JP2008546811A - 病気の研究、予防及び治療のためのアポトーシス活性調節剤としての、masg−タンパク質結合受容体アゴニスト及びアンタゴニストの使用 - Google Patents

病気の研究、予防及び治療のためのアポトーシス活性調節剤としての、masg−タンパク質結合受容体アゴニスト及びアンタゴニストの使用 Download PDF

Info

Publication number
JP2008546811A
JP2008546811A JP2008518575A JP2008518575A JP2008546811A JP 2008546811 A JP2008546811 A JP 2008546811A JP 2008518575 A JP2008518575 A JP 2008518575A JP 2008518575 A JP2008518575 A JP 2008518575A JP 2008546811 A JP2008546811 A JP 2008546811A
Authority
JP
Japan
Prior art keywords
agonists
mas
protein
peptides
coupled receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2008518575A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008546811A5 (enExample
Inventor
ドス サントス,ロブソン アウグスト ソウザ
ブラント ピネイロ,セルジオ ベロゾ
ファリア イ シルバ,ラファエル デ
ルラ,イバナ シルバ
ヂ ソウサ,フレデリコ バロス
ジャン ジョルジェス フレザルド,フレデリック
ヘイス,アデリナ マルタ ドス
フランカ ルイス ヘナト ヂ
フェレイラ,アンデルソン,ジョゼ
ダリオ シニステラ,ルーベン
ジェゼ カンパグノリ−サントス,マリア
オリベイラ サンパイオ,ウァルキリア ネイヂ ヂ
カストロ レアル,マルセロ ヂ
ベッケル,レニシ カペス
Original Assignee
ウニベルシダーヂ フェデラル ヂ ミナス ジェライス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウニベルシダーヂ フェデラル ヂ ミナス ジェライス filed Critical ウニベルシダーヂ フェデラル ヂ ミナス ジェライス
Publication of JP2008546811A publication Critical patent/JP2008546811A/ja
Publication of JP2008546811A5 publication Critical patent/JP2008546811A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/085Angiotensins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008518575A 2005-06-28 2006-06-28 病気の研究、予防及び治療のためのアポトーシス活性調節剤としての、masg−タンパク質結合受容体アゴニスト及びアンタゴニストの使用 Withdrawn JP2008546811A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI0502497-8A BRPI0502497A (pt) 2005-06-28 2005-06-28 uso de agonistas e antagonistas do receptor acoplado a proteìna g, mas, como moduladores de atividade apoptótica para o estudo, a prevenção e o tratamento de doenças
PCT/BR2006/000125 WO2007000036A2 (en) 2005-06-28 2006-06-28 Use of mas g-protein-coupled receptor agonists and antagonists as apoptotic activity modulators for prevention and treatment of diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013000248A Division JP2013075911A (ja) 2005-06-28 2013-01-04 病気の研究、予防及び治療のためのアポトーシス活性調節剤としての、masg−タンパク質結合受容体アゴニスト及びアンタゴニストの使用

Publications (2)

Publication Number Publication Date
JP2008546811A true JP2008546811A (ja) 2008-12-25
JP2008546811A5 JP2008546811A5 (enExample) 2009-08-20

Family

ID=37595483

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008518575A Withdrawn JP2008546811A (ja) 2005-06-28 2006-06-28 病気の研究、予防及び治療のためのアポトーシス活性調節剤としての、masg−タンパク質結合受容体アゴニスト及びアンタゴニストの使用
JP2013000248A Pending JP2013075911A (ja) 2005-06-28 2013-01-04 病気の研究、予防及び治療のためのアポトーシス活性調節剤としての、masg−タンパク質結合受容体アゴニスト及びアンタゴニストの使用
JP2017036611A Pending JP2017114901A (ja) 2005-06-28 2017-02-28 病気の研究、予防及び治療のためのアポトーシス活性調節剤としての、mas g−タンパク質結合受容体アゴニスト及びアンタゴニストの使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013000248A Pending JP2013075911A (ja) 2005-06-28 2013-01-04 病気の研究、予防及び治療のためのアポトーシス活性調節剤としての、masg−タンパク質結合受容体アゴニスト及びアンタゴニストの使用
JP2017036611A Pending JP2017114901A (ja) 2005-06-28 2017-02-28 病気の研究、予防及び治療のためのアポトーシス活性調節剤としての、mas g−タンパク質結合受容体アゴニスト及びアンタゴニストの使用

Country Status (7)

Country Link
US (1) US20080312129A1 (enExample)
EP (1) EP1904087A2 (enExample)
JP (3) JP2008546811A (enExample)
CN (1) CN101247818A (enExample)
BR (1) BRPI0502497A (enExample)
CA (1) CA2613126A1 (enExample)
WO (1) WO2007000036A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015532291A (ja) * 2012-10-02 2015-11-09 タリックス ファーマシューティカルズ リミテッド 脳状態の処置におけるアンジオテンシン

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0602366B1 (pt) 2006-04-26 2017-12-12 Universidade Federal De Minas Gerais Use of agonists of the receptor coupled to protein g, but, in the treatment of metabolic syndrome, its components and their complications
WO2008052295A1 (en) * 2006-10-30 2008-05-08 Universidade Federal De Minas Gerais Process for the preparation of compounds of at1 receptor antagonists with angiotensin-(1-7), analogues thereof and/or mixtures of these systems, pharmaceutical compositions thereof and use of their derivative products
BRPI0806230A2 (pt) 2007-01-26 2021-05-25 Universidade Federal De Minas Gerais - Ufmg composições farmacêuticas, método para tratar a disfunção erétil e método para restaurar a capacidade de ereção
BRPI0800585B8 (pt) 2008-02-13 2021-05-25 Univ Minas Gerais composições farmacêuticas do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7) e uso do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7)
EP2163259B1 (en) 2008-09-12 2012-06-13 Charité-Universitätsmedizin Berlin (Charité) Use of an Ang-(1-7) receptor agonist in acute lung injury
DE102009013456A1 (de) * 2009-03-18 2010-09-23 GÖPFERICH, Achim, Prof. Dr. Nanopartikel für die Erkennung von Zellen, durch Bindung an G-Protein gekoppelte Rezeptoren
CN102337298B (zh) * 2011-08-19 2013-11-06 黄开红 一种输送siRNA的免疫纳米载体及其制备方法和应用
WO2013119870A1 (en) * 2012-02-10 2013-08-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of peripheral vascular disease
US8557958B1 (en) 2012-06-18 2013-10-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of diabetes
BR132012028005E2 (pt) * 2012-10-31 2014-11-18 Univ Minas Gerais Composições farmacêuticas contendo um agonista do receptor mas para o tratamento de doenças degenerativas musculares.
CA2916701A1 (en) * 2013-07-03 2015-01-08 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method for treating cognitive dysfunction
US9333233B2 (en) 2014-02-25 2016-05-10 Tarix Pharmaceuticals Ltd. Methods and compositions for the delayed treatment of stroke
US10183055B2 (en) 2014-07-21 2019-01-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications
EP3171886A4 (en) 2014-07-21 2018-01-24 The Arizona Board of Regents On Behalf of the University of Arizona Ang-(1-7) derviative oligopeptides and methods for using and producing the same
CN113207799B (zh) * 2021-03-19 2022-03-15 中山大学 一种二型糖尿病小鼠快速心衰模型的构建方法
EP4371556A1 (en) 2022-11-15 2024-05-22 Explicat Pharma GmbH Angiotensin(1-7) pharmaceutical compositions for inhalation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030203834A1 (en) * 2002-02-27 2003-10-30 Tallant E. Ann Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
JP2004516036A (ja) * 2000-12-22 2004-06-03 アストラゼネカ・アクチエボラーグ Mas受容体に結合するダイノルフィンaのアゴニストまたはアンタゴニストを分析する方法
JP2005511577A (ja) * 2001-11-05 2005-04-28 ユニベルシダデ フェデラル デ ミナス ジェライス − ユーエフエムジー シクロデキストリン、リポソーム及び生分解性ポリマー並びに/或いはそれらの混合物及び生成物を用いる、ペプチドアンギオテンシン−(1−7)並びにその類似体、作動薬及び拮抗薬の製剤の調製方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989363B1 (en) * 1997-12-11 2006-01-24 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
EP1096957A1 (en) * 1998-06-18 2001-05-09 Johns Hopkins University School of Medicine Methods and reagents for intramuscular delivery of nucleic acids
US6236766B1 (en) * 1998-09-11 2001-05-22 General Electric Company Method and apparatus for zooming digital images
JP2002528390A (ja) * 1998-10-02 2002-09-03 セント エリザベス メディカル センター, インコーポレイテッド 細胞の生存を増強するためのakt組成物
DE69911226D1 (de) * 1998-10-22 2003-10-16 Curagen Corp Prädiktive und therapeutische für nierenerkrankungen gene und proteine
JP2003524624A (ja) * 1999-04-09 2003-08-19 ジェシー エル エス オウ 治療薬の組織への送達を高める方法及び組成物
YU78601A (sh) * 1999-05-05 2005-07-19 Aventis Pharma Deutschland Gmbh. 1-(p-tienilbenzil)-imidazoli kao agonisti angiotenzin-(1-7)- receptora, postupak za njihovu proizvodnju, njihova primena i farmaceutski preparati koji ih sadrže
CA2373693A1 (en) * 1999-05-20 2000-11-30 Human Genome Sciences, Inc. Seven transmembrane receptor genes
NZ521625A (en) * 2000-03-29 2004-09-24 Beth Israel Hospital Anti-angiogenic and anti-tumor properties of matin and other laminin domains
JP2003532623A (ja) * 2000-06-30 2003-11-05 バイエル アクチェンゲゼルシャフト 抗脈管形成性アンジオテンシン−7およびそれをコードするポリヌクレオチドを使用することによる脈管形成の調節方法
WO2006005470A2 (en) * 2004-07-15 2006-01-19 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with mas related g-protein coupled receptor e (mrge)
BRPI0503122A (pt) * 2005-05-30 2007-05-02 Univ Minas Gerais composições farmacêuticas do peptìdeo angiotensina-(1-7) [ang-(1-7)] e seus análogos, agonistas e antagonistas usando as ciclodextrinas, seus derivados, e o polìmeros biodegradáveis e/ou dos produtos derivados para uso no controle das funções do sistema reprodutivo

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004516036A (ja) * 2000-12-22 2004-06-03 アストラゼネカ・アクチエボラーグ Mas受容体に結合するダイノルフィンaのアゴニストまたはアンタゴニストを分析する方法
JP2005511577A (ja) * 2001-11-05 2005-04-28 ユニベルシダデ フェデラル デ ミナス ジェライス − ユーエフエムジー シクロデキストリン、リポソーム及び生分解性ポリマー並びに/或いはそれらの混合物及び生成物を用いる、ペプチドアンギオテンシン−(1−7)並びにその類似体、作動薬及び拮抗薬の製剤の調製方法
US20030203834A1 (en) * 2002-02-27 2003-10-30 Tallant E. Ann Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015532291A (ja) * 2012-10-02 2015-11-09 タリックス ファーマシューティカルズ リミテッド 脳状態の処置におけるアンジオテンシン
JP2018090625A (ja) * 2012-10-02 2018-06-14 タリックス ファーマシューティカルズ リミテッド 脳状態の処置におけるアンジオテンシン

Also Published As

Publication number Publication date
US20080312129A1 (en) 2008-12-18
WO2007000036A2 (en) 2007-01-04
WO2007000036A3 (en) 2007-05-18
BRPI0502497A (pt) 2007-02-06
EP1904087A2 (en) 2008-04-02
JP2017114901A (ja) 2017-06-29
JP2013075911A (ja) 2013-04-25
CN101247818A (zh) 2008-08-20
CA2613126A1 (en) 2007-01-04

Similar Documents

Publication Publication Date Title
JP2017114901A (ja) 病気の研究、予防及び治療のためのアポトーシス活性調節剤としての、mas g−タンパク質結合受容体アゴニスト及びアンタゴニストの使用
Paul et al. Physiology of local renin-angiotensin systems
Dinh et al. Angiotensin receptors: distribution, signalling and function
Bader et al. Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
Gutkowska et al. Oxytocin revisited: its role in cardiovascular regulation
François et al. Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition
EP1158998B1 (en) Use of neuregulin for manipulating cardiac muscle function
Adiarto et al. ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy
Tallant et al. Angiotensin-(1–7) inhibits growth of cardiac myocytes through activation of the mas receptor
Cao et al. Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion
Gutkowska et al. The role of oxytocin in cardiovascular regulation
McCollum et al. Angiotensin-(1–7) attenuates angiotensin II-induced cardiac remodeling associated with upregulation of dual-specificity phosphatase 1
Pagliaro et al. Rethinking the renin-angiotensin system and its role in cardiovascular regulation
Boccalini et al. Relaxin protects cardiac muscle cells from hypoxia/reoxygenation injury: involvement of the Notch‐1 pathway
McCollum et al. Angiotensin-(1–7) abrogates mitogen-stimulated proliferation of cardiac fibroblasts
He et al. Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium
Zhang et al. Ghrelin protects heart against ERS-induced injury and apoptosis by activating AMP-activated protein kinase
Steckelings et al. The Renin—Angiotensin—Aldosterone System
Sun et al. Crosstalk between endothelial cell-specific calpain inhibition and the endothelial-mesenchymal transition via the HSP90/Akt signaling pathway
Gutkowska et al. Oxytocin revisited: It is also a cardiovascular hormone
Xiang et al. Cardiomyocyte-specific overexpression of human stem cell factor protects against myocardial ischemia and reperfusion injury
Lu et al. Ghrelin inhibited pressure overload–induced cardiac hypertrophy by promoting autophagy via CaMKK/AMPK signaling pathway
Ahmad et al. Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR
Yao et al. Tissue kallikrein and kinin infusion rescues failing myocardium after myocardial infarction
Jiang et al. Relationship between the contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of spontaneously hypertensive rats

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090629

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090629

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111129

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120228

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120306

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120529

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120904

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130104

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20130326

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20130415