CN101239081A - Composition for treating cancer and preparation thereof - Google Patents
Composition for treating cancer and preparation thereof Download PDFInfo
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- CN101239081A CN101239081A CNA2007100071539A CN200710007153A CN101239081A CN 101239081 A CN101239081 A CN 101239081A CN A2007100071539 A CNA2007100071539 A CN A2007100071539A CN 200710007153 A CN200710007153 A CN 200710007153A CN 101239081 A CN101239081 A CN 101239081A
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Abstract
The invention relates to a compound for curing cancer and is characterized in that the compound includes the following ingredients with certain content (weight percentage): mythic fungus germ-entity extract: lucidum spore: Zhiling capsule is 10 to 30 percent: 10 to 30 percent: 40 to 80 percent, with the optimum ratio of 1:1:1.5. The compound can be made into hard capsules, soft capsules, tablets (including ordinary tablets, disintegrating tablets, buccal tablets and chewable tablets), grains and pills, which can be taken by mouth. The preparing method of the compound is characterized in that the mythic fungus germ-entity is firstly extracted with 60 percent ethanol and then with water, with the mythic fungus germ-entity extract obtained after the compounding; the lucidum spore has the shell physically broken up at a low temperature and under the normal pressure, with the shell breaking rate over 95 percent and the grain diameter of 0.4 to 0.5 microns. The lucidum spore which has the shell physically broken up can be firstly extracted with 60 percent ethanol and then with water, with the lucidum spore extract obtained after the compounding. When such extract is used to substitute for the lucidum spore which has the shell broken up, the content (weight percentage) of the ingredients of the compound is that mythic fungus germ-entity: lucidum spore extract: Zhiling capsule is 1 to 3: 0.1 to 0.5: 4 to 8, with the optimum ratio of 1:0.3:1.5. The lucidum spore or the lucidum spore extract can be separately made into hard capsules, soft capsules, tablets (including ordinary tablets, disintegrating tablets, buccal tablets and chewable tablets), grains and pills, which can be taken by mouth. The hard capsules, after mixed with the medical accessorial materials, are firstly made into grains which are then placed into capsules. The compound is easy to be absorbed by the human body and convenient to be used.
Description
One, technical field
The present invention is a kind of compositions for the treatment of cancer, hepatitis, and the method for preparation.With Ganoderma, Ganoderma spore retrofit and extraction, and then add ZHILING and carry out the science compatibility, make the anticancer effective component of Ganoderma, Ganoderma spore and ZHILING bring into play effect better.
Two, background technology
Phase earlier 1990s, the research and development of the relevant Ganoderma of China are active." 2005 editions records of Chinese pharmacopoeia: Ganoderma is Polyporaceae fungus Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganoderma lucidum (Leyss.exFr.) Karst. or Ganoderma Ganoderma sinense Zhao, the dry sporophore of Xu et Zhang and cultivation product.Major function is an invigorating QI and tranquilization, relieving cough and asthma; Be used for the treatment of dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.Modern study shows that its effective ingredient is mainly ganoderan, triterpene, polypeptide etc., and is effective in cure to diseases such as hepatitis, leukemia, tumor, diabetes, coronary heart disease, neurasthenias.
Ganoderma spore has more surprising medical value.Ganoderma spore contains all effective ingredient of Ganoderma, and the content height, can significantly improve the activity of immune cell, kills and wounds pathogen and cancerous cell, and will more help absorption by human body behind the breaking trachytectum of glossy ganoderma.Utilization the technology of the present invention, the Ganoderma spore powder with cellular wall broken capsule of production has finely been brought into play its antineoplastic action, and has passed through the national drug registration.
ZHILING is that manual method is cultivated isolating fermentation Cordyceps fungus powder.Be mainly used in the chronic cough dyspnea due to deficiency, chronic cough spitting of blood, impotence and seminal emission, soreness of waist and knee joint, and aspect such as tumor.With ZHILING and Ganoderma and Ganoderma spore compatibility, the effect of three's tonifying deficiency, beneficial vital essence, enhancing immunity is brought out the best in each other, more remarkable.
Ganoderma spore preparation (capsule, tablet, tea beverage, pill)
[1], Ganoderma extract and sporoderm-broken Ganoderma spore mixture powder
[2]And capsule
[3], Cordyceps and Ganoderma spore health product
[4]Have patent, but do not find any patent of Ganoderma extract, sporoderm-broken Ganoderma spore and ZHILING three mixture.
The Ganoderma spore powder with cellular wall broken that the present invention makes has passed through the clinical verification in national clinical verification base, has certain anti-tumor activity, and its functional component and pharmacological action see the following form.The capsular best usage and dosage of Ganoderma spore powder with cellular wall broken is oral, every day 3.6g.And other patented products are not seen clinical verification.
Ganoderma spore among the present invention picking again behind breaking cellular wall, the preparation of making promptly help absorbing, and help again taking.Undrawn dosage is big, is difficult to take.Do not see that extract makes capsular patent.Ganoderma spore powder among the present invention adds suitable adjuvant, makes granule, has improved flowability, is convenient to make capsule and control dosage.It is to be difficult to the control loading amount that other patented technologies are made capsule, thereby content uniformity is often defective.
The functional component of Ganoderma spore powder and pharmacological action
| Functional component | Pharmacological action |
| Triterpenoid compound | This triterpene is the Ganoderma endemic element, and the content height, have purify the blood, liver function protecting, the whole biological activity such as body resistance against diseases that improves |
| Polysaccharide | Be the main functional component of Ganoderma, have antitumor, immunomodulating, blood sugar lowering, blood fat reducing, antioxidation, the anti-ageing pharmacological action of waiting for a long time |
| Polypeptide | Provide 18 kinds among 20 seed amino acids of needed by human body, human body immunity improving power |
| Trace element | Contain various trace elements (as organic germanium, selenium etc.), have the effect of eliminating cancer current potential in the human body |
Three, summary of the invention
The purpose of this invention is to provide a kind of quality controllable, the compositions that is used for cancer, treating hepatitis that curative effect is more superior, and the preparation method.Purpose of the present invention can realize by following technology:
A kind of compositions is characterized in that, said composition comprises following component and content (percentage by weight): Ganoderma sporophore extract: Ganoderma spore: ZHILING is 10%-30%: 10%-30%: 40%-80%, and best proportioning is 1: 1: 1.5.
The preparation method of said composition is characterized in that, this method comprises following processing step:
1. the preparation of Ganoderma sporophore extract
Get Ganoderma powder and be broken into coarse powder, add 5 times of amounts of 60% ethanol, heating and refluxing extraction three times was extracted 1 hour at every turn, filtered (medicinal residues are standby), merging filtrate, and decompression recycling ethanol, and be condensed into the extractum of the about 1.05-1.10 of relative density (60 ℃), standby; Medicinal residues add 8 times of amounts of water and decoct three times, and each 1.5 hours, merging filtrate filtered, and filtrate decompression is condensed into the extractum of relative density 1.05-1.10 (60 ℃), and is standby; Merge above-mentioned two kinds of extractum, it is the extractum of 1.05 (60 ℃) that thin up becomes relative density, and spray drying promptly gets Ganoderma sporophore extract.
2. the preparation of sporoderm-broken Ganoderma spore
Ganoderma spore adopted carry out physical wall breaking under the low-temperature atmosphere-pressure, the applying vibration shearing mechanism carries out the air-flow superfine disruption, and machinery is furnished with cooling system, and temperature is controlled at below 35 ℃, and the antitumor effective ingredient is not destroyed.Sporoderm-broken rate reaches more than 95%, and particle diameter is 0.4～0.5 μ m.
Because the Ganoderma spore outer wall is the chitin shell that human body can not decompose fully, the effective ingredient behind the breaking cellular wall in the spore is released, and shell itself is nugatory.Therefore, the Ganoderma spore of the present invention after to breaking cellular wall carried out extracting research.Step is as follows:
The present invention is Ganoderma sporophore extract, sporoderm-broken ganoderma spores extract, ZHILING compositions, this constituent content (percentage by weight): Ganoderma sporophore extract: sporoderm-broken ganoderma spores extract: ZHILING is 10%-30%: 0.2%-1.0%: 40%-80%, and best proportioning is 1: 0.2: 1.5.
Above-mentioned Ganoderma sporophore extract, sporoderm-broken ganoderma spores extract, ZHILING are mixed according to a certain ratio, and add an amount of pharmaceutic adjuvant, make hard capsule, soft capsule, tablet (comprising ordinary tablet, disintegrating tablet, buccal tablet, chewable tablet), granule, pill etc. for oral dosage form.
Ganoderma sporophore is extracted processing, and design is used 60% ethanol extraction earlier, and the route of reuse water extraction is all fully extracted the triterpene of pure dissolubility and effective ingredient such as water miscible polysaccharide, peptide class.Water extract is only used in the production of LINGZHI JIAONANG at present.
Get the Ganoderma spore behind the breaking cellular wall, add 5 times of amounts of 60% ethanol, heating and refluxing extraction three times was extracted 1 hour at every turn, filter (medicinal residues are standby), and merging filtrate, decompression recycling ethanol, and be condensed into the extractum of the about 1.05-1.10 of relative density (60 ℃), standby; Medicinal residues add 8 times of amounts of water and decoct three times, and each 1.5 hours, merging filtrate filtered, and filtrate decompression is condensed into the extractum of relative density 1.05-1.10 (60 ℃), and is standby; Merge above-mentioned two kinds of extractum, it is the extractum of 1.05 (60 ℃) that thin up becomes relative density, and spray drying promptly gets sporoderm-broken ganoderma spores extract.The Ganoderma spore of breaking cellular wall is extracted, and is the improvement of patent (2) in the past with the Ganoderma extract compatibility again, and effective ingredient is proposed, and has dwindled the volume of compositions, helps making the dosage form of taking convenience.
Four. the specific embodiment
In conjunction with specific embodiments, the invention will be further described.
The preparation of embodiment 1. Ganoderma sporophore extract
Get Ganoderma powder and be broken into coarse powder, add 5 times of amounts of 60% ethanol, heating and refluxing extraction three times was extracted 1 hour at every turn, filtered (medicinal residues are standby), merging filtrate, and decompression recycling ethanol, and be condensed into the extractum of the about 1.05-1.10 of relative density (60 ℃), standby; Medicinal residues add 8 times of amounts of water and decoct three times, and each 1.5 hours, merging filtrate filtered, and filtrate decompression is condensed into the extractum of relative density 1.05-1.10 (60 ℃), and is standby; Merge above-mentioned two kinds of extractum, it is the extractum of 1.05 (60 ℃) that thin up becomes relative density, and spray drying promptly gets Ganoderma sporophore extract.
The preparation of embodiment 2. sporoderm-broken Ganoderma spores
Ganoderma spore powder is added in the jet mill, and the open cold radiator cooler is regulated pulverizer rotating speed and input and output material speed, and temperature is controlled at below 35 ℃, guarantees that sporoderm-broken rate reaches more than 95%, and particle diameter is 0.4～0.5 μ m.
The preparation of embodiment 3. sporoderm-broken ganoderma spores extracts
Get the Ganoderma spore powder behind the embodiment 2. described breaking cellular walls, add 5 times of amounts of 60% ethanol, heating and refluxing extraction three times, the each extraction 1 hour filters (medicinal residues are standby) merging filtrate, decompression recycling ethanol, and be condensed into the extractum of the about 1.05-1.10 of relative density (60 ℃), standby; Medicinal residues add 8 times of amounts of water and decoct three times, and each 1.5 hours, merging filtrate filtered, and filtrate decompression is condensed into the extractum of relative density 1.05-1.10 (60 ℃), and is standby; Merge above-mentioned two kinds of extractum, it is the extractum of 1.05 (60 ℃) that thin up becomes relative density, and spray drying promptly gets sporoderm-broken ganoderma spores extract.
The preparation of embodiment 4. composition capsules
According to Ganoderma sporophore extract: Ganoderma spore powder with cellular wall broken: ZHILING (percentage by weight) is that (Ganoderma spore powder with cellular wall broken can replace with embodiment 3. described spore powder extracts for 1: 1: 1.5 proportioning, spore powder extract consumption calculates by the amount of extracting the forespore powder), add an amount of pharmaceutic adjuvant, mix homogeneously, make granule, dress up the compositions hard capsule with the 1# capsule.
Above-mentioned capsule is taken 3 every day, each 5.
The capsular preparation of embodiment 5. sporoderm-broken Ganoderma spores
The preparation of embodiment 6. composition tablets
According to Ganoderma sporophore extract: Ganoderma spore powder with cellular wall broken: ZHILING (percentage by weight) is that (Ganoderma spore powder with cellular wall broken can replace with embodiment 3. described spore powder extracts for 1: 1: 1.5 proportioning, spore powder extract consumption calculates by the amount of extracting the forespore powder), add an amount of pharmaceutic adjuvant, mix homogeneously, make granule, focus on by sheet and be pressed into composition tablet on the tablet machine.
The preparation of embodiment 7. composition granules
According to Ganoderma sporophore extract: Ganoderma spore powder with cellular wall broken: ZHILING (percentage by weight) is that (Ganoderma spore powder with cellular wall broken can replace with embodiment 3. described spore powder extracts for 1: 1: 1.5 proportioning, spore powder extract consumption calculates by the amount of extracting the forespore powder), add an amount of pharmaceutic adjuvant, mix homogeneously, make granule, granulate (make and can not and can be no more than 15% by the summation of No. five sieves by a sieve), 60 ℃ of dryings promptly get composition granule.
Embodiment 8. clinical verifications
Clinical trial shows, the compositions that the present invention mentions can improve put, the patient before and after the chemotherapy, especially make chemotherapy patients's insufficiency of the spleen disease, improve patient's mental status, guarantee that chemotherapy normally carries out.Appetite stimulator is arranged simultaneously, alleviate put, the effect of chemotherapy toxic side effect.
Affiliated Hospital of Medical University Of Anhui, Affiliated Hospital of Wannan Medical College belong to insufficiency of the spleen tumor patient to 160 routine Chinese medical discriminations, and to use rich spirit of the brave departed Ganoderma lucidum spore powder capsule result of the test as follows:
1, to tumor put, chemotherapy patients's total effective rate reaches more than 91%.This medicine as put, the paramedicines of chemotherapy, can improve insufficiency of the spleen disease, guarantee to put, chemotherapy normally carries out, alleviate put, chemotherapy toxic side effect, and own without any side effects.
2, safety observation index such as blood, urine, stool routine examination, hepatic and renal function do not have significant change before and after the case administration.
3, above clinical test results shows the antitumor medicine of rich spirit of the brave departed Ganoderma lucidum spore powder capsule as a kind of development of novel, as put, the adjuvant drug of chemotherapy truly has certain clinical value, be worth further promoting and using.
Anhui Chinese Medicine College Affiliated Hospital by clinical research embodiment treatment hepatitis B, observes the therapeutical effect of its liver protecting and ALT lowering with rich spirit of the brave departed Ganoderma lucidum spore powder capsule, and the result is as follows:
1, be more than 92% to the Patients with Viral Hepatitis total effective rate.
2, except that only a few has slight gastrointestinal reaction, almost there is not clinical toxic and side effects.
Appendix: the patent situation of mentioning in this description
[1] a kind of anticancer preparation preparation method application number 200410014761.9 publication number CN1569214A of Ganoderma spore
[2] a kind of Ganoderma preparation and preparation method thereof patent No. 97106520.9 Granted publication CN1056536C
[3] capsules of wall broken spore powder of ganoderma lucidum application number 02117141.6 publication number CN1377702A
[4] contain the health product application number 200510050603.3 publication number CN1709152A of Cordyceps and Ganoderma spore powder
Claims (5)
1. compositions that is used for cancer, treating hepatitis, it is characterized in that, said composition comprises following component and content (percentage by weight), Ganoderma sporophore extract: Ganoderma spore: ZHILING is 10%-30%: 10%-30%: 40%-80%, and best proportioning is 1: 1: 1.5.
2. compositions according to claim 1, when making extract, the content of said composition (percentage by weight), Ganoderma sporophore extract: Ganoderma spore extract: Ganoderma is 1-3: 0.1-0.5: 4-8, best proportioning is 1: 0.3: 1.5.
3. compositions according to claim 1 adds an amount of pharmaceutic adjuvant, makes hard capsule, soft capsule, tablet (comprising ordinary tablet, disintegrating tablet, buccal tablet, chewable tablet), granule, pill, promptly supplies oral dosage form.
4. sporoderm-broken Ganoderma spore of the present invention, or sporoderm-broken ganoderma spores extract, can directly add an amount of pharmaceutic adjuvant, make hard capsule, soft capsule, tablet (comprising ordinary tablet, disintegrating tablet, buccal tablet, chewable tablet), granule, pill, promptly supply oral dosage form.
5. preparation of compositions method according to claim 1 is characterized in that, this method comprises following processing step:
(1). the preparation of Ganoderma sporophore extract
Get Ganoderma powder and be broken into coarse powder, add 5 times of amounts of 60% ethanol, heating and refluxing extraction three times was extracted 1 hour at every turn, filtered (medicinal residues are standby), merging filtrate, and decompression recycling ethanol, and be condensed into the extractum of the about 1.05-1.10 of relative density (60 ℃), standby; Medicinal residues add 8 times of amounts of water and decoct three times, and each 1.5 hours, merging filtrate filtered, and filtrate decompression is condensed into the extractum of relative density 1.05-1.10 (60 ℃), and is standby; Merge above-mentioned two kinds of extractum, it is the extractum of 1.05 (60 ℃) that thin up becomes relative density, and spray drying promptly gets Ganoderma sporophore extract.
(2). the preparation of sporoderm-broken Ganoderma spore
Ganoderma spore adopted carry out physical wall breaking under the low-temperature atmosphere-pressure, the applying vibration shearing mechanism carries out the air-flow superfine disruption, and machinery is furnished with cooling system, and temperature is controlled at below 35 ℃, and the antitumor effective ingredient is not destroyed.Sporoderm-broken rate reaches more than 95%, and particle diameter is 0.4～0.5 μ m.
Perhaps get the Ganoderma spore behind the above-mentioned breaking cellular wall, add 5 times of amounts of 60% ethanol, heating and refluxing extraction three times was extracted 1 hour at every turn, filter (medicinal residues are standby), and merging filtrate, decompression recycling ethanol, and be condensed into the extractum of the about 1.05-1.10 of relative density (60 ℃), standby; Medicinal residues add 8 times of amounts of water and decoct three times, and each 1.5 hours, merging filtrate filtered, and filtrate decompression is condensed into the extractum of relative density 1.05-1.10 (60 ℃), and is standby; Merge above-mentioned two kinds of extractum, it is the extractum of 1.05 (60 ℃) that thin up becomes relative density, and spray drying promptly gets sporoderm-broken ganoderma spores extract.
Extract with sporoderm-broken Ganoderma spore substitutes sporoderm-broken Ganoderma spore, the constituent content of the described compositions of claim 1 (percentage by weight): Ganoderma sporophore extract: sporoderm-broken ganoderma spores extract: ZHILING is 10%-30%: 0.1%-1.0%: 40%-80%, and best proportioning is 1: 0.2: 1.5.
(3). capsule of the present invention, with after pharmaceutic adjuvant mixes, make granule earlier, reinstall capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100071539A CN101239081A (en) | 2007-02-06 | 2007-02-06 | Composition for treating cancer and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100071539A CN101239081A (en) | 2007-02-06 | 2007-02-06 | Composition for treating cancer and preparation thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201310057596 Division CN103169736A (en) | 2007-02-06 | 2007-02-06 | Composition for treating cancer and preparation method thereof |
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| CN101239081A true CN101239081A (en) | 2008-08-13 |
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| CNA2007100071539A Pending CN101239081A (en) | 2007-02-06 | 2007-02-06 | Composition for treating cancer and preparation thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485450A (en) * | 2009-02-20 | 2009-07-22 | 陈淑燕 | Health food containing Cordyceps sinensis and glossy ganoderma spore powder |
| CN102228107A (en) * | 2011-05-13 | 2011-11-02 | 宜兴市鸿润食用菌种植专业合作社 | Ganoderma lucidum tea and preparation method thereof |
| CN102379907A (en) * | 2011-10-31 | 2012-03-21 | 广西亿康药业股份有限公司 | Ganoderma lucidum double vitamin methionine preparation and production method thereof |
| CN102551040A (en) * | 2011-12-31 | 2012-07-11 | 上海善力健生物科技有限公司 | Method of preparing functional food by taking cordyceps sinensis and ganoderma lucidum spore powder as materials |
| CN102584968A (en) * | 2011-12-31 | 2012-07-18 | 上海善力健生物科技有限公司 | Method for extracting and purifying macromolecular active ingredients of plant |
| CN102793728A (en) * | 2012-08-24 | 2012-11-28 | 安徽哈博药业有限公司 | High-frequency oscillation wall-broken ganoderma lucidum spore powder |
| CN103054909A (en) * | 2013-02-04 | 2013-04-24 | 福建仙芝楼生物科技有限公司 | Capsule for alleviating physical fatigue and preparation method thereof |
| CN103239485A (en) * | 2013-01-24 | 2013-08-14 | 上海同济生物制品有限公司 | Cordyceps sinensis soft capsule and preparation method thereof |
| CN103932000A (en) * | 2014-04-30 | 2014-07-23 | 吉林市盛誉美康科技有限公司 | Ganoderma lucidum spore chewable tablet combined with bifidus factor as well as preparation technology thereof |
| CN104983751A (en) * | 2015-07-10 | 2015-10-21 | 广西仙草堂制药有限责任公司 | Immunity-boosting ganoderma lucidum health care product and preparing method thereof |
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2007
- 2007-02-06 CN CNA2007100071539A patent/CN101239081A/en active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485450A (en) * | 2009-02-20 | 2009-07-22 | 陈淑燕 | Health food containing Cordyceps sinensis and glossy ganoderma spore powder |
| CN102228107B (en) * | 2011-05-13 | 2013-05-08 | 宜兴市鸿润食用菌种植专业合作社 | Ganoderma lucidum tea and preparation method thereof |
| CN102228107A (en) * | 2011-05-13 | 2011-11-02 | 宜兴市鸿润食用菌种植专业合作社 | Ganoderma lucidum tea and preparation method thereof |
| CN102379907A (en) * | 2011-10-31 | 2012-03-21 | 广西亿康药业股份有限公司 | Ganoderma lucidum double vitamin methionine preparation and production method thereof |
| CN102379907B (en) * | 2011-10-31 | 2014-01-15 | 广西亿康药业股份有限公司 | Ganoderma lucidum double vitamin methionine preparation and production method thereof |
| CN102551040B (en) * | 2011-12-31 | 2013-07-24 | 上海善力健生物科技有限公司 | Method of preparing functional food by taking cordyceps sinensis and ganoderma lucidum spore powder as materials |
| CN102584968A (en) * | 2011-12-31 | 2012-07-18 | 上海善力健生物科技有限公司 | Method for extracting and purifying macromolecular active ingredients of plant |
| CN102584968B (en) * | 2011-12-31 | 2014-01-08 | 上海善力健生物科技有限公司 | Method for extracting and purifying macromolecular active ingredients of plant |
| CN102551040A (en) * | 2011-12-31 | 2012-07-11 | 上海善力健生物科技有限公司 | Method of preparing functional food by taking cordyceps sinensis and ganoderma lucidum spore powder as materials |
| CN102793728A (en) * | 2012-08-24 | 2012-11-28 | 安徽哈博药业有限公司 | High-frequency oscillation wall-broken ganoderma lucidum spore powder |
| CN103239485A (en) * | 2013-01-24 | 2013-08-14 | 上海同济生物制品有限公司 | Cordyceps sinensis soft capsule and preparation method thereof |
| CN103239485B (en) * | 2013-01-24 | 2014-11-26 | 上海同济生物制品有限公司 | Cordyceps sinensis soft capsule and preparation method thereof |
| CN103054909A (en) * | 2013-02-04 | 2013-04-24 | 福建仙芝楼生物科技有限公司 | Capsule for alleviating physical fatigue and preparation method thereof |
| CN103054909B (en) * | 2013-02-04 | 2014-09-10 | 福建仙芝楼生物科技有限公司 | Capsule for alleviating physical fatigue and preparation method thereof |
| CN103932000A (en) * | 2014-04-30 | 2014-07-23 | 吉林市盛誉美康科技有限公司 | Ganoderma lucidum spore chewable tablet combined with bifidus factor as well as preparation technology thereof |
| CN103932000B (en) * | 2014-04-30 | 2015-11-18 | 吉林市盛誉美康科技有限公司 | A kind of Reishi sporule powder chewable tablet of compound Oilgosaccharkdes and preparation technology thereof |
| CN104983751A (en) * | 2015-07-10 | 2015-10-21 | 广西仙草堂制药有限责任公司 | Immunity-boosting ganoderma lucidum health care product and preparing method thereof |
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