CN101249181A - Removing blood stasisTongmai Chinese medicine compound preparations and method of preparing the same - Google Patents
Removing blood stasisTongmai Chinese medicine compound preparations and method of preparing the same Download PDFInfo
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Abstract
The invention discloses a Chinese herbal medicine compound preparation for invigorating pulse and a preparation method thereof. The active components of the Chinese herbal medicine compound preparation are made from raw ingredients by weight parts as follows: ginseng is 5 to 16 parts, aweto is 5 to 16 parts, saffron is 4 to 10 parts, mother-of-pearl is 21 to 32 parts, Caulis Spatholobi is 11 to 23 parts, turtle shell is 18 to 30 parts, Salvia miltiorrhiza is 6 to 12 parts, and storax is 11 to 22 parts. The raw ingredients of the invention are crushed, and then sufficient water or alcohols are added, and auxiliary materials are added after being mixed to make the Chinese herbal medicine compound preparation. The Chinese herbal medicine compound preparation is obtained through repeated filtration and scientific compatibility of medicines and is used for treating obstruction of Qi in chest and apoplexy, and the clinical curative effect is good, the security is high, thereby being worth spreading and applying.
Description
Technical field
The present invention relates to Chinese medicine preparation and fabricating technology field, be specifically related to compound Chinese medicinal preparation that a kind of blood stasis dispelling promotes blood circulation and preparation method thereof.
Background technology
" thoracic obstruction " and apoplexy are traditional Chinese medical science common diseases, are equivalent to the cardio-cerebralvascular diseases of modern medicine, are one of worldwide three generally acknowledged big diseases of World Health Organization (WHO), also are the topmost diseases of harm humans life and health.According to The World Health Organization's statistics, the whole world has 1,200 ten thousand people to die from cardiovascular and cerebrovascular disease every year approximately, and the morbidity of China's cardiovascular and cerebrovascular disease is just becoming ascendant trend with mortality rate.China has 3,000,000 people to die from cardiovascular and cerebrovascular disease every year approximately according to statistics.
" thoracic obstruction " is traditional Chinese medical science common disease, is equivalent to categories such as modern medicine coronary heart disease, angina pectoris.Apoplexy also is a traditional Chinese medical science common disease, is equivalent to the category such as cerebral thrombosis, cerebral infarction of modern medicine, and is very common clinically.Modern medicine thinks, cerebral ischemia due to the normal because coronary artery of middle-aged and elderly people, the cerebral arteriosclerosis, and high blood viscosity, hyperlipidemia, composite factors such as cardio cerebrovascular affection cause the thoracic obstruction and apoplexy morbidity.The traditional Chinese medical science is then with wind, fire, and expectorant, stasis of blood void is pathogenesis.Chinese traditional treatment is then with suppressing the hyperactive liver to relieve the wind syndrome, and the kidney invigorating is relieved inflammation or internal heat, and benefiting QI for activating blood circulation, nourishing blood to tranquillize the mind are main.
The western medical treatment thoracic obstruction and apoplexy generally adopt blood vessel dilating class medicine, thrombolytic class medicine and dilute blood class medicine etc. to adopt symptomatic treatment clinically, mitigate the disease to a certain extent, but therapeutic effect is undesirable, and the sequela that easily occurs together.Blood vessel dilating class medicine can make intravascular pressure dwindle, and alleviates blood vessel wall deposition fat and stops up, and blood flow increasing improves disease, but the long meeting of administration time causes the vessel wall elasticity variation, can't alleviate atherosclerotic degree, cures the symptoms, not the disease.Thrombolytic class medicine can thrombus, improves blood supply insufficiency at short notice, blood flow increasing, but dissolved thrombosis composition and atherosclerotic plaque do not excrete, but be trapped in the liver position, the harm liver; Simultaneously its thrombolytic by force washes away blood vessel by medicine and may cause blood vessel injury, and easy excitated thrombin makes the thrombosis residue condense artery-clogging again, and danger is very big, non-extra urgent high-risk patient medication cautiously.Dilute blood class medicine can blood viscosity lowering, and dilute blood improves condition of blood, but simple dilute blood has destroyed blood component, and therefore blood thickness more also after the drug withdrawal offsets except that the blood vessel atherosclerosis and do not have basic effect.
Present general methods such as Chinese patent medicine that adopt of the Chinese traditional treatment thoracic obstruction and apoplexy with blood circulation promoting and blood stasis dispelling, dredging the meridian drug effect, though action temperature and toxic and side effects are less, mitigate the disease to a certain extent, therapeutic effect is undesirable mostly.
Summary of the invention
The compound Chinese medicinal preparation that the object of the present invention is to provide a kind of blood stasis dispelling to promote blood circulation is used for the treatment of the thoracic obstruction and apoplexy disease, this compound Chinese medicinal preparation reasonable recipe, and determined curative effect, therapeutic effect is reliable.
Another object of the present invention is to provide the preparation method of this compound Chinese medicinal preparation.
For realizing goal of the invention of the present invention, the inventor is according to the traditional Chinese medical science pathogenesis and the Therapeutic Principle of the thoracic obstruction and apoplexy, through clinical secular practice, screening has obtained the compound Chinese medicinal preparation of a kind of effective treatment thoracic obstruction and apoplexy on the basis of scientific analysis and experiment repeatedly, through clinical verification, chest-rheumatisms such as apoplexies such as cerebral thrombosis, cerebral infarction and coronary heart disease, angina pectoris had special efficacy.
The objective of the invention is to be achieved through the following technical solutions:
The compound Chinese medicinal preparation that a kind of blood stasis dispelling is promoted blood circulation comprises active component and adjuvant, it is characterized in that described active component is that raw material by following weight portion makes:
Radix Ginseng 5-16 part, Cordyceps 5-16 part, Stigma Croci 4-10 part, Concha Margaritifera 21-32 part, Caulis Spatholobi 11-23 part, Carapax Trionycis 18-30 part, Radix Salviae Miltiorrhizae 6-12 part, Styrax 11-22 part.
Preferably, described active component is that raw material by following weight portion makes:
9 parts of Radix Ginsengs, 9 parts of Cordyceps, 6 parts of Stigma Crocis, 25 parts of Concha Margaritiferas, 15 parts of Caulis Spatholobis, 25 parts of Carapax Trionycis, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Styrax.
Above-mentioned compound preparation can be atomized inhalation or oral formulations, and wherein said oral formulations comprises capsule, tablet, oral liquid, sucks agent, granule, electuary, pill, powder, unguentum, sublimed preparation or suspensoid.Preferred atomized inhalation or capsule.
Prepare the method for the compound Chinese medicinal preparation that above-mentioned blood stasis dispelling promotes blood circulation, comprise the steps:
1) take by weighing raw material by following weight portion:
Radix Ginseng 5-16 part, Cordyceps 5-16 part, Stigma Croci 4-10 part, Concha Margaritifera 21-32 part, Caulis Spatholobi 11-23 part, Carapax Trionycis 18-30 part, Radix Salviae Miltiorrhizae 6-12 part, Styrax 11-22 part;
2) above-mentioned raw materials is pulverized, added water or ethanol extraction respectively, mixed extract adds adjuvant, makes described compound preparation.
Above-mentioned steps 2) after adding adjuvant in, makes compound preparation of the present invention according to the conventional preparation method of Chinese medicine preparation.Used adjuvant of compound preparation of the present invention or excipient comprise: starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, cyclodextrin, beta-schardinger dextrin-etc.
Wherein, the described row weight portion of pressing of step 1) takes by weighing raw material, is specially:
9 parts of Radix Ginsengs, 9 parts of Cordyceps, 6 parts of Stigma Crocis, 25 parts of Concha Margaritiferas, 15 parts of Caulis Spatholobis, 25 parts of Carapax Trionycis, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Styrax.
The step 2 of above-mentioned preparation method) be specially:
Carapax Trionycis and Concha Margaritifera are pulverized, decocted with water, decoction liquor filters, filtrate for later use; All the other raw medicinal materials are pulverized, added water infiltration respectively to saturating, the after-filtration of squeezing the juice, the filtrate heated and boiled is filtered filtrate for later use; Standby filtrate is mixed, make atomized inhalation.
The step 2 of above-mentioned preparation method) can also be:
Radix Ginseng, Cordyceps, Stigma Croci, Radix Salviae Miltiorrhizae powder are broken into fine powder, sieving for standby; All the other crude drug add water or ethanol extraction, and filtrate is condensed into thick paste, drying, and it is standby to be ground into fine powder; Standby fine powder is mixed, make capsule.
Chinese medicine composition of the present invention has the curative effect that benefiting QI for activating blood circulation, blood stasis dispelling are promoted blood circulation, and can be used for preparing the medicine of the treatment thoracic obstruction and apoplexy.Wherein the thoracic obstruction and apoplexy comprise coronary heart disease, angina pectoris, myocardial infarction, hypertension, atherosclerosis, cerebral thrombosis, cerebral infarction or cerebral hemorrhage convalescent period.
Compound preparation of the present invention can be made into atomizing and sucks preparation or various peroral dosage form, can use as one feels fit according to the state of an illness under doctor's guidance.The atomized inhalation that makes with preparation embodiment 1 is an example, need have children outside the state plan atomizing during use, and per nasal sucks, every day 1 time, and each 50ml, 2 months is a course of treatment.Other preparation is taken according to a conventional method, and taking dose is with reference to above-mentioned effective dose.
The raw material prescription of compound preparation of the present invention is through repeated screening and science compatibility gained, this medicine is with suppressing the hyperactive liver to relieve the wind syndrome, and the kidney invigorating is relieved inflammation or internal heat, benefiting QI for activating blood circulation, nourishing blood to tranquillize the mind is main Therapeutic Principle, truly has curative effect for " thoracic obstruction ", apoplexy diseases such as treatment coronary heart disease, angina pectoris, cerebral thrombosis and cerebral infarction.From the clinical practice situation, medicine of the present invention is obvious to stroke patient therapeutic effect such as cerebral thrombosis, cerebral infarction, total effective rate reaches 90%, therapeutic effect to thoracic obstruction patients such as coronary heart disease, angina pectoriss is obvious, total effective rate reaches 100%, significant difference p＜0.05-0.01 has obtained ideal curative effect before and after the treatment.
Medicine of the present invention can reach good effect in treatment clinical course, do not need the other drug auxiliary treatment, has reduced drug combination.In clinical trial, do not find anaphylaxis and toxic and side effects, this product clinical drug safety is described, avirulence.
The specific embodiment
For further specifying the beneficial effect of compound preparation of the present invention, below further prove the good therapeutic effect of this medicine to the thoracic obstruction and apoplexy by the clinical trial example.
Test example 1 medicine of the present invention is used for the treatment of thoracic obstruction patient 126 routine clinical observation tests.
Select to be subjected to examination disease 126 examples of being in hospital at random according to traditional Chinese medical science thoracic obstruction clinical diagnosis standard, male's 74 examples wherein, women's 52 examples, age 30-70 year, average 50 years old.Above-mentioned patient comprises turbid phlegm blocking the clear orifices disease 68 examples by clinical card marquis, qi depression to blood stasis disease 58 examples.Above-mentioned patient all is diagnosed as ischemic heart desease (coronary heart disease) by the diagnostic criteria of doctor trained in Western medicine ischemic heart desease.Above-mentioned case selection has been got rid of below 30 years old or more than 80 years old, allergic constitution and to this medicine allergy sufferers.
Medication:
The atomized inhalation that makes according to preparation embodiment 1 atomizes through the excusing from death nebulizer, and per nasal sucks, and each 50ml sucked every day 1 time in each 30-40 minute, and 2 months is a course of treatment.
Curative effect determinate standard is divided into:
1) clinic control: cardinal symptom is recovered normally to take care of oneself substantially, can recover general social activity.
2) produce effects: cardinal symptom is most of recovers normal, takes care of oneself, and is quick on the draw, and hypermnesia participates in social activity.
3) effective: main malaise symptoms disappears, and life is taken care of oneself substantially, reacts not good enough.
Therapeutic effect is as follows:
Turbid phlegm blocking the clear orifices disease is totally 68 examples, clinic control 28 examples (accounting for 41.25%), produce effects 25 examples (accounting for 36.85%), effective 15 examples (accounting for 22.05%);
Qi depression to blood stasis disease 58 examples, clinic control 28 examples (accounting for 41.25%), produce effects 22 examples (accounting for 32.4%), effective 8 examples (accounting for 13.79%).
Total effective rate is 98%, and duration of test is not seen toxicity.
Test example 2 medicines of the present invention are used for the treatment of the thoracic obstruction and each 50 routine clinical observation test of stroke patient.
Select to be tried stroke patient 50 example and thoracic obstruction patient 50 examples at random according to the traditional Chinese medical science thoracic obstruction and apoplexy clinical diagnosis standard, male 30 examples of apoplexy (comprising cerebral thrombosis and cerebral infarction) patient wherein, age 38-70 year, women 20 examples, age 38-60 year; The thoracic obstruction (comprising coronary heart disease and angina pectoris) patient man 30 examples wherein, age 45-70 year, women 20 examples, age 40-60 year.
Medication:
The atomized inhalation that makes according to preparation embodiment 1 atomizes through the excusing from death nebulizer, and per nasal sucks, and each 50ml sucked every day 1 time in each 30-40 minute, and 2 months is a course of treatment.
Efficacy determination is with reference to the evaluation of thoracic obstruction efficacy assessment standard and apoplexy efficacy assessment standard, and above-mentioned patient produce effects, effective and doing well,improving situation through treating after see Table 1 and table 2.Clinical observation result shows in the table, various symptoms truly had curative effect due to compound preparation of the present invention was obstructed to the dizzy dizzy microcirculation that improves patient, treatment total effective rate to apoplexy (comprising cerebral thrombosis and cerebral infarction) patient is 90%, treatment total effective rate to the thoracic obstruction (comprising coronary heart disease and angina pectoris) patient is 100%, significant difference p＜0.05-0.01 has obtained ideal curative effect before and after the treatment.
Duration of test does not see that toxic and side effects appears in patient, and drug safety is reliable.
Table 1 compound preparation treatment of the present invention apoplexy thoracic obstruction patient doing well,improving situation
Table 2 compound preparation treatment of the present invention apoplexy thoracic obstruction patient clinical efficacy
Experimental example 3 medicines of the present invention are used for the treatment of the thoracic obstruction and stroke patient model case clinical observation material
1) cerebral infarction case
Zhang Shulin, the man, 62 years old, petrochemical industry cadre of office in Shaanxi Province's suffered from the other cerebral infarction (on October 24th, 1996, CT examination was made a definite diagnosis) of right frontal lobe three ventricles of the brain bodies.Brought into use compound preparation atomization inspiration treatment of the present invention 2 months on the 25th, December in 1996 CT check on the 26th no abnormality seen.
2) thromboangiitis obliterans case
Lu Zhixia, the woman, 24 years old, rising tone town, Baoji, Shaanxi province county Rhizoma Zingiberis Recens Ma Cun, the peasant suffers from right strand of inboard thromboangiitis obliterans down, does the thermal infrared imager inspection before being admitted to hospital to make a definite diagnosis, and uses 20 recoveries from illness of compound preparation atomization inspiration treatment of the present invention to leave hospital.
3) cerebral blood supply insufficiency case
Zhang Junfen, the woman, 47 years old, the cadre of supply and marketing company of Xibei Chemical Inst, the trouble cerebral blood supply is bad, uses compound preparation atomization inspiration treatment of the present invention recovery from illness in 2 months and leaves hospital, and patient does not have recurrence over nearly 1 year through following up a case by regular visits to.
4) angina pectoris case
Liu Chengye, the man, 62 years old, petrochemical industry cadre of office in Shaanxi Province's suffered from angina pectoris and is admitted to hospital June 6 nineteen ninety-five, used compound preparation atomization inspiration treatment of the present invention recovery from illness in 2 months and left hospital, and followed up a case by regular visits to readme not recurrence so far after the medication first time through phone.
5) cardiomyopathy case
Zhang Hongquan, the man, 22 years old, the postgraduate student of Shaanxi Northwest University was backflowed (slightly) because of trouble cardiomyopathy, right ventricle, left room increase Tricuspid valve, leaves hospital through compound preparation atomization inspiration treatment of the present invention recovery from illness in 2 months.
Below by the preparation embodiment further set forth the preparation method of Chinese medicine preparation of the present invention.Used medical material and adjuvant all are commonly used also can the obtaining by commercial sources in this area among the preparation embodiment of following compound preparation, and its preparation method also adopts the formulation preparation method of this area routine if no special instructions.
Preparation embodiment 1
Take by weighing Radix Ginseng 9g, Cordyceps 9g, Stigma Croci 6g, Concha Margaritifera 25g, Caulis Spatholobi 15g, Carapax Trionycis 25g, Radix Salviae Miltiorrhizae 10g, Styrax 15g, standby;
Above-mentioned Carapax Trionycis and Concha Margaritifera powder are broken into coarse powder to be added 8 times of amount distilled water and decocts secondaries, each 1 hour (time counting) from boiling, merging the secondary decoction liquor filters, be concentrated into relative density 1: 1 clear paste of (80 ℃ of surveys), place hermetic container to leave standstill 24 hours for 0 ℃ Celsius above-mentioned clear paste, take out and filter, filtrate is put in the hermetic container standby;
All the other prescription medical materials are ground into coarse powder, add the equivalent distilled water and soak into, soaked into 24 hours, squeeze the juice to saturating, filter, get filtrate then and put in the extractor, heated and boiled 5 minutes, filtered while hot, filtrate places hermetic container to leave standstill 24 hours for 0 ℃ Celsius, takes out and filters, and filtrate is put in the hermetic container standby;
Above-mentioned standby filtrate is mixed, and adding distil water transfers to 100ml, and relative density 0.9-1.10 (20 ℃ of surveys) bottles during pH value 5.5-5.6, and gland seal promptly gets atomized inhalation of the present invention.
Preparation embodiment 2
Take by weighing Radix Ginseng 5g, Cordyceps 5g, Stigma Croci 4g, Concha Margaritifera 21g, Caulis Spatholobi 11g, Carapax Trionycis 18g, Radix Salviae Miltiorrhizae 6g, Styrax 11g, standby;
Above-mentioned Carapax Trionycis and Concha Margaritifera powder are broken into coarse powder to be added 8 times of amount distilled water and decocts secondaries, each 1 hour (time counting) from boiling, merging the secondary decoction liquor filters, be concentrated into relative density 1: 1 clear paste of (80 ℃ of surveys), place hermetic container to leave standstill 24 hours for 0 ℃ Celsius above-mentioned clear paste, take out and filter, filtrate is put in the hermetic container standby;
All the other prescription medical materials are ground into coarse powder, add the equivalent distilled water and soak into, soaked into 24 hours, squeeze the juice to saturating, filter, get filtrate then and put in the extractor, heated and boiled 5 minutes, filtered while hot, filtrate places hermetic container to leave standstill 24 hours for 0 ℃ Celsius, takes out and filters, and filtrate is put in the hermetic container standby;
Above-mentioned standby filtrate is mixed, and adding distil water transfers to 100ml, and relative density 0.9-1.10 (20 ℃ of surveys) bottles during pH value 5.5-5.6, and gland seal promptly gets atomized inhalation of the present invention.
Preparation embodiment 3
Take by weighing Radix Ginseng 16g, Cordyceps 16g, Stigma Croci 10g, Concha Margaritifera 32g, Caulis Spatholobi 23g, Carapax Trionycis 30g, Radix Salviae Miltiorrhizae 12g, Styrax 22g, standby;
Above-mentioned Carapax Trionycis and Concha Margaritifera powder are broken into coarse powder to be added 8 times of amount distilled water and decocts secondaries, each 1 hour (time counting) from boiling, merging the secondary decoction liquor filters, be concentrated into relative density 1: 1 clear paste of (80 ℃ of surveys), place hermetic container to leave standstill 24 hours for 0 ℃ Celsius above-mentioned clear paste, take out and filter, filtrate is put in the hermetic container standby;
All the other prescription medical materials are ground into coarse powder, add the equivalent distilled water and soak into, soaked into 24 hours, squeeze the juice to saturating, filter, get filtrate then and put in the extractor, heated and boiled 5 minutes, filtered while hot, filtrate places hermetic container to leave standstill 24 hours for 0 ℃ Celsius, takes out and filters, and filtrate is put in the hermetic container standby;
Above-mentioned standby filtrate is mixed, and adding distil water transfers to 100ml, and relative density 0.9-1.10 (20 ℃ of surveys) bottles during pH value 5.5-5.6, and gland seal promptly gets atomized inhalation of the present invention.
Preparation embodiment 4
Take by weighing Radix Ginseng 50g, Cordyceps 50g, Stigma Croci 50g, Concha Margaritifera 200g, Caulis Spatholobi 120g, Carapax Trionycis 200g, Radix Salviae Miltiorrhizae 100g, Styrax 100g, standby;
With Radix Ginseng, Cordyceps, Stigma Croci, Radix Salviae Miltiorrhizae oven dry (below 60 ℃), be ground into fine powder, cross 80 mesh sieves, standby; All the other crude drug decoct with water secondary, add 6 times of amounts of water at every turn, decoct 2 hours, and merging filtrate and concentrating under reduced pressure become density to be the thick paste of 1.30-1.35, and be standby; Above-mentioned standby fine powder and standby thick paste are mixed, and oven dry (below 60 ℃) is ground into fine powder, incapsulates and promptly gets capsule of the present invention.
Preparation embodiment 5
Take by weighing Radix Ginseng 42g, Cordyceps 44g, Stigma Croci 42g, Concha Margaritifera 182g, Caulis Spatholobi 110g, Carapax Trionycis 182g, Radix Salviae Miltiorrhizae 82g, Styrax 82g, standby;
With Radix Ginseng, Cordyceps, Stigma Croci, Radix Salviae Miltiorrhizae oven dry (below 60 ℃), be ground into fine powder, cross 80 mesh sieves, standby; All the other crude drug decoct with water secondary, add 6 times of amounts of water at every turn, decoct 2 hours, and merging filtrate and concentrating under reduced pressure become density to be the thick paste of 1.30-1.35, and be standby; Above-mentioned standby fine powder and standby thick paste are mixed, and oven dry (below 60 ℃) is ground into fine powder, incapsulates and promptly gets capsule of the present invention.
Preparation embodiment 6
Take by weighing Radix Ginseng 61g, Cordyceps 65g, Stigma Croci 62g, Concha Margaritifera 210g, Caulis Spatholobi 150g, Carapax Trionycis 210g, Radix Salviae Miltiorrhizae 115g, Styrax 115g, standby;
With Radix Ginseng, Cordyceps, Stigma Croci, Radix Salviae Miltiorrhizae oven dry (below 60 ℃), be ground into fine powder, cross 80 mesh sieves, standby; All the other crude drug decoct with water secondary, add 6 times of amounts of water at every turn, decoct 2 hours, and merging filtrate and concentrating under reduced pressure become density to be the thick paste of 1.30-1.35, and be standby; Above-mentioned standby fine powder and standby thick paste are mixed, and oven dry (below 60 ℃) is ground into fine powder, incapsulates and promptly gets capsule of the present invention.
Preparation embodiment 7
Take by weighing Radix Ginseng 9g, Cordyceps 9g, Stigma Croci 6g, Concha Margaritifera 25g, Caulis Spatholobi 15g, Carapax Trionycis 25g, Radix Salviae Miltiorrhizae 10g, Styrax 15g, standby;
Above-mentioned Carapax Trionycis and Concha Margaritifera powder are broken into coarse powder to be added 8 times of amount distilled water and decocts secondaries, each 1 hour (time counting) from boiling, merging the secondary decoction liquor filters, be concentrated into the extractum of density 1.35, the ethanol that adds 90%-95% carries out precipitate with ethanol, reclaim ethanol and concentrated, 45-50 ℃ dry down, makes dry extract 1;
All the other prescription medical materials are ground into coarse powder, add the equivalent distilled water and soak into, soaked into 24 hours to saturating, squeeze the juice, filter, get filtrate then and put in the extractor, heated and boiled 5 minutes, filtered while hot, filtrate concentrates, and the ethanol that adds 90%-95% carries out precipitate with ethanol, reclaims ethanol and concentrated, 45-50 ℃ dry down, makes dry extract 2;
Merge dry extract 1 and dry extract 2, it is ground into powder, add adhesive and filler, be pressed into tablet.
Preparation embodiment 8
Take by weighing Radix Ginseng 9g, Cordyceps 9g, Stigma Croci 6g, Concha Margaritifera 25g, Caulis Spatholobi 15g, Carapax Trionycis 25g, Radix Salviae Miltiorrhizae 10g, Styrax 15g, standby;
Above-mentioned Carapax Trionycis and Concha Margaritifera powder are broken into coarse powder to be added 8 times of amount distilled water and decocts secondaries, each 1 hour (time counting) from boiling, merging the secondary decoction liquor filters, be concentrated into the extractum of density 1.35, the ethanol that adds 90%-95% carries out precipitate with ethanol, reclaim ethanol and concentrated, 45-50 ℃ dry down, makes dry extract 1;
All the other prescription medical materials are ground into coarse powder, add the equivalent distilled water and soak into, soaked into 24 hours to saturating, squeeze the juice, filter, get filtrate then and put in the extractor, heated and boiled 5 minutes, filtered while hot, filtrate concentrates, and the ethanol that adds 90%-95% carries out precipitate with ethanol, reclaims ethanol and concentrated, 45-50 ℃ dry down, makes dry extract 2;
Merge dry extract 1 and dry extract 2, it is ground into powder, add adhesive and filler, be pressed into granule.
Above embodiment just is used to further specify the present invention, rather than is used for limiting protection scope of the present invention.Every specific embodiment of being made in protection domain of the present invention and a little change on the range of application also belong to protection scope of the present invention.
Claims (10)
1. the compound Chinese medicinal preparation that blood stasis dispelling is promoted blood circulation comprises active component and adjuvant, it is characterized in that described active component is that raw material by following weight portion makes:
Radix Ginseng 5-16 part, Cordyceps 5-16 part, Stigma Croci 4-10 part, Concha Margaritifera 21-32 part, Caulis Spatholobi 11-23 part, Carapax Trionycis 18-30 part, Radix Salviae Miltiorrhizae 6-12 part, Styrax 11-22 part.
2. compound Chinese medicinal preparation according to claim 1 is characterized in that described active component is that raw material by following weight portion makes:
9 parts of Radix Ginsengs, 9 parts of Cordyceps, 6 parts of Stigma Crocis, 25 parts of Concha Margaritiferas, 15 parts of Caulis Spatholobis, 25 parts of Carapax Trionycis, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Styrax.
3. compound Chinese medicinal preparation according to claim 1 and 2 is characterized in that described compound preparation is atomized inhalation or oral formulations.
4. compound Chinese medicinal preparation according to claim 3 is characterized in that described oral formulations comprises capsule, tablet, oral liquid, sucks agent, granule, electuary, pill, powder, unguentum, sublimed preparation or suspensoid.
5. the preparation method of the blood stasis dispelling compound Chinese medicinal preparation of promoting blood circulation is characterized in that, comprises the steps:
1) take by weighing raw material by following weight portion:
Radix Ginseng 5-16 part, Cordyceps 5-16 part, Stigma Croci 4-10 part, Concha Margaritifera 21-32 part, Caulis Spatholobi 11-23 part, Carapax Trionycis 18-30 part, Radix Salviae Miltiorrhizae 6-12 part, Styrax 11-22 part;
2) above-mentioned raw materials is pulverized, added water or ethanol extraction respectively, mixed extract adds adjuvant, makes described compound preparation.
6. according to the described preparation method of claim 5, it is characterized in that the described row weight portion of pressing of step 1) takes by weighing raw material, is specially:
9 parts of Radix Ginsengs, 9 parts of Cordyceps, 6 parts of Stigma Crocis, 25 parts of Concha Margaritiferas, 15 parts of Caulis Spatholobis, 25 parts of Carapax Trionycis, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Styrax.
7. according to claim 5 or 6 described preparation methoies, it is characterized in that step 2) be specially:
Carapax Trionycis and Concha Margaritifera are pulverized, decocted with water, decoction liquor filters, filtrate for later use; All the other raw medicinal materials are pulverized, added water infiltration respectively to saturating, the after-filtration of squeezing the juice, the filtrate heated and boiled is filtered filtrate for later use; Standby filtrate is mixed, make atomized inhalation.
8. according to claim 5 or 6 described preparation methoies, it is characterized in that step 2) be specially:
Radix Ginseng, Cordyceps, Stigma Croci, Radix Salviae Miltiorrhizae powder are broken into fine powder, sieving for standby; All the other crude drug add water or ethanol extraction, and filtrate is condensed into thick paste, drying, and it is standby to be ground into fine powder; Standby fine powder is mixed, make capsule.
9. claim 1 or the 2 described compound Chinese medicinal preparation application in the preparation treatment thoracic obstruction and apoplexy disease medicament.
10. application according to claim 9, the described thoracic obstruction and apoplexy disease comprise coronary heart disease, angina pectoris, myocardial infarction, hypertension, atherosclerosis, cerebral thrombosis, cerebral infarction or cerebral hemorrhage convalescent period.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600342A (en) * | 2012-04-01 | 2012-07-25 | 任涛 | Specific medicine for treating coronary disease |
| CN104147571A (en) * | 2014-08-25 | 2014-11-19 | 王秀华 | Traditional Chinese medicine composition used for treating thrombus and preparation method thereof |
| CN105770081A (en) * | 2016-04-21 | 2016-07-20 | 张效珏 | Composition preparation used for promoting healing after cerebral hemorrhage operation and preparation method thereof |
-
2008
- 2008-04-09 CN CN2008101036414A patent/CN101249181B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600342A (en) * | 2012-04-01 | 2012-07-25 | 任涛 | Specific medicine for treating coronary disease |
| CN104147571A (en) * | 2014-08-25 | 2014-11-19 | 王秀华 | Traditional Chinese medicine composition used for treating thrombus and preparation method thereof |
| CN105770081A (en) * | 2016-04-21 | 2016-07-20 | 张效珏 | Composition preparation used for promoting healing after cerebral hemorrhage operation and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101249181B (en) | 2010-10-20 |
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