CN101259130B - Antidiarrheal pharmaceutical composition - Google Patents
Antidiarrheal pharmaceutical composition Download PDFInfo
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- CN101259130B CN101259130B CN2008100111066A CN200810011106A CN101259130B CN 101259130 B CN101259130 B CN 101259130B CN 2008100111066 A CN2008100111066 A CN 2008100111066A CN 200810011106 A CN200810011106 A CN 200810011106A CN 101259130 B CN101259130 B CN 101259130B
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- antidiarrheal
- hydrochlorothiazide
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- composition
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Abstract
The invention discloses a composition of an antidiarrheal agent, which consists of the following weight portions of ingredients: 1.5-3 portions of compound diphenoxylate, 2.5-6 portions of prednisone and 5-15 portions of hydrochlorothiazide. The composition of the antidiarrheal agent has clear curative effect, good efficacy, rapid disappearance of diarrhea; diuresis effect of the hydrochlorothiazide is utilized to absorb water and reduce intestinal water, and the anti-inflammatory and anti-infection functions of prednisone are applied to mitigate clinic sympton, the cooperation of these three medicines accelerates the antidiarrheal speed and relieves the pain of the sufferers. The composition of the antidiarrheal agent has low cost, which is lower than Xieliting by 5-6 times.
Description
Technical field
The present invention relates to a kind of diarrhea, is a kind of compositions of antidiarrheal specifically.
Background technology
Present antidiarrheal is a lot, but antidiarrheal is slow, and it is big that the diarrhoeal diseases time has been grown physical demands, be difficult for to recover, and also increases complication easily, as dehydration etc., brings misery to patient; Existing medicine such as compound diphenoxylate, it directly acts on intestinal smooth muscle, by suppressing the intestinal mucosa sensor, eliminate the wriggling reflection of local mucous membrane and weaken wriggling, the segmental that can increase simultaneously intestinal is shunk, thereby prolongs contacting of intestinal contents and intestinal mucosa, promotes the resorption receipts of enteral moisture; Be used for acute and chronic functional diarrhea and chronic enteritis, but curative effect is slower.
Summary of the invention
The object of the present invention is to provide a kind of antidiarrheal pharmaceutical composition, it accelerates antidiarrheal speed, shortens the antidiarrheal time, alleviates patient's misery, and the patient is got well as early as possible.
Medicine of the present invention is made up of the crude drug component of following parts by weight:
Compound diphenoxylate 1.5-3 part,
Prednisone 2.5-6 part,
Hydrochlorothiazide 5-15 part.
Nearly step scheme of said ratio is:
2.5 parts of compound diphenoxylates,
5 parts of prednisones,
10 parts of hydrochlorothiazide.
Usage: be grown up each 2, every day 3 times is oral, generally takes 2 days, no longer than 3 days, or rushes down and stops withdrawal.
Untoward reaction: excessive or take medicine for a long time can occur feeling sick, vomiting, dry stool.
Medicine of the present invention adds adjuvant can make tablet or capsule.
The invention has the advantages that: 1, curative effect of medication of the present invention is definite, rapid-action, transference cure is fast, this medicine absorbs moisture content with the diuresis of hydrochlorothiazide, the moisture of intestinal is reduced, be used for alleviating clinical symptoms with antiinflammatory, the anti-infective of prednisone, three medicines share, accelerated the antidiarrheal speed of compound diphenoxylate, shortened the antidiarrheal time, antidiarrheal is fast, alleviates the patient suffering.2, cost is low, and is lower 5-6 times than the cost of XIELITING.
Clinical trial
With medicine group of the present invention: mostly 720 people are the acute diarrhea patient, the lighter every day just 3-4 time, heavy every day 5-10 time, age 23-58 year, make 1 with compound diphenoxylate 2.5mg, prednisone 5mg, three kinds of medicines of hydrochlorothiazide 10mg, each 2, every day 3 times is oral, takes 2 days.
Matched group: 25 people, the patient of acute enteritis, in age 23-60 year, the state of an illness and matched group are basic identical, and compound diphenoxylate 2.5mg a slice is grown up each 2, and every day 3 times is oral, takes 2 days.
Two groups of ages, the course of disease, symptom does not all have significant difference between group, has comparability.Treatment criterion of therapeutical effect: formulate with reference to " the sick quality control criterion of planting " (tentative draft) that in December, 1992 Ministry of Health of the People's Republic of China writes.Produce effects: stool day 1 time, just matter is normal, and clinical symptoms and sign disappear.Effectively: times of defecation reduces before the treatment, and just matter takes a turn for the better, and clinical symptoms and sign alleviate.Invalid: symptom and sign do not have improvement before and after the treatment.
Table 1 medicine of the present invention and existing curative effect of medication synopsis
Table 2 medicine of the present invention and existing Drug therapy time synopsis
By table 1 can see the treatment took two days, medicine of the present invention is higher more than 2 times than the matched group effective percentage, curative effect obviously be better than the contrast.
Can see that by table 2 take that symptom of diarrhea is lighter medicine of the present invention effective percentage once is 67%, and comparison needle need be taken medicine 2-3 time to the same state of an illness, effective percentage 37%, comparison is fast according to curative effect, significant difference.
The specific embodiment
Embodiment 1: 2.5 parts of compound diphenoxylates, 5 parts of prednisones, 10 parts of hydrochlorothiazide.
Embodiment 2: 1.5 parts of compound diphenoxylates, 3 parts of prednisones, 5 parts of hydrochlorothiazide.
Embodiment 3: 3 parts of compound diphenoxylates, 6 parts of prednisones, 14 parts of hydrochlorothiazide.
Claims (2)
1. the compositions of an antidiarrheal, it is characterized in that: it is made up of the crude drug component of following parts by weight:
Compound diphenoxylate 1.5-3 part,
Prednisone 2.5-6 part,
Hydrochlorothiazide 5-15 part.
2. according to the compositions of the described antidiarrheal of claim 1, it is characterized in that: it is made up of the crude drug component of following parts by weight:
2.5 parts of compound diphenoxylates,
5 parts of prednisones,
10 parts of hydrochlorothiazide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100111066A CN101259130B (en) | 2008-04-16 | 2008-04-16 | Antidiarrheal pharmaceutical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100111066A CN101259130B (en) | 2008-04-16 | 2008-04-16 | Antidiarrheal pharmaceutical composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101259130A CN101259130A (en) | 2008-09-10 |
| CN101259130B true CN101259130B (en) | 2010-07-28 |
Family
ID=39959962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008100111066A Expired - Fee Related CN101259130B (en) | 2008-04-16 | 2008-04-16 | Antidiarrheal pharmaceutical composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101259130B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104706867A (en) * | 2015-03-18 | 2015-06-17 | 马亮英 | Medicinal component for treating infantile diarrhea and preparation method thereof |
-
2008
- 2008-04-16 CN CN2008100111066A patent/CN101259130B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 张寄平.思密达与复方地芬诺酯片联合治疗病毒性肠炎44 例报告.中国实用儿科杂志年13 2.1998,13(2),98. |
| 张寄平.思密达与复方地芬诺酯片联合治疗病毒性肠炎44 例报告.中国实用儿科杂志年13 2.1998,13(2),98. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101259130A (en) | 2008-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100728 Termination date: 20130416 |