CN101244125B - Medicament for treating exogenous fever - Google Patents
Medicament for treating exogenous fever Download PDFInfo
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- CN101244125B CN101244125B CN2008100814790A CN200810081479A CN101244125B CN 101244125 B CN101244125 B CN 101244125B CN 2008100814790 A CN2008100814790 A CN 2008100814790A CN 200810081479 A CN200810081479 A CN 200810081479A CN 101244125 B CN101244125 B CN 101244125B
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Abstract
The invention discloses a drug for the treatment of exogenous fever, belonging to the technical field of Chinese medicines, which is obtained by preparing honeysuckle, dandelion, bupleurum, forsythia suspense, gypsum and aspidium in a given weight ratio, the drug can be prepared into any common oral dosage form. The drug has the advantages of heat clearing and detoxication, defervescence, 92.6% cure rate in 24 hours, and 99.8% cure rate in 48 hours.
Description
Technical field
The present invention relates to the field of Chinese medicines, especially a kind of medicine for the treatment of fever caused by exogenous pathogens.
Background technology
The sign feature of fever caused by exogenous pathogens is based on heating, because the evil character of each internal organs sense is different with severe extent, sick position and the change of disease, its heating characteristics are also different.Clinical manifestation is varied, as fever with chills but generate heat not aversion to cold, alternate attack of chill and fever, hectic fever etc.The lighter's calorific potential is not high, and the time is of short duration, recovery following sweating; Weight person's high fever is persistent, the very then smart language of coma, or convulsion with unconsciousness, and consequence is serious.Because the very fast going from the exterior into the interior of pathogenic heat epidemic disease poison, so it is of short duration to defend exterior syndrome time time of occurrence clinically.Moreover pathogenic heat damage body fluid, show diseases such as xerostomia excessive thirst simultaneously in heating.The assertive evidence onset is hurried, moderate heating and hyperpyrexia about 2 weeks is arranged, with relevant disease with protopathy more, or cardiopalmus giddy uncomfortable in chest, or cough with asthma chest pain abundant expectoration, or the vomiting and nausea stomachache of having loose bowels, or thirsty frequent micturition is easily hungry weak, or dribbling urination shoot, or the macule jaundice, or the sucutaneous nodule scrofula, or gather hemorrhage, or stiffness of the nape coma hemiplegia etc., serious threat human healthy.The medicine of treatment fever caused by exogenous pathogens mostly is based on Western medicine analgesic, antiinflammatory at present, side effect is bigger, some Chinese medicine products are also arranged, but onset is slow, curative effect is not good enough, therefore treatment cycle is long, develops and produce a kind ofly can treat heating paresthesia rapidly, effectively shortens the course of treatment and the medicine that has no side effect is that people expect.
Summary of the invention
Task of the present invention is the medicine that the febrile conditions that a kind of rapid treatment causes because of diseases caused by exogenous pathogenic factor is provided at the weak point of above existing issue, the effect that this medicine has heat-clearing and toxic substances removing, brings down a fever.
Medicament selection Flos Lonicerae of the present invention, Herba Taraxaci, Radix Bupleuri, Fructus Forsythiae, Gypsum Fibrosum, Rhizoma Osmundae make up, and make the effect of each medicine produce synergism these drug regimens, thereby can effectively treat the cat fever disease.Flos Lonicerae wherein: nature and flavor, sweet cold, heat-clearing and toxic substances removing.Be the dry flower of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera Dasystyla Rehd. or the flower that band is just opened.The flowers are in blossom gathers drying before putting for early summer; Or with the smoked after drying of sulfur.
Herba Taraxaci: the property bitter but sweet flavor is cold, heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Be Compositae herbaceos perennial Herba Taraxaci Herba Taraxaci.The Compendium of Material Medica record, the flat sweet and slightly bitter taste of its property has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds effect.
Radix Bupleuri: the nature and flavor hardship is slightly cold, induce sweat bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI.Dry root for umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd..
Fructus Forsythiae: the nature and flavor hardship is slightly cold, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Dry fruit for Oleaceae plant Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.
Gypsum Fibrosum: the property acrid-sweet flavor is cold, clearing away lung-heat, rushes down stomach-fire, and relieving restlessness is quenched the thirst.Gypsum Fibrosum Gypsum Fibrosuum is mainly the product of chemical deposition effect, often forms huge ore bed or lenticular body, composes to be stored in limestone, red shale and sandstone, marl and the clay series of rocks, symbiosis such as normal and anhydrite, halite.Generally excavate, after digging out, remove clean earth and assorted stone winter.
Rhizoma Osmundae: nature and flavor are bitter little slightly poisonous, heat-clearing and toxic substances removing.Be Dryopteridaceae plant Dryopteris bissetiaha (Bak) C. Chr-Nephrodium bisseianum Bak Dryopteris setosa (Thunb.) Akasawa rhizome.
By the said medicine combination, interact complementarity and mutual benefit, the effect of have heat-clearing and toxic substances removing, bringing down a fever.
In order to reach better therapeutic, medicine of the present invention also makes up with Cortex Moutan, Radix Paeoniae Rubra, Radix Isatidis, Radix Glycyrrhizae, wherein Cortex Moutan: the property bitter but sweet flavor is slightly cold, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Dry root bark for cohosh Paeonia suffruticosa Paeonia suffrutico Andr..Excavate root autumn, remove radicula, strip root bark, dry.
Radix Paeoniae Rubra: nature and flavor are bitter to be slightly cold.Clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.Root for ranunculaceae plant Radix Paeoniae (wild species), Paeonia obovata Maxim., river Radix Paeoniae Rubra etc." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " the purgation of spleen excess fire, sending down the abnormal ascending QI, promoting the circulation of blood, removing blood stasis with potent drugs, the clot that looses ends stomachache, moves back heat in blood, attacks the carbuncle skin ulcer, controls mange.″
Radix Isatidis: nature and flavor bitter Great Cold, heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Root for crucifer ancient name for Chinese cabbage basket and careless Folium Isatidis; Or acanthaceous vegetable acanthaceous indigo rhizome and root." Chinese medicinal herbal ": the detoxifcation of relieving inflammation or internal heat, cooling blood for hemostasis.
Radix Glycyrrhizae: nature and flavor are sweet flat, invigorating the heart and spleen, nourishing the lung to arrest cough, eliminating fire and detoxication, slow convulsion pain relieving.Be pulse family herbaceos perennial Radix Glycyrrhizae Radix Glycyrrhizae." Japan hanako materia medica " record: " the peace soul is decided soul.Mend five kinds of strain and seven kinds of impairment, all are deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle is separated cold and hot.”
Drug dose of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in the scope of following portions by weight: Flos Lonicerae 7-12 part, Herba Taraxaci 7-12 part, Radix Bupleuri 8-13 part, Fructus Forsythiae 3-7 part, Gypsum Fibrosum 30-45 part, Rhizoma Osmundae 7-12 part.
Its optimum ratio is: 9 parts of Flos Loniceraes, 9 parts of Herba Taraxacis, 10 parts of Radix Bupleuri, 5 parts of Fructus Forsythiaes, 38 parts in Gypsum Fibrosum, 9 parts of Rhizoma Osmundae.
Each amounts of components of medicine of the present invention can also be Flos Lonicerae 7-12 part, Herba Taraxaci 7-12 part, Radix Bupleuri 8-13 part, Fructus Forsythiae 3-7 part, Gypsum Fibrosum 30-45 part, Rhizoma Osmundae 7-12 part, Cortex Moutan 3-7 part, Radix Paeoniae Rubra 3-7 part, Radix Isatidis 7-12 part, Radix Glycyrrhizae 1-4 part.
Its optimum ratio is: 9 parts of Flos Loniceraes, 9 parts of Herba Taraxacis, 10 parts of Radix Bupleuri, 5 parts of Fructus Forsythiaes, 5 parts of Cortex Moutans, 5 parts of Radix Paeoniae Rubras, 38 parts in Gypsum Fibrosum, 9 parts of Rhizoma Osmundae, 9 parts of Radix Isatidis, 2 parts in Radix Glycyrrhizae.
Medicine of the present invention can adopt the conventional method of preparation Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, capsule, oral liquid etc.For example these crude drug pulverize mix homogeneously can be made the powder electuary; Can use decocting, get filtrate after filtration, add antiseptic and make oral liquid; Also can directly take decoction in case of necessity.
Effect such as medicine of the present invention has heat-clearing and toxic substances removing, bring down a fever, short treating period, evident in efficacy, without any side effects, according to clinical 120 routine patients being observed statistics, taking 24 hours cure rates of medicine of the present invention is that 92.6%, 48 hour cure rate is 99.8%.
The specific embodiment
Embodiment one, 7 parts of Flos Loniceraes, 7 parts of Herba Taraxacis, 8 parts of Radix Bupleuri, 3 parts of Fructus Forsythiaes, 30 parts in Gypsum Fibrosum, 7 parts of Rhizoma Osmundae.
Embodiment two, 9 parts of Flos Loniceraes, 9 parts of Herba Taraxacis, 10 parts of Radix Bupleuri, 5 parts of Fructus Forsythiaes, 38 parts in Gypsum Fibrosum, 9 parts of Rhizoma Osmundae.
Embodiment three, 12 parts of Flos Loniceraes, 12 parts of Herba Taraxacis, 13 parts of Radix Bupleuri, 7 parts of Fructus Forsythiaes, 38 parts in Gypsum Fibrosum, 9 parts of Rhizoma Osmundae.
Embodiment four, 7 parts of Flos Loniceraes, 7 parts of Herba Taraxacis, 8 parts of Radix Bupleuri, 3 parts of Fructus Forsythiaes, 3 parts of Cortex Moutans, 3 parts of Radix Paeoniae Rubras, 30 parts in Gypsum Fibrosum, 7 parts of Rhizoma Osmundae, 7 parts of Radix Isatidis, 1 part in Radix Glycyrrhizae.
Embodiment five, 9 parts of Flos Loniceraes, 9 parts of Herba Taraxacis, 10 parts of Radix Bupleuri, 5 parts of Fructus Forsythiaes, 5 parts of Cortex Moutans, 5 parts of Radix Paeoniae Rubras, 38 parts in Gypsum Fibrosum, 9 parts of Rhizoma Osmundae, 9 parts of Radix Isatidis, 2 parts in Radix Glycyrrhizae.
Embodiment six, 12 parts of Flos Loniceraes, 12 parts of Herba Taraxacis, 13 parts of Radix Bupleuri, 7 parts of Fructus Forsythiaes, 7 parts of Cortex Moutans, 7 parts of Radix Paeoniae Rubras, 45 parts in Gypsum Fibrosum, 12 parts of Rhizoma Osmundae, 12 parts of Radix Isatidis, 4 parts in Radix Glycyrrhizae.
Be the clinical observation of medicine of the present invention below:
One, general material
Accept out-patient's totally 120 examples for medical treatment, male's 50 examples wherein, women's 70 examples, men and women's ratio 0.7: 1.Age 8-20 year 50 examples, 21-30 year 18 examples, 31-40 year 22 examples, 30 examples more than 41 years old.
Two, diagnostic criteria
1, tcm diagnosis standard
Five serial symptoms:
(1), defend watch series: fever with aversion to cold maybe wouldn't be generated heat, and has a headache, and body is stranded, and antiperspirant or lossless is arranged, floating pulse, thin white fur of tongue;
(2), lung is defended series: fever with aversion to cold has antiperspirant or lossless, cough, sneeze, nasal obstruction, watery nasal discharge, pharyngalgia, floating and rapid pulse, tongue fur BOHUANG;
(3), Taiyang channel series: fever with aversion to cold, the headache, the person's back discomfort, general pain, lossless, aching pain in waist and back, floating and tense pulse, thin white fur of tongue;
(4), gastrointestinal series: fever with aversion to cold, feel sick, bitter taste, vomiting, stomachache, diarrhoea, floating-rolling pulse, tongue fur are greasy partially, Se Bai or Huang;
(5), mix series: fever with aversion to cold, headache, general pain, cough, pharyngalgia, vomiting, stomachache, diarrhoea, floating-rolling pulse number, tongue fur white spirit.
2, Western medicine diagnose standard
The human body normal body temperature is the 36.3-37.2 degree, is higher than this temperature and has a fever exactly.Based on infective fever, its diagnostic criteria is that heating all can appear in the acute and chronic infection due to the various pathogen (as virus, mycoplasma, rickettsia, antibacterial, spirillum, protozoon, parasite, fungus etc.) clinically.Its reason system is owing to metabolite or its detoxifying function of pathogen produce pyrogen in leukocyte.
3, Therapeutic Method
According to drug ratios of the present invention, take by weighing raw material (daily dose), obtain medicinal liquid according to the method for boiling medicine usually, every day, potion serviced once sooner or later.
4, efficacy assessment standard
Cure: body temperature is reduced to below 37 degree, and heating paresthesia does not have bounce-back.
Do not heal: body temperature is more than 37 degree, and heating paresthesia has bounce-back.
5, therapeutic outcome statistics
Claims (2)
1. a medicine for the treatment of fever caused by exogenous pathogens is characterized in that it is to be made by following bulk drugs: Flos Lonicerae 7-12 part, Herba Taraxaci 7-12 part, Radix Bupleuri 8-13 part, Fructus Forsythiae 3-7 part, Gypsum Fibrosum 30-45 part, Rhizoma Osmundae 7-12 part, Cortex Moutan 3-7 part, Radix Paeoniae Rubra 3-7 part, Radix Isatidis 7-12 part, Radix Glycyrrhizae 1-4 part.
2. medicine according to claim 1 is characterized in that wherein each amounts of components is 9 parts of Flos Loniceraes, 9 parts of Herba Taraxacis, 10 parts of Radix Bupleuri, 5 parts of Fructus Forsythiaes, 5 parts of Cortex Moutans, 5 parts of Radix Paeoniae Rubras, 38 parts in Gypsum Fibrosum, 9 parts of Rhizoma Osmundae, 9 parts of Radix Isatidis, 2 parts in Radix Glycyrrhizae.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100814790A CN101244125B (en) | 2008-02-17 | 2008-02-17 | Medicament for treating exogenous fever |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100814790A CN101244125B (en) | 2008-02-17 | 2008-02-17 | Medicament for treating exogenous fever |
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| CN101244125A CN101244125A (en) | 2008-08-20 |
| CN101244125B true CN101244125B (en) | 2010-12-15 |
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| CN2008100814790A Expired - Fee Related CN101244125B (en) | 2008-02-17 | 2008-02-17 | Medicament for treating exogenous fever |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074723A (en) * | 2016-08-01 | 2016-11-09 | 中山市中医院 | A kind of silver Artemisia Determination of Jiere mixture and preparation method thereof |
| CN109010642A (en) * | 2018-10-11 | 2018-12-18 | 方向坤 | A kind of Chinese medicine composition and preparation method thereof for treating fever |
| CN111840414A (en) * | 2020-08-15 | 2020-10-30 | 江西省科学院应用物理研究所 | Preparation method of Chinese patent medicine for strengthening prevention of 2019-nCoV infection |
| CN115813987A (en) * | 2022-11-09 | 2023-03-21 | 上海市嘉定区中医医院 | Traditional Chinese medicine composition for treating children's exogenous wind-heat syndrome and application thereof |
Citations (3)
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| CN1634437A (en) * | 2004-11-02 | 2005-07-06 | 北京正大绿洲医药科技有限公司 | Oral drop pills with fever allaying and detoxification function |
| CN1748736A (en) * | 2005-08-05 | 2006-03-22 | 北京阜康仁生物制药科技有限公司 | New medicine administration path for reducing heat and detoxicating injection an dits preparing process |
| CN1883651A (en) * | 2006-05-24 | 2006-12-27 | 佛山冯了性药业有限公司 | Chinese medicinal composition for treating wind-heat cold and preparation method thereof |
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- 2008-02-17 CN CN2008100814790A patent/CN101244125B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634437A (en) * | 2004-11-02 | 2005-07-06 | 北京正大绿洲医药科技有限公司 | Oral drop pills with fever allaying and detoxification function |
| CN1748736A (en) * | 2005-08-05 | 2006-03-22 | 北京阜康仁生物制药科技有限公司 | New medicine administration path for reducing heat and detoxicating injection an dits preparing process |
| CN1883651A (en) * | 2006-05-24 | 2006-12-27 | 佛山冯了性药业有限公司 | Chinese medicinal composition for treating wind-heat cold and preparation method thereof |
Non-Patent Citations (3)
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| 李文惠等.中医药对防治急性上呼吸道感染的临床应用.《哈尔滨医药》.2006,第26卷(第1期),41－43. * |
| 王茂盛.贯众.《中药学》.2004,(第1版), * |
| 米继强等.小儿外感热病中医药治疗近况.《中医儿科杂志》.2007,第3卷(第6期),50-52. * |
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