397B (zh) * 2018-08-28 2021-12-10 广东工业大学 一种喹啉芳香乙烯类衍生物及其制备方法和应用
CN109111396B (zh) * 2018-08-28 2021-09-03 广东工业大学 一种喹啉芳香乙烯衍生物及其制备方法和应用
CN112110907B (zh) * 2020-10-09 2021-12-21 中央民族大学 一种含1，4-二氧六环二聚双噻吩结构的化合物及其制备方法和应用
CN112079825B (zh) * 2020-10-09 2021-12-21 中央民族大学 含1，3-二氧戊环二聚双噻吩结构的化合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006047A1 (en) * 1993-08-23 1995-03-02 Fujisawa Pharmaceutical Co., Ltd. Antimicrobial quinolinyl-(1h-1,2,4-triazol-1-yl)alkanol derivatives
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

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* Cited by examiner, † Cited by third party
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GB807750A (en) * 1956-06-15 1959-01-21 Rhone Poulenc Sa Improvements in or relating to piperazine derivatives
US5965572A (en) * 1996-10-28 1999-10-12 The United States Of America As Respresented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
PL360102A3 (en) 2003-05-13 2004-11-15 "ENERGOMAR-NORD" Sp.z o.o. Method for manufacturing highly reactive calcium sorbing agents and facility designed for manufacturing highly reactive calcium sorbing agents
US7902225B2 (en) 2004-01-23 2011-03-08 Janssen Pharmaceutica Nv Mycobacterial inhibitors
BRPI0507076B8 (pt) 2004-01-23 2021-05-25 Janssen Pharmaceutica Nv quinolinas substituídas, seu processo de preparação, composição farmacêutica que as compreende e seu uso como inibidores micobacterianos
UA83875C2 (ru) * 2004-01-29 2008-08-26 Янссен Фармацевтика Н.В. Производные хинолина для применения в качестве микобактериальных ингибиторов
CA2528849C (en) * 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
US20070018948A1 (en) 2005-07-22 2007-01-25 Elaine Chen Apparatus for stabilizing an electronic device during data input and device control

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006047A1 (en) * 1993-08-23 1995-03-02 Fujisawa Pharmaceutical Co., Ltd. Antimicrobial quinolinyl-(1h-1,2,4-triazol-1-yl)alkanol derivatives
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis;Andries K. et al;《Science》;20050114;第307卷;223-227 *

Also Published As

Publication number Publication date
JO2855B1 (en) 2015-03-15
CN101277696A (zh) 2008-10-01
US8802671B2 (en) 2014-08-12
DK1912648T3 (da) 2013-06-24
EA014833B1 (ru) 2011-02-28
JP5302680B2 (ja) 2013-10-02
BRPI0614493B1 (pt) 2019-11-12
HK1124234A1 (zh) 2009-07-10
US20080207687A1 (en) 2008-08-28
PT1912648E (pt) 2013-06-27
EP1912648B1 (en) 2013-04-10
UA95915C2 (ru) 2011-09-26
BRPI0614493A2 (pt) 2011-03-29
BRPI0614493B8 (pt) 2021-05-25
EA200800508A1 (ru) 2008-06-30
IL189142A0 (en) 2008-08-07
TWI422374B (zh) 2014-01-11
AP2654A (en) 2013-04-25
WO2007014941A2 (en) 2007-02-08
AR054890A1 (es) 2007-07-25
CA2615903A1 (en) 2007-02-08
CY1114318T1 (el) 2016-08-31
NZ565947A (en) 2011-05-27
NO341242B1 (no) 2017-09-25
HRP20130540T1 (en) 2013-07-31
SI1912648T1 (sl) 2013-07-31
NO20081026L (no) 2008-02-27
WO2007014941A8 (en) 2007-05-31
JP2009503025A (ja) 2009-01-29
AU2006274880B2 (en) 2012-12-13
ZA200801110B (en) 2011-10-26
ME01616B (me) 2014-09-20
KR101413997B1 (ko) 2014-07-01
KR20080035666A (ko) 2008-04-23
PL1912648T3 (pl) 2013-08-30
CN101277696B (zh) 2015-09-02
RS52808B (sr) 2013-10-31
AU2006274880A1 (en) 2007-02-08
CA2615903C (en) 2016-08-30
EP1912648A2 (en) 2008-04-23
TW200744595A (en) 2007-12-16
ES2414956T3 (es) 2013-07-23
MX2008001603A (es) 2008-02-19
MY159560A (en) 2017-01-13
WO2007014941A3 (en) 2007-03-29

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Legal Events

Date Code Title Description
PB01 Publication
SE01 Entry into force of request for substantive examination
GR01 Patent grant
CI01 Publication of corrected invention patent application

Correction item: PCT international application published data

Correct: WO2007 / 0l4941 E N 2007.02.08

False: WO2007 / 014941 EN 2007.03.29

Number: 35

Volume: 31

CI03 Correction of invention patent

Correction item: PCT international application published data

Correct: WO2007 / 0l4941 E N 2007.02.08

False: WO2007 / 014941 EN 2007.03.29

Number: 35

Page: The title page

Volume: 31

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150902