CN101264192A - Chinese medicinal composition for treating ovarian cancer and preparation thereof - Google Patents
Chinese medicinal composition for treating ovarian cancer and preparation thereof Download PDFInfo
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- CN101264192A CN101264192A CN 200810106122 CN200810106122A CN101264192A CN 101264192 A CN101264192 A CN 101264192A CN 200810106122 CN200810106122 CN 200810106122 CN 200810106122 A CN200810106122 A CN 200810106122A CN 101264192 A CN101264192 A CN 101264192A
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Abstract
The invention relates to a Chinese medicine composition used to cure ovarian cancer, which comprises the following components: radix geutianae, radix codonopsitis, radix scutellariae, liquorice, pinellia, forsythia, Tuckahoe, semen plantaginis, radix rehmanniae, immature tangerine, heracleum hemsleyanum michaux, rhizoma ligustici wallichii, algae, cassia stem, sea tangle, peach kernel, radix paeoniae rubra, cortex moutan and/or pharmaceutically acceptable carriers. The invention also relates to the preparation method of the Chinese medicine composition. The Chinese medicine composition in the invention has the advantages of clearing away dampness and heat, invigorating spleen and removing dampness through diuresis, promoting Qi and enhancing blood circulation, and detoxificating and resisting tumor growth; therefore, the Chinese medicine composition can be applied to the treatment of inferior belly malaise, bellyache, abdominal bump, menstruation disorder and pressure symptoms due to ovarian cancer.
Description
Technical field
This belongs to technical field of Chinese medicines, specifically, relates to a kind of Chinese medicine composition for the treatment of ovarian cancer and preparation method thereof.
Background technology
Ovarian cancer is meant the malignant tumor that betides ovary surface body cavity upper limb and its below stroma of ovary.Its age of onset is the wideest in the gynecological tumor, can occur in women's any period in life.Because ovarian tumor is hidden in pelvic cavity deeply, seldom there is symptom at the ill initial stage, so that 60%～70% malignant tumor of ovary has belonged to late period when making a definite diagnosis.5 years survival rates of ovarian cancer are still paced up and down at reduced levels (20%～30%) over nearly 20 years.Have data to show, the sickness rate of malignant tumor of ovary still constantly rises, and International Union Against Cancer (UICC) statistics age corrected mortality in 1985 is the highest with Denmark, reaches 9.78/10 ten thousand; Greece is minimum, is 2.59/10 ten thousand.By statistics, in the period of 1955～1985, the Japan and the U.S. are because of among the lethal crowd of tumor, and ovarian cancer is the tendency of continuous rising.It is reported that the sickness rate of China's malignant tumor of ovary in 1988 is 5.37/10 ten thousand, therefore further carries out the research that prevents and treats ovarian tumor and comes into one's own just day by day.
The malignant tumor of ovary growth is easily spread rapidly.But the patient is normal asymptomatic or lighter symptom is arranged in early days, often chances on when gynecologial examination, or treats that tumor growth exceeds to a certain size beyond pelvic cavity, and abdominal part can be laid one's hand in time, or just is found when developing complications, and has often belonged to late period when by the time seeking medical advice.The symptom of ovarian cancer can be because of size, the time of origin of tumor, have or not complication different.Common symptom has:
(1) the initial stage idol has a hypogastric region discomfort or a side lower abdomen that the painful sense of bob is arranged.
(2) abdominal distension sense is because tumor growth can have abdominal distention rapidly, abdominal mass and ascites in a short time.What tumor was little only could find when pelvioscopy that lump is grown up when exceeding pelvic cavity gradually, and abdominal part can contact lump.
(3) pressure symptom when tumor towards periphery when tissue infiltration or pressuring nerve, can cause stomachache, lumbago or sciatica, if edema of lower limbs can appear in compressing pelvic cavity vein; Huge tumor can be oppressed bladder, frequent micturition is arranged, the difficulty of urinating, urine retention; The compressing rectum is dyschesia then; The compressing gastrointestinal tract just has symptom of digestive tract; Dyspnea can take place in the compressing diaphram, can not put down for sleeping in.
(4) because the ramp of tumor, malnutrition appears and body constitution is become thin, form dyscrasia.
(5) corresponding symptom occurs because of cancerous protuberance shifts, malignant tumor of ovary seldom causes pain, breaks as tumor takes place, hemorrhage or infect or can cause stomachache, lumbago owing to soak into the compressing adjacent organ.
(6) menoxenia, vaginal hemorrhage can appear.If bilateral ovaries is all destroyed by cancerous tissue, can cause menoxenia and amenorrhea, lung shifts cough, hemoptysis, breast water can occur; Bone shifts and can cause metastasis local acute painful.Intestinal shifts can have blood in stool serious caused intestinal obstruction.
(7) in addition, if functioning tumour can produce the too much symptom of corresponding estrogen or androgen.As: cause early function dysfunctional metrorrhagia, vaginal hemorrhage after menopause or manlike sign occurs.End-stage patients then show obviously and become thin, cachexia phenomenons such as serious anemia.Can touch the hard tuberosity, the lump that are dispersed at posterior fornix during gynecologial examination and mostly be bilateral, substantive, surface irregularity maintain static, often with bloody ascites.Sometimes at groin, can touch the lymph node of enlargement on oxter or the clavicle.
The traditional Chinese medical science thinks that ovarian cancer belongs to categories such as " lump in the abdomen ", " intestinal gill fungus ", " stomachache ".Chinese medicine is to the understanding of primary disease, and classics doctor's nationality Huangdi's Internal Classics " Ling Shu Miraculous Pivot or Divine Axis watery distension " piece of writing that can trace back to before more than 2000 year is loaded with: " the cold visitor outside intestinal, with to defend gas phase rich, gas must not be sought, because of direct bearing is arranged, and addiction and interior work, bad odor has been that polyp is living.Its beginning gives birth to also, and is big as ovum gallinaceum, big with benefit slightly, to its one-tenth, enlarged abdomen like that of pregnant woman, for a long time the person from the year, that presses is then hard, what push away then moves, regular menstrual cycle, this its time also." this describes with ovarian tumor similar.Though the pathogenic factors of primary disease has all many-sides, its main pathogenesis is cold coagulation, the stagnation of QI, blood stasis.The lid cold being a kind of YIN pathogen, its property stagnates, and the invasion and attack body easily causes to be held back the liter that hinders yang-energy and sends out the operation of QI and blood.The married woman is through preceding or menstrual period, or puerperal, owing to be affected by the cold, or eating cold and uncooked food excessively, or factor body yang deficiency, cold originating from the interior, and cause cold visitor in the uterus passages through which vital energy circulates, the retardance QI-blood circulation causes the long-pending born of the same parents official of the stasis of blood then, with the passing of time forms lump in the abdomen.Because of qi as the commander of blood, the capable then blood of gas is capable again, and the stagnation of QI is blood stasis then, because feelings will is not smooth or depressed, or tired anger hinders gallbladder, or excessive thinking, and causes qi depression to blood stasis, and blood stasis stagnates among vessels of the uterus, gradually becomes this disease.
To the treatment of this disease, in " interior warp ", propose: the principle of " hard masses should be resolved gradually, knot is bitter to loose it, the disease with retention of pathogen in the body should be treated by elimination therapy, stagnant person leads it ", mainly evil in controlling to attack.But the generation of ovarian tumor development is the process of a vital QI being weakened and pathogen being violent, so " Yizong Jinjian gynecological heart method gist " day: " the Fan Zhizhu lump in the abdomen should select a little less than the strengthening of careful figure, the emergency of patient's condition and control it; as people's void, then QI and blood is weak, does not appoint and sends an expedition against; though the patient's condition Sheng is set upright gas in the ban, then controls its disease; If symptoms and signs is all real, suitable its disease of first rose also." " Medicine Comprehended gather a piece of writing " then further write up discuss stage by stage and controls: " control the accumulator, by the three therapeutic methods of traditional Chinese medicine of junior middle school end here when, pathogen is the visitor just, gathers heavily fortified point, should directly disappear it, then and it.If gather with the passing of time, evil Sheng is weakened body resistance, and method is therefrom controlled, and must hold concurrently mutually with reinforcing and reducing is usefulness.Piece disappears and half, makes with the end and controls, and promptly lives the medicine of attacks, but and middle nourishing the stomach, the dodar passages through which vital energy circulates, in order to do the Rong Wei circulation, and piece disappears certainly.More have empty people to suffer from long-pending person, must mend its void earlier, manage its spleen, increase its diet, medication attacks that it is long-pending then, and this does good and controls, the method for this tonifying first and then eliminating the pathogen." basic principle of these treatments, still continued to use so far by clinical.
The traditional Chinese medical science adopts this disease of decoction for the treatment of eliminating damp-heat, strong Pi dampness removing, promoting flow of QI and blood, the anti-tumor of detoxifcation.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of ovarian cancer.
The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.
In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of ovarian cancer, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:
Radix Gentianae 10-20 part Radix Codonopsis 15-25 part Radix Scutellariae 10-15 part
Radix Glycyrrhizae 20-30 part Rhizoma Pinelliae 5-15 part Fructus Forsythiae 10-20 part
Poria 15-25 part Semen Plantaginis 10-25 part Radix Rehmanniae 10-15 part
Pericarpium Citri Reticulatae Viride 15-20 part Radix Angelicae Pubescentis 15-25 part Rhizoma Chuanxiong 10-20 part
Sargassum 10-20 part Ramulus Cinnamomi 15-20 part Thallus Laminariae (Thallus Eckloniae) 15-25 part
Semen Persicae 5-15 part Radix Paeoniae Rubra 15-25 part Cortex Moutan 20-30 part
Effective ingredient is preferably made by weight by following raw materials according:
13 parts of 21 parts of Radix Scutellariaes of 16 parts of Radix Codonopsis of Radix Gentianae
16 parts of 10 parts of Fructus Forsythiaes of 25 parts of Rhizoma Pinelliaes of Radix Glycyrrhizae
13 parts in 18 parts of Radix Rehmanniae of 21 portions of Semen Plantaginiss of Poria
16 parts of 21 parts of Rhizoma Chuanxiongs of 18 parts of Radix Angelicae Pubescentiss of Pericarpium Citri Reticulatae Viride
21 parts of 18 parts of Thallus Laminariae (Thallus Eckloniae)s of 16 parts of Ramulus Cinnamomi of Sargassum
26 parts of 21 parts of Cortex Moutans of 11 parts of Radix Paeoniae Rubra of Semen Persicae
The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:
(1) Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae, Ramulus Cinnamomi, Thallus Laminariae (Thallus Eckloniae) are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(2) Radix Gentianae, Radix Codonopsis, Radix Scutellariae, the Rhizoma Pinelliae, Fructus Forsythiae, Poria, Semen Plantaginis, the Radix Rehmanniae, Radix Angelicae Pubescentis, Rhizoma Chuanxiong, Sargassum, Semen Persicae, Radix Paeoniae Rubra, Cortex Moutan decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned clear paste, drying, be ground into fine powder, make granule, capsule, tablet with receivable carrier pharmaceutically.
Chinese medicine composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.
Chinese medicine composition of the present invention has effects such as eliminating damp-heat, strong Pi dampness removing, promoting flow of QI and blood, the anti-tumor of detoxifcation, is used for diseases such as lower abdomen discomfort that ovarian cancer causes, stomachache, abdominal mass, menoxenia, compressing.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: Chinese medicinal composition granules of the present invention
(1) Pericarpium Citri Reticulatae Viride 180g, Radix Glycyrrhizae 250g, Ramulus Cinnamomi 180g, Thallus Laminariae (Thallus Eckloniae) 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(2) Radix Gentianae 160g, Radix Codonopsis 210g, Radix Scutellariae 130g, Rhizoma Pinelliae 100g, Fructus Forsythiae 160g, Poria 210g, Semen Plantaginis 180g, Radix Rehmanniae 130g, Radix Angelicae Pubescentis 210g, Rhizoma Chuanxiong 160g, Sargassum 160g, Semen Persicae 110g, Radix Paeoniae Rubra 210g, Cortex Moutan 260g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned clear paste, drying, be ground into fine powder, add dextrin 700g, lactose 200g, mixing, with 70% ethanol wet granulation, pack promptly.
Embodiment 2: Chinese medicinal composition capsules agent of the present invention
(1) Pericarpium Citri Reticulatae Viride 180g, Radix Glycyrrhizae 250g, Ramulus Cinnamomi 180g, Thallus Laminariae (Thallus Eckloniae) 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(2) Radix Gentianae 160g, Radix Codonopsis 210g, Radix Scutellariae 130g, Rhizoma Pinelliae 100g, Fructus Forsythiae 160g, Poria 210g, Semen Plantaginis 180g, Radix Rehmanniae 130g, Radix Angelicae Pubescentis 210g, Rhizoma Chuanxiong 160g, Sargassum 160g, Semen Persicae 110g, Radix Paeoniae Rubra 210g, Cortex Moutan 260g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned clear paste and dextrin 300g, dry, be ground into fine powder, mixing, in the capsulae vacuus of packing into promptly.
Embodiment 3: Chinese medicine composition tablet of the present invention
(1) Pericarpium Citri Reticulatae Viride 180g, Radix Glycyrrhizae 250g, Ramulus Cinnamomi 180g, Thallus Laminariae (Thallus Eckloniae) 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(2) Radix Gentianae 160g, Radix Codonopsis 210g, Radix Scutellariae 130g, Rhizoma Pinelliae 100g, Fructus Forsythiae 160g, Poria 210g, Semen Plantaginis 180g, Radix Rehmanniae 130g, Radix Angelicae Pubescentis 210g, Rhizoma Chuanxiong 160g, Sargassum 160g, Semen Persicae 110g, Radix Paeoniae Rubra 210g, Cortex Moutan 260g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned clear paste, dry, be ground into fine powder, add starch 300g, low substituted cellulose 50g, mixing, with 70% ethanol wet granulation, tabletting, coating are promptly.
Claims (4)
1, a kind of Chinese medicine composition for the treatment of ovarian cancer is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:
Radix Gentianae 10-20 part Radix Codonopsis 15-25 part Radix Scutellariae 10-15 part
Radix Glycyrrhizae 20-30 part Rhizoma Pinelliae 5-15 part Fructus Forsythiae 10-20 part
Poria 15-25 part Semen Plantaginis 10-25 part Radix Rehmanniae 10-15 part
Pericarpium Citri Reticulatae Viride 15-20 part Radix Angelicae Pubescentis 15-25 part Rhizoma Chuanxiong 10-20 part
Sargassum 10-20 part Ramulus Cinnamomi 15-20 part Thallus Laminariae (Thallus Eckloniae) 15-25 part
Semen Persicae 5-15 part Radix Paeoniae Rubra 15-25 part Cortex Moutan 20-30 part.
2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:
13 parts of 21 parts of Radix Scutellariaes of 16 parts of Radix Codonopsis of Radix Gentianae
16 parts of 10 parts of Fructus Forsythiaes of 25 parts of Rhizoma Pinelliaes of Radix Glycyrrhizae
13 parts in 18 parts of Radix Rehmanniae of 21 portions of Semen Plantaginiss of Poria
16 parts of 21 parts of Rhizoma Chuanxiongs of 18 parts of Radix Angelicae Pubescentiss of Pericarpium Citri Reticulatae Viride
21 parts of 18 parts of Thallus Laminariae (Thallus Eckloniae)s of 16 parts of Ramulus Cinnamomi of Sargassum
26 parts of 21 parts of Cortex Moutans of 11 parts of Radix Paeoniae Rubra of Semen Persicae.
3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.
4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:
(1) Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae, Ramulus Cinnamomi, Thallus Laminariae (Thallus Eckloniae) are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(2) Radix Gentianae, Radix Codonopsis, Radix Scutellariae, the Rhizoma Pinelliae, Fructus Forsythiae, Poria, Semen Plantaginis, the Radix Rehmanniae, Radix Angelicae Pubescentis, Rhizoma Chuanxiong, Sargassum, Semen Persicae, Radix Paeoniae Rubra, Cortex Moutan decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.
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| CN 200810106122 CN101264192A (en) | 2008-05-08 | 2008-05-08 | Chinese medicinal composition for treating ovarian cancer and preparation thereof |
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| CN 200810106122 CN101264192A (en) | 2008-05-08 | 2008-05-08 | Chinese medicinal composition for treating ovarian cancer and preparation thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055027A (en) * | 2010-07-21 | 2013-04-24 | 李政育 | Traditional Chinese medicine composition for inhibiting growth of cancer cells and traditional Chinese medicine extract thereof |
| CN109432251A (en) * | 2018-10-16 | 2019-03-08 | 吴蓓莉 | It is a kind of for treating the Chinese medicine composition of oophoroma |
-
2008
- 2008-05-08 CN CN 200810106122 patent/CN101264192A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055027A (en) * | 2010-07-21 | 2013-04-24 | 李政育 | Traditional Chinese medicine composition for inhibiting growth of cancer cells and traditional Chinese medicine extract thereof |
| CN109432251A (en) * | 2018-10-16 | 2019-03-08 | 吴蓓莉 | It is a kind of for treating the Chinese medicine composition of oophoroma |
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Open date: 20080917 |