CN101223425B - 使用多层衬底结构的发光传感器 - Google Patents

使用多层衬底结构的发光传感器 Download PDF

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Publication number
CN101223425B
CN101223425B CN2006800261946A CN200680026194A CN101223425B CN 101223425 B CN101223425 B CN 101223425B CN 2006800261946 A CN2006800261946 A CN 2006800261946A CN 200680026194 A CN200680026194 A CN 200680026194A CN 101223425 B CN101223425 B CN 101223425B
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CN
China
Prior art keywords
sensor
luminescence
layer
substrat structure
radiation
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Expired - Fee Related
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CN2006800261946A
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English (en)
Chinese (zh)
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CN101223425A (zh
Inventor
M·M·J·W·范赫佩恩
D·J·W·克隆德
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Koninklijke Philips NV
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Koninklijke Philips Electronics NV
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CN2006800261946A 2005-07-18 2006-07-07 使用多层衬底结构的发光传感器 Expired - Fee Related CN101223425B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05106551.4 2005-07-18
EP05106551 2005-07-18
PCT/IB2006/052300 WO2007010428A2 (en) 2005-07-18 2006-07-07 Luminescence sensor using multi-layer substrate structure

Publications (2)

Publication Number Publication Date
CN101223425A CN101223425A (zh) 2008-07-16
CN101223425B true CN101223425B (zh) 2011-03-30

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CN2006800261946A Expired - Fee Related CN101223425B (zh) 2005-07-18 2006-07-07 使用多层衬底结构的发光传感器

Country Status (5)

Country Link
US (1) US7560708B2 (enExample)
EP (1) EP1907805B1 (enExample)
JP (1) JP2009543023A (enExample)
CN (1) CN101223425B (enExample)
WO (1) WO2007010428A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101395463B (zh) * 2005-09-22 2011-05-25 皇家飞利浦电子股份有限公司 包括至少两个线栅的发光传感器
JP5149299B2 (ja) * 2006-10-31 2013-02-20 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 空洞エネルギーを増加させるためのワイヤグリッドを使用したバイオセンサ
JP5409391B2 (ja) * 2007-02-12 2014-02-05 コーニンクレッカ フィリップス エヌ ヴェ ワイヤグリッドモニタ装置
US20110195516A1 (en) 2008-09-09 2011-08-11 Koninklijke Philips Electronics N.V. Wire grid substrate structure and method for manufacturing such a substrate
EP2182075A1 (en) 2008-10-20 2010-05-05 Koninklijke Philips Electronics N.V. Real-time high multiplex detection by primer extension on solid surfaces
JP2012509078A (ja) 2008-11-21 2012-04-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 二本鎖核酸特異色素を用いる固体表面でのリアルタイムマルチプレックスｐｃｒ検出
EP2198965A1 (en) 2008-12-19 2010-06-23 Koninklijke Philips Electronics N.V. Integrated device for automated simultaneous detection of multiple specific targets using nucleic acid amplification
EP2618130A1 (en) * 2012-01-17 2013-07-24 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
JP5798649B2 (ja) * 2014-03-05 2015-10-21 コーニンクレッカ フィリップス エヌ ヴェ マルチレイヤ基板構造を用いた発光センサ
WO2019055013A1 (en) * 2017-09-14 2019-03-21 Hewlett-Packard Development Company, L.P. DETECTION BY CHROMATOGRAPHY AND SPECTROSCOPY BY SURFACE ENHANCED LUMINESCENCE (SEL)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
CN1509210A (zh) * 2001-02-16 2004-06-30 维尔有限公司 光(生物)化学传感器装置的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009757B1 (en) 1978-09-25 1983-05-18 E.I. Du Pont De Nemours And Company Polyamide resins and process for preparing the same
US5418136A (en) * 1991-10-01 1995-05-23 Biostar, Inc. Devices for detection of an analyte based upon light interference
EP1105535A1 (en) * 1998-08-13 2001-06-13 U.S. Genomics Optically characterizing polymers
US6917726B2 (en) * 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6998251B2 (en) * 2001-01-12 2006-02-14 Syngenta Participations Ag Nanoporous membrane reactor for miniaturized reactions and enhanced reaction kinetics
DE60216735D1 (de) * 2001-02-21 2007-01-25 Univ Rochester Mikrokavitätsbiosensor, herstellungsverfahren und verwendungen davon
JP3897703B2 (ja) * 2002-01-11 2007-03-28 キヤノン株式会社 センサ装置およびそれを用いた検査方法
US6962822B2 (en) * 2002-08-07 2005-11-08 International Business Machines Corporation Discrete nano-textured structures in biomolecular arrays, and method of use
JP2004163122A (ja) * 2002-11-11 2004-06-10 Univ Waseda 微小開口膜、及び生体分子間相互作用解析装置とその解析方法
JP2005016963A (ja) * 2003-06-23 2005-01-20 Canon Inc 化学センサ、化学センサ装置
US7271896B2 (en) * 2003-12-29 2007-09-18 Intel Corporation Detection of biomolecules using porous biosensors and raman spectroscopy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
CN1509210A (zh) * 2001-02-16 2004-06-30 维尔有限公司 光(生物)化学传感器装置的制备方法

Also Published As

Publication number Publication date
WO2007010428A2 (en) 2007-01-25
US20080197292A1 (en) 2008-08-21
JP2009543023A (ja) 2009-12-03
EP1907805B1 (en) 2012-10-10
EP1907805A2 (en) 2008-04-09
US7560708B2 (en) 2009-07-14
CN101223425A (zh) 2008-07-16
WO2007010428A3 (en) 2007-04-05

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