CN101228175A - 具有肌肉松弛和抗炎活性的硫秋水仙苷类似物 - Google Patents

具有肌肉松弛和抗炎活性的硫秋水仙苷类似物 Download PDF

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Publication number
CN101228175A
CN101228175A CNA2006800267270A CN200680026727A CN101228175A CN 101228175 A CN101228175 A CN 101228175A CN A2006800267270 A CNA2006800267270 A CN A2006800267270A CN 200680026727 A CN200680026727 A CN 200680026727A CN 101228175 A CN101228175 A CN 101228175A
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CN
China
Prior art keywords
exch
colchicine
demethoxylation
amino thio
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800267270A
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English (en)
Chinese (zh)
Inventor
G·丰塔纳
E·邦巴尔代利
A·里瓦
P·莫拉佐尼
D·波卡尔
M·L·杰尔米
G·蓬特雷莫利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Publication of CN101228175A publication Critical patent/CN101228175A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CNA2006800267270A 2005-07-22 2006-07-20 具有肌肉松弛和抗炎活性的硫秋水仙苷类似物 Pending CN101228175A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001418A ITMI20051418A1 (it) 2005-07-22 2005-07-22 Analoghi del tiocolchicoside ad attivita'miorilassante e antiinfiammatoria
ITMI2005A001418 2005-07-22

Publications (1)

Publication Number Publication Date
CN101228175A true CN101228175A (zh) 2008-07-23

Family

ID=37420844

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800267270A Pending CN101228175A (zh) 2005-07-22 2006-07-20 具有肌肉松弛和抗炎活性的硫秋水仙苷类似物

Country Status (14)

Country Link
EP (1) EP1907405A1 (it)
JP (1) JP2009502755A (it)
KR (1) KR20080036585A (it)
CN (1) CN101228175A (it)
AU (1) AU2006271923A1 (it)
BR (1) BRPI0613680A2 (it)
CA (1) CA2615860A1 (it)
IL (1) IL188900A0 (it)
IT (1) ITMI20051418A1 (it)
MX (1) MX2008000968A (it)
NO (1) NO20080377L (it)
NZ (1) NZ565265A (it)
RU (1) RU2008102251A (it)
WO (1) WO2007009772A1 (it)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102448930A (zh) * 2009-05-27 2012-05-09 共有药物有限公司 硫代秋水仙碱衍生物、其制造方法和使用方法
CN102741223A (zh) * 2010-01-22 2012-10-17 共有药物有限公司 硫代秋水仙碱和秋水仙碱类似物、其制备方法和使用方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8421747B2 (en) * 2008-09-24 2013-04-16 Microsoft Corporation Object detection and user settings

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291550B1 (it) * 1997-04-11 1999-01-11 Indena Spa Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102448930A (zh) * 2009-05-27 2012-05-09 共有药物有限公司 硫代秋水仙碱衍生物、其制造方法和使用方法
CN102741223A (zh) * 2010-01-22 2012-10-17 共有药物有限公司 硫代秋水仙碱和秋水仙碱类似物、其制备方法和使用方法

Also Published As

Publication number Publication date
AU2006271923A1 (en) 2007-01-25
IL188900A0 (en) 2008-04-13
MX2008000968A (es) 2008-03-26
NO20080377L (no) 2008-02-01
EP1907405A1 (en) 2008-04-09
KR20080036585A (ko) 2008-04-28
NZ565265A (en) 2010-01-29
JP2009502755A (ja) 2009-01-29
RU2008102251A (ru) 2009-07-27
CA2615860A1 (en) 2007-01-25
WO2007009772A1 (en) 2007-01-25
BRPI0613680A2 (pt) 2011-01-25
ITMI20051418A1 (it) 2007-01-23

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