CA2615860A1 - Thiocolchicoside analogues with myorelaxant and anti-inflammatory activity - Google Patents

Thiocolchicoside analogues with myorelaxant and anti-inflammatory activity Download PDF

Info

Publication number
CA2615860A1
CA2615860A1 CA002615860A CA2615860A CA2615860A1 CA 2615860 A1 CA2615860 A1 CA 2615860A1 CA 002615860 A CA002615860 A CA 002615860A CA 2615860 A CA2615860 A CA 2615860A CA 2615860 A1 CA2615860 A1 CA 2615860A1
Authority
CA
Canada
Prior art keywords
exch
aminothiocolchicine
demethoxy
meoh
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002615860A
Other languages
English (en)
French (fr)
Inventor
Gabriele Fontana
Ezio Bombardelli
Antonella Riva
Paolo Morazzoni
Donato Pocar
Maria Luisa Gelmi
Guido Pontremoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Publication of CA2615860A1 publication Critical patent/CA2615860A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CA002615860A 2005-07-22 2006-07-20 Thiocolchicoside analogues with myorelaxant and anti-inflammatory activity Abandoned CA2615860A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT001418A ITMI20051418A1 (it) 2005-07-22 2005-07-22 Analoghi del tiocolchicoside ad attivita'miorilassante e antiinfiammatoria
ITMI2005A001418 2005-07-22
PCT/EP2006/007108 WO2007009772A1 (en) 2005-07-22 2006-07-20 Thiocolchicoside analogues with myorelaxant and anti-inflammatory activity

Publications (1)

Publication Number Publication Date
CA2615860A1 true CA2615860A1 (en) 2007-01-25

Family

ID=37420844

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002615860A Abandoned CA2615860A1 (en) 2005-07-22 2006-07-20 Thiocolchicoside analogues with myorelaxant and anti-inflammatory activity

Country Status (14)

Country Link
EP (1) EP1907405A1 (it)
JP (1) JP2009502755A (it)
KR (1) KR20080036585A (it)
CN (1) CN101228175A (it)
AU (1) AU2006271923A1 (it)
BR (1) BRPI0613680A2 (it)
CA (1) CA2615860A1 (it)
IL (1) IL188900A0 (it)
IT (1) ITMI20051418A1 (it)
MX (1) MX2008000968A (it)
NO (1) NO20080377L (it)
NZ (1) NZ565265A (it)
RU (1) RU2008102251A (it)
WO (1) WO2007009772A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8421747B2 (en) * 2008-09-24 2013-04-16 Microsoft Corporation Object detection and user settings
WO2010138670A2 (en) * 2009-05-27 2010-12-02 Mutual Pharmaceutical Company, Inc. Thiocolchicine derivatives, method of making and methods of use thereof
WO2011091114A2 (en) * 2010-01-22 2011-07-28 Mutual Pharmaceutical Company, Inc. Thiocolchicine and colchicine analogs, methods of making and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291550B1 (it) * 1997-04-11 1999-01-11 Indena Spa Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.

Also Published As

Publication number Publication date
AU2006271923A1 (en) 2007-01-25
IL188900A0 (en) 2008-04-13
MX2008000968A (es) 2008-03-26
NO20080377L (no) 2008-02-01
EP1907405A1 (en) 2008-04-09
KR20080036585A (ko) 2008-04-28
CN101228175A (zh) 2008-07-23
NZ565265A (en) 2010-01-29
JP2009502755A (ja) 2009-01-29
RU2008102251A (ru) 2009-07-27
WO2007009772A1 (en) 2007-01-25
BRPI0613680A2 (pt) 2011-01-25
ITMI20051418A1 (it) 2007-01-23

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Legal Events

Date Code Title Description
FZDE Discontinued