CN101229279A - Collateral-dredging antihyperlipidemic product containing dark tea active substance and preparing method thereof - Google Patents
Collateral-dredging antihyperlipidemic product containing dark tea active substance and preparing method thereof Download PDFInfo
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Abstract
The invention provides a collateral-dredging lipid reduction product comprising active materials of black tea and a preparation method; the product consists of extracts of Anhua Red Tea and drug-food homologous substances; the preparation method of the invention produces a special and brand-new preparation method resulting from the formula specialty; the invention has the comprehensive functions of collateral dredging, lipid reduction, sugar reduction, decompression and weight reduction.
Description
Technical field:
The invention belongs to the natural biological technical field.Relate in particular to and be used to utilize a kind of collateral-dredging antihyperlipidemic product and preparation method that contains dark tea active substance.
Background technology:
Fat having become the most serious public health problem that developed country and the people of developing country face, also is the new great society difficult medical problem in the whole world.According to the statistics of World Health Organization (WHO), just have a people overweight among per two people, so World Health Organization (WHO) carry out keypoint control with obesity as a kind of serious chronic disease.What allow people's melancholy is that along with growth in the living standard, obese people just increases progressively with the speed in every year 20%, and is developing to the crowd that becomes younger.And have a large amount of scientific researches, experimental results show that obesity is closely related with multiple disease, as hypertension, hyperlipidemia, diabetes, cardiovascular and cerebrovascular disease, breast carcinoma, infertility, children's intelligence is low inferior.The fat generation that can cause diseases such as cardiovascular, gallbladder disease and hypertension, hyperlipidemia, type ii diabetes, apoplexy, cancer.There is statistics to show, 1 unit of the every increase of BMI (Body Mass Index), the initiation potential of hypertension just increases by 10%.China's population of being obese ratio increases rapidly at present, it is more and more outstanding that the puppy fat problem has seemed, with BMI (Body Mass Index) male greater than 27.8, the women greater than 27.3 as obesity standard, present population of being obese sum about 7,600 ten thousand in 18-74 year population, account for 5.85% of population, and about 13,000,000,000 RMB of consumption total value that be used to lose weight every year and obesity-related disease is treated.
The exploitation of slimming medicine is main according to two principles in the world at present: the first, and appetite-suppressing is such as sibutramine (sibutramine); The second, reduce absorption, such as Orlistat (orlistat).The two also is only two appetrol on the present Chinese market, and the former commodity Qu Mei by name can be elegant and difficult to understand bent light, latter's commodity celestial Buddhist nun's gram by name.The side effect of the two is fairly obvious, and sibutramine causes xerostomia, cardiopalmus, weak, and Orlistat causes oiliness just and fat-soluble avitaminosis.Western countries are also developing slimming medicine according to new principle always, such as, find that xanthine derivative class material can add the macro-energy expenditure by accelerating the vivo oxidation metabolism, a large amount of clinical trial proof caffeine (csffeine), ephedrine (ephedrine) uses separately or unites to use has certain fat-reducing effect, but because it can cause the side effect of tachycardias and cardiopalmus not obtain clinical permission always; Mice ob expression of gene product leptin (leptin) is found and cloned to middle nineteen nineties in last century, and prove that its rat for the genotype obesity has certain antiobesity action, but the individuality of genotype obesity only accounts for the 5-10% of obese individuals sum, and cause serious local congestion and swelling pain during this material drug administration by injection, therefore also do not obtain clinical permission so far.In sum, the main weak point of existing slimming medicine is that side effect is big and clinical effective rate is low, and to design not enough science relevant and these 2 deficiencies are all with drug target.
The Chinese herbal medicine particularly integration of edible and medicinal herbs class article in the Chinese herbal medicine is functional food resources of Chinese unique advantage, records the example of a large amount of Chinese herbal medicine Weight-reducing and lipid-lowerings at all times in the classic of TCM.But because existing research exists some defective and corresponding restriction, therefore China's slimming medicine and functional food of also really not having independent intellectual property right so far.Beijing in 2000 world obesity and fat-reducing conference propose to develop as early as possible the target that China has the Weight-reducing and lipid-lowering new drug of independent intellectual property right.National Development and Reform Committee, the Department of Science and Technology, Department of Commerce, four ministries and commissions of State Intellectual Property Office united hereinafter in 2007, and the fat-reducing, blood fat reducing, blood sugar lowering, the buck functionality food that development are had self-intellectual property are listed the biotechnology special project that China's emphasis is supported in.Therefore seek from Chinese herbal medicine Chinese medicine food homology class article can be used for losing weight, be unique target of the present invention the blood fat reducing, blood pressure lowering, functional food blood sugar lowering, effective.
Summary of the invention:
The purpose of a kind of collateral-dredging antihyperlipidemic product that contains dark tea active substance of the present invention and preparation method is really to solve in the weight losing function food merely loses weight for fat-reducing simply, clinical effectiveness is poor, side effect is big, can not really embody the principles of science of Chinese medicine aggregate balancing and the problem of clinical practice, and provide a kind of and can really embody the Chinese medicine synthesis treatment, mechanism is clear, target spot is clear and definite, effect obviously, a kind of collateral-dredging antihyperlipidemic product and preparation method that contains dark tea active substance of having no side effect substantially
Technical scheme of the present invention is as follows:
Of the present inventionly a kind ofly contain the collateral-dredging antihyperlipidemic product of dark tea active substance and the technical scheme of preparation method is, prescription of the present invention is made up of the extract of the article of ANHUA HEI CHA and multiple integration of edible and medicinal herbs; Preparation method of the present invention has produced special brand-new preparation method because of the particularity of prescription.What the recipe design of product of the present invention was the most outstanding a bit is, selecting of its formulation media, be to pass through a large amount of tests according to the back discovery, in the functional food that contains the teas material in the past, its selected green tea often, oolong tea, black tea etc., though its compatibility effect has certain antiobesity action, actual effect exists many indeterminate or places repeatedly.We are surprised to find that under study for action, and have a kind of by teas material that people ignored: ANHUA HEI CHA (having another name called FUZHUAN tea, brick tea, ornamental slab for paving the floor, blue bricks etc.), it is having aspect fat-reducing, blood fat reducing, blood pressure lowering, the blood sugar lowering and the diverse effect of other teas.ANHUA HEI CHA is the most special a kind of in China's six big teas.Its raw material is special, complex process, processing mechanism is special and unusual complicated, taste is unique and preserve, the effect uniqueness.What is meant by postfermented tea? say exactly, postfermented tea is that big, middle period colony's kind in employing tea district, snowy peak mountain range, Hunan is raw material, through completing, knead, four big processes such as wet heap, loose CHAIMING fire drying form have the dark brown pool of doing dark brown glossy, flavour is pure and mild or little puckery, the soup color is red bright and beautiful bright, the raw tea of the qualitative characteristics of slightly unique pine smoky flavour and be the general name that the raw material steaming is pressed into the compressed tea of shape with it.Of paramount importance is that postfermented tea is under the decomposition and metabolism of microorganism, has produced the secondary metabolite of a series of small molecule structure.This compounds facts have proved to have significant Weight-reducing and lipid-lowering, improve special efficacies such as diabetic symptom through drinking over the past thousands of years.Modern scientific research confirms that postfermented tea has effect and the effect that other teas does not have for aspects such as improving lipid metabolism, insulin metabolism.We can say that postfermented tea is a kind of natural function food of action range.Being used as formulation media of the present invention with postfermented tea, is a quantum jump that the modern times fat-reducing is also had simultaneously concurrently the comprehensive weight losing function food of blood fat reducing, blood sugar lowering, hypotensive effect, is epoch-making creation.
I find that under study for action (PeroxisomeProliferator-Activated Receptor PPAR) is a kind of nuclear receptor to peroxidase paraphyte activated receptor.This nuclear receptor and many diseases such as lipid metabolism, cardiovascular disease, cancer, diabetes and obesity etc. have confidential relation.PPAR only just has transcriptional activity when combining with part and being activated, and the therefore expression of may command target gene.PPAR has stored important effect well to nutraceutical metabolism.Method Buddhist nun's ester derivant X receptor (FXR) is a kind of bile acid receptor, there are four kinds of hypotypes to be FXR α 1, FXR α 2, FXR β 1 and FXR β 2, in bile acid biosynthesis and cholesterol metabolism, play a significant role, and be expected to become cholesterol reducing, treat the treatment target spot of some cardiovascular diseases and hepatic disease.Liver X receptor (liver X-activated receptor, LXR) be the member of nuclear receptor superfamily, comprise two kinds of homology hypotype LXR α (NR1H3) and LXR β (NR1H2), by metabolism, storage, absorption and the transhipment of transcriptional regulatory regulation and control cholesterol, thereby keep sterol and fatty acid metabolism balance.In addition, LXR also involved in sugar metabolism regulates, and activatory LXRs can be by suppressing the novel targets that the liver glyconeogenesis changes type ii diabetes.3T3-L1 is a kind of preceding adipose cell differentiation model, and adipose cell differentiation speed is proportionate with the accumulation degree of fat.
Therefore, adopting high flux screening is the means of innovating the advanced person of extensive use in natural drug and the development of functional food at present, and it can seek reactive compound quickly and efficiently, for the exploitation of natural product provides more drug candidate.Unusual lipidemia and obesity often adopt PPAR α, PPAR γ, PPAR δ, LXR, FXR and 3T3-L1 model to carry out the high flux screening medicine.The lowering blood-fat and reducing weight effect of these 6 kinds of scale-model investigation FUZHUAN tea is selected in this research for use, find that ANHUA HEI CHA all has activity to PPAR γ, PPAR δ, LXR, four kinds of models of FXR, illustrate that ANHUA HEI CHA itself has many blood fat reducing approach, be a kind of natural antihyperlipidemic product of action range, have stronger blood fat reducing activity.ANHUA HEI CHA as a kind of natural, drink time-honored beverage, be safe, and the MTS experimental result of ANHUA HEI CHA also further proves this point, therefore integration of edible and medicinal herbs class article in ANHUA HEI CHA and the Chinese herbal medicine combined to be expected to be developed to ideal natural fat-reducing medicament.This is because ANHUA HEI CHA has the ideal role that can reduce hyperlipemia by the cholesterol regulating metabolism.That is to say, after LXR is activated, can regulate and control metabolism, storage, absorption and the transhipment of cholesterol by transcriptional regulatory, increase cholesterol and from liver, discharge, reduce the absorption of small intestinal, keep sterol and lipid metabolism balance steroid, thereby the level of blood lipid regulation, and regulate lipoprotein metabolism.FXR is as the bile acid receptor, and it has different physiological roles, and the metabolic balance of keeping cholesterol is had important regulatory role.FXR activates and can suppress that cholesterol decomposition becomes bile acid in the liver, promote that bile acid is circulated back to liver by liver and gall, and the hydrolysis of increase very low density lipoprotein (VLDL) (VLDL) and the middle triglyceride of Chylomicron (CM), to reduce the level of VLDL and low density lipoprotein, LDL (LDL), increase the synthetic of high density lipoprotein (HDL), reduce the level of plasma triglyceride, may become the ideal medicament of treatment triglyceride.The isolating active substance of ethyl acetate extract in the ANHUA HEI CHA is very high to the activation degree of FXR, and the value of inducing is respectively 124 and 125, is the desirable feedstock that is developed to treatment hypertriglyceridemia medicine.The FXR antagonist can promote in the liver cholesterol decomposition to become bile acid to be excreted in the small intestinal side by side outside the class origin, reduces content of cholesterol in the blood, thereby plays the function of blood fat reducing.All there is inhibitory action at this explanation ANHUA HEI CHA each position to FXR, proves that all there is the effect of blood fat reducing at each position of ANHUA HEI CHA, and this also may be one of ethnic groups brother major reason that the hyperlipemia prevalence is low after taking ANHUA HEI CHA for a long time such as Xinjiang.Its same explanation ANHUA HEI CHA can be passed through the cholesterol regulating metabolic balance, reduces the content of cholesterol in liver and the blood, thereby reaches the purpose of lowering blood-fat and reducing weight.
Simultaneously, we find that also from Switzerland Roche Holding Ag in 1987 had found fat-reducing to be had effective lipase inhibitor lipstatin of obvious effect from Streptomyces toxytricini after, the orlistat character after its hydrogenation was more stable, and activity is stronger.The big quantity research of China's Chinese medicine circle also confirms, have many plants to exist the lipase inhibitor of this class and other active substance in Chinese herbal medicine, and the active substance that has is stronger, more effective than lipase inhibitor lipstatin.But the research of single composition has often been paid attention in existing research, and it is not studied following on the basis of theory of Chinese medical science the compatibility to these materials, comprises whole compatibility research and the side's of tearing open research.Thereby, in many weight losing function food, be difficult to obtain more science, more reasonable, better this series products.We have found that in the screening experiment to the integration of edible and medicinal herbs class article in a large amount of Chinese herbal medicine a peculiar compatibility phenomenon is, postfermented tea has goodish concertedness with the integration of edible and medicinal herbs class article extract that contains lipase inhibitor isoreactivity composition.The integration of edible and medicinal herbs class article of indication of the present invention have comprised following plant extract, as the solid and leaf of Radix Ginseng, Radix Salviae Miltiorrhizae, the Radix Polygoni Multiflori, Herba Epimedii, Flos Caryophylli, Radix Puerariae, Radix Et Rhizoma Rhei, Rhizoma Nelumbinis, Fructus Crataegi, Radix Notoginseng, Fructus Lycii, Poria, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Semen Ginkgo, Semen Astragali Complanati, Fructus Phyllanthi, Rhizoma amorphophalli, Fructus Fici, Herb Gynostemmae Pentaphylli, Semen Cassiae etc.These plants contain the biotin material and are meant its active component, and it can be polysaccharide, flavone, also can be glycoside etc., and they all contain and suppress fatty acid synthetase, activate fatty acyl-CoA synthetase and suppress the active component that adipose cell breaks up.These biotin active matters all with postfermented tea in small molecule active composition HP have goodish concertedness and homology.Both compatibilities make it also to have owned together trace copper, zinc, ferrum, magnesium, chromium and compositions such as VE, VC except that above-mentioned substance.
Common a kind of collateral-dredging antihyperlipidemic product and the preparation method that contains dark tea active substance formed of above-mentioned active component, it has not only embodied the principle of Chinese medicine synthesis treatment better.Importantly, basic ideas of the present invention are that novelty has formed the active component in the product of the present invention, obese people is comprised hyperlipidemia, hypertension, hyperglycemia population has played the important function of regulating the human body stable state, clear and definite adjusting human body stable state is that Chinese medicine is cured fat-reducing, blood fat reducing, blood pressure lowering, the principle of the basic outlet of blood sugar lowering patient crowd, and then formed the plant gene composition that exists already in the Chinese medicine can be effectively to obesity, hyperlipidemia, hypertension, the secretion of harmful substance and drainage in the hyperglycemia population human body, and the viewpoint of the comprehensive targeting symmetry treatment that the assimilation and the alienation of sugar imposed general equilibrium.This be because, I progressively recognize in scientific research for many years, the treatment of human diseases and rehabilitation course come down to that Chinese medicine genome compound (comprising the biotin material) is repaired the formed focus of the damaged gene of human body or the process of Organ Reconstruction.That is to say, the combination gene material that exists already in the Chinese medicine participated in the overall process human organ and even whole machine body health, damaged, repair, reproduce, healthy process.Body biomolecule and Chinese medicine drug molecule can be effectively carry out adjusting on the cellular level to the human body network, realize with the molecular network adjusting between gene expression aspect biological organs cell regeneration.Assortment of genes material in this Chinese medicine, the inventor temporarily is called Chinese medicine gene group or human organ translation factor.It can rebuild people's homeostasis comprehensively, and human body environment top layer, middle level, deep layer stable state are rebuild.With regard to the overweight people, it can make glycoprotein, lipid metabolism balance; Hormonal system and neural, immune system co-ordination; Insulin β cell function must send out performance normal, and gene is able to normal expression, and stable state reaches health value, and fat, blood pressure, blood glucose, glucose in urine are replied normal, and related complication disappears gradually and even all.This meets the traditional Chinese medical science fully mainly is the theory of animal economy functional disorder about the generation of disease.What differentiation of tcm was emphasized is the harmony of animal economy function because the treatment by Chinese herbs disease is not to emphasize that medicine directly removes to resist single virulence factor, it focus on regulating the body function state, the performance body resistance against diseases.In this process, relate to molecule---a plurality of aspects, number of ways that cell---organ---is whole realizing from hereditary information to whole steady state function.For example, the traditional Chinese medical science thinks, hyperlipidemia many by eating and drinking without temperance, consult food delicious food, strong, the lipid fortuneization mistake department of spleen fortune, and the unfavorable store essential substances liquid of deficiency of the kidney yin, Vent are in blood, in the raising blood due to the lipid concentration.And deficiency of kidney yin, edema with the liver involved lose to be supported, and embarrass and dredge Vent, so that the lipid metabolism imbalance, stay with fixed attention in blood, amass down for a long time, and QI-blood circulation is obstructed, and influences the five internal organs again and is in harmonious proportion, and further cause blood fat to increase and cause disease to develop and development.Therefore, must spleen invigoratingization turbid, supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling are able to spleen, kidney, liver fortuneization smoothly.Often from lung, spleen, kidney three dirty setting about, this is the summary that Chinese medicine enriched clinical experience in several thousand to TCM treatment of diabetes for another example.The act spleen is an example, spleen transfer function if not normal, then will cause the defeated cloth of water paddy body fluid and utilize unbalance and metabolism disorder in the process, this is the basic of morbidity.The traditional Chinese medical science thinks that disease is this earlier, and the back is sick to be mark.With regard to diabetes, transferring the defeated cloth of water paddy body fluid that functional imbalance causes and utilizing unbalance, metabolism disorder in the process of spleen must cause hyperglycemia, glucosuria, and this be; The various complication of association thus again, as hyperlipemia etc., this is mark.Therefore, must specimen in the treatment furthermore.Studies have shown that in a large number of modern medicine and modern Chinese medicine pharmacy, insulin resistant (insulin can not combine well with receptor) is one of topmost paathogenic factor of diabetes; Diabetes with Hypertension and atherosclerosis have a common basis, and promptly insulin resistant and hyperinsulinemia may be the main approach of curing type ii diabetes so reduce insulin resistant.The present invention has on the one hand also embodied its advantage at this, that is to say that the triple effect unification is held concurrently and controlled it, giving consideration to both the incidental and fundamental.Therefore, the other tool clever thought of the present invention ground in prescription compatibility the bioactive molecule HP in the ANHUA HEI CHA, it can make blood fat, blood pressure, blood glucose be controlled better, and solves the root and the complication of problem of obesity better from the source.This is because no matter HP is and other drug matching, also or single use, existing correlation test shows that HP can make the defeated cloth of general metabolite promote the biopotency of insulin by increasing blood flow; By reducing whole blood viscosity, HP can make matter transportation sugar and insulin get over the raising of film (as muscle, adipose cell etc.) ability, and carbohydrate metabolism improves obviously, the lipid metabolism increased activity, and lipid is drained and is quickened, and blood fat effectively reduces.It is as my discovery when studying TPS, and this will be to seek the breakthrough that the efficacious prescriptions medicine is arranged.Also must indicate out, we should pay attention to the trace element effect of Chinese medicine.Modern pharmacological research discloses, and the morbidity of human Simple Obesity also has certain genetic background.Human obesity be it is generally acknowledged the genus polygenic inheritance, and heredity plays a part one in its morbidity easily sends out, and fat formation still interacts relevant with living habits, trophic behavior, hobby, insulin response and socio-psychological factors.Exist two pairs of nucleuss relevant in the human hypothalamus with trophic behavior.A pair of for abdomen offside nuclear, claim satiety center again; Another is to claiming hungry maincenter again for ventral lateral nucleus.The satiety center excitation time has full sense and refusing to eat, during destruction then appetite heighten; Honey stomach during the famine central excitation, then anorexia refusing to eat during destruction.Under physiological condition, be in dynamic balance state, make appetite stimulator keep normal type normal range.A little less than the hypothalamus place blood brain barrier effect relative thin, the characteristics in this dissection make that multiple bioactie agent is easy to divide a word with a hyphen at the end of a line to this place in the blood, thereby trophic behavior is exerted an influence.These factors comprise: glucose, free fatty, norepinephrine, dopamine, 5-hydroxy tryptamine, insulin etc.In addition, Nervous and Mental Factors often influences appetite, and the function of feeding center is limited by the mental status, when spiritual hypertonicity and when sympathetic activation or adrenergic nerve irriate (especially the α receptor is preponderated), appetite is suppressed; When vagal excitation and insulin secretion when increasing, appetite is often hyperfunction.The effect of hyperinsulinemia in the obesity morbidity in recent years is noticeable.Fat normal with hyperinsulinemia and deposit, both cause effect relations remain further discussion, but it is generally acknowledged to be that hyperinsulinemia causes obesity.Hyperinsulinemia overweight people's insulin release is about 3 times of normal person.Islets of langerhans have the effect of significant promotion lipopexia, can be used as the fat monitoring factor in a sense.The effect that the promotion body fat of insulin increases is worked by following link: 1. promote glucose to enter in the cell, and then synthetic neutral fat; 2. the fat that suppresses in the adipose cell is employed.Hyperphagia and hyperinsulinemia and to deposit usually be the fat key factor that takes place and keep.The unusual brown adipose tissue of brown adipose tissue is just found in recent years a kind of fatty tissue, organizes corresponding with the white adipose around mainly being distributed in subcutaneous and internal organs.Brown adipose tissue has a very limited distribution, and only is distributed between omoplate, around nape portion, axillary region, mediastinum and the kidney, and its tissue appearance is light brown, and cell volume changes less relatively.The white adipose tissue is a kind of energy storage form, body with the energy of surplus with the neutral fat form preserve in, the white adipose cell volume with release can and the energy storage variation greatly.Brown adipose tissue is a kind of heat production organ on function, promptly when body is ingested or be subjected to cold stimulation, and fat combustion in the brown fat cell, thereby the energy metabolism level of decision body.More than two kinds of situations be referred to as meaning respectively and ingest and induce heat production and cold to induce heat production.This heat production tissue of brown adipose tissue is participated in total adjusting of intimate heat directly, and unnecessary heat in the body is distributed to external, and the human body energy metabolism is tended to balance.The research of relevant human obesity person brown adipose tissue is few, but can observe the patient of part heat production dysfunction obesity really.Other, hormone is to regulate lipometabolic key factor, especially the synthetic and mobilization of triglyceride is decomposed, and determines its increase and decrease trend by hormone by the adjusting to enzyme, and wherein insulin and PGE1 are to promote lipogenesis and suppress the decomposition major hormone; Catechol amines, glicentin, ACTH, MSH, TSH, GH, ADH and glucocorticoid, for promoting that steatolysis suppresses synthetic hormone, as the former supersecretion, the latter secretes minimizing; Can cause that lipogenesis increases, surpass and decompose and the generation obesity.The relation of this group endocrine factors and secondary obesity is more close.The pathogeny of obesity is the minimizing of blood fat, insulin beta cell excreting insulin.And the beta cell surface is the film that is made of a large amount of multiple proteins, to protect and to keep the 26S Proteasome Structure and Function of cell.Body is when some trace element of famine, and as copper, chromium, zinc, potassium, particularly when lacking copper, the special albumen of a kind of GLUT-2 by name can synthesize deficiency, and it must have influence on secretion of insulin, promotes the generation of diabetes.This is because secretion of insulin is subjected to the adjusting of nervus centralis, and copper is the conduction mediator of nervus centralis, can affect the nerves and transmits and reduce secretion of insulin and cause or increase the weight of diabetes so lack copper.Prescription of the present invention contains trace element and vitamin Cs such as copper, chromium, zinc, vitamin B, can significantly improve insulin resistant, increase the sensitivity of Insulin receptor INSR, increase the utilization of glucose, and can improve the microcirculation of insulin, alleviate insulin β cellular edema, be beneficial to the recovery of islet function, thereby make blood glucose, glucose in urine obtain permanently effective control, and progressively return to normal.Therefore, fat-reducing of the present invention, blood fat reducing, blood sugar lowering, blood pressure lowering mechanism and the homeostasis of regulating body, regulate immunologic function, improve insulin and its receptors bind, and enhancing β emiocytosis insulin, the activity of enzyme behind the recovery receptor, fundamentally regulate sugar, fat, proteinic metabolism, the aspects such as ability of enhancing body removing oxygen-derived free radicals demonstrate its advantage, this may pass through to recover the human body stable state for the biotin bioactive molecule component in the Chinese medicine, improves the immunity of body and comes to open up a new effective way for fat-reducing, blood fat reducing, blood sugar lowering, blood pressure lowering.
The specific embodiment
A kind of collateral-dredging antihyperlipidemic product and preparation method that contains dark tea active substance, it is characterized in that making: 2～500 parts of ANHUA HEI CHA, 3～35 parts of Radix Ginsengs by following material component and weight proportion, 3～40 parts of Radix Salviae Miltiorrhizaes, 2～30 parts of the Radixs Polygoni Multiflori, 2～50 parts of Herba Epimedii, 2～36 parts of Flos Caryophyllis, 3～42 parts of Radix Puerariaes, 2～16 parts of Radix Et Rhizoma Rhei, 3～28 parts on the solid and leaf of Rhizoma Nelumbinis, 4～18 parts of Fructus Crataegis, 2～20 parts of Radix Notoginseng, 5～50 parts of Fructus Lyciis, 3～25 parts in Poria, 3～18 parts of Pericarpium Citri Reticulataes, 2～16 parts of Rhizoma Alismatis, 2～16 parts of Semen Ginkgoes, 3～22 parts of Semen Astragali Complanatis, 3～22 parts of Fructus Phyllanthis, 4～12 parts of Rhizoma amorphophallis, 4～16 parts of Fructus Ficis, 3～40 parts of Herb Gynostemmae Pentaphyllis, 3～20 parts of Semen Cassiae.
Preparation method:
1, gather Anhua The Cloud Terrace daye tea by raw dark green tea preparation technology through complete, just rub, wet heap, rub again, technology such as drying makes postfermented tea tea base, and then it is dry about 100～200 ℃ of temperature, treat that it is available wind-force chipper chopping that water content reduces at 5～6.5% o'clock, screening, making diameter is 5～15mm, and black tea slices or the coarser powder of thickness between 1.5～4.5mm is standby.
2, any component in the solid and leaf of Radix Ginseng, Radix Salviae Miltiorrhizae, the Radix Polygoni Multiflori, Herba Epimedii, Flos Caryophylli, Radix Puerariae, Radix Et Rhizoma Rhei, Rhizoma Nelumbinis, Fructus Crataegi, Radix Notoginseng, Fructus Lycii, Poria, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Semen Ginkgo, Semen Astragali Complanati, Fructus Phyllanthi, Rhizoma amorphophalli, Fructus Fici, Herb Gynostemmae Pentaphylli, the Semen Cassiae is formed optimum component in preferred range, and letter sorting, be ground into coarser powder, add 8 times of water gaging digestions 2 times, 3 hours for the first time, 2 hours for the second time, collecting decoction left standstill 24 hours, get supernatant, concentrate standby.
3, making pharmacy of the present invention or functional food by all dosage forms that can adopt such as tablet, granule, capsule, medicinal tea respectively learns institute and allows the dosage form for preparing.
Above embodiment, to every those skilled in the art or the personnel relevant with this area may cause with association, expansion, mode such as contrast change, extend, situation in the analogy protection domain of the present invention all can be considered and occupies of the present invention.The above embodiments are only just given an example or proof to of the present invention.It can carry out the association or the expansion of wide in range property on this basis, and it also can carry out unconfined according to duplicating and recreating based on this.A kind of collateral-dredging antihyperlipidemic product and preparation method that contains dark tea active substance of the present invention advocates or makes to have protection equally to the principle, method, the technology that do not surmount category of the present invention, that is to say that it all belongs to protection scope of the present invention.
Claims (6)
1. a collateral-dredging antihyperlipidemic product and preparation method that contains dark tea active substance, it is characterized in that providing a kind of and can really embody the Chinese medicine synthesis treatment, mechanism is clear, target spot is clear and definite, effect obviously, a kind of collateral-dredging antihyperlipidemic product and preparation method that contains dark tea active substance of having no side effect substantially.
2. a kind of collateral-dredging antihyperlipidemic product and preparation method that contains dark tea active substance according to claim 1 is characterized in that its prescription is made up of the extract of the solid and leaf of the article Radix Ginseng of ANHUA HEI CHA and multiple integration of edible and medicinal herbs, Radix Salviae Miltiorrhizae, the Radix Polygoni Multiflori, Herba Epimedii, Flos Caryophylli, Radix Puerariae, Radix Et Rhizoma Rhei, Rhizoma Nelumbinis, Fructus Crataegi, Radix Notoginseng, Fructus Lycii, Poria, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Semen Ginkgo, Semen Astragali Complanati, Fructus Phyllanthi, Rhizoma amorphophalli, Fructus Fici, Herb Gynostemmae Pentaphylli, Semen Cassiae etc.These plants contain the biotin material and are meant its active component, and it can be polysaccharide, flavone, also can be glycoside, also have postfermented tea active small molecular material HP.
3. a kind of collateral-dredging antihyperlipidemic product and preparation method that contains dark tea active substance according to claim 1, it is characterized in that the active component in the product of the present invention, obese people is comprised hyperlipidemia, hypertension, hyperglycemia population has played the important function of regulating the human body stable state, clear and definite adjusting human body stable state is that Chinese medicine is cured fat-reducing, blood fat reducing, blood pressure lowering, the principle of the basic outlet of blood sugar lowering patient crowd, and then formed the plant gene composition that exists already in the Chinese medicine can be effectively to obesity, hyperlipidemia, hypertension, the secretion of harmful substance and drainage in the hyperglycemia population human body, and the viewpoint of the comprehensive targeting symmetry treatment that the assimilation and the alienation of sugar imposed general equilibrium.
4. a kind of collateral-dredging antihyperlipidemic product and preparation method that contains dark tea active substance according to claim 1, it is characterized in that gathering Anhua The Cloud Terrace daye tea by raw dark green tea preparation technology through complete, just rub, wet heap, rub again, technology such as drying makes postfermented tea tea base, and then it is dry about 100～200 ℃ of temperature, treat that it is available wind-force chipper chopping that water content reduces at 5～6.5% o'clock, screening, making diameter is 5～15mm, black tea slices or the coarser powder of thickness between 1.5～4.5mm.
5. a kind of collateral-dredging antihyperlipidemic product and preparation method that contains dark tea active substance according to claim 1, it is characterized in that Radix Ginseng, Radix Salviae Miltiorrhizae, the Radix Polygoni Multiflori, Herba Epimedii, Flos Caryophylli, Radix Puerariae, Radix Et Rhizoma Rhei, solid and the leaf of Rhizoma Nelumbinis, Fructus Crataegi, Radix Notoginseng, Fructus Lycii, Poria, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Semen Ginkgo, Semen Astragali Complanati, Fructus Phyllanthi, Rhizoma amorphophalli, Fructus Fici, Herb Gynostemmae Pentaphylli, any component in the Semen Cassiae is formed optimum component in preferred range, and letter sorting, be ground into coarser powder, add 8 times of water gaging digestions 2 times, 3 hours for the first time, 2 hours for the second time, collecting decoction, left standstill 24 hours, get supernatant, concentrate standby.
6. a kind of collateral-dredging antihyperlipidemic product and preparation method that contains dark tea active substance according to claim 1 is characterized in that it can make pharmacy that all dosage forms that can adopt such as tablet, granule, capsule, medicinal tea make or functional food and learn institute and allow the dosage form for preparing.
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