CN103239485B - Cordyceps sinensis soft capsule and preparation method thereof - Google Patents
Cordyceps sinensis soft capsule and preparation method thereof Download PDFInfo
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Abstract
The invention provides a cordyceps sinensis soft capsule and a preparation method thereof. The soft capsule comprises 24-28% of cordyceps sinensis extracting solution after enzymolysis, 25-32% of cordyceps sinensis mycelia extracting solution after enzymolysis, 40-48% of ganoderma lucidum spore oil and 3-5% of water-in-oil emulsifier. The preparation method of the soft capsule comprises the following steps of: (A) carrying out enzymolysis for 1-1.5 hours under the conditions that the pH value is 4-5 and the temperature is 45-55 DEG C; and (B) preparing the soft capsule by controlling the temperature at 25+/-2 DEG C and the humidity at 45%+/-5%: (1) fully mixing the cordyceps sinensis extracting solution and the ganoderma lucidum spore oil; (2) adding the emulsifier for stirring and emulsifying, and treating by a colloid mill; (3) dissolving; and (4) pelleting. According to the invention, the cordyceps sinensis extracting solution and the ganoderma lucidum spore oil are matched reasonably so as to form the water-in-oil emulsion in which a ganoderma lucidum spore oil film is coated outside the cordyceps sinensis extracting solution, thereby avoiding oil leakage; by carrying out enzymolysis on the cordyceps sinensis extracting solution, inactive substances in the cordyceps sinensis extracting solution are changed to active substances; and the cordyceps sinensis extracting solution is directly used, thereby avoiding the loss of active components and increasing the contents of functional components.
Description
Technical field
The invention belongs to health food technology field, relate to a kind of Dongchong Xiacao capsule and preparation method thereof.
Background technology
Traditional soft capsule preparation method has two kinds at present: the one, directly prepared by extractum.Another kind method is to be prepared by dried cream powder.These two kinds of method comparison of ingredients are single, and curative effect is limited.
Soft capsule because of crust be that gelatin can not be met water, meet after water rubber melt and miss content and softening can not final molding, therefore soft capsule content is carried out emulsifying and makes it to be transformed into the emulsifying form of water-in-oil type, prevent that soft capsule rubber from dissolving.
The emulsifying form of Water-In-Oil shape obtains wide model application in relevant industries such as cosmetics, medicine ointments.But this kind of technique is not applied in production process of soft capsules at present.Soft capsule is for the filling of the medicine oil solutions such as cod-liver oil, vitamin E, and people are not strange, but for Chinese medicine, are still in the incipient stage, belong to newer dosage form.Due to soft capsule have advantages of aesthetic in appearance, be uniformly dispersed, stablize, install accurately, bioavailability is high, its application at the field of Chinese medicines is also increasingly extensive, particularly contain for those Chinese medicine extract that volatile component is more and nature and flavor are pained, have more its unique embedding and cover effect.
Cordyceps not only has good therapeutic effect to cancer, diabetes, hepatopathy, pneumonopathy, nephropathy, anaphylactic disease, cardiovascular and cerebrovascular disease etc., the more important thing is, it is at two-ways regulation immunity, strong tonify deficiency and balance conditioning, keep fit, alleviate and prophylactic generation, especially the aspect such as the preventive effect to cancer, promotion recovery after being ill has definite effect.But in Cordyceps, some material can only be present in aqueous solution, can not extract and separate separately, can not be subject to the impact of humiture or just lose activity and volatile material after dehydration, as cordycepic acid, cordycepin, Cordyceps polysaccharide, aminoacid, Chinese caterpillar fungus polypeptide, protein and more than 40 are planted volatile material, various active enzyme etc., temperature can degeneration during higher than 60 DEG C, volatilization, thereby cause Cordyceps functional component obviously reduce or lose.Therefore, Cordyceps is more suitable for being prepared into soft capsule and takes, and makes after Dongchong Xiacao capsule, and the effective ingredient of Cordyceps is difficult for losing, and effect significantly promotes.
The existing production specifications of preparing Dongchong Xiacao capsule are:
Production environment: 25 ± 2 DEG C of temperature; Humidity 45% ± 5%.Use equipment: soft capsule production line.Workshop; Meet the requirement of 300,000 grades of sterile workshop of GMP regulation.
The formula of existing Dongchong Xiacao capsule is:
A. content formula: appropriate soybean oil, Cordyceps extract or powder, add appropriate suspending agent.
B. the formula of rubber: appropriate edible Gelatinum oxhide, appropriate purified water and glycerol.
Its processing technology is: batching, colloidal sol, pelleting, wash ball, the ball that dries in the air, lamp inspection.
The shortcoming of prior art is:
Content is more single, and only, with Cordyceps extract or powder, effective ingredient obviously reduces or loses, therefore large the and weak curative effect of consumption.
The physical attribute of edible Gelatinum oxhide is water solublity, " Cordyceps extract or powder " in its content done " Brownian movement " in the time storing, the random edible Gelatinum oxhide rubber wrapping up that clashes into, cause thus rubber damage, form pore, cause content seepage.
In addition, existing soft capsule content mostly is powder and grease class, and they are in the process through links such as high temperature, dry, pulverizing, and wherein contained active component is very easily destroyed and cause losing.
Summary of the invention
The object of this invention is to provide a kind of content of avoiding active component to run off, increase functional component, improve Dongchong Xiacao capsule of curative effect and preparation method thereof.
For achieving the above object, the present invention has adopted following technical scheme:
A kind of Dongchong Xiacao capsule, the content of this soft capsule is composed of the following components by weight percentage:
The formula that is Dongchong Xiacao capsule of the present invention is:
A: content formula: through Cordyceps mycelium extracting solution and the Cordyceps extracting solution of enzymolysis, appropriate Ganoderma spore oil, adds appropriate water-in-oil emulsifier (preferably S-80).
B: the formula of rubber: appropriate edible Gelatinum oxhide, adds purified water and glycerol.
The preparation method of above-mentioned Dongchong Xiacao capsule, carry out as follows:
(1) by Cordyceps extracting solution and the abundant enzymolysis of Cordyceps mycelium extracting solution: regulating extracting solution pH is 4～5, and temperature is 45～55 DEG C, after enzyme-added enzymolysis 1～1.5hr, carries out enzyme denaturing;
(2) making of soft capsule: control 25 ± 2 DEG C of temperature, humidity 45% ± 5%, comprises batching, mixing, emulsifying, colloidal sol, pelleting operation, carries out as follows:
(1) press formula ratio and fully mix homogeneously with Ganoderma spore oil through the Cordyceps extracting solution of enzymolysis with through the Cordyceps mycelium extracting solution of enzymolysis water in oil needs, incorporation time 20～40min;
(2) add and can reach the emulsifier for mixing emulsifying that is emulsified into water-in-oil type emulsion by formula ratio, cross colloid mill;
(3) colloidal sol;
(4) content good emulsifying is carried out to pelleting on soft capsule pellet press, make soft capsule soft gelatin capsule.
After above-mentioned mixing, emulsifying, colloidal sol, pelleting operation, also can wash ball, the ball that dries in the air, lamp inspection operation.
In above-mentioned manufacturing condition, the best pH of enzymolysis is 4.5, temperature is that 50 DEG C, time are 1h.
The disinfectant measure of workshop is: regularly weekly two hours ozone sterilizations, meet the requirement of 300,000 grades of sterile workshop of Chinese GMP regulation.
Dongchong Xiacao capsule of the present invention is by Cordyceps extracting solution, Cordyceps mycelium extracting solution through enzymolysis, carry out reasonable compatibility with Ganoderma spore oil, add appropriate emulsifying agent carries out emulsifying and makes it be transformed into water-in-oil type solution simultaneously, improved thus its curative effect, also having solved soft capsule content can only be by the problem of grease agent.
Ganoderma spore oil has two-ways regulation body immunity.The physiologically active of inhibition tumor cell, regeneration and the transfer of prevention cancerous cell.The meeting of creation therapy apparatus, make can only expectant treatment patient can have an opportunity to undergo surgery and Radiotherapy chemotherapy.Alleviate the toxic and side effects that patient causes because of Radiotherapy chemotherapy, especially leukopenia.Improve the toleration of patient to Radiotherapy chemotherapy; Reduce transfer, relapse rate after corrective surgery, Radiotherapy chemotherapy.
Dongchong Xiacao capsule of the present invention, by Cordyceps extracting solution and Cordyceps mycelium extracting solution and Ganoderma spore oil reasonable compatibility, simultaneously, " Cordyceps extracting solution " appearance in the content of soft capsule forms Ganoderma spore oil film, cut off contacting of contained humidity and surface water dissolubility edible Gelatinum oxhide in extracting solution, whole soft capsule content is made up of W/O (water/oil) two-phase, thus, overcome the shortcoming that prior art easily causes soft capsule leakage of oil, fully improve its curative effect, reduced dose.
The present invention, by enzymolysis Cordyceps extracting solution, Cordyceps mycelium extracting solution, makes wherein inert matter be converted into active substance; Directly use Cordyceps extracting solution simultaneously, avoided being extracted into powder and lose effective ingredient, solved thus and avoided that active component runs off, the problem of increase functional component content.
Beneficial effect of the present invention:
Dongchong Xiacao capsule of the present invention, oil phase in the content of soft capsule is through emulsifying, whole soft capsule content is made up of W/O (water/oil) two-phase, make the appearance of Cordyceps extracting solution to form firm oil film, cut off contacting of hydrone and surface water dissolubility edible Gelatinum oxhide; Enzymatic hydrolyzed extract, makes inert matter wherein be transformed into active substance simultaneously.The one, solve the shortcoming that prior art causes soft capsule leakage of oil; The 2nd, solve Cordyceps decoction and lost by being extracted into powder the problem of effective ingredient; By enzymolysis Cordyceps extracting solution, Cordyceps mycelium extracting solution, make inert matter wherein change into active substance simultaneously, increase the content of functional component; Directly, with Cordyceps extracting solution and Cordyceps mycelium extracting solution and Ganoderma spore oil reasonable compatibility, soft capsule curative effect is improved, reduced dose.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but the invention is not restricted to these detailed description of the invention.
Embodiment 1
A kind of Dongchong Xiacao capsule, the content of this soft capsule is composed of the following components by weight percentage:
The preparation method of above-mentioned Dongchong Xiacao capsule, carry out as follows:
(1) by Cordyceps extracting solution and the abundant enzymolysis of Cordyceps mycelium extracting solution: regulating extracting solution pH is 4.5, and temperature is 50 DEG C, after enzyme-added enzymolysis 1hr, carries out enzyme denaturing;
(2) making of soft capsule: control 25 ± 2 DEG C of temperature, humidity 45% ± 5%, comprises batching, mixing, emulsifying, colloidal sol, pelleting operation, carries out as follows:
(1) will need water in oil Cordyceps extracting solution and Cordyceps mycelium extracting solution fully to mix homogeneously with Ganoderma spore oil by formula ratio, incorporation time 20min;
(2) add and can reach the emulsifier for mixing emulsifying that is emulsified into water-in-oil type emulsion by formula ratio, cross colloid mill;
(3) colloidal sol;
(4) content good emulsifying is carried out to pelleting on soft capsule pellet press, make soft capsule soft gelatin capsule;
(5) after above-mentioned mixing, emulsifying, colloidal sol, pelleting operation, then wash ball, the ball that dries in the air, lamp inspection operation.
In addition, workshop is regularly carried out to ozone sterilization sterilization in weekly two hours.
Functional component content and the effect of the above-mentioned Dongchong Xiacao capsule making:
By enzymolysis processing Cordyceps extracting solution and Cordyceps mycelium extracting solution, make the content of Cordyceps polysaccharide in Cordyceps extracting solution improve 20%, cordycepin has improved 25%, and in Cordyceps mycelium extracting solution, the content of Cordyceps polysaccharide has improved 15%, and cordycepin has improved 17%; Meanwhile, directly use Cordyceps extracting solution and Cordyceps mycelium extracting solution and Ganoderma spore oil reasonable compatibility, improved the curative effect of soft capsule, reduced dose; And, the mixture of water solublity content Cordyceps extracting solution and Ganoderma spore oil is carried out to emulsifying together with emulsifying agent, make content be transformed into the emulsifying state of water-in-oil type, then at the content outer surface of water-in-oil emulsion state, wrap again one deck rubber, make the Dongchong Xiacao capsule containing water-in-oil type content, avoided the loss of Cordyceps polysaccharide in Cordyceps extracting solution, cordycepin isoreactivity composition, improved curative effect.
Embodiment 2
A kind of Dongchong Xiacao capsule, the content of this soft capsule is composed of the following components by weight percentage:
The preparation method of above-mentioned Dongchong Xiacao capsule, carry out as follows:
(1) by Cordyceps extracting solution and the abundant enzymolysis of Cordyceps mycelium extracting solution: regulating extracting solution pH is 4, and temperature is 55 DEG C, after enzyme-added enzymolysis 1.2hr, carries out enzyme denaturing;
(2) making of soft capsule: control 25 ± 2 DEG C of temperature, humidity 45% ± 5%, comprises batching, mixing, emulsifying, colloidal sol, pelleting operation, carries out as follows:
(1) will need water in oil Cordyceps extracting solution and Cordyceps mycelium extracting solution fully to mix homogeneously with Ganoderma spore oil by formula ratio, incorporation time 30min;
(2) add and can reach the emulsifier for mixing emulsifying that is emulsified into water-in-oil type emulsion by formula ratio, cross colloid mill;
(3) colloidal sol;
(4) content good emulsifying is carried out to pelleting on soft capsule pellet press, make soft capsule soft gelatin capsule;
(5) after above-mentioned mixing, emulsifying, colloidal sol, pelleting operation, then wash ball, the ball that dries in the air, lamp inspection operation.
In addition, workshop is regularly carried out to ozone sterilization sterilization in weekly two hours.
Functional component content and the effect of the above-mentioned Dongchong Xiacao capsule making:
By enzymolysis processing Cordyceps extracting solution and Cordyceps mycelium extracting solution, make the content of Cordyceps polysaccharide in Cordyceps extracting solution improve 19%, cordycepin has improved 24%, and in Cordyceps mycelium extracting solution, the content of Cordyceps polysaccharide has improved 14%, and cordycepin has improved 16%; Meanwhile, directly use Cordyceps extracting solution and Cordyceps mycelium extracting solution and Ganoderma spore oil reasonable compatibility, improved the curative effect of soft capsule, reduced dose; And, the mixture of water solublity content Cordyceps extracting solution and Ganoderma spore oil is carried out to emulsifying together with emulsifying agent, make content be transformed into the emulsifying state of water-in-oil type, then at the content outer surface of water-in-oil emulsion state, wrap again one deck rubber, make the Dongchong Xiacao capsule containing water-in-oil type content, avoided the loss of Cordyceps polysaccharide in Cordyceps extracting solution, cordycepin isoreactivity composition, improved curative effect.
Embodiment 3
A kind of Dongchong Xiacao capsule, the content of this soft capsule is composed of the following components by weight percentage:
The preparation method of above-mentioned Dongchong Xiacao capsule, carry out as follows:
(1) by Cordyceps extracting solution and the abundant enzymolysis of Cordyceps mycelium extracting solution: regulating extracting solution pH is 5, and temperature is 45 DEG C, after enzyme-added enzymolysis 1.5hr, carries out enzyme denaturing;
(2) making of soft capsule: control 25 ± 2 DEG C of temperature, humidity 45% ± 5%, comprises batching, mixing, emulsifying, colloidal sol, pelleting operation, carries out as follows:
(1) will need water in oil Cordyceps extracting solution and Cordyceps mycelium extracting solution fully to mix homogeneously with Ganoderma spore oil by formula ratio, incorporation time 40min;
(2) add and can reach the emulsifier for mixing emulsifying that is emulsified into water-in-oil type emulsion by formula ratio, cross colloid mill;
(3) colloidal sol;
(4) content good emulsifying is carried out to pelleting on soft capsule pellet press, make soft capsule soft gelatin capsule.
In addition, workshop is regularly carried out to ozone sterilization sterilization in weekly two hours.
Functional component content and the effect of the above-mentioned Dongchong Xiacao capsule making:
By enzymolysis processing Cordyceps extracting solution and Cordyceps mycelium extracting solution, make the content of Cordyceps polysaccharide in Cordyceps extracting solution improve 20%, cordycepin has improved 24%, and in Cordyceps mycelium extracting solution, the content of Cordyceps polysaccharide has improved 15%, and cordycepin has improved 16%; Meanwhile, directly use Cordyceps extracting solution and Cordyceps mycelium extracting solution and Ganoderma spore oil reasonable compatibility, improved the curative effect of soft capsule, reduced dose; And, the mixture of water solublity content Cordyceps extracting solution and Ganoderma spore oil is carried out to emulsifying together with emulsifying agent, make content be transformed into the emulsifying state of water-in-oil type, then at the content outer surface of water-in-oil emulsion state, wrap again one deck rubber, make the Dongchong Xiacao capsule containing water-in-oil type content, avoided the loss of Cordyceps polysaccharide in Cordyceps extracting solution, cordycepin isoreactivity composition, improved curative effect.
Embodiment 4
A kind of Dongchong Xiacao capsule, the content of this soft capsule is composed of the following components by weight percentage:
The preparation method of above-mentioned Dongchong Xiacao capsule, carry out as follows:
(1) by Cordyceps extracting solution and the abundant enzymolysis of Cordyceps mycelium extracting solution: regulating extracting solution pH is 4.5, and temperature is 50 DEG C, after enzyme-added enzymolysis 1hr, carries out enzyme denaturing;
(2) making of soft capsule: control 25 ± 2 DEG C of temperature, humidity 45% ± 5%, comprises batching, mixing, emulsifying, colloidal sol, pelleting operation, carries out as follows:
(1) will need water in oil Cordyceps extracting solution and Cordyceps mycelium extracting solution fully to mix homogeneously with Ganoderma spore oil by formula ratio, incorporation time 30min;
(2) add and can reach the emulsifier for mixing emulsifying that is emulsified into water-in-oil type emulsion by formula ratio, cross colloid mill;
(3) colloidal sol;
(4) content good emulsifying is carried out to pelleting on soft capsule pellet press, make soft capsule soft gelatin capsule.
In addition, workshop is regularly carried out to ozone sterilization sterilization in weekly two hours.
Functional component content and the effect of the above-mentioned Dongchong Xiacao capsule making:
By enzymolysis processing Cordyceps extracting solution and Cordyceps mycelium extracting solution, make the content of Cordyceps polysaccharide in Cordyceps extracting solution improve 21%, cordycepin has improved 26%, and in Cordyceps mycelium extracting solution, the content of Cordyceps polysaccharide has improved 16%, and cordycepin has improved 18%; Meanwhile, directly use Cordyceps extracting solution and Cordyceps mycelium extracting solution and Ganoderma spore oil reasonable compatibility, improved the curative effect of soft capsule, reduced dose; And, the mixture of water solublity content Cordyceps extracting solution and Ganoderma spore oil is carried out to emulsifying together with emulsifying agent, make content be transformed into the emulsifying state of water-in-oil type, then at the content outer surface of water-in-oil emulsion state, wrap again one deck rubber, make the Dongchong Xiacao capsule containing water-in-oil type content, avoided the loss of Cordyceps polysaccharide in Cordyceps extracting solution, cordycepin isoreactivity composition, improved curative effect.
Claims (7)
1. a Dongchong Xiacao capsule, is characterized in that, the content of this soft capsule is composed of the following components by weight percentage:
Described through the Cordyceps extracting solution of enzymolysis and through the Cordyceps mycelium extracting solution of enzymolysis as follows enzymolysis obtain: it is 4～5 that Cordyceps extracting solution or Cordyceps mycelium extracting solution are regulated to pH, temperature is 45～55 DEG C, after enzyme-added enzymolysis 1～1.5hr, carry out enzyme denaturing.
2. Dongchong Xiacao capsule according to claim 1, is characterized in that, described water-in-oil emulsifier is S-80.
3. a preparation method for Dongchong Xiacao capsule according to claim 1 and 2, is characterized in that, carries out as follows:
(1) by Cordyceps extracting solution and the abundant enzymolysis of Cordyceps mycelium extracting solution: regulating extracting solution pH is 4～5, and temperature is 45～55 DEG C, after enzyme-added enzymolysis 1～1.5hr, carries out enzyme denaturing;
(2) making of soft capsule: control 25 ± 2 DEG C of temperature, humidity 45% ± 5%, comprises batching, mixing, emulsifying, colloidal sol, pelleting operation, carries out as follows:
(1) press formula ratio and fully mix homogeneously with Ganoderma spore oil through the Cordyceps extracting solution of enzymolysis with through the Cordyceps mycelium extracting solution of enzymolysis water in oil needs, incorporation time 20～40min;
(2) add and can reach the emulsifier for mixing emulsifying that is emulsified into water-in-oil type emulsion by formula ratio, cross colloid mill;
(3) colloidal sol;
(4) content good emulsifying is carried out to pelleting on soft capsule pellet press, make soft capsule soft gelatin capsule.
4. the preparation method of Dongchong Xiacao capsule according to claim 3, is characterized in that, after above-mentioned mixing, emulsifying, colloidal sol, pelleting operation, also washes ball, the ball that dries in the air, lamp inspection operation.
5. according to the preparation method of the Dongchong Xiacao capsule described in claim 3 or 4, it is characterized in that, the pH of enzymolysis is 4.5, temperature is that 50 DEG C, time are 1h.
6. according to the preparation method of the Dongchong Xiacao capsule described in claim 3 or 4, it is characterized in that, workshop is regularly carried out to ozone sterilization sterilization in weekly two hours.
7. the preparation method of Dongchong Xiacao capsule according to claim 5, is characterized in that, workshop is regularly carried out to ozone sterilization sterilization in weekly two hours.
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Citations (3)
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| CN1839711A (en) * | 2005-03-31 | 2006-10-04 | 陈顺志 | Production method of Chinese caterpillar fungus soft capsule |
| CN101239081A (en) * | 2007-02-06 | 2008-08-13 | 周窑生 | Composition for treating cancer and preparation thereof |
| CN102308977A (en) * | 2010-07-09 | 2012-01-11 | 王润蛟 | Production technology of high cordycepin cordyceps militaris drink |
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|---|---|---|---|---|
| CN1839711A (en) * | 2005-03-31 | 2006-10-04 | 陈顺志 | Production method of Chinese caterpillar fungus soft capsule |
| CN101239081A (en) * | 2007-02-06 | 2008-08-13 | 周窑生 | Composition for treating cancer and preparation thereof |
| CN102308977A (en) * | 2010-07-09 | 2012-01-11 | 王润蛟 | Production technology of high cordycepin cordyceps militaris drink |
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| 谢红旗等.酶法提取蛹虫草中虫草素的研究.《时珍国医国药》.2011,第22卷(第9期), * |
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