CN101247818A - Mas g-蛋白偶联受体激动剂和拮抗剂作为凋亡活性调节剂用于预防和治疗疾病的用途 - Google Patents
Mas g-蛋白偶联受体激动剂和拮抗剂作为凋亡活性调节剂用于预防和治疗疾病的用途 Download PDFInfo
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- CN101247818A CN101247818A CNA2006800302306A CN200680030230A CN101247818A CN 101247818 A CN101247818 A CN 101247818A CN A2006800302306 A CNA2006800302306 A CN A2006800302306A CN 200680030230 A CN200680030230 A CN 200680030230A CN 101247818 A CN101247818 A CN 101247818A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/085—Angiotensins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0502497-8A BRPI0502497A (pt) | 2005-06-28 | 2005-06-28 | uso de agonistas e antagonistas do receptor acoplado a proteìna g, mas, como moduladores de atividade apoptótica para o estudo, a prevenção e o tratamento de doenças |
| BRPI05024978 | 2005-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101247818A true CN101247818A (zh) | 2008-08-20 |
Family
ID=37595483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800302306A Pending CN101247818A (zh) | 2005-06-28 | 2006-06-28 | Mas g-蛋白偶联受体激动剂和拮抗剂作为凋亡活性调节剂用于预防和治疗疾病的用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080312129A1 (enExample) |
| EP (1) | EP1904087A2 (enExample) |
| JP (3) | JP2008546811A (enExample) |
| CN (1) | CN101247818A (enExample) |
| BR (1) | BRPI0502497A (enExample) |
| CA (1) | CA2613126A1 (enExample) |
| WO (1) | WO2007000036A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105873598A (zh) * | 2013-07-03 | 2016-08-17 | 代表亚利桑那大学的亚利桑那校董会 | 用于治疗认知功能障碍的方法 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0602366B1 (pt) | 2006-04-26 | 2017-12-12 | Universidade Federal De Minas Gerais | Use of agonists of the receptor coupled to protein g, but, in the treatment of metabolic syndrome, its components and their complications |
| US8653031B2 (en) * | 2006-10-30 | 2014-02-18 | Universidade Federal De Minas Gerais | Process for the preparation of compositions of AT1 receptor antagonist and Angiotensin—(1-7) |
| WO2008089532A1 (en) * | 2007-01-26 | 2008-07-31 | Universidade Federal De Minas Gerais - Ufmg | Pharmaceutical compositions and methods for treating erectile dysfunction |
| BRPI0800585B8 (pt) | 2008-02-13 | 2021-05-25 | Univ Minas Gerais | composições farmacêuticas do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7) e uso do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7) |
| ES2393455T3 (es) | 2008-09-12 | 2012-12-21 | Charité-Universitátsmedizin Berlin (Charité) | Uso de un agonista del receptor Ang-(1-7) en lesiones pulmonares agudas |
| DE102009013456A1 (de) * | 2009-03-18 | 2010-09-23 | GÖPFERICH, Achim, Prof. Dr. | Nanopartikel für die Erkennung von Zellen, durch Bindung an G-Protein gekoppelte Rezeptoren |
| CN102337298B (zh) * | 2011-08-19 | 2013-11-06 | 黄开红 | 一种输送siRNA的免疫纳米载体及其制备方法和应用 |
| KR20140140546A (ko) * | 2012-02-10 | 2014-12-09 | 타릭스 파마슈티컬스 엘티디. | 말초 혈관 질환의 치료를 위한 조성물 및 방법 |
| US8557958B1 (en) | 2012-06-18 | 2013-10-15 | Tarix Pharmaceuticals Ltd. | Compositions and methods for treatment of diabetes |
| US8633158B1 (en) * | 2012-10-02 | 2014-01-21 | Tarix Pharmaceuticals Ltd. | Angiotensin in treating brain conditions |
| BR132012028005E2 (pt) * | 2012-10-31 | 2014-11-18 | Univ Minas Gerais | Composições farmacêuticas contendo um agonista do receptor mas para o tratamento de doenças degenerativas musculares. |
| US9333233B2 (en) | 2014-02-25 | 2016-05-10 | Tarix Pharmaceuticals Ltd. | Methods and compositions for the delayed treatment of stroke |
| US10183055B2 (en) | 2014-07-21 | 2019-01-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications |
| AU2015294371B2 (en) | 2014-07-21 | 2018-02-01 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Ang-(1-7) derivative oligopeptides and methods for using and producing the same |
| CN113207799B (zh) * | 2021-03-19 | 2022-03-15 | 中山大学 | 一种二型糖尿病小鼠快速心衰模型的构建方法 |
| EP4371556A1 (en) | 2022-11-15 | 2024-05-22 | Explicat Pharma GmbH | Angiotensin(1-7) pharmaceutical compositions for inhalation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1349530A (zh) * | 1999-05-05 | 2002-05-15 | 阿文蒂斯药物德国有限公司 | 作为血管紧张肽(1-7)受体兴奋剂的1-(p-噻吩基苄基)咪唑,其制备方法,其用途和含有它们的药物制剂 |
| CN1599620A (zh) * | 2001-11-05 | 2005-03-23 | 米纳斯吉拉斯联合大学 | 采用环糊精、脂质体和生物降解性聚合物和/或其混合物及其制品制备肽血管紧张素-(1-7 )和类似物、激动剂和拮抗剂制剂的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6989363B1 (en) * | 1997-12-11 | 2006-01-24 | Millennium Pharmaceuticals, Inc. | Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor |
| EP1096957A1 (en) * | 1998-06-18 | 2001-05-09 | Johns Hopkins University School of Medicine | Methods and reagents for intramuscular delivery of nucleic acids |
| US6236766B1 (en) * | 1998-09-11 | 2001-05-22 | General Electric Company | Method and apparatus for zooming digital images |
| JP2002528390A (ja) * | 1998-10-02 | 2002-09-03 | セント エリザベス メディカル センター, インコーポレイテッド | 細胞の生存を増強するためのakt組成物 |
| AU1449500A (en) * | 1998-10-22 | 2000-05-08 | Curagen Corporation | Genes and proteins predictive and therapeutic for renal disease and associated disorders |
| JP2003524624A (ja) * | 1999-04-09 | 2003-08-19 | ジェシー エル エス オウ | 治療薬の組織への送達を高める方法及び組成物 |
| CA2373693A1 (en) * | 1999-05-20 | 2000-11-30 | Human Genome Sciences, Inc. | Seven transmembrane receptor genes |
| WO2001073033A2 (en) * | 2000-03-29 | 2001-10-04 | Beth Israel Deaconess Medical Center, Inc. | Anti-angiogenic and anti-tumor properties of matin and other laminin domains |
| JP2003532623A (ja) * | 2000-06-30 | 2003-11-05 | バイエル アクチェンゲゼルシャフト | 抗脈管形成性アンジオテンシン−7およびそれをコードするポリヌクレオチドを使用することによる脈管形成の調節方法 |
| JP2004516036A (ja) * | 2000-12-22 | 2004-06-03 | アストラゼネカ・アクチエボラーグ | Mas受容体に結合するダイノルフィンaのアゴニストまたはアンタゴニストを分析する方法 |
| WO2003072059A2 (en) * | 2002-02-27 | 2003-09-04 | Wake Forest University | Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth |
| WO2006005470A2 (en) * | 2004-07-15 | 2006-01-19 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with mas related g-protein coupled receptor e (mrge) |
| BRPI0503122A (pt) * | 2005-05-30 | 2007-05-02 | Univ Minas Gerais | composições farmacêuticas do peptìdeo angiotensina-(1-7) [ang-(1-7)] e seus análogos, agonistas e antagonistas usando as ciclodextrinas, seus derivados, e o polìmeros biodegradáveis e/ou dos produtos derivados para uso no controle das funções do sistema reprodutivo |
-
2005
- 2005-06-28 BR BRPI0502497-8A patent/BRPI0502497A/pt not_active Application Discontinuation
-
2006
- 2006-06-28 JP JP2008518575A patent/JP2008546811A/ja not_active Withdrawn
- 2006-06-28 CA CA002613126A patent/CA2613126A1/en not_active Abandoned
- 2006-06-28 WO PCT/BR2006/000125 patent/WO2007000036A2/en not_active Ceased
- 2006-06-28 EP EP06741348A patent/EP1904087A2/en not_active Withdrawn
- 2006-06-28 CN CNA2006800302306A patent/CN101247818A/zh active Pending
- 2006-06-28 US US11/922,949 patent/US20080312129A1/en not_active Abandoned
-
2013
- 2013-01-04 JP JP2013000248A patent/JP2013075911A/ja active Pending
-
2017
- 2017-02-28 JP JP2017036611A patent/JP2017114901A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1349530A (zh) * | 1999-05-05 | 2002-05-15 | 阿文蒂斯药物德国有限公司 | 作为血管紧张肽(1-7)受体兴奋剂的1-(p-噻吩基苄基)咪唑,其制备方法,其用途和含有它们的药物制剂 |
| CN1599620A (zh) * | 2001-11-05 | 2005-03-23 | 米纳斯吉拉斯联合大学 | 采用环糊精、脂质体和生物降解性聚合物和/或其混合物及其制品制备肽血管紧张素-(1-7 )和类似物、激动剂和拮抗剂制剂的方法 |
Non-Patent Citations (2)
| Title |
|---|
| 余琴等: "心血管结构和功能增龄性变化的超声评价研究进", 《泸州医学院学报》 * |
| 霍美蓉等: "药用辅料研究新进展--生物可降解聚合物", 《中国天然药物》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105873598A (zh) * | 2013-07-03 | 2016-08-17 | 代表亚利桑那大学的亚利桑那校董会 | 用于治疗认知功能障碍的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1904087A2 (en) | 2008-04-02 |
| WO2007000036A2 (en) | 2007-01-04 |
| BRPI0502497A (pt) | 2007-02-06 |
| JP2008546811A (ja) | 2008-12-25 |
| CA2613126A1 (en) | 2007-01-04 |
| US20080312129A1 (en) | 2008-12-18 |
| JP2013075911A (ja) | 2013-04-25 |
| JP2017114901A (ja) | 2017-06-29 |
| WO2007000036A3 (en) | 2007-05-18 |
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